DE69730966D1 - Morphogenische behandlung des chronischen nierenversagens - Google Patents
Morphogenische behandlung des chronischen nierenversagensInfo
- Publication number
- DE69730966D1 DE69730966D1 DE69730966T DE69730966T DE69730966D1 DE 69730966 D1 DE69730966 D1 DE 69730966D1 DE 69730966 T DE69730966 T DE 69730966T DE 69730966 T DE69730966 T DE 69730966T DE 69730966 D1 DE69730966 D1 DE 69730966D1
- Authority
- DE
- Germany
- Prior art keywords
- treatment
- chronic kidney
- kidney failure
- risk
- morphogenic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/643,321 US6498142B1 (en) | 1996-05-06 | 1996-05-06 | Morphogen treatment for chronic renal failure |
US643321 | 1996-05-06 | ||
PCT/US1997/007816 WO1997041881A1 (en) | 1996-05-06 | 1997-05-06 | Morphogen treatment for chronic renal failure |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69730966D1 true DE69730966D1 (de) | 2004-11-04 |
DE69730966T2 DE69730966T2 (de) | 2006-02-23 |
Family
ID=24580305
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69723845T Expired - Lifetime DE69723845T2 (de) | 1996-05-06 | 1997-05-06 | Therapien des chronischen nierenversagens |
DE69730966T Expired - Lifetime DE69730966T2 (de) | 1996-05-06 | 1997-05-06 | Morphogenische behandlung des chronischen nierenversagens |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69723845T Expired - Lifetime DE69723845T2 (de) | 1996-05-06 | 1997-05-06 | Therapien des chronischen nierenversagens |
Country Status (11)
Country | Link |
---|---|
US (5) | US6498142B1 (de) |
EP (2) | EP0910400B1 (de) |
JP (4) | JP2000510835A (de) |
AT (2) | ATE245997T1 (de) |
AU (2) | AU2832297A (de) |
CA (2) | CA2254953C (de) |
DE (2) | DE69723845T2 (de) |
DK (2) | DK0910400T3 (de) |
ES (2) | ES2230604T3 (de) |
PT (2) | PT910400E (de) |
WO (2) | WO1997041880A1 (de) |
Families Citing this family (78)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2363965C (en) * | 1991-03-11 | 2010-05-18 | Curis, Inc. | Protein-induced morphogenesis |
US6077823A (en) * | 1991-03-11 | 2000-06-20 | Creative Biomolecules, Inc. | Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury |
US20030167492A1 (en) | 1994-07-08 | 2003-09-04 | Johns Hopkins University School Of Medicine | Transgenic non-human animals expressing a gdf-11 dominant negative polypeptide, and methods of making and using same |
US6498142B1 (en) | 1996-05-06 | 2002-12-24 | Curis, Inc. | Morphogen treatment for chronic renal failure |
AU743510B2 (en) * | 1997-05-05 | 2002-01-24 | Stryker Corporation | Therapies for acute renal failure |
WO1998050061A1 (en) * | 1997-05-07 | 1998-11-12 | Biogen, Inc. | Novel therapies for cystic kidney disease |
EP0896825B1 (de) | 1997-08-14 | 2002-07-17 | Sulzer Innotec Ag | Zusammensetzung und Vorrichtung zur Reparatur von Knorpelgewebe in vivo bestehend aus Nanokapseln mit osteoinduktiven und/oder chondroinduktiven Faktoren |
US6203788B1 (en) * | 1997-09-29 | 2001-03-20 | Adherex Inc. | Compounds and methods for regulating cell adhesion |
WO1999028341A2 (en) * | 1997-12-04 | 1999-06-10 | Creative Biomolecules, Inc. | Maintenance of smooth muscle integrity by morphogenic proteins |
