DE69720479D1 - Fragmentierte polymere hydrogele zur verhinderung von gewebeverklebung und ihre herstellung - Google Patents

Fragmentierte polymere hydrogele zur verhinderung von gewebeverklebung und ihre herstellung

Info

Publication number
DE69720479D1
DE69720479D1 DE69720479T DE69720479T DE69720479D1 DE 69720479 D1 DE69720479 D1 DE 69720479D1 DE 69720479 T DE69720479 T DE 69720479T DE 69720479 T DE69720479 T DE 69720479T DE 69720479 D1 DE69720479 D1 DE 69720479D1
Authority
DE
Germany
Prior art keywords
production
prevent tissue
tissue bonding
hydrogels
fragmented
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69720479T
Other languages
English (en)
Other versions
DE69720479T2 (de
Inventor
G Wallace
J Reich
S Shargill
Felix Vega
Edward Osawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter Healthcare Corp
Original Assignee
Fusion Medical Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27107390&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69720479(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Fusion Medical Technologies Inc filed Critical Fusion Medical Technologies Inc
Application granted granted Critical
Publication of DE69720479D1 publication Critical patent/DE69720479D1/de
Publication of DE69720479T2 publication Critical patent/DE69720479T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001Use of materials characterised by their function or physical properties
    • A61L24/0015Medicaments; Biocides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001Use of materials characterised by their function or physical properties
    • A61L24/0031Hydrogels or hydrocolloids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52Hydrogels or hydrocolloids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/145Hydrogels or hydrocolloids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/418Agents promoting blood coagulation, blood-clotting agents, embolising agents
DE69720479T 1996-08-27 1997-08-14 Fragmentierte polymere hydrogele zur verhinderung von gewebeverklebung und ihre herstellung Expired - Lifetime DE69720479T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US70485296A 1996-08-27 1996-08-27
US704852 1996-08-27
US903674 1997-07-31
US08/903,674 US6063061A (en) 1996-08-27 1997-07-31 Fragmented polymeric compositions and methods for their use
PCT/US1997/015262 WO1998008550A1 (en) 1996-08-27 1997-08-14 Fragmented polymeric hydrogels for adhesion prevention and their preparation

Publications (2)

Publication Number Publication Date
DE69720479D1 true DE69720479D1 (de) 2003-05-08
DE69720479T2 DE69720479T2 (de) 2004-03-04

Family

ID=27107390

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69720479T Expired - Lifetime DE69720479T2 (de) 1996-08-27 1997-08-14 Fragmentierte polymere hydrogele zur verhinderung von gewebeverklebung und ihre herstellung

Country Status (10)

Country Link
US (1) US6063061A (de)
EP (1) EP0927053B1 (de)
JP (3) JP4418535B2 (de)
AU (1) AU719534B2 (de)
BR (1) BR9711241B8 (de)
CA (1) CA2264647C (de)
DE (1) DE69720479T2 (de)
IL (1) IL128496A (de)
RU (1) RU2207882C2 (de)
WO (1) WO1998008550A1 (de)

Families Citing this family (235)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6183497B1 (en) * 1998-05-01 2001-02-06 Sub-Q, Inc. Absorbable sponge with contrasting agent
US6071300A (en) * 1995-09-15 2000-06-06 Sub-Q Inc. Apparatus and method for percutaneous sealing of blood vessel punctures
US7871637B2 (en) * 1996-08-27 2011-01-18 Baxter International Inc. Dry hemostatic compositions and methods for their preparation
US8603511B2 (en) * 1996-08-27 2013-12-10 Baxter International, Inc. Fragmented polymeric compositions and methods for their use
US6706690B2 (en) 1999-06-10 2004-03-16 Baxter Healthcare Corporation Hemoactive compositions and methods for their manufacture and use
US6063061A (en) * 1996-08-27 2000-05-16 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US8303981B2 (en) 1996-08-27 2012-11-06 Baxter International Inc. Fragmented polymeric compositions and methods for their use
US7435425B2 (en) * 2001-07-17 2008-10-14 Baxter International, Inc. Dry hemostatic compositions and methods for their preparation
US7320962B2 (en) 1996-08-27 2008-01-22 Baxter International Inc. Hemoactive compositions and methods for their manufacture and use
US6066325A (en) * 1996-08-27 2000-05-23 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
