DE69735963D1 - Aminoalkohole enthaltende ophthalmische Zusammensetzungen - Google Patents

Aminoalkohole enthaltende ophthalmische Zusammensetzungen

Info

Publication number
DE69735963D1
DE69735963D1 DE69735963T DE69735963T DE69735963D1 DE 69735963 D1 DE69735963 D1 DE 69735963D1 DE 69735963 T DE69735963 T DE 69735963T DE 69735963 T DE69735963 T DE 69735963T DE 69735963 D1 DE69735963 D1 DE 69735963D1
Authority
DE
Germany
Prior art keywords
ophthalmic compositions
amino
containing ophthalmic
efficacy
enhance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69735963T
Other languages
English (en)
Other versions
DE69735963T2 (de
Inventor
Bahram Asgharian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Vision LLC
Original Assignee
Alcon Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Laboratories Inc filed Critical Alcon Laboratories Inc
Publication of DE69735963D1 publication Critical patent/DE69735963D1/de
Application granted granted Critical
Publication of DE69735963T2 publication Critical patent/DE69735963T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/22—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
    • A61L12/147—Alcohols or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
DE69735963T 1996-12-13 1997-11-17 Aminoalkohole enthaltende ophthalmische Zusammensetzungen Expired - Lifetime DE69735963T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3307996P 1996-12-13 1996-12-13
US33079P 1996-12-13

Publications (2)

Publication Number Publication Date
DE69735963D1 true DE69735963D1 (de) 2006-06-29
DE69735963T2 DE69735963T2 (de) 2007-01-25

Family

ID=21868442

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69713388T Expired - Lifetime DE69713388T2 (de) 1996-12-13 1997-11-17 Verwendung von niedermolekularen aminoalkoholen in ophthalmologischen präparaten
DE69735963T Expired - Lifetime DE69735963T2 (de) 1996-12-13 1997-11-17 Aminoalkohole enthaltende ophthalmische Zusammensetzungen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69713388T Expired - Lifetime DE69713388T2 (de) 1996-12-13 1997-11-17 Verwendung von niedermolekularen aminoalkoholen in ophthalmologischen präparaten

Country Status (15)

