DE69725587D1 - Verwendung von wnt polypeptiden - Google Patents
Verwendung von wnt polypeptidenInfo
- Publication number
- DE69725587D1 DE69725587D1 DE69725587T DE69725587T DE69725587D1 DE 69725587 D1 DE69725587 D1 DE 69725587D1 DE 69725587 T DE69725587 T DE 69725587T DE 69725587 T DE69725587 T DE 69725587T DE 69725587 D1 DE69725587 D1 DE 69725587D1
- Authority
- DE
- Germany
- Prior art keywords
- wnt polypeptides
- wnt
- polypeptides
- hematopoiesis
- differentiation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/696,566 US5851984A (en) | 1996-08-16 | 1996-08-16 | Method of enhancing proliferation or differentiation of hematopoietic stem cells using Wnt polypeptides |
US696566 | 1996-08-16 | ||
PCT/US1997/013910 WO1998006747A2 (en) | 1996-08-16 | 1997-08-07 | USE OF WNT POLYPEPTIDES |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69725587D1 true DE69725587D1 (de) | 2003-11-20 |
DE69725587T2 DE69725587T2 (de) | 2004-07-29 |
Family
ID=24797608
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69725587T Expired - Lifetime DE69725587T2 (de) | 1996-08-16 | 1997-08-07 | Verwendung von wnt polypeptiden |
Country Status (9)
Country | Link |
---|---|
US (1) | US5851984A (de) |
EP (1) | EP0918794B1 (de) |
JP (1) | JP3759623B2 (de) |
AT (1) | ATE252113T1 (de) |
AU (1) | AU721947B2 (de) |
DE (1) | DE69725587T2 (de) |
ES (1) | ES2208943T3 (de) |
IL (2) | IL128129A0 (de) |
WO (1) | WO1998006747A2 (de) |
Families Citing this family (87)
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WO2000061630A1 (en) * | 1999-04-08 | 2000-10-19 | President And Fellows Of Harvard College | Induction of kidney tubule formation |
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CA2434672C (en) * | 2001-01-10 | 2014-03-25 | Jeffrey S. Rubin | Sfrp and peptide motifs that interact with sfrp and methods of their use |
KR100973615B1 (ko) | 2001-02-14 | 2010-08-02 | 안트로제네시스 코포레이션 | 산후 포유류의 태반, 이의 용도 및 태반 줄기세포 |
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WO2002088081A2 (en) * | 2001-05-01 | 2002-11-07 | The Regents Of The University Of California | Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas |
US7713526B2 (en) * | 2001-05-01 | 2010-05-11 | The Regents Of The University Of California | Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas |
US7101693B2 (en) * | 2001-09-07 | 2006-09-05 | Brigham Young University | Plasticized hydrophilic glasses for improved stabilization of biological agents |
IL152904A0 (en) | 2002-01-24 | 2003-06-24 | Gamida Cell Ltd | Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations |
EP1465982A4 (de) | 2002-01-25 | 2006-06-07 | Gamida Cell Ltd | Verfahren zur expansion von stamm- und vorläuferzellen und damit erhaltene expandierte zellpopulationen |
DE10209822A1 (de) | 2002-03-06 | 2003-09-25 | Biotechnologie Ges Mittelhesse | Kopplung niedermolekularer Substanzen an ein modifiziertes Polysaccharid |
DE10209821A1 (de) * | 2002-03-06 | 2003-09-25 | Biotechnologie Ges Mittelhesse | Kopplung von Proteinen an ein modifiziertes Polysaccharid |
WO2003076613A1 (fr) * | 2002-03-11 | 2003-09-18 | Reprocell Inc. | Proteine maintenant des cellules souches non differentiees comme telles |
DE10212867B4 (de) * | 2002-03-22 | 2005-07-21 | Hans Prof. Dr. Wolf | Verwendung Harnstoff-adjuvierter Polypeptide zur Diagnose, Prophylaxe und Therapie |