AT407117B (de) * 1997-09-19 2000-12-27 Immuno Ag Fibrinschwamm
US6315753B1 (en) * 1998-05-01 2001-11-13 Sub-Q, Inc. System and method for facilitating hemostasis of blood vessel punctures with absorbable sponge
US20010045575A1 (en) * 1998-05-01 2001-11-29 Mark Ashby Device and method for facilitating hemostasis of a biopsy tract
EP1109498A4 (de) * 1998-08-04 2003-01-08 Fusion Medical Technologies Perkutane gewebekanalverschlussvorrichtung und verfahren
US6605294B2 (en) * 1998-08-14 2003-08-12 Incept Llc Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
US7335220B2 (en) 2004-11-05 2008-02-26 Access Closure, Inc. Apparatus and methods for sealing a vascular puncture
US6152943A (en) * 1998-08-14 2000-11-28 Incept Llc Methods and apparatus for intraluminal deposition of hydrogels
US7347850B2 (en) * 1998-08-14 2008-03-25 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
GB9826658D0 (en) * 1998-12-03 1999-01-27 Univ London Tissue repair
US20080114092A1 (en) * 1998-12-04 2008-05-15 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
US6679870B1 (en) * 1999-07-23 2004-01-20 Vasca, Inc. Methods and kits for locking and disinfecting implanted catheters
US6685694B2 (en) * 1999-07-23 2004-02-03 Vasca, Inc. Methods and kits for locking and disinfecting implanted catheters
US6371984B1 (en) * 1999-09-13 2002-04-16 Keraplast Technologies, Ltd. Implantable prosthetic or tissue expanding device
US6783546B2 (en) 1999-09-13 2004-08-31 Keraplast Technologies, Ltd. Implantable prosthetic or tissue expanding device
US6984219B2 (en) * 1999-09-23 2006-01-10 Mark Ashby Depth and puncture control for blood vessel hemostasis system
DE60137489D1 (de) * 2000-02-03 2009-03-12 Tissuemed Ltd Gerät zum verschliessen einer chirurgischen punktionswunde
GB0011169D0 (en) * 2000-05-10 2000-06-28 Reckitt & Colmann Prod Ltd Improvements in or relating to medicinal compositions
WO2002034304A1 (en) * 2000-10-23 2002-05-02 Tissuemed Limited Self-adhesive hydratable matrix for topical therapeutic use
US9080146B2 (en) 2001-01-11 2015-07-14 Celonova Biosciences, Inc. Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface
US8187625B2 (en) 2001-03-12 2012-05-29 Boston Scientific Scimed, Inc. Cross-linked gelatin composition comprising a wetting agent
FI20010540A0 (fi) * 2001-03-16 2001-03-16 Yli Urpo Antti Komposiitti pehmyt- ja kovakudosvammojen korjaamiseksi ja mainitun komposiitin käyttö
EP1392182A1 (de) * 2001-05-04 2004-03-03 Concentric Medical Hydrogel-vorrichtung zum verschluss eines blutgefässes
US7008440B2 (en) * 2001-11-08 2006-03-07 Sub-Q, Inc. System and method for delivering hemostasis promoting material to a blood vessel puncture site by fluid pressure
US6592608B2 (en) * 2001-12-07 2003-07-15 Biopsy Sciences, Llc Bioabsorbable sealant
WO2003035722A1 (en) 2001-09-25 2003-05-01 Southwest Research Institute Methods for controlling peptide solubility, chemically modified peptides, and stable solvent systems for producing same
US7923431B2 (en) 2001-12-21 2011-04-12 Ferrosan Medical Devices A/S Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis
CA2474723A1 (en) 2002-01-28 2003-08-07 Keraplast Technologies, Ltd. Bioactive keratin peptides
US7001987B2 (en) 2002-04-22 2006-02-21 Keraplast Technologies, Ltd. Hydrogel with controllable mechanical, chemical, and biological properties and method for making same
US6989437B2 (en) 2002-04-10 2006-01-24 Keraplast Technologies, Ltd. Methods for producing, films comprising, and methods for using heterogeneous crosslinked protein networks
US6914126B2 (en) 2002-04-10 2005-07-05 Keraplast Technologies, Ltd. Methods for producing, films comprising, and methods for using heterogenous crosslinked protein networks
US20080226723A1 (en) * 2002-07-05 2008-09-18 Celonova Biosciences, Inc. Loadable Polymeric Particles for Therapeutic Use in Erectile Dysfunction and Methods of Preparing and Using the Same
US7135027B2 (en) * 2002-10-04 2006-11-14 Baxter International, Inc. Devices and methods for mixing and extruding medically useful compositions
CN1739017B (zh) * 2002-12-11 2011-04-06 弗罗桑医疗设备公司 用作拭子的基于明胶的材料
SI1617823T1 (sl) * 2003-01-24 2019-07-31 Nicachet Ab Vrečka, ki obsega nikotinski sestavek za transmukozno dajanje
SE0302947D0 (sv) 2003-01-24 2003-11-07 Magle Ab A composition material for transmucosal delivery
CA2521661A1 (en) * 2003-04-04 2004-10-14 Tissuemed Limited Tissue-adhesive formulations