WO2000006716A1 (en) * | 1998-07-28 | 2000-02-10 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-11 |
US7087577B2 (en) * | 1998-10-16 | 2006-08-08 | Zimmer Orthobiologies, Inc. | Method of promoting natural bypass |
US6992066B2 (en) * | 1998-10-16 | 2006-01-31 | Zimmer Orthobiologics, Inc. | Povidone-containing carriers for polypeptide growth factors |
EP1214091B1 (de) * | 1999-09-14 | 2006-05-10 | Biogen Idec MA Inc. | Therapien für chronische niereninsuffizienz unter verwendung von einem oder mehreren integrinantagonist(en) |
US20020173453A1 (en) * | 2000-12-15 | 2002-11-21 | Rama Akella | Method of treating renal injury |
US7700819B2 (en) | 2001-02-16 | 2010-04-20 | Kci Licensing, Inc. | Biocompatible wound dressing |
US7763769B2 (en) | 2001-02-16 | 2010-07-27 | Kci Licensing, Inc. | Biocompatible wound dressing |
US7232802B2 (en) * | 2001-12-21 | 2007-06-19 | Zimmer Orthobiologics, Inc. | Compositions and methods for promoting myocardial and peripheral angiogenesis |
US7622562B2 (en) | 2002-06-26 | 2009-11-24 | Zimmer Orthobiologics, Inc. | Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue |
WO2004019876A2 (en) * | 2002-08-28 | 2004-03-11 | Curis, Inc. | Conjoint administration of morphogens and ace inhibitors in treatment of chronic renal failure |
WO2005037232A2 (en) | 2003-10-17 | 2005-04-28 | Joslin Diabetes Center, Inc. | Methods and compositions for modulating adipocyte function |
US7844367B2 (en) | 2003-12-23 | 2010-11-30 | Rain Bird Corporation | Code replacement for irrigation controllers |
CA2558029C (en) | 2004-03-30 | 2013-05-07 | Ilypsa, Inc. | Ion binding polymers and uses thereof |
EP1730186A2 (de) * | 2004-03-31 | 2006-12-13 | Xencor, Inc. | Bmp-7 varianten mit verbesserten eigenschaften |
WO2006130690A2 (en) * | 2005-06-01 | 2006-12-07 | Joslin Diabetes Center, Inc. | Methods and compositions for inducing brown adipogenesis |
JP2009515529A (ja) * | 2005-11-14 | 2009-04-16 | メリアル リミテッド | 腎不全のための遺伝子療法 |
US7771995B2 (en) * | 2005-11-14 | 2010-08-10 | Merial Limited | Plasmid encoding human BMP-7 |
WO2007087570A2 (en) | 2006-01-24 | 2007-08-02 | Northfield Laboratories, Inc. | Polymerized hemoglobin media and its use in isolation and transplantation of islet cells |
US20090004159A1 (en) * | 2006-01-24 | 2009-01-01 | The Board Of Trustees Of The University Of Illinoi | Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells |
US20080090765A1 (en) * | 2006-05-25 | 2008-04-17 | The Trustees Of Columbia University In The City Of New York | Compositions for modulating growth of embryonic and adult kidney tissue and uses for treating kidney damage |
US20090197280A1 (en) * | 2006-05-30 | 2009-08-06 | Kristian Bangert | Methods and Devices for Rapid Assessment of Severity of Injury |
US7722665B2 (en) * | 2006-07-07 | 2010-05-25 | Graft Technologies, Inc. | System and method for providing a graft in a vascular environment |
WO2008010556A1 (fr) * | 2006-07-21 | 2008-01-24 | Chugai Seiyaku Kabushiki Kaisha | Médicament agissant contre une maladie rénale |
CA2672560A1 (en) * | 2006-12-15 | 2008-06-26 | Ruprecht-Karls-Universitaet Heidelberg | Methods for treating podocyte-related disorders |