US7498171B2 (en) * | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
EP1501928A4 (de) * | 2002-05-09 | 2007-08-15 | Univ New York | Melanogenesetest |
EP2361966A1 (de) * | 2002-05-17 | 2011-08-31 | Mount Sinai School of Medicine of New York University | Zellen von Mesoderm und vom entgültigen Endoderm |
US20040028660A1 (en) * | 2002-05-30 | 2004-02-12 | Anthrogenesis Corporation | Methods of using JNK or MKK inhibitors to modulate cell differentiation and to treat myeloproliferative disorders and myelodysplastic syndromes |
JP2005528115A (ja) * | 2002-05-31 | 2005-09-22 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ | 幹細胞および癌幹細胞を同定および単離する方法 |
PL217085B1 (pl) * | 2002-09-11 | 2014-06-30 | Fresenius Kabi Gmbh | Koniugat hydroksyalkiloskrobi i polipeptydu, sposób wytwarzania koniugatu hydroksyalkiloskrobi i polipeptydu, zastosowanie koniugatu hydroksyalkiloskrobi i polipeptydu oraz kompozycja farmaceutyczna koniugatu hydroksyalkiloskrobi i polipeptydu |
US20040247593A1 (en) * | 2002-10-04 | 2004-12-09 | Regents Of The University Of California, | Methods for treating cancer by inhibiting Wnt signaling |
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WO2004047757A2 (en) * | 2002-11-21 | 2004-06-10 | University Of Massachusets | Diagnosing and treating hematopoietic cancers |
EP1571910A4 (de) | 2002-11-26 | 2009-10-28 | Anthrogenesis Corp | Zytotherapeutika, zytotherapeutischeeinheiten und behandlungsverfahren, bei denen diese verwendet werden |
US7803783B2 (en) * | 2002-12-06 | 2010-09-28 | The Board Of Trustees Of The Leland Stanford Junior University | Use of WNT inhibitors to augment therapeutic index of chemotherapy |
CA2507581A1 (en) * | 2002-12-06 | 2004-06-24 | The Board Of Trustees Of The Leland Stanford Junior University | Protection of stem cells from cytotoxic agents by modulation of .beta.-catenin signaling pathways |
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WO2004091647A1 (en) | 2003-04-07 | 2004-10-28 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions of active wnt protein |
WO2004094610A2 (en) * | 2003-04-21 | 2004-11-04 | Baylor College Of Medicine | Wnt as a factor for cardiac myogenesis |
JP4838710B2 (ja) * | 2003-06-25 | 2011-12-14 | オタワ ヘルス リサーチ インスティテュート | カルジオトロフィンの幹細胞増殖調節への使用 |
JP4750697B2 (ja) * | 2003-06-25 | 2011-08-17 | オタワ ヘルス リサーチ インスティテュート | 幹細胞の成長及び分化を調節する方法及び組成物 |
US7939058B2 (en) * | 2003-07-03 | 2011-05-10 | University Of Southern California | Uses of IL-12 in hematopoiesis |
WO2005014655A2 (en) | 2003-08-08 | 2005-02-17 | Fresenius Kabi Deutschland Gmbh | Conjugates of hydroxyalkyl starch and a protein |
CA2558738C (en) | 2004-03-11 | 2013-02-05 | Fresenius Kabi Deutschland Gmbh | Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination |
CN102302787A (zh) * | 2004-03-11 | 2012-01-04 | 费森尤斯卡比德国有限公司 | 羟烷基淀粉和蛋白质的接合物 |
US20060040883A1 (en) * | 2004-05-14 | 2006-02-23 | The Regents Of The University Of California | Methods for treating cancer using anti-Wnt2 monoclonal antibodies and siRNA |
EP1799812A4 (de) | 2004-09-16 | 2009-09-09 | Gamida Cell Ltd | Verfahren zur ex-vivo-expansion von progenitor- und stammzellen durch gemeinsame kultivierung mit mesenchymzellen |
CN100572528C (zh) * | 2004-09-28 | 2009-12-23 | 中国人民解放军军事医学科学院野战输血研究所 | 一种体外扩增造血干/祖细胞的方法 |
