DE69730966D1 - Morphogenische behandlung des chronischen nierenversagens - Google Patents
Morphogenische behandlung des chronischen nierenversagensInfo
- Publication number
- DE69730966D1 DE69730966D1 DE69730966T DE69730966T DE69730966D1 DE 69730966 D1 DE69730966 D1 DE 69730966D1 DE 69730966 T DE69730966 T DE 69730966T DE 69730966 T DE69730966 T DE 69730966T DE 69730966 D1 DE69730966 D1 DE 69730966D1
- Authority
- DE
- Germany
- Prior art keywords
- treatment
- chronic kidney
- kidney failure
- risk
- morphogenic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US643321 | 1996-05-06 | ||
US08/643,321 US6498142B1 (en) | 1996-05-06 | 1996-05-06 | Morphogen treatment for chronic renal failure |
PCT/US1997/007816 WO1997041881A1 (en) | 1996-05-06 | 1997-05-06 | Morphogen treatment for chronic renal failure |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69730966D1 true DE69730966D1 (de) | 2004-11-04 |
DE69730966T2 DE69730966T2 (de) | 2006-02-23 |
Family
ID=24580305
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69730966T Expired - Lifetime DE69730966T2 (de) | 1996-05-06 | 1997-05-06 | Morphogenische behandlung des chronischen nierenversagens |
DE69723845T Expired - Lifetime DE69723845T2 (de) | 1996-05-06 | 1997-05-06 | Therapien des chronischen nierenversagens |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69723845T Expired - Lifetime DE69723845T2 (de) | 1996-05-06 | 1997-05-06 | Therapien des chronischen nierenversagens |
Country Status (11)
Country | Link |
---|---|
US (5) | US6498142B1 (de) |
EP (2) | EP0914146B1 (de) |
JP (4) | JP4766722B2 (de) |
AT (2) | ATE245997T1 (de) |
AU (2) | AU2832297A (de) |
CA (2) | CA2254953C (de) |
DE (2) | DE69730966T2 (de) |
DK (2) | DK0914146T3 (de) |
ES (2) | ES2203803T3 (de) |
PT (2) | PT914146E (de) |
WO (2) | WO1997041880A1 (de) |
Families Citing this family (78)
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US20030167492A1 (en) | 1994-07-08 | 2003-09-04 | Johns Hopkins University School Of Medicine | Transgenic non-human animals expressing a gdf-11 dominant negative polypeptide, and methods of making and using same |
US6498142B1 (en) * | 1996-05-06 | 2002-12-24 | Curis, Inc. | Morphogen treatment for chronic renal failure |
AU743510B2 (en) * | 1997-05-05 | 2002-01-24 | Stryker Corporation | Therapies for acute renal failure |
WO1998050061A1 (en) * | 1997-05-07 | 1998-11-12 | Biogen, Inc. | Novel therapies for cystic kidney disease |
EP0896825B1 (de) | 1997-08-14 | 2002-07-17 | Sulzer Innotec Ag | Zusammensetzung und Vorrichtung zur Reparatur von Knorpelgewebe in vivo bestehend aus Nanokapseln mit osteoinduktiven und/oder chondroinduktiven Faktoren |
US6203788B1 (en) * | 1997-09-29 | 2001-03-20 | Adherex Inc. | Compounds and methods for regulating cell adhesion |
CA2314423A1 (en) * | 1997-12-04 | 1999-06-10 | Creative Biomolecules, Inc. | Maintenance of smooth muscle integrity by morphogenic proteins |
CA2336536A1 (en) * | 1998-07-28 | 2000-02-10 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-11 |
US6992066B2 (en) | 1998-10-16 | 2006-01-31 | Zimmer Orthobiologics, Inc. | Povidone-containing carriers for polypeptide growth factors |
US7087577B2 (en) * | 1998-10-16 | 2006-08-08 | Zimmer Orthobiologies, Inc. | Method of promoting natural bypass |
CA2384948C (en) * | 1999-09-14 | 2013-07-16 | Biogen, Inc. | Therapies for chronic renal failure using one or more integrin antagonists |