EP2148706A2 (de) * | 2007-04-24 | 2010-02-03 | Advanced Technologies and Regenerative Medicine, LLC | Gentechnisch hergestelltes nierengewebe |
DE102007034580B4 (de) * | 2007-07-13 | 2012-11-08 | NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen | Biomaterial basierend auf einem hydrophilen polymeren Träger |
US20090155245A1 (en) * | 2007-12-18 | 2009-06-18 | Fang Carrie H | Treatment for Organ Regeneration with Combination of Drug and Biologics |
US20110104133A1 (en) * | 2008-05-06 | 2011-05-05 | Joslin Diabetes Center, Inc. | Methods and compositions for inducing brown adipogenesis |
WO2009157165A1 (ja) * | 2008-06-24 | 2009-12-30 | 株式会社根本杏林堂 | 薬液注入装置、この薬液注入装置を有する透視撮像システム、薬液注入装置のコンピュータプログラムおよびデータ処理方法 |
EP2324355B1 (de) * | 2008-08-28 | 2014-01-22 | Astute Medical, Inc. | Verfahren und zusammensetzungen zur diagnose und prognose von nierenverletzungen und niereninsuffizienz |
CN102187219B (zh) * | 2008-08-29 | 2015-08-05 | 阿斯图特医药公司 | 用于诊断和预后肾损伤和肾衰竭的方法和组合物 |
CA2740923A1 (en) * | 2008-10-21 | 2010-04-29 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
CN102246035B (zh) | 2008-10-21 | 2014-10-22 | 阿斯图特医药公司 | 用于诊断和预后肾损伤和肾衰竭的方法和组合物 |
WO2010054389A1 (en) | 2008-11-10 | 2010-05-14 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
EP2811036A3 (de) * | 2008-11-22 | 2015-02-18 | Astute Medical, Inc. | Verfahren und Zusammensetzungen zur Diagnose und Prognose von Nierenläsion und Niereninsuffizienz |
US9229010B2 (en) | 2009-02-06 | 2016-01-05 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
CN106546752A (zh) * | 2009-02-06 | 2017-03-29 | 阿斯图特医药公司 | 肾损伤和肾衰竭的诊断及预后 |
EP2396025A2 (de) | 2009-02-12 | 2011-12-21 | Stryker Corporation | Periphere verabreichung von proteinen einschliesslich mitglieder der tgf-beta-superfamilie zur systemischen behandlung von störungen und erkrankungen |
CN102369017A (zh) * | 2009-02-12 | 2012-03-07 | 史赛克公司 | 用于微创系统性递送包含TGF-β超家族成员的蛋白质的组合物和方法 |
US8828937B2 (en) * | 2009-03-12 | 2014-09-09 | Haase Investments Ug | Bone morphogenetic protein 2 (BMP2) variants with reduced BMP antagonist sensitivity |
WO2010144696A1 (en) | 2009-06-11 | 2010-12-16 | Burnham Institute For Medical Research | Directed differentiation of stem cells |
KR20120061863A (ko) | 2009-08-07 | 2012-06-13 | 아스튜트 메디컬 인코포레이티드 | 신장 손상 및 신부전증의 진단과 예후를 위한 방법 및 조성물 |
US20110224410A1 (en) | 2009-09-17 | 2011-09-15 | Hile David | Buffers for Controlling the pH of Bone Morphogenetic Proteins |
NZ628085A (en) | 2009-11-07 | 2015-12-24 | Astute Medical Inc | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
KR20120123056A (ko) | 2009-12-20 | 2012-11-07 | 아스튜트 메디컬 인코포레이티드 | 신손상 및 신부전을 진단 및 예측하는 방법 및 조성물 |
CN102822197A (zh) | 2009-12-22 | 2012-12-12 | 史赛克公司 | 具有降低的免疫原性的bmp-7变体 |
MX366653B (es) | 2010-02-05 | 2019-07-17 | Astute Medical Inc | Metodos y composiciones para diagnosis y prognosis de lesion renal y falla renal. |
WO2011162819A1 (en) | 2010-06-23 | 2011-12-29 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
WO2011106746A1 (en) | 2010-02-26 | 2011-09-01 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
WO2011149962A1 (en) | 2010-05-24 | 2011-12-01 | The Trustees Of Columbia University In The City Of New York | Mutant ngal proteins and uses thereof |
