DE69725587D1 - Verwendung von wnt polypeptiden - Google Patents

Verwendung von wnt polypeptiden

Info

Publication number
DE69725587D1
DE69725587D1 DE69725587T DE69725587T DE69725587D1 DE 69725587 D1 DE69725587 D1 DE 69725587D1 DE 69725587 T DE69725587 T DE 69725587T DE 69725587 T DE69725587 T DE 69725587T DE 69725587 D1 DE69725587 D1 DE 69725587D1
Authority
DE
Germany
Prior art keywords
wnt polypeptides
wnt
polypeptides
hematopoiesis
differentiation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69725587T
Other languages
English (en)
Other versions
DE69725587T2 (de
Inventor
William Matthews
W Austin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of DE69725587D1 publication Critical patent/DE69725587D1/de
Publication of DE69725587T2 publication Critical patent/DE69725587T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus
DE69725587T 1996-08-16 1997-08-07 Verwendung von wnt polypeptiden Expired - Lifetime DE69725587T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US696566 1996-08-16
US08/696,566 US5851984A (en) 1996-08-16 1996-08-16 Method of enhancing proliferation or differentiation of hematopoietic stem cells using Wnt polypeptides
PCT/US1997/013910 WO1998006747A2 (en) 1996-08-16 1997-08-07 USE OF WNT POLYPEPTIDES

Publications (2)

Publication Number Publication Date
DE69725587D1 true DE69725587D1 (de) 2003-11-20
DE69725587T2 DE69725587T2 (de) 2004-07-29

Family

ID=24797608

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69725587T Expired - Lifetime DE69725587T2 (de) 1996-08-16 1997-08-07 Verwendung von wnt polypeptiden

Country Status (9)