US9289195B2 (en) 2003-06-04 2016-03-22 Access Closure, Inc. Auto-retraction apparatus and methods for sealing a vascular puncture
US7331979B2 (en) * 2003-06-04 2008-02-19 Access Closure, Inc. Apparatus and methods for sealing a vascular puncture
US8834864B2 (en) * 2003-06-05 2014-09-16 Baxter International Inc. Methods for repairing and regenerating human dura mater
US20070020314A1 (en) * 2003-06-30 2007-01-25 Hirotaka Haro Adhesion inhibiting material for vertebral/spinal operation
US20050033157A1 (en) * 2003-07-25 2005-02-10 Klein Dean A. Multi-modality marking material and method
US8440225B2 (en) * 2003-08-07 2013-05-14 Ethicon, Inc. Process of making flowable hemostatic compositions and devices containing such compositions
US20060019868A1 (en) * 2004-01-30 2006-01-26 Pendharkar Sanyog M Hemostatic compositions and devices
US7927626B2 (en) * 2003-08-07 2011-04-19 Ethicon, Inc. Process of making flowable hemostatic compositions and devices containing such compositions
US20050036955A1 (en) * 2003-08-13 2005-02-17 Degould Michael D. Bioresorbable tooth extraction socket dressing
WO2005065079A2 (en) * 2003-11-10 2005-07-21 Angiotech International Ag Medical implants and fibrosis-inducing agents
US20050208095A1 (en) * 2003-11-20 2005-09-22 Angiotech International Ag Polymer compositions and methods for their use
US7875043B1 (en) 2003-12-09 2011-01-25 Sub-Q, Inc. Cinching loop
ATE475434T1 (de) * 2004-01-30 2010-08-15 Ferrosan As Hämostatische sprays und zusammensetzungen
US7109163B2 (en) * 2004-01-30 2006-09-19 Ethicon, Inc. Hemostatic compositions and devices
US20060275273A1 (en) * 2004-02-20 2006-12-07 Seyedin Mitchell S Intervertebral Disc Repair, Methods and Devices Therefor
EP1753860B1 (de) * 2004-02-20 2012-04-11 Isto Technologies Inc. Bandscheibenreparatur und verfahren dafür
US20050187429A1 (en) * 2004-02-23 2005-08-25 Poppas Dix P. Vaginal rejuvenation
US20050226936A1 (en) * 2004-04-08 2005-10-13 Q-Med Ab Method of soft tissue augmentation
US8119160B2 (en) * 2004-06-29 2012-02-21 Ethicon, Inc. Hemostatic compositions and devices
WO2006005340A1 (en) * 2004-07-09 2006-01-19 Ferrosan A/S Haemostatic composition comprising hyaluronic acid
KR20070051297A (ko) * 2004-08-03 2007-05-17 티슈메드 리미티드 조직-접착성 물질
US7439012B2 (en) 2004-08-17 2008-10-21 Wake Forest University Health Sciences Ambient stored blood plasma expanders containing keratose
US8348971B2 (en) 2004-08-27 2013-01-08 Accessclosure, Inc. Apparatus and methods for facilitating hemostasis within a vascular puncture
DE102004047115B9 (de) 2004-09-27 2007-10-31 Universität Hamburg Verfahren zur Herstellung einer Wundauflage
US7235592B2 (en) 2004-10-12 2007-06-26 Zimmer Gmbh PVA hydrogel
US9114162B2 (en) * 2004-10-25 2015-08-25 Celonova Biosciences, Inc. Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same
US9107850B2 (en) * 2004-10-25 2015-08-18 Celonova Biosciences, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
US20210299056A9 (en) 2004-10-25 2021-09-30 Varian Medical Systems, Inc. Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods
ATE503465T1 (de) 2004-10-25 2011-04-15 Celonova Biosciences Germany Gmbh Beladbare polyphosphazenhaltige teilchen für therapeutische und/oder diagnostische anwendungen sowie herstellungs- und verwendungsverfahren dafür
US8262693B2 (en) * 2004-11-05 2012-09-11 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
US8663225B2 (en) 2004-11-12 2014-03-04 Medtronic, Inc. Hydrogel bone void filler
US7530578B2 (en) * 2004-11-17 2009-05-12 Continental Commercial Products, Llc Step-on receptacle with tip prevention
AU2006216655B2 (en) 2005-02-23 2012-05-31 Zimmer Technology, Inc. Blend hydrogels and methods of making
US7857856B2 (en) * 2005-03-15 2010-12-28 Warsaw Ortho Pedic, Inc. Composite spinal nucleus implant with water absorption and swelling capabilities
US20060222596A1 (en) 2005-04-01 2006-10-05 Trivascular, Inc. Non-degradable, low swelling, water soluble radiopaque hydrogel polymer
US8257438B2 (en) * 2005-04-12 2012-09-04 Warsaw Orthopedic, Inc. Methods and devices for preserving motion in an articulating prosthetic disc
US9119901B2 (en) 2005-04-28 2015-09-01 Warsaw Orthopedic, Inc. Surface treatments for promoting selective tissue attachment to medical impants
US8414907B2 (en) 2005-04-28 2013-04-09 Warsaw Orthopedic, Inc. Coatings on medical implants to guide soft tissue healing
US20070009602A1 (en) 2005-06-24 2007-01-11 Setton Lori A Direct drug delivery system based on thermally responsive biopolymers