US20020173453A1 (en) * | 2000-12-15 | 2002-11-21 | Rama Akella | Method of treating renal injury |
US7700819B2 (en) | 2001-02-16 | 2010-04-20 | Kci Licensing, Inc. | Biocompatible wound dressing |
US7763769B2 (en) | 2001-02-16 | 2010-07-27 | Kci Licensing, Inc. | Biocompatible wound dressing |
US7232802B2 (en) * | 2001-12-21 | 2007-06-19 | Zimmer Orthobiologics, Inc. | Compositions and methods for promoting myocardial and peripheral angiogenesis |
US7622562B2 (en) | 2002-06-26 | 2009-11-24 | Zimmer Orthobiologics, Inc. | Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue |
CA2497048A1 (en) * | 2002-08-28 | 2004-03-11 | Curis, Inc. | Conjoint administration of morphogens and ace inhibitors in treatment of chronic renal failure |
DK1677735T3 (da) | 2003-10-17 | 2014-10-27 | Joslin Diabetes Center Inc | Fremgangsmåder og sammensætninger til modulering af adipocytfunktion |
US7844367B2 (en) | 2003-12-23 | 2010-11-30 | Rain Bird Corporation | Code replacement for irrigation controllers |
GB2430367B (en) | 2004-03-30 | 2009-08-05 | Ilypsa Inc | Ion binding polymers and uses thereof |
US7459527B2 (en) * | 2004-03-31 | 2008-12-02 | Xencor, Inc. | BMP-7 variants with improved properties |
US20100150885A1 (en) | 2005-06-01 | 2010-06-17 | Joslin Diabetes Center, Inc. | Methods and compositions for inducing brown adipogenesis |
US7771995B2 (en) * | 2005-11-14 | 2010-08-10 | Merial Limited | Plasmid encoding human BMP-7 |
JP2009515529A (ja) * | 2005-11-14 | 2009-04-16 | メリアル リミテッド | 腎不全のための遺伝子療法 |
US20090004159A1 (en) * | 2006-01-24 | 2009-01-01 | The Board Of Trustees Of The University Of Illinoi | Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells |
JP2009524436A (ja) * | 2006-01-24 | 2009-07-02 | ノースフィールド ラボラトリーズ、インコーポレイテッド | 重合したヘモグロビンの培地、並びに島細胞の単離及び移植におけるその使用 |
US20080090765A1 (en) * | 2006-05-25 | 2008-04-17 | The Trustees Of Columbia University In The City Of New York | Compositions for modulating growth of embryonic and adult kidney tissue and uses for treating kidney damage |
US20090197280A1 (en) * | 2006-05-30 | 2009-08-06 | Kristian Bangert | Methods and Devices for Rapid Assessment of Severity of Injury |
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EP2047862B9 (de) * | 2006-07-21 | 2013-04-10 | Chugai Seiyaku Kabushiki Kaisha | Mittel zur behandlung von nierenerkrankungen |
US20080255181A1 (en) * | 2006-12-15 | 2008-10-16 | University Of Heidelberg | Methods for treating podocyte-related disorders |
AU2008245900B2 (en) * | 2007-04-24 | 2013-07-25 | Advanced Technologies And Regenerative Medicine, Llc | Engineered renal tissue |
DE102007034580B4 (de) * | 2007-07-13 | 2012-11-08 | NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen | Biomaterial basierend auf einem hydrophilen polymeren Träger |
US20090155245A1 (en) * | 2007-12-18 | 2009-06-18 | Fang Carrie H | Treatment for Organ Regeneration with Combination of Drug and Biologics |
CA2725208A1 (en) * | 2008-05-06 | 2009-11-12 | Joslin Diabetes Center, Inc. | Methods and compositions for inducing brown adipogenesis |
WO2009157165A1 (ja) * | 2008-06-24 | 2009-12-30 | 株式会社根本杏林堂 | 薬液注入装置、この薬液注入装置を有する透視撮像システム、薬液注入装置のコンピュータプログラムおよびデータ処理方法 |
BRPI0917711A2 (pt) * | 2008-08-28 | 2017-06-20 | Astute Medical Inc | método para avaliar o estado renal em um paciente, e, uso de um ou mais marcadores de lesão renal |
CN105021826A (zh) * | 2008-08-29 | 2015-11-04 | 阿斯图特医药公司 | 用于诊断和预后肾损伤和肾衰竭的方法和组合物 |