Country Link
US (1) US5851984A (de)
EP (1) EP0918794B1 (de)
JP (1) JP3759623B2 (de)
AT (1) ATE252113T1 (de)
AU (1) AU721947B2 (de)
DE (1) DE69725587T2 (de)
ES (1) ES2208943T3 (de)
IL (2) IL128129A0 (de)
WO (1) WO1998006747A2 (de)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6159462A (en) * 1996-08-16 2000-12-12 Genentech, Inc. Uses of Wnt polypeptides
WO2000018885A1 (en) 1998-09-29 2000-04-06 Gamida Cell Ltd. Methods of controlling proliferation and differentiation of stem and progenitor cells
DE69920002T2 (de) * 1998-04-28 2005-09-22 Applied Research Systems Ars Holding N.V. Konjugate aus polyole und beta-interferon
US6485972B1 (en) * 1998-10-15 2002-11-26 President And Fellows Of Harvard College WNT signalling in reproductive organs
BR9905867A (pt) * 1998-11-06 2001-01-23 Bio Sidus S A Linhagem celular produtora de eritropoietina humana recombinante e a eritropoietina humana recombinante produzida por esta célula
US20030104561A1 (en) * 1999-02-09 2003-06-05 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2000061630A1 (en) * 1999-04-08 2000-10-19 President And Fellows Of Harvard College Induction of kidney tubule formation
US20020034772A1 (en) * 1999-06-29 2002-03-21 Orlow Seth J. Methods and compositions that affect melanogenesis
CA2396576A1 (en) * 2000-01-18 2001-07-26 Tannishtha Reya Expansion of stem and progenitor cells by beta-catenin
US6653448B1 (en) * 2000-03-29 2003-11-25 Curagen Corporation Wnt-7B-like polypeptides and nucleic acids encoding same
US6600018B1 (en) * 2000-04-10 2003-07-29 The United States Of America As Represented By The Department Of Health And Human Services Secreted frizzled related protein, sFRP, fragments and methods of use thereof
MXPA03000190A (es) * 2000-06-26 2004-09-13 Rxkinetix Inc Composicion para el suministro del factor de crecimiento hamtopoyetico.
DE60107022T2 (de) 2000-07-24 2005-11-24 Health Research Inc. Verfahren zur Detektion von Prostata-spezifischem Membran-Antigen in Serum
US7311905B2 (en) 2002-02-13 2007-12-25 Anthrogenesis Corporation Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells
US20030032179A1 (en) 2000-12-06 2003-02-13 Hariri Robert J. Post-partum mammalian placenta, its use and placental stem cells therefrom
AU2002220209B2 (en) 2000-12-06 2006-05-25 Robert J. Hariri Method of collecting placental stem cells
JP4029041B2 (ja) * 2001-01-10 2008-01-09 アメリカ合衆国 ｓＦＲＰおよびｓＦＲＰと相互作用するペプチドモチーフならびにそれらの使用法
KR101012952B1 (ko) 2001-02-14 2011-02-08 안트로제네시스 코포레이션 산후 포유류의 태반, 이의 용도 및 태반 줄기세포
US7087586B2 (en) * 2001-04-24 2006-08-08 Bioniche Life Sciences, Inc. Oligonucleotide compositions and their use to induce differentiation of cells
US7713526B2 (en) * 2001-05-01 2010-05-11 The Regents Of The University Of California Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas
US20030044409A1 (en) * 2001-05-01 2003-03-06 Carson Dennis A. Immunologic compositions and methods for studying and treating cancers expressing frizzled antigens
US7682607B2 (en) * 2001-05-01 2010-03-23 The Regents Of The University Of California Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas
US7101693B2 (en) * 2001-09-07 2006-09-05 Brigham Young University Plasticized hydrophilic glasses for improved stabilization of biological agents
IL152904A0 (en) 2002-01-24 2003-06-24 Gamida Cell Ltd Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations
WO2003062404A1 (en) 2002-01-25 2003-07-31 Gamida-Cell Ltd. Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby
DE10209822A1 (de) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung niedermolekularer Substanzen an ein modifiziertes Polysaccharid
DE10209821A1 (de) * 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung von Proteinen an ein modifiziertes Polysaccharid