EP1940439B1 (de) 2005-08-11 2010-10-27 University Of Saskatchewan Verringerung von postoperativer adhäsionsbildung mit intraperitonealem glutamin
US20070074980A1 (en) * 2005-09-02 2007-04-05 Bankoski Brian R Implant rehydration packages and methods of use
US8920827B2 (en) 2005-10-21 2014-12-30 Wake Forest University Health Sciences Keratin bioceramic compositions
EP1940499B1 (de) * 2005-10-28 2016-06-08 Baxter International Inc. Applikator und verfahren zu seiner verwendung
US9101742B2 (en) * 2005-10-28 2015-08-11 Baxter International Inc. Gastrointestinal applicator and method of using same
US20070110788A1 (en) * 2005-11-14 2007-05-17 Hissong James B Injectable formulation capable of forming a drug-releasing device
US8262730B2 (en) 2005-12-07 2012-09-11 Zimmer, Inc. Methods of bonding or modifying hydrogels using irradiation
US20130172274A1 (en) 2005-12-20 2013-07-04 Duke University Methods and compositions for delivering active agents with enhanced pharmacological properties
US8841255B2 (en) * 2005-12-20 2014-09-23 Duke University Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides
CN101384272B (zh) 2005-12-20 2013-05-01 杜克大学 用于递送具有增强的药理性质的活性剂的方法和组合物
JP2007177244A (ja) 2005-12-22 2007-07-12 Zimmer Inc ペルフルオロシクロブタン架橋ハイドロゲル
JP2007177074A (ja) * 2005-12-28 2007-07-12 Tohoku Univ 組成物およびその製造方法
US8133336B2 (en) 2006-02-03 2012-03-13 Tissuemed Limited Tissue-adhesive materials
EP1991253B1 (de) 2006-02-10 2013-07-31 Wake Forest University Health Sciences Nervenregenerierung mit keratinbiomaterial
JP2009527274A (ja) 2006-02-17 2009-07-30 ウェイク・フォレスト・ユニヴァーシティ・ヘルス・サイエンシズ ケラチン医用生体材料から形成されるコーティングおよび生体用インプラント
US8273702B2 (en) 2006-02-17 2012-09-25 Wake Forest University Health Sciences Wound healing compositions containing keratin biomaterials
US20090018575A1 (en) * 2006-03-01 2009-01-15 Tissuemed Limited Tissue-adhesive formulations
US8110242B2 (en) 2006-03-24 2012-02-07 Zimmer, Inc. Methods of preparing hydrogel coatings
US8795709B2 (en) 2006-03-29 2014-08-05 Incept Llc Superabsorbent, freeze dried hydrogels for medical applications
EP2023941B1 (de) * 2006-04-24 2016-12-21 Incept, LLC Proteinvernetzer, vernetzungsverfahren und ihre anwendungen
US7993675B2 (en) 2006-05-10 2011-08-09 Medtronic Xomed, Inc. Solvating system and sealant for medical use in the sinuses and nasal passages
US7976873B2 (en) * 2006-05-10 2011-07-12 Medtronic Xomed, Inc. Extracellular polysaccharide solvating system for treatment of bacterial ear conditions
US7959943B2 (en) * 2006-05-10 2011-06-14 Medtronics Xomed, Inc. Solvating system and sealant for medical use in the middle or inner ear
US20070264296A1 (en) * 2006-05-10 2007-11-15 Myntti Matthew F Biofilm extracellular polysachharide solvating system
US7872068B2 (en) 2006-05-30 2011-01-18 Incept Llc Materials formable in situ within a medical device
CA2651941C (en) * 2006-05-31 2015-02-17 Baxter International Inc. Method for directed cell in-growth and controlled tissue regeneration in spinal surgery
US8167847B2 (en) 2006-06-22 2012-05-01 Excelsior Medical Corporation Antiseptic cap and antiseptic cap equipped plunger and syringe barrel assembly
TWI436793B (zh) * 2006-08-02 2014-05-11 Baxter Int 快速作用之乾密封膠及其使用和製造方法
US7671014B2 (en) 2006-08-14 2010-03-02 Warsaw Orthopedic, Inc. Flowable carrier matrix and methods for delivering to a patient
WO2008030581A1 (en) * 2006-09-08 2008-03-13 Symphony Medical, Inc. Intramyocardial patterning for treating localized anomalies of the heart
US20090012413A1 (en) * 2006-09-08 2009-01-08 Sabbah Hani N Cardiac patterning for improving diastolic function
WO2008033964A2 (en) 2006-09-13 2008-03-20 Accessclosure, Inc. Apparatus for sealing a vascular puncture
FR2909285A1 (fr) * 2006-12-01 2008-06-06 Anteis Sa "utilisation d'un gel anti-adhesif et anti fibrotique"
US9017664B2 (en) 2006-12-15 2015-04-28 Lifebond Ltd. Gelatin-transglutaminase hemostatic dressings and sealants
US8088095B2 (en) 2007-02-08 2012-01-03 Medtronic Xomed, Inc. Polymeric sealant for medical use
CA2578647A1 (en) * 2007-02-15 2008-08-15 University Of Saskatchewan Reducing post-operative adhesion formation with intraperitoneal glutamine
US8932560B2 (en) 2007-09-04 2015-01-13 University of Maryland, College Parke Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells
EP2146667A2 (de) * 2007-04-11 2010-01-27 Henry Ford Health System Herzreparatur, grössen- und formanapassung anhand des herzvenensystems