NZ605698A (en) | 2010-06-23 | 2015-03-27 | Astute Medical Inc | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
CN105198981B (zh) | 2010-08-20 | 2019-07-16 | 惠氏有限责任公司 | 经设计的成骨蛋白 |
US9688735B2 (en) | 2010-08-20 | 2017-06-27 | Wyeth Llc | Designer osteogenic proteins |
ES2933570T3 (es) | 2011-12-08 | 2023-02-10 | Astute Medical Inc | Métodos y composiciones para el diagnóstico y el pronóstico de una lesión renal y de una insuficiencia renal |
AU2013329451B2 (en) | 2012-10-08 | 2018-08-09 | Vifor (International) Ltd. | Potassium-binding agents for treating hypertension and hyperkalemia |
WO2014081980A2 (en) | 2012-11-21 | 2014-05-30 | The Trustees Of Columbia University In The City Of New York | Mutant ngal proteins and uses thereof |
CN107976547B (zh) | 2013-01-17 | 2020-08-25 | 阿斯图特医药公司 | 用于肾损伤和肾衰竭的诊断及预后的方法和组合物 |
US9051389B2 (en) | 2013-01-25 | 2015-06-09 | Warsaw Orthopedic, Inc. | Expression conditions and methods of human recombinant growth and differentiation factor-5 (rhGDF-5) |
US8956829B2 (en) | 2013-01-25 | 2015-02-17 | Warsaw Orthopedic, Inc. | Human recombinant growth and differentiaton factor-5 (rhGDF-5) |
US9169308B2 (en) | 2013-01-25 | 2015-10-27 | Warsaw Orthopedic, Inc. | Methods and compositions of human recombinant growth and differentiation factor-5 (rhGDF-5) isolated from inclusion bodies |
US9359417B2 (en) | 2013-01-25 | 2016-06-07 | Warsaw Orthopedic, Inc. | Cell cultures and methods of human recombinant growth and differentiaton factor-5 (rhGDF-5) |
US8945872B2 (en) | 2013-01-25 | 2015-02-03 | Warsaw Orthopedic, Inc. | Methods of purifying human recombinant growth and differentiation factor-5 (rhGDF-5) protein |
EP2784083A1 (de) | 2013-03-28 | 2014-10-01 | Charité - Universitätsmedizin Berlin | Knochenmorphogenetische Protein (BMP)-Varianten mit hoch reduzierter Antagonisten-Sensibilität und erweiterter spezifischer biologischer Aktivität |
WO2015069998A1 (en) * | 2013-11-11 | 2015-05-14 | General Electric Company | Method for reducing error in rotor speed measurements |
EP2944326B1 (de) | 2014-05-16 | 2018-11-21 | Cyanagen Srl | Tricarbocyanin-cyclodextrin-konjugate und deren verwendung zur diagnose von nierenkrankheiten |
WO2016131052A1 (en) | 2015-02-13 | 2016-08-18 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
US11243217B2 (en) | 2016-06-06 | 2022-02-08 | Astute Medical, Inc. | Management of acute kidney injury using insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase 2 |
WO2018035377A1 (en) | 2016-08-17 | 2018-02-22 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
JP2019039673A (ja) * | 2017-08-22 | 2019-03-14 | セイコーエプソン株式会社 | 時間デジタル変換回路、回路装置、物理量測定装置、電子機器及び移動体 |
Family Cites Families (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1156741B (it) * | 1978-05-15 | 1987-02-04 | Sigma Tau Ind Farmaceuti | Applicazione terapeutica della carnitina e di alcuni derivati acilati della carnitina nell'emodialisi |
US4342828A (en) | 1979-07-20 | 1982-08-03 | Morinaga Milk Industry Co., Ltd. | Method for producing substance capable of stimulating differentiation and proliferation of human granulopoietic stem cells |
US4627839A (en) * | 1985-11-21 | 1986-12-09 | American Hospital Supply Corporation | Patient controlled analgesia conversion |