CA2479056A1 (en) * 2002-03-11 2003-09-18 Reprocell Inc. Protein sustaining undifferentiated stem cells as such
DE10212867B4 (de) * 2002-03-22 2005-07-21 Hans Prof. Dr. Wolf Verwendung Harnstoff-adjuvierter Polypeptide zur Diagnose, Prophylaxe und Therapie
US7498171B2 (en) * 2002-04-12 2009-03-03 Anthrogenesis Corporation Modulation of stem and progenitor cell differentiation, assays, and uses thereof
US7378232B2 (en) * 2002-05-09 2008-05-27 New York University Assay for melanogenesis
AU2003304106C1 (en) 2002-05-17 2010-10-28 Mount Sinai School Of Medicine Of New York University Mesoderm and definitive endoderm cell populations
JP2005528105A (ja) * 2002-05-30 2005-09-22 セルジーン・コーポレーション 細胞分化をモジュレートするため、並びに骨髄増殖性疾患及び骨髄異形成症候群を治療するためのｊｎｋ又はｍｋｋ阻害剤の使用方法
US7217568B2 (en) * 2002-05-31 2007-05-15 The Board Of Trustees Of The Leland Stanford Junior University Methods of identifying and isolating stem cells and cancer stem cells
WO2004024776A1 (en) * 2002-09-11 2004-03-25 Fresenius Kabi Deutschland Gmbh Method of producing hydroxyalkyl starch derivatives
WO2004032838A2 (en) * 2002-10-04 2004-04-22 The Regents Of The University Of California Methods for treating cancer by inhibiting wnt signaling
AU2003274748A1 (en) * 2002-11-08 2004-06-07 Reprocell Inc. Expansion agents for stem cells
AU2003293013A1 (en) * 2002-11-21 2004-06-18 University Of Massachusets Diagnosing and treating hematopoietic cancers
KR101042448B1 (ko) 2002-11-26 2011-06-16 안트로제네시스 코포레이션 세포요법제, 세포요법제 단위 및 이를 이용한 치료방법
EP1567008A4 (de) * 2002-12-06 2008-10-08 Univ Leland Stanford Junior Schutz von stammzellen gegen cytotoxischesubstanzen durch modulation der beta-catenin-signalleitungswege
US7803783B2 (en) * 2002-12-06 2010-09-28 The Board Of Trustees Of The Leland Stanford Junior University Use of WNT inhibitors to augment therapeutic index of chemotherapy
EP1577380B1 (de) * 2002-12-27 2013-06-05 Mitsubishi Heavy Industries, Ltd. Verfahren zur kultivierung von multipotenten stammzellen und kulturvorrichtung dafür
WO2004091647A1 (en) 2003-04-07 2004-10-28 The Board Of Trustees Of The Leland Stanford Junior University Compositions of active wnt protein
US20050043260A1 (en) * 2003-04-21 2005-02-24 Baylor College Of Medicine Wnt as a factor for cardiac myogenesis
WO2004113380A1 (en) * 2003-06-25 2004-12-29 Ottawa Health Research Institute Use of cardiotrophin to modulate stem cell proliferation
JP4750697B2 (ja) * 2003-06-25 2011-08-17 オタワ ヘルス リサーチ インスティテュート 幹細胞の成長及び分化を調節する方法及び組成物
US7939058B2 (en) * 2003-07-03 2011-05-10 University Of Southern California Uses of IL-12 in hematopoiesis
WO2005014655A2 (en) 2003-08-08 2005-02-17 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein
CN102302787A (zh) * 2004-03-11 2012-01-04 费森尤斯卡比德国有限公司 羟烷基淀粉和蛋白质的接合物
TWI417303B (zh) 2004-03-11 2013-12-01 Fresenius Kabi De Gmbh 經由還原胺化作用製得之羥烷基澱粉及蛋白質的接合物
US20060040883A1 (en) * 2004-05-14 2006-02-23 The Regents Of The University Of California Methods for treating cancer using anti-Wnt2 monoclonal antibodies and siRNA
WO2006030442A2 (en) 2004-09-16 2006-03-23 Gamida-Cell Ltd. Methods of ex vivo progenitor and stem cell expansion by co-culture with mesenchymal cells
WO2006034602A1 (fr) * 2004-09-28 2006-04-06 Beijing Institute Of Transfusion Medicine Procedes pour la proliferation de cellules souches/hematopoietiques in vitro
ES2667169T3 (es) 2004-10-19 2018-05-09 Regeneron Pharmaceuticals, Inc. Método para generar un animal no humano homocigótico para una modificación genética
AU2012200875B2 (en) * 2004-12-30 2012-08-30 Robarts Research Institute Methods for regulation of stem cells
US7850960B2 (en) * 2004-12-30 2010-12-14 University Of Washington Methods for regulation of stem cells