US7731988B2 (en) 2007-08-03 2010-06-08 Zimmer, Inc. Multi-polymer hydrogels
DE102007038125A1 (de) * 2007-08-03 2009-02-05 Aesculap Ag Kombination zum Verkleben von biologischen Geweben
CN101485897B (zh) * 2008-01-14 2015-05-20 纪欣 生物相容性止血、防粘连、促愈合、外科封闭的变性淀粉材料
GB0715514D0 (en) * 2007-08-10 2007-09-19 Tissuemed Ltd Coated medical devices
US9068162B2 (en) 2007-08-17 2015-06-30 Wake Forest University Health Sciences Keratin biomaterials for cell culture and methods of use
US8062739B2 (en) 2007-08-31 2011-11-22 Zimmer, Inc. Hydrogels with gradient
US7993367B2 (en) * 2007-09-28 2011-08-09 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
US20090111763A1 (en) * 2007-10-26 2009-04-30 Celonova Biosciences, Inc. Loadable polymeric particles for bone augmentation and methods of preparing and using the same
US20090110738A1 (en) * 2007-10-26 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Particles for Cosmetic and Reconstructive Tissue Augmentation Applications and Methods of Preparing and Using the Same
US20090110731A1 (en) * 2007-10-30 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Microparticles for Therapeutic Use in Alopecia and Methods of Preparing and Using the Same
CA2703103C (en) 2007-10-30 2017-05-09 Baxter Healthcare S.A. Use of a regenerative biofunctional collagen biomatrix for treating visceral or parietal defects
WO2009059217A2 (en) * 2007-11-02 2009-05-07 Incept, Llc Apparatus and methods for sealing a vascular puncture
US7947784B2 (en) 2007-11-16 2011-05-24 Zimmer, Inc. Reactive compounding of hydrogels
US8299316B2 (en) * 2007-12-18 2012-10-30 Ethicon, Inc. Hemostatic device
US8034362B2 (en) 2008-01-04 2011-10-11 Zimmer, Inc. Chemical composition of hydrogels for use as articulating surfaces
US8642831B2 (en) * 2008-02-29 2014-02-04 Ferrosan Medical Devices A/S Device for promotion of hemostasis and/or wound healing
CA2716010C (en) * 2008-04-03 2019-10-01 Zymogenetics, Inc. Hemostatic microspheres
US8029533B2 (en) * 2008-04-04 2011-10-04 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
US9364206B2 (en) 2008-04-04 2016-06-14 Access Closure, Inc. Apparatus and methods for sealing a vascular puncture
US8801665B2 (en) * 2008-04-10 2014-08-12 Henry Ford Health System Apparatus and method for controlled depth of injection into myocardial tissue
US20090259210A1 (en) * 2008-04-10 2009-10-15 Sabbah Hani N Method, apparatus and kits for forming structural members within the cardiac venous system
CA2727432C (en) 2008-06-12 2016-10-11 Medtronic Xomed, Inc. Method for treating chronic wounds with an extracellular polymeric substance solvating system
EP2543394A1 (de) * 2008-06-18 2013-01-09 Lifebond Ltd Verfahren zur enzymatischen Vernetzung eines Proteins
CA2728187C (en) 2008-06-18 2014-04-29 Lifebond Ltd Improved cross-linked compositions
US20110112573A1 (en) * 2008-06-18 2011-05-12 Orahn Preiss Bloom Methods and devices for use with sealants
CA2726894A1 (en) 2008-06-27 2009-12-30 Duke University Therapeutic agents comprising elastin-like peptides
WO2010027693A2 (en) 2008-08-26 2010-03-11 Killion Douglas P Method and system for sealing percutaneous punctures
EP2341953B1 (de) 2008-09-04 2018-11-21 The General Hospital Corporation Hydrogele für die verstärkung und reparatur der stimmbänder und weichgewebe
EP2346324A4 (de) 2008-10-06 2012-10-10 Microbial Defense Systems Llc Antimikrobielle zusammensetzung sowie verfahren zu ihrer herstellung und verwendung
EP3821817A3 (de) 2008-11-12 2021-11-03 Access Closure, Inc. Vorrichtung zur versiegelung einer vaskulären punktur
CA2977830C (en) 2009-05-04 2019-09-17 Incept, Llc Biomaterials for track and puncture closure
US9039783B2 (en) * 2009-05-18 2015-05-26 Baxter International, Inc. Method for the improvement of mesh implant biocompatibility
KR101699992B1 (ko) 2009-06-16 2017-01-26 백스터 인터내셔널 인코포레이티드 지혈용 스펀지
JP2011025013A (ja) * 2009-06-25 2011-02-10 Doshisha 癒着防止材及びその製造方法
IN2012DN02120A (de) 2009-08-14 2015-08-21 Phasebio Pharmaceuticals Inc
US9649331B2 (en) * 2009-08-27 2017-05-16 Ara Medical Llc Sprayable polymers as adhesion barriers
NZ599527A (en) 2009-11-09 2014-04-30 Spotlight Technology Partners Llc Fragmented hydrogels
WO2011057131A1 (en) 2009-11-09 2011-05-12 Spotlight Technology Partners Llc Polysaccharide based hydrogels