US5013649A (en) * | 1986-07-01 | 1991-05-07 | Genetics Institute, Inc. | DNA sequences encoding osteoinductive products |
IL83003A (en) | 1986-07-01 | 1995-07-31 | Genetics Inst | Factors that soak bone formation |
US5266683A (en) * | 1988-04-08 | 1993-11-30 | Stryker Corporation | Osteogenic proteins |
US5011691A (en) * | 1988-08-15 | 1991-04-30 | Stryker Corporation | Osteogenic devices |
US5045452A (en) * | 1988-09-02 | 1991-09-03 | Brigham And Women's Hospital | Method for evaluating nephrotoxicity |
CA2030518C (en) | 1989-03-28 | 2000-03-21 | Elizabeth A. Wang | Osteoinductive compositions |
ATE209251T1 (de) | 1990-05-16 | 2001-12-15 | Genetics Inst | Knochen- und knorpel-bildung hervorrufende proteine |
JPH0426624A (ja) * | 1990-05-18 | 1992-01-29 | Tsumura & Co | 慢性腎不全改善剤 |
EP0533840B1 (de) * | 1990-06-22 | 1996-12-11 | E.I. Du Pont De Nemours And Company | Behandlung des chronischen nierenversagens mit imidazol-angiotensin-ii-rezeptorantagonisten |
US7056882B2 (en) * | 1991-03-11 | 2006-06-06 | Curis, Inc. | Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases |
US6077823A (en) * | 1991-03-11 | 2000-06-20 | Creative Biomolecules, Inc. | Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury |
CA2363965C (en) * | 1991-03-11 | 2010-05-18 | Curis, Inc. | Protein-induced morphogenesis |
US6194376B1 (en) * | 1991-03-11 | 2001-02-27 | Creative Biomolecules, Inc. | Method for modulating inflammatory response comprising administering morphogen |
US5849686A (en) * | 1991-03-11 | 1998-12-15 | Creative Biomolecules, Inc. | Morphogen-induced liver regeneration |
AU660019B2 (en) | 1991-03-11 | 1995-06-08 | Stryker Corporation | Protein-induced morphogenesis |
US6287816B1 (en) | 1991-06-25 | 2001-09-11 | Genetics Institute, Inc. | BMP-9 compositions |
CA2116562C (en) | 1991-08-30 | 1999-04-13 | Thangavel Kuberasampath | Morphogen-induced modulation of inflammatory response |
ATE197611T1 (de) | 1991-08-30 | 2000-12-15 | Creative Biomolecules Inc | Screeningverfahren von morphogenischen proteinen |
JP4235689B2 (ja) | 1991-08-30 | 2009-03-11 | ストライカー・コーポレーション | 骨疾患を処置するための骨形成タンパク質 |
US6120760A (en) * | 1992-02-12 | 2000-09-19 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung | Growth/differentiation factors of the TGF-β family |
JP4344012B2 (ja) | 1992-07-31 | 2009-10-14 | ストライカー・コーポレーション | 組織形成因子誘導による神経の再生と修復 |
KR950702627A (ko) | 1992-07-31 | 1995-07-29 | 찰스 엠. 코헨 | 모르포겐 단백질의 가용성 복합체 및 그의 조성물(Morphogenic Protein Soluble Complex and Composition Thereof) |
JPH07509720A (ja) | 1992-07-31 | 1995-10-26 | クリエイティブ バイオモレキュルズ,インコーポレイテッド | モルフォゲン強化栄養組成物 |
ATE162078T1 (de) | 1992-09-16 | 1998-01-15 | Creative Biomolecules Inc | Morphogeninduzierte regenerierung der leber |
WO1994010203A2 (en) | 1992-11-03 | 1994-05-11 | Creative Biomolecules, Inc. | Op-3-induced morphogenesis |
US5372335A (en) | 1992-12-18 | 1994-12-13 | Scott H. Yenzer | Aerial marker ball and method of placement |
CA2157387C (en) | 1993-03-04 | 1998-12-15 | David C. Rueger | Method and compositions for recombinant osteogenic protein production |
US5631159A (en) | 1993-09-22 | 1997-05-20 | Creative Biomolecules, Inc. | Lipid-modified serum free media |