AU2006222187A1 (en) * 2005-03-11 2006-09-14 Fresenius Kabi Deutschland Gmbh Production of bioactive glycoproteins from inactive starting material by conjugation with hydroxyalkylstarch
WO2007030658A2 (en) * 2005-09-08 2007-03-15 Children's Hospital Medical Center Compositions useful for and methods of modulating angiogenesis
EP1762250A1 (de) * 2005-09-12 2007-03-14 Fresenius Kabi Deutschland GmbH Konjugate welche durch chemische Ligation zwischen Hydroxyalkylstärken und aktiven Substanzen mit Bildung eines Thiazolidin-Ringes entstehen
ES2452595T3 (es) 2005-10-13 2014-04-02 Anthrogenesis Corporation Inmunomodulación usando células madre de la placenta
US8846393B2 (en) 2005-11-29 2014-09-30 Gamida-Cell Ltd. Methods of improving stem cell homing and engraftment
KR20210122908A (ko) 2005-12-29 2021-10-12 안트로제네시스 코포레이션 태반 줄기 세포 집단
AU2006332679A1 (en) 2005-12-29 2007-07-12 Anthrogenesis Corporation Co-culture of placental stem cells and stem cells from a second source
DK2120977T3 (da) 2007-02-12 2013-08-12 Anthrogenesis Corp Behandling af inflammatoriske sygdomme under anvendelse af placenta-stamceller
EP2129775A1 (de) 2007-02-12 2009-12-09 Anthrogenesis Corporation Hepatocyten und chondrocyten aus adhärenten plazentastammzellen sowie cd34+, cd45- plazentastammzellenangereicherte zellpopulationen
US20080226707A1 (en) * 2007-03-05 2008-09-18 Jill Helms WNT compositions and methods of use thereof
EP2148569B1 (de) * 2007-04-23 2014-07-16 Stowers Institute for Medical Research Verfahren und zusammensetzungen für die selbsterneuerung von haematopoetische stammzellen
US9200253B1 (en) 2007-08-06 2015-12-01 Anthrogenesis Corporation Method of producing erythrocytes
KR20210022148A (ko) 2007-09-28 2021-03-02 안트로제네시스 코포레이션 인간 태반 관류액 및 인간 태반-유래 중간체 천연 킬러 세포를 사용한 종양 억제 방법
GB0803076D0 (en) 2008-02-20 2008-03-26 Univ Ghent Mucosal Membrane Receptor and uses thereof
KR20110050688A (ko) 2008-08-22 2011-05-16 안트로제네시스 코포레이션 태반 세포 집단을 이용한 골 결함의 치료 방법 및 골 결함 치료 조성물
AU2009316541B2 (en) 2008-11-19 2015-08-06 Celularity Inc. Amnion derived adherent cells
EP3284818B1 (de) 2010-01-26 2022-03-09 Celularity Inc. Behandlung von knochenbedingten karzinomen mit plazentastammzellen
KR20230054905A (ko) 2010-04-07 2023-04-25 셀룰래리티 인코포레이티드 태반 줄기 세포를 사용한 혈관신생
WO2011127113A1 (en) 2010-04-08 2011-10-13 Anthrogenesis Corporation Treatment of sarcoidosis using placental stem cells
EP2571516B1 (de) 2010-05-18 2017-11-15 Neumedicines, Inc Formulierungen enthaltend il-12 zur erhöhung der hematopoese
ES2666746T3 (es) 2010-07-13 2018-05-07 Anthrogenesis Corporation Métodos para generar linfocitos citolíticos naturales
WO2012034070A1 (en) 2010-09-09 2012-03-15 The Board Of Trustees Of The Leland Stanford Junior University Use of liposomal wnt compositions to enhance osseointegration
US8969315B2 (en) 2010-12-31 2015-03-03 Anthrogenesis Corporation Enhancement of placental stem cell potency using modulatory RNA molecules
PL2714059T3 (pl) 2011-06-01 2019-04-30 Celularity Inc Leczenie bólu z użyciem komórek macierzystych łożyska
WO2013055476A1 (en) 2011-09-09 2013-04-18 Anthrogenesis Corporation Treatment of amyotrophic lateral sclerosis using placental stem cells
WO2013121426A1 (en) 2012-02-13 2013-08-22 Gamida-Cell Ltd. Culturing of mesenchymal stem cells
US9175266B2 (en) 2012-07-23 2015-11-03 Gamida Cell Ltd. Enhancement of natural killer (NK) cell proliferation and activity
US9567569B2 (en) 2012-07-23 2017-02-14 Gamida Cell Ltd. Methods of culturing and expanding mesenchymal stem cells
US9763983B2 (en) 2013-02-05 2017-09-19 Anthrogenesis Corporation Natural killer cells from placenta
US20180360025A1 (en) * 2015-07-22 2018-12-20 Ramot At Tel-Aviv University Ltd. Article of manufacture and methods for increasing survival of red blood cells
JP2020506208A (ja) * 2017-02-10 2020-02-27 ゲンマブ ビー．ブイ． ポリペプチドバリアントおよびそれらの使用