EP3246707B1 (de) * | 2008-10-21 | 2020-09-30 | Astute Medical, Inc. | Verfahren und zusammensetzungen zur diagnose und prognose von nierenläsion und niereninsuffizienz |
US20110207161A1 (en) * | 2008-10-21 | 2011-08-25 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
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CN104034901A (zh) * | 2008-11-22 | 2014-09-10 | 阿斯图特医药公司 | 用于诊断和预后肾损伤和肾衰竭的方法和组合物 |
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US9229010B2 (en) | 2009-02-06 | 2016-01-05 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
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SG2014010680A (en) * | 2009-02-12 | 2014-04-28 | Stryker Corp | Peripheral administration of proteins including tgf-beta superfamily members for treatment of systemic disorders and disease |
JP5749659B2 (ja) * | 2009-03-12 | 2015-07-15 | ハーゼ インベストメンツ ウーゲー | Bmpアンタゴニスト感受性が低下した骨形成タンパク質2(bmp2)変異体 |
US20110002897A1 (en) | 2009-06-11 | 2011-01-06 | Burnham Institute For Medical Research | Directed differentiation of stem cells |
EA201290056A1 (ru) | 2009-08-07 | 2012-08-30 | Астьют Медикал, Инк. | Способы и композиции для диагностики и прогнозирования повреждений почек и почечной недостаточности |
AU2010295509A1 (en) | 2009-09-17 | 2012-04-19 | Stryker Corporation | Buffers for controlling the pH of bone morphogenetic proteins |
NZ599773A (en) | 2009-11-07 | 2014-09-26 | Astute Medical Inc | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
CA2784889C (en) | 2009-12-20 | 2018-06-19 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
EP2516456A1 (de) | 2009-12-22 | 2012-10-31 | Stryker Corporation | Bmp-7-varianten mit reduzierter immunogenität |
CN102791885B (zh) | 2010-02-05 | 2015-09-09 | 阿斯图特医药公司 | 用于肾损伤和肾衰竭的诊断及预后的方法和组合物 |
EP3070474A3 (de) | 2010-02-26 | 2016-12-07 | Astute Medical, Inc. | Verfahren und zusammensetzungen zur diagnose und prognose von nierenläsion und niereninsuffizienz |
EP2576587B1 (de) | 2010-05-24 | 2018-03-21 | The Trustees of Columbia University in the City of New York | Mutante ngal-proteine und verwendungen davon |
EP3339860A1 (de) | 2010-06-23 | 2018-06-27 | Astute Medical, Inc. | Verfahren und zusammensetzungen zur diagnose und prognose von nierenläsion und niereninsuffizienz |
IN2012MN02812A (de) | 2010-06-23 | 2015-05-22 | Astute Medical Inc | |
US9688735B2 (en) | 2010-08-20 | 2017-06-27 | Wyeth Llc | Designer osteogenic proteins |
KR101630501B1 (ko) | 2010-08-20 | 2016-06-15 | 와이어쓰 엘엘씨 | 디자이너 골형성 단백질 |
WO2013086359A1 (en) | 2011-12-08 | 2013-06-13 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
AU2013329451B2 (en) | 2012-10-08 | 2018-08-09 | Vifor (International) Ltd. | Potassium-binding agents for treating hypertension and hyperkalemia |
WO2014081980A2 (en) | 2012-11-21 | 2014-05-30 | The Trustees Of Columbia University In The City Of New York | Mutant ngal proteins and uses thereof |
PL2946211T3 (pl) | 2013-01-17 | 2018-08-31 | Astute Medical, Inc. | Sposoby i kompozycje do diagnozowania i prognozowania uszkodzenia oraz niewydolności nerek |
US9359417B2 (en) | 2013-01-25 | 2016-06-07 | Warsaw Orthopedic, Inc. | Cell cultures and methods of human recombinant growth and differentiaton factor-5 (rhGDF-5) |
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EP2784083A1 (de) | 2013-03-28 | 2014-10-01 | Charité - Universitätsmedizin Berlin | Knochenmorphogenetische Protein (BMP)-Varianten mit hoch reduzierter Antagonisten-Sensibilität und erweiterter spezifischer biologischer Aktivität |