Country Link
US (5) US6319464B1 (de)
EP (1) EP0948357B1 (de)
JP (2) JP3724813B2 (de)
KR (1) KR100366676B1 (de)
CN (1) CN1157227C (de)
AT (2) ATE326983T1 (de)
AU (1) AU718199B2 (de)
CA (1) CA2272308C (de)
DE (2) DE69713388T2 (de)
DK (1) DK0948357T3 (de)
ES (2) ES2178786T3 (de)
HK (1) HK1022089A1 (de)
NZ (1) NZ336031A (de)
PT (2) PT1190718E (de)
WO (1) WO1998025649A1 (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1190718E (pt) * 1996-12-13 2006-08-31 Alcon Lab Inc Composicoes oftalmicas contendo aminoalcoois
US20020082288A1 (en) * 1999-09-16 2002-06-27 Gerald Horn Ophthalmic formulations comprising an imidazoline
US6730065B1 (en) * 2000-09-15 2004-05-04 Ocularis Pharma, Inc. Night vision composition
US8889112B2 (en) * 1999-09-16 2014-11-18 Ocularis Pharma, Llc Ophthalmic formulations including selective alpha 1 antagonists
US20020039975A1 (en) * 2000-07-31 2002-04-04 Stone Ralph P. Simplified process for cleaning and disinfecting contact lenses with a single solution
US20060211753A1 (en) * 2000-11-03 2006-09-21 Ocularis Pharma, Inc. Method and composition which reduces stimulation of muscles which dilate the eye
DE10106230A1 (de) * 2001-02-10 2002-08-14 Creavis Tech & Innovation Gmbh Verfahren zur Herstellung mikrobizider Oberflächen durch Immobilisierung von Aminoalkoholen
MXPA04004915A (es) * 2001-12-21 2004-08-11 Alcon Inc Nanoparticulas inorganicas para modificar la viscosidad y las propiedades fisicas de composiciones oftalmicas y oticas.
CA2467759C (en) * 2001-12-21 2012-04-03 Alcon, Inc. Use of nanoparticles as carriers for biocides in ophthalmic compositions
CA2467763C (en) 2001-12-21 2011-09-13 Alcon, Inc. Use of synthetic inorganic nanoparticles as carriers for ophthalmic and otic drugs
US7928147B2 (en) * 2002-04-11 2011-04-19 Teva Animal Health, Inc. Antimicrobial wash and carrier solutions, and uses thereof
US20040115160A1 (en) * 2002-12-13 2004-06-17 Salamone Joseph C. Quaternary ammonium esters for disinfection and preservation
TWI322828B (en) * 2002-12-23 2010-04-01 Alcon Inc Use of multifunctional surface active agents to clean contact lenses
US20040185028A1 (en) * 2003-03-19 2004-09-23 Zhenze Hu Antimicrobial compositions containing ethanolamine buffer and biguanide disinfectant
JP3894945B2 (ja) * 2003-08-20 2007-03-22 株式会社メニコン コンタクトレンズ用液剤
US6936640B2 (en) * 2003-12-04 2005-08-30 Alcon, Inc. Biguanide/quaternary ammonium containing copolymeric biocides and use thereof in pharmaceutical compositions
DK1692092T3 (da) 2003-12-09 2009-06-22 Alcon Inc Anvendelse af bis-aminer til forstærkning af den antimikrobielle aktivitet af vandige sammensætninger
AU2004305535A1 (en) * 2003-12-09 2005-07-07 Alcon, Inc. Use of organic buffering agents to enhance the antimicrobial activity of pharmaceutical compositions
US7022740B2 (en) * 2004-04-29 2006-04-04 Leonard Mackles Lubricious ophthalmic solutions
US20060047005A1 (en) * 2004-08-26 2006-03-02 Salamone Joseph C Compositions containing N,N,N',N'-tetrakis(hydroxyalkyl)diamine-or N,N,N',N'-tetrakis(hydroxyalkoxy)diamine-based buffers
US7629386B2 (en) * 2004-08-26 2009-12-08 Bausch + Lomb Incorporated Compositions containing trialkanolamine alkoxylate buffer
US20060141059A1 (en) * 2004-12-27 2006-06-29 Alcon, Inc. Self-preserved ophthalmic pharmaceutical compositions containing tobramycin
JP5108234B2 (ja) * 2005-02-07 2012-12-26 日本特殊陶業株式会社 マイクロヒータ及びセンサ
US20060229219A1 (en) * 2005-04-11 2006-10-12 Advanced Medical Optics, Inc. Borate-polyol mixtures as a buffering system
US20070053948A1 (en) * 2005-09-08 2007-03-08 Bausch & Lomb Incorporated Lens care solution demonstration kit
US8071345B2 (en) * 2006-03-31 2011-12-06 Novozymes A/S Stabilized subtilisin composition
US20070287752A1 (en) * 2006-06-08 2007-12-13 Burke Susan E Ophthalmic Compositions Comprising A Branched, Glycerol Compound
TWI394564B (zh) * 2006-09-21 2013-05-01 Alcon Res Ltd 自行保存型水性藥學組成物
US20100021561A1 (en) * 2006-09-21 2010-01-28 Chowhan Masood A Self-preserved aqueous pharmaceutical compositions
EP2066300B2 (de) * 2006-09-28 2019-01-23 Novartis Ag Sich selbst konservierende pharmazeutische zusammensetzungen
WO2008052031A2 (en) * 2006-10-24 2008-05-02 Alcon Research, Ltd. 2-pyrrolidone derivatives for preservation of ophthalmic, otic and nasal compositions
TWI434926B (zh) * 2006-12-11 2014-04-21 Alcon Res Ltd 眼用組成物中聚氧化乙烯-聚氧化丁烯（ｐｅｏ-ｐｂｏ）嵌段共聚物之使用
EP2308466B1 (de) * 2008-03-17 2017-05-31 Novartis Ag Wässrige Pharmazeutische Zusammensetzungen mit Borat-Polyol-Komplexen
TWI544927B (zh) 2008-03-17 2016-08-11 愛爾康研究有限公司 具有低濃度的表面活性劑以促進治療劑之生物可利用性的藥學組成物
US8163684B2 (en) 2008-03-26 2012-04-24 Abbott Medical Optics Inc. Antimicrobials having polyquaternary ammoniums and alcohol-bearing amidoamines and methods for their use
TWI495469B (zh) 2008-06-09 2015-08-11 Alcon Res Ltd 含有氟喹諾酮抗生素藥物之經改良藥學組成物
US8093352B2 (en) * 2008-08-05 2012-01-10 Alcon Research, Ltd. Polyalkylene oxide polyquaternary ammonium biocides
TW201023912A (en) * 2008-12-05 2010-07-01 Alcon Res Ltd Pharmaceutical suspension
US8431751B1 (en) 2008-12-24 2013-04-30 Alcon Research, Ltd. Polymeric quaternary ammonium compounds with vicinal hydroxy groups
US8912236B2 (en) 2009-03-03 2014-12-16 Alcon Research, Ltd. Pharmaceutical composition for delivery of receptor tyrosine kinase inhibiting (RTKi) compounds to the eye
TWI489997B (zh) 2009-06-19 2015-07-01 Alcon Res Ltd 含有硼酸－多元醇錯合物之水性藥學組成物
TWI547522B (zh) * 2009-07-07 2016-09-01 愛爾康研究有限公司 環氧乙烷環氧丁烷嵌段共聚物組成物