CA2780898A1 (en) 2009-11-13 2011-05-19 University Of Maryland, College Park Advanced functional biocompatible foam used as a hemostatic agent for compressible and non-compressible acute wounds
EP3960215A1 (de) 2009-12-15 2022-03-02 Incept, LLC Implantate und biologisch abbaubare bezugsmarkierungen
JP2013514093A (ja) 2009-12-16 2013-04-25 バクスター・インターナショナル・インコーポレイテッド 止血スポンジ
DK2515957T3 (en) 2009-12-22 2015-11-09 Lifebond Ltd CHANGE OF ENZYMATIC CIRCULATORS FOR MANAGEMENT OF CHARACTERISTICS BY CIRCUIT MATRIX
WO2011109730A2 (en) 2010-03-04 2011-09-09 The General Hospital Corporation Methods and systems of matching voice deficits with a tunable mucosal implant to restore and enhance individualized human sound and voice production
AU2011222540B2 (en) 2010-03-05 2016-09-29 Wake Forest University Health Sciences Controlled delivery system
WO2011112575A1 (en) 2010-03-08 2011-09-15 Wake Forest University Health Sciences Keratin biomaterials for treatment of ischemia
SA111320355B1 (ar) 2010-04-07 2015-01-08 Baxter Heathcare S A إسفنجة لايقاف النزف
GB201008404D0 (en) * 2010-05-20 2010-07-07 Fujifilm Mfg Europe Bv Hemostatic compositions
AU2011260258B2 (en) 2010-06-01 2015-07-09 Baxter Healthcare S.A. Process for making dry and stable hemostatic compositions
KR20130083393A (ko) 2010-06-01 2013-07-22 백스터 인터내셔널 인코포레이티드 건조 및 안정한 지혈 조성물의 제조 방법
CA2801120C (en) 2010-06-01 2019-08-20 Baxter International Inc. Process for making dry and stable hemostatic compositions
AU2011287215B2 (en) 2010-08-05 2015-09-10 Lifebond Ltd. Dry composition wound dressings and adhesives
JP5721379B2 (ja) * 2010-09-21 2015-05-20 学校法人同志社 親水性高分子を含む自動縫合器用縫合補強材
CA2818166C (en) 2010-11-17 2019-04-30 Wake Forest University Health Sciences Keratin compositions for treatment of bone deficiency or injury
US9820728B2 (en) 2011-01-19 2017-11-21 Access Closure, Inc. Apparatus and methods for sealing a vascular puncture
US10182800B2 (en) 2011-01-19 2019-01-22 Access Closure, Inc. Apparatus and methods for sealing a vascular puncture
KR101272484B1 (ko) * 2011-01-19 2013-06-10 세원셀론텍(주) 방사선 가교화된 콜라겐 겔 및 그 제조방법과 사용방법
EP2484387A1 (de) 2011-02-03 2012-08-08 Q-Med AB Hyaluronsäurezusammensetzung
US9447169B2 (en) 2011-03-04 2016-09-20 Orthovita, Inc. Flowable collagen-based hemostat and methods of use
EP2694660B1 (de) 2011-04-03 2018-08-08 The General Hospital Corporation Effiziente in-vivo-proteinexpression mittels modifizierter rna (mod-rna)
CA2835211C (en) 2011-05-10 2019-09-24 Next Science, Llc Antimicrobial solid and methods of making and using same
US9386968B2 (en) 2011-05-11 2016-07-12 Access Closure, Inc. Apparatus and methods for sealing a vascular puncture
WO2012170524A1 (en) 2011-06-06 2012-12-13 Phasebio Pharmaceuticals, Inc. Use of modified vasoactive intestinal peptides in the treatment of hypertension
US9149511B2 (en) 2011-06-30 2015-10-06 Ethicon, Inc. Procoagulant peptides and their derivatives and uses therefor
JP5779249B2 (ja) * 2011-08-02 2015-09-16 大日精化工業株式会社 癒着防止用医用材料及びその製造方法
MX356185B (es) 2011-10-11 2018-05-17 Baxter Int Composiciones hemostaticas.
EP2766060B1 (de) 2011-10-11 2022-11-23 Baxter International Inc. Hämostatische zusammensetzung
AU2012318258B2 (en) 2011-10-11 2015-07-09 Baxter Healthcare S.A. Hemostatic compositions
AU2012318259A1 (en) 2011-10-11 2013-05-02 Baxter Healthcare S.A. Hemostatic compositions
AU2012330450B2 (en) * 2011-10-27 2017-04-27 Baxter Healthcare Sa Hemostatic compositions
WO2013060769A2 (en) 2011-10-27 2013-05-02 Baxter International Inc. Hemostatic compositions
KR20190090048A (ko) 2011-12-05 2019-07-31 인셉트, 엘엘씨 의료용 유기젤 방법 및 조성물
US20130202675A1 (en) 2012-02-03 2013-08-08 Dynasil Biomedical Corporation Systems and methods for the fabrication of tissue patches
EP2822474B1 (de) 2012-03-06 2018-05-02 Ferrosan Medical Devices A/S Druckbehälter mit einer blutstillenden paste
US8721680B2 (en) 2012-03-23 2014-05-13 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
US9757105B2 (en) 2012-03-23 2017-09-12 Accessclosure, Inc. Apparatus and methods for sealing a vascular puncture
KR20130134447A (ko) * 2012-05-31 2013-12-10 리젠프라임 주식회사 신규한 나노섬유막 및 이의 제조방법
EP2977066A3 (de) 2012-06-12 2016-07-27 Ferrosan Medical Devices A/S Trockene blutstillende zusammensetzung
CA2914610C (en) 2013-03-13 2022-08-02 University Of Maryland Advanced functional biocompatible polymer putty used as a hemostatic agent for treating damaged tissue and cells
EP3010419B1 (de) 2013-06-21 2020-05-20 Ferrosan Medical Devices A/S Vakuumerweiterte trockenzusammensetzung und spritze zum zurückhalten davon