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE266710C (de) *
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US3691016A (en) * 1970-04-17 1972-09-12 Monsanto Co Process for the preparation of insoluble enzymes
CA1023287A (en) * 1972-12-08 1977-12-27 Boehringer Mannheim G.M.B.H. Process for the preparation of carrier-bound proteins
US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4002531A (en) * 1976-01-22 1977-01-11 Pierce Chemical Company Modifying enzymes with polyethylene glycol and product produced thereby
US4195128A (en) * 1976-05-03 1980-03-25 Bayer Aktiengesellschaft Polymeric carrier bound ligands
US4330440A (en) * 1977-02-08 1982-05-18 Development Finance Corporation Of New Zealand Activated matrix and method of activation
CA1093991A (en) * 1977-02-17 1981-01-20 Hideo Hirohara Enzyme immobilization with pullulan gel
USRE30985E (en) * 1978-01-01 1982-06-29 Serum-free cell culture media
FR2413974A1 (fr) * 1978-01-06 1979-08-03 David Bernard Sechoir pour feuilles imprimees par serigraphie
US4229537A (en) * 1978-02-09 1980-10-21 New York University Preparation of trichloro-s-triazine activated supports for coupling ligands
US4275149A (en) * 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
JPS6023084B2 (ja) * 1979-07-11 1985-06-05 味の素株式会社 代用血液
US4399216A (en) * 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
ZA811368B (en) * 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
US4376110A (en) * 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
JPS6045849B2 (ja) * 1980-08-25 1985-10-12 林原 健 ヒトエリトロポエチンの製造方法
US4419446A (en) * 1980-12-31 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA process utilizing a papilloma virus DNA as a vector
US4485045A (en) * 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
NZ201705A (en) * 1981-08-31 1986-03-14 Genentech Inc Recombinant dna method for production of hepatitis b surface antigen in yeast
US4640835A (en) * 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
US4943529A (en) * 1982-05-19 1990-07-24 Gist-Brocades Nv Kluyveromyces as a host strain
US4601978A (en) * 1982-11-24 1986-07-22 The Regents Of The University Of California Mammalian metallothionein promoter system
US4560655A (en) * 1982-12-16 1985-12-24 Immunex Corporation Serum-free cell culture medium and process for making same
US4657866A (en) * 1982-12-21 1987-04-14 Sudhir Kumar Serum-free, synthetic, completely chemically defined tissue culture media
US4713339A (en) * 1983-01-19 1987-12-15 Genentech, Inc. Polycistronic expression vector construction
AU2353384A (en) * 1983-01-19 1984-07-26 Genentech Inc. Amplification in eukaryotic host cells
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4544545A (en) * 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
AU3145184A (en) * 1983-08-16 1985-02-21 Zymogenetics Inc. High expression of foreign genes in schizosaccharomyces pombe
US4767704A (en) * 1983-10-07 1988-08-30 Columbia University In The City Of New York Protein-free culture medium
US4496689A (en) * 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
US4965199A (en) * 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
US4879231A (en) * 1984-10-30 1989-11-07 Phillips Petroleum Company Transformation of yeasts of the genus pichia
EP0206448B1 (de) * 1985-06-19 1990-11-14 Ajinomoto Co., Inc. Hämoglobin, das an ein Poly(alkenylenoxid) gebunden ist
GB8516415D0 (en) * 1985-06-28 1985-07-31 Celltech Ltd Culture of animal cells
US4676980A (en) * 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
AU597574B2 (en) * 1986-03-07 1990-06-07 Massachusetts Institute Of Technology Method for enhancing glycoprotein stability
US4927762A (en) * 1986-04-01 1990-05-22 Cell Enterprises, Inc. Cell culture medium with antioxidant
GB8610600D0 (en) * 1986-04-30 1986-06-04 Novo Industri As Transformation of trichoderma
US4791192A (en) * 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
US4946783A (en) * 1987-01-30 1990-08-07 President And Fellows Of Harvard College Periplasmic protease mutants of Escherichia coli
US5010182A (en) * 1987-07-28 1991-04-23 Chiron Corporation DNA constructs containing a Kluyveromyces alpha factor leader sequence for directing secretion of heterologous polypeptides
IL87737A (en) * 1987-09-11 1993-08-18 Genentech Inc Method for culturing polypeptide factor dependent vertebrate recombinant cells
GB8724885D0 (en) * 1987-10-23 1987-11-25 Binns M M Fowlpox virus promotors
EP0321196A3 (de) * 1987-12-18 1990-07-18 Mycogen Plant Science, Inc. Transkriptionsaktivator des 780 T-DNA-Gens
DE3889546T2 (de) * 1987-12-21 1994-09-08 Univ Toledo Transformation von keimenden pflanzensamen mit hilfe von agrobacterium.
AU4005289A (en) * 1988-08-25 1990-03-01 Smithkline Beecham Corporation Recombinant saccharomyces
WO1990003430A1 (en) * 1988-09-23 1990-04-05 Cetus Corporation Cell culture medium for enhanced cell growth, culture longevity and product expression
US5116964A (en) * 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
ATE144281T1 (de) * 1989-04-28 1996-11-15 Rhein Biotech Proz & Prod Gmbh Hefezellen der gattung-schwanniomyces
FR2646437B1 (fr) * 1989-04-28 1991-08-30 Transgene Sa Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant
EP0402226A1 (de) * 1989-06-06 1990-12-12 Institut National De La Recherche Agronomique Transformationsvektoren für Hefe Yarrowia
ATE144793T1 (de) * 1989-06-29 1996-11-15 Medarex Inc Bispezifische reagenzien für die aids-therapie
DK168302B1 (da) * 1989-06-29 1994-03-07 Danisco Fremgangsmåde til indføring af molekyler, især genetisk materiale i planteceller
FR2649120B1 (fr) * 1989-06-30 1994-01-28 Cayla Nouvelle souche et ses mutants de champignons filamenteux, procede de production de proteines recombinantes a l'aide de ladite souche et souches et proteines obtenues selon ce procede
US5013556A (en) * 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
WO1991008291A2 (en) * 1989-11-22 1991-06-13 Genentech, Inc. Latency associated peptide and uses therefor
US5122469A (en) * 1990-10-03 1992-06-16 Genentech, Inc. Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
US5206161A (en) * 1991-02-01 1993-04-27 Genentech, Inc. Human plasma carboxypeptidase B
WO1992020373A1 (en) * 1991-05-14 1992-11-26 Repligen Corporation Heteroconjugate antibodies for treatment of hiv infection
WO1993008829A1 (en) * 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
US5672346A (en) * 1992-07-27 1997-09-30 Indiana University Foundation Human stem cell compositions and methods
CA2140280A1 (en) * 1992-08-17 1994-03-03 Avi J. Ashkenazi Bispecific immunoadhesins
SE9203831L (sv) * 1992-12-18 1994-02-21 Sp Wm Dricksvatten Ab Anordning för avskiljande av emulsioner genom elektrokemisk fällning
CA2177061A1 (en) * 1993-12-22 1995-06-29 Gideon A. Rodan Dna encoding the wnt-x growth factor
US5635388A (en) * 1994-04-04 1997-06-03 Genentech, Inc. Agonist antibodies against the flk2/flt3 receptor and uses thereof