US5585237A (en) | 1993-10-25 | 1996-12-17 | Creative Biomolecules, Inc. | Methods and compositions for high protein production from recombinant DNA |
CA2176709A1 (en) * | 1993-11-15 | 1995-05-26 | Howard R. Higley | Method of treating renal disease by administering igf-i and igfbp-3 |
US5525621A (en) * | 1994-05-20 | 1996-06-11 | Cytos Pharmaceuticals Llc | Imidazole derivatives as protective agents in reperfusion injury and severe inflammatory responses |
US5714511A (en) * | 1995-07-31 | 1998-02-03 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Selective prevention of organ injury in sepsis and shock using selection release of nitric oxide in vulnerable organs |
US5723411A (en) * | 1995-10-31 | 1998-03-03 | E. I. Du Pont De Nemours And Company | Herbicidal pyridazinones |
ES2201287T5 (es) * | 1996-03-22 | 2007-10-16 | Curis, Inc. | Metodo para mejorar la recuperacion funcional de la coordinacion motora, del habla o la percepcion sensorial tras una isquemia o trauma del sistema nervioso central. |
US5820589A (en) * | 1996-04-30 | 1998-10-13 | Medtronic, Inc. | Implantable non-invasive rate-adjustable pump |
US6498142B1 (en) * | 1996-05-06 | 2002-12-24 | Curis, Inc. | Morphogen treatment for chronic renal failure |
US5879908A (en) * | 1997-04-30 | 1999-03-09 | Smithkline Beecham Corporation | CRFG-1a, a target and marker for chronic renal failure |
US7147839B2 (en) * | 1998-05-29 | 2006-12-12 | Curis, Inc. | Methods for evaluating tissue morphogenesis and activity |
-
1996
- 1996-05-06 US US08/643,321 patent/US6498142B1/en not_active Expired - Lifetime
-
1997
- 1997-05-06 AT AT97923567T patent/ATE245997T1/de not_active IP Right Cessation
- 1997-05-06 DK DK97923567T patent/DK0910400T3/da active
- 1997-05-06 EP EP97923567A patent/EP0910400B1/de not_active Expired - Lifetime
- 1997-05-06 PT PT97923567T patent/PT910400E/pt unknown
- 1997-05-06 ES ES97922726T patent/ES2230604T3/es not_active Expired - Lifetime
- 1997-05-06 EP EP97922726A patent/EP0914146B1/de not_active Expired - Lifetime
- 1997-05-06 DK DK97922726T patent/DK0914146T3/da active
- 1997-05-06 PT PT97922726T patent/PT914146E/pt unknown
- 1997-05-06 ES ES97923567T patent/ES2203803T3/es not_active Expired - Lifetime
- 1997-05-06 DE DE69723845T patent/DE69723845T2/de not_active Expired - Lifetime
- 1997-05-06 WO PCT/US1997/007655 patent/WO1997041880A1/en active IP Right Grant
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- 1997-05-06 AU AU28322/97A patent/AU2832297A/en not_active Abandoned
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- 1997-05-06 WO PCT/US1997/007816 patent/WO1997041881A1/en active IP Right Grant
- 1997-05-06 JP JP09540150A patent/JP2000510835A/ja active Pending
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- 1997-05-06 CA CA002254954A patent/CA2254954C/en not_active Expired - Fee Related
- 1997-05-06 AT AT97922726T patent/ATE277629T1/de active
- 1997-05-06 AU AU29339/97A patent/AU2933997A/en not_active Abandoned
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2004
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2009
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