AU2014361291B2 (en) 2013-12-11 2017-11-30 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer
EP3139949B1 (de) 2014-05-08 2020-07-29 Phasebio Pharmaceuticals, Inc. Zusammensetzungen enthaltend ein vip-elp fusionsprotein zur verwendung in der behandlung von mukoviszidose
CA2955357A1 (en) * 2014-07-17 2016-01-21 The Regents Of The University Of California Self-annealing microgel particles for biomedical applications
JP6726852B2 (ja) 2014-10-13 2020-07-22 フェッローサン メディカル ディバイス エー/エス 止血および創傷治癒に使用するための乾燥組成物
JP6747650B2 (ja) 2014-12-24 2020-08-26 フェロサン メディカル デバイシーズ エイ/エス 第1の物質と第2の物質を保持し混合するためのシリンジ
RU2606990C2 (ru) * 2014-12-26 2017-01-10 Общество с ограниченной ответственностью "Проект Экопак" Биоразлагаемое вещество на основе возобновляемого сырья
ES2822598T3 (es) 2015-02-09 2021-05-04 Phasebio Pharmaceuticals Inc Métodos y composiciones para tratar enfermedades y trastornos musculares
CN104861179B (zh) * 2015-06-03 2017-09-12 西北师范大学 一种羽毛角蛋白‑海藻酸钠复合高分子双敏感水凝胶的制备及作为药物载体的应用
CN104892864B (zh) * 2015-06-03 2017-09-22 西北师范大学 一种角蛋白‑海藻酸钠复合微孔凝胶的制备及作为药物载体的应用
JP6747651B2 (ja) 2015-07-03 2020-08-26 フェロサン メディカル デバイシーズ エイ/エス 保管状態で真空を保持するための、及び2種の成分を混合するためのシリンジ
US10588998B2 (en) 2015-08-07 2020-03-17 Xcede Technologies, Inc. Adhesive compositions and related methods
US9833538B2 (en) 2015-08-07 2017-12-05 Xcede Technologies, Inc. Adhesive compositions and related methods
US10660945B2 (en) 2015-08-07 2020-05-26 Victor Matthew Phillips Flowable hemostatic gel composition and its methods of use
US9540548B1 (en) 2015-08-07 2017-01-10 Xcede Technologies, Inc. Adhesive compositions and related methods
US10751444B2 (en) 2015-08-07 2020-08-25 Victor Matthew Phillips Flowable hemostatic gel composition and its methods of use
EP3943127A1 (de) 2015-09-01 2022-01-26 Baxter International Inc Hämostatisches material
WO2017142879A1 (en) 2016-02-16 2017-08-24 The Regents Of The University Of California Methods for immune system modulation with microporous annealed particle gels
WO2017149584A1 (ja) * 2016-02-29 2017-09-08 川澄化学工業株式会社 癒着防止材
RU2628809C1 (ru) * 2016-06-30 2017-08-22 Федеральное государственное бюджетное учреждение Гематологический научный центр Министерства здравоохранения Российской Федерации (ФГБУ ГНЦ Минздрава России) Гемостатическая губка и способ ее получения
CN117582559A (zh) 2016-12-29 2024-02-23 泰普治疗公司 用于治疗医疗植入物部位的方法和系统
US11679177B2 (en) 2017-08-08 2023-06-20 Baxter International Inc. Polymeric compositions, delivery devices, and methods
ES2902773T3 (es) 2017-11-03 2022-03-29 Baxter Int Composiciones poliméricas, dispositivos de administración y métodos
KR20200105680A (ko) 2017-12-29 2020-09-08 백스터 인터내셔널 인코포레이티드 분무-건조된 트롬빈, 및 분무-건조된 트롬빈의 사용 및 제조 방법
PL3731807T3 (pl) * 2017-12-29 2022-05-09 Matex Lab S.P.A. Sposób przygotowania wypełniacza na bazie kwasu hialuronowego obejmujący etap zobojętniania
CN108314790A (zh) * 2018-03-16 2018-07-24 东华大学 一种用于组织粘合剂的光交联巯基壳聚糖-聚乙二醇甲基丙烯酸酯水凝胶及其制备方法
CN108853598A (zh) * 2018-03-23 2018-11-23 中南大学湘雅二医院 一种自体生物蛋白水凝胶的制备及其在视网膜手术中的应用
CN108498871A (zh) * 2018-03-23 2018-09-07 中南大学湘雅二医院 一种自体生物蛋白水凝胶的制备及其在眼科的应用
EP4321182A2 (de) 2018-05-09 2024-02-14 Ferrosan Medical Devices A/S Verfahren zur herstellung einer hämostatischen zusammensetzung
JP7043369B2 (ja) * 2018-08-24 2022-03-29 日立Geニュークリア・エナジー株式会社 耐放射線性ハイドロゲル材およびその製造方法
JP7042730B2 (ja) 2018-10-31 2022-03-28 株式会社ハイレックスコーポレーション 生体内非分解性癒着阻止材
CN109529098A (zh) * 2018-12-03 2019-03-29 广州润虹医药科技股份有限公司 一种外科医用粘合剂
US11739166B2 (en) 2020-07-02 2023-08-29 Davol Inc. Reactive polysaccharide-based hemostatic agent
KR102441137B1 (ko) * 2022-02-07 2022-09-06 김환철 분해속도 조절이 가능한 에테르기를 포함하는 생체적합성 고분자 하이드로겔

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4013078A (en) * 1974-11-25 1977-03-22 Feild James Rodney Intervertebral protector means
DE3036033A1 (de) * 1980-09-24 1982-05-06 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Wundbehandlungsmittel in pulverform und verfahren zu seiner herstellung
DE3105624A1 (de) * 1981-02-16 1982-09-02 Hormon-Chemie München GmbH, 8000 München Material zum abdichten und heilen von wunden
JPS60222045A (ja) * 1984-04-20 1985-11-06 日立化成工業株式会社 血管塞栓剤
SE456346B (sv) * 1984-07-23 1988-09-26 Pharmacia Ab Gel for att forhindra adhesion mellan kroppsvevnader och sett for dess framstellning
GB8422950D0 (en) * 1984-09-11 1984-10-17 Warne K J Hydrogel
JPS61122222A (ja) * 1984-11-19 1986-06-10 Koken:Kk コラ−ゲン又はゼラチンとプロタミンとよりなる止血剤