JP2016536588A (ja) * | 2013-11-11 | 2016-11-24 | ゼネラル・エレクトリック・カンパニイ | ロータ速度の測定における誤差を低減する方法 |
EP2944326B1 (de) | 2014-05-16 | 2018-11-21 | Cyanagen Srl | Tricarbocyanin-cyclodextrin-konjugate und deren verwendung zur diagnose von nierenkrankheiten |
AU2016218977C1 (en) | 2015-02-13 | 2023-03-23 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
US11243217B2 (en) | 2016-06-06 | 2022-02-08 | Astute Medical, Inc. | Management of acute kidney injury using insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase 2 |
CA3033788A1 (en) | 2016-08-17 | 2018-02-22 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
JP2019039673A (ja) * | 2017-08-22 | 2019-03-14 | セイコーエプソン株式会社 | 時間デジタル変換回路、回路装置、物理量測定装置、電子機器及び移動体 |
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IT1156741B (it) * | 1978-05-15 | 1987-02-04 | Sigma Tau Ind Farmaceuti | Applicazione terapeutica della carnitina e di alcuni derivati acilati della carnitina nell'emodialisi |
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-
1996
- 1996-05-06 US US08/643,321 patent/US6498142B1/en not_active Expired - Lifetime
-
1997
- 1997-05-06 CA CA002254953A patent/CA2254953C/en not_active Expired - Fee Related
- 1997-05-06 WO PCT/US1997/007655 patent/WO1997041880A1/en active IP Right Grant
- 1997-05-06 EP EP97922726A patent/EP0914146B1/de not_active Expired - Lifetime
- 1997-05-06 WO PCT/US1997/007816 patent/WO1997041881A1/en active IP Right Grant
- 1997-05-06 JP JP54021197A patent/JP4766722B2/ja not_active Expired - Fee Related
- 1997-05-06 JP JP09540150A patent/JP2000510835A/ja active Pending
- 1997-05-06 AT AT97923567T patent/ATE245997T1/de not_active IP Right Cessation
- 1997-05-06 DE DE69730966T patent/DE69730966T2/de not_active Expired - Lifetime
- 1997-05-06 AU AU28322/97A patent/AU2832297A/en not_active Abandoned
- 1997-05-06 PT PT97922726T patent/PT914146E/pt unknown
- 1997-05-06 DK DK97922726T patent/DK0914146T3/da active
- 1997-05-06 ES ES97923567T patent/ES2203803T3/es not_active Expired - Lifetime
- 1997-05-06 US US08/851,628 patent/US6861404B1/en not_active Expired - Fee Related
- 1997-05-06 PT PT97923567T patent/PT910400E/pt unknown
- 1997-05-06 CA CA002254954A patent/CA2254954C/en not_active Expired - Fee Related
- 1997-05-06 AT AT97922726T patent/ATE277629T1/de active
- 1997-05-06 EP EP97923567A patent/EP0910400B1/de not_active Expired - Lifetime
- 1997-05-06 DE DE69723845T patent/DE69723845T2/de not_active Expired - Lifetime
- 1997-05-06 DK DK97923567T patent/DK0910400T3/da active
- 1997-05-06 ES ES97922726T patent/ES2230604T3/es not_active Expired - Lifetime
- 1997-05-06 AU AU29339/97A patent/AU2933997A/en not_active Abandoned
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2004
- 2004-12-17 US US11/016,499 patent/US7524817B2/en not_active Expired - Fee Related
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2009
- 2009-03-16 US US12/404,559 patent/US8017580B2/en not_active Expired - Fee Related
- 2009-05-26 JP JP2009126963A patent/JP5247593B2/ja not_active Expired - Fee Related
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2011
- 2011-08-11 US US13/207,584 patent/US8377878B2/en not_active Expired - Fee Related
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2012
- 2012-08-14 JP JP2012179876A patent/JP2012229268A/ja not_active Withdrawn
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