EP1802193B1 (de) | 2004-10-19 | 2014-04-30 | Regeneron Pharmaceuticals, Inc. | Verfahren zur erzeugung einer für eine genetische modifikation homozygoten maus |
US7850960B2 (en) * | 2004-12-30 | 2010-12-14 | University Of Washington | Methods for regulation of stem cells |
AU2012200875B2 (en) * | 2004-12-30 | 2012-08-30 | Robarts Research Institute | Methods for regulation of stem cells |
EP1861124A2 (de) * | 2005-03-11 | 2007-12-05 | Fresenius Kabi Deutschland GmbH | Herstellung von bioaktiven glykoproteinen aus inaktiven ausgangsmaterialien durch konjugation mit hydroxyalkylstärke |
WO2007030658A2 (en) * | 2005-09-08 | 2007-03-15 | Children's Hospital Medical Center | Compositions useful for and methods of modulating angiogenesis |
EP1762250A1 (de) * | 2005-09-12 | 2007-03-14 | Fresenius Kabi Deutschland GmbH | Konjugate welche durch chemische Ligation zwischen Hydroxyalkylstärken und aktiven Substanzen mit Bildung eines Thiazolidin-Ringes entstehen |
KR101378874B1 (ko) | 2005-10-13 | 2014-03-27 | 안트로제네시스 코포레이션 | 태반 줄기세포를 이용한 면역 조절 |
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EP3443968A1 (de) | 2011-06-01 | 2019-02-20 | Celularity, Inc. | Schmerzbehandlung mithilfe von stammzellen aus der plazenta |
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BR112014020119A2 (pt) | 2012-02-13 | 2020-10-27 | Gamida-Cell Ltd | cultura de células-tronco mesenquimais |
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CN105142651A (zh) | 2013-02-05 | 2015-12-09 | 人类起源公司 | 来自胎盘的自然杀伤细胞 |
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BR112019015900A2 (pt) * | 2017-02-10 | 2020-04-07 | Genmab B.V. | polipeptídeo, métodos para aumentar a atividade agonística de um polipeptídeo, para aumentar a atividade de cdc de um polipeptídeo e de tratamento de um indivíduo tendo uma doença, composição, kit de partes, e, uso de um polipeptídeo ou uma composição |
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-
1996
- 1996-08-16 US US08/696,566 patent/US5851984A/en not_active Expired - Lifetime
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1997
- 1997-08-07 IL IL12812997A patent/IL128129A0/xx active IP Right Grant
- 1997-08-07 WO PCT/US1997/013910 patent/WO1998006747A2/en active IP Right Grant
- 1997-08-07 AU AU39112/97A patent/AU721947B2/en not_active Expired
- 1997-08-07 JP JP50986198A patent/JP3759623B2/ja not_active Expired - Lifetime
- 1997-08-07 ES ES97936448T patent/ES2208943T3/es not_active Expired - Lifetime
- 1997-08-07 DE DE69725587T patent/DE69725587T2/de not_active Expired - Lifetime
- 1997-08-07 AT AT97936448T patent/ATE252113T1/de not_active IP Right Cessation
- 1997-08-07 EP EP97936448A patent/EP0918794B1/de not_active Expired - Lifetime
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1999
- 1999-01-19 IL IL128129A patent/IL128129A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
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IL128129A0 (en) | 1999-11-30 |
US5851984A (en) | 1998-12-22 |
DE69725587T2 (de) | 2004-07-29 |
WO1998006747A2 (en) | 1998-02-19 |
JP2000516466A (ja) | 2000-12-12 |
EP0918794B1 (de) | 2003-10-15 |
AU721947B2 (en) | 2000-07-20 |
EP0918794A2 (de) | 1999-06-02 |
ATE252113T1 (de) | 2003-11-15 |
AU3911297A (en) | 1998-03-06 |
ES2208943T3 (es) | 2004-06-16 |
WO1998006747A3 (en) | 1998-05-07 |
JP3759623B2 (ja) | 2006-03-29 |
IL128129A (en) | 2006-12-31 |
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