US4600533A (en) * 1984-12-24 1986-07-15 Collagen Corporation Collagen membranes for medical use
US5007916A (en) * 1985-08-22 1991-04-16 Johnson & Johnson Medical, Inc. Method and material for prevention of surgical adhesions
US4803075A (en) * 1986-06-25 1989-02-07 Collagen Corporation Injectable implant composition having improved intrudability
US5080893A (en) * 1988-05-31 1992-01-14 University Of Florida Method for preventing surgical adhesions using a dilute solution of polymer
US5017229A (en) * 1990-06-25 1991-05-21 Genzyme Corporation Water insoluble derivatives of hyaluronic acid
US5350573A (en) * 1988-05-31 1994-09-27 University Of Florida Research Foundation, Inc. Method and composition for preventing surgical adhesions
US5140016A (en) * 1988-05-31 1992-08-18 University Of Florida Method and composition for preventing surgical adhesions using a dilute solution of polymer
US5135751A (en) * 1988-11-16 1992-08-04 Mediventures Incorporated Composition for reducing postsurgical adhesions
US5126141A (en) * 1988-11-16 1992-06-30 Mediventures Incorporated Composition and method for post-surgical adhesion reduction with thermo-irreversible gels of polyoxyalkylene polymers and ionic polysaccharides
US4891359A (en) * 1988-12-08 1990-01-02 Johnson & Johnson Patient Care, Inc. Hemostatic collagen paste composition
US5196185A (en) * 1989-09-11 1993-03-23 Micro-Collagen Pharmaceutics, Ltd. Collagen-based wound dressing and method for applying same
US5061274A (en) * 1989-12-04 1991-10-29 Kensey Nash Corporation Plug device for sealing openings and method of use
US5219328A (en) * 1990-01-03 1993-06-15 Cryolife, Inc. Fibrin sealant delivery method
US5134229A (en) * 1990-01-12 1992-07-28 Johnson & Johnson Medical, Inc. Process for preparing a neutralized oxidized cellulose product and its method of use
JPH0813750B2 (ja) * 1990-03-01 1996-02-14 持田製薬株式会社 経口用トロンビン製剤
US5634943A (en) * 1990-07-12 1997-06-03 University Of Miami Injectable polyethylene oxide gel implant and method for production
US5108421A (en) * 1990-10-01 1992-04-28 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
US5192300A (en) * 1990-10-01 1993-03-09 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
US5129882A (en) * 1990-12-27 1992-07-14 Novoste Corporation Wound clotting device and method of using same
US5605938A (en) * 1991-05-31 1997-02-25 Gliatech, Inc. Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate
NL9101051A (nl) * 1991-06-18 1993-01-18 Ashridge Ag Sluitinrichting voor een bloedvat of dergelijke.
US5204382A (en) * 1992-02-28 1993-04-20 Collagen Corporation Injectable ceramic compositions and methods for their preparation and use
US5468505A (en) * 1992-02-28 1995-11-21 Board Of Regents, The University Of Texas System Local delivery of fibrinolysis enhancing agents
JPH07504106A (ja) * 1992-02-28 1995-05-11 コラーゲン コーポレイション 注射可能なセラミック組成物及びそれらの製造及び使用のための方法
CA2128504C (en) * 1992-02-28 2009-02-03 George Chu High concentration homogenized collagen compositions
CA2134071C (en) * 1992-04-23 1999-04-27 Sew Wah Tay Apparatus and method for sealing vascular punctures
US5413571A (en) * 1992-07-16 1995-05-09 Sherwood Medical Company Device for sealing hemostatic incisions
ATE206602T1 (de) * 1992-11-12 2001-10-15 Neville Alleyne Einrichtung zum schutz des herzens
JP3639593B2 (ja) * 1993-05-31 2005-04-20 科研製薬株式会社 塩基性線維芽細胞増殖因子含有架橋ゼラチンゲル製剤
FR2715309B1 (fr) * 1994-01-24 1996-08-02 Imedex Composition adhésive, à usage chirurgical, à base de collagène modifié par coupure oxydative et non réticulé.
US5531759A (en) * 1994-04-29 1996-07-02 Kensey Nash Corporation System for closing a percutaneous puncture formed by a trocar to prevent tissue at the puncture from herniating
US5599735A (en) * 1994-08-01 1997-02-04 Texas Instruments Incorporated Method for doped shallow junction formation using direct gas-phase doping
US5516532A (en) * 1994-08-05 1996-05-14 Children's Medical Center Corporation Injectable non-immunogenic cartilage and bone preparation
US5677284A (en) * 1995-06-06 1997-10-14 Regen Biologics, Inc. Charged collagen particle-based delivery matrix
US5902832A (en) * 1996-08-20 1999-05-11 Menlo Care, Inc. Method of synthesizing swollen hydrogel for sphincter augmentation
US6063061A (en) * 1996-08-27 2000-05-16 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use

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