Also Published As

Publication number Publication date
IL128129A0 (en) 1999-11-30
WO1998006747A2 (en) 1998-02-19
ATE252113T1 (de) 2003-11-15
WO1998006747A3 (en) 1998-05-07
DE69725587T2 (de) 2004-07-29
EP0918794A2 (de) 1999-06-02
AU721947B2 (en) 2000-07-20
ES2208943T3 (es) 2004-06-16
US5851984A (en) 1998-12-22
AU3911297A (en) 1998-03-06
JP2000516466A (ja) 2000-12-12
JP3759623B2 (ja) 2006-03-29
EP0918794B1 (de) 2003-10-15
IL128129A (en) 2006-12-31

Similar Documents

Publication Publication Date Title
ATE252113T1 (de) Verwendung von wnt polypeptiden
DE69527540D1 (de) Verwendung von stammzellenfaktor und löslichen interleukin-6-rezeptor zur vermehrung der hämatopoietischen vorläuferzellen
AU1750297A (en) Humanized green fluorescent protein genes and methods
HK1091228A1 (en) Methods for making recombinant proteins using apoptosis inhibitors
WO2000053761A3 (en) Human cytokine as ligand of the zalpha receptor and uses thereof
DK0772624T3 (da) Interleukin-15
AR018023A1 (es) Procedimiento para la fabricacion de polipeptidos con glicosilacion apropiada
EP0559769A4 (en) Heparin binding mitogen with homology to epidermal growth factor (egf)
IL148008A0 (en) Conditional immortalisation of cells
IL132496A0 (en) Mammalian cytokine-like factor 7
DE69526395D1 (de) Verwendung von Interferon-gamma zur Vermeidung der Proliferation und Differenzierung der primitiven Hämapoietischen Vorläuferzellen
ATE314477T1 (de) An der streptogramin biosynthese beteiligte polypeptide, ihre kodierenden nukleotidsequenzen und ihre verwendung
ATE225806T1 (de) D-2-alkyltryptophan enthaltende polypeptide mit wachstumhormon freisetzender aktivitaet
TR199901190T2 (xx) Interferon-(alfa) N�kleik asitlerinin verilmesi ve sentezlenmesi i�in y�ntemler ve bile�imler.
AU2002304249A1 (en) Polypeptide having an activity to support proliferation or survival of hematopoietic stem cell and hematopoietic progenitor cell, and dna coding for the same
DE69903559D1 (de) Verwendung von neuen zelltod inducierenden mitteln im synergismus mit interferon
AU590861B2 (en) New human lymphotoxin (TNF-beta) polypeptides their prepartion and use
CA2262469A1 (en) Uses for wnt polypeptides
ATE253634T1 (de) Polypeptide mit serotoninerger (5ht5a) rezeptor- aktivität, für sie kodierende nukleinsäuren und ihre verwendung
AU1141695A (en) Interferon-alpha/beta binding protein, its preparation and use
BR9407357A (pt) Novos tripeptideos utilizáveis em terapia cns e imune
ATE469229T1 (de) Herstellung von sekretierten polypeptiden

Legal Events

Date Code Title Description
8364 No opposition during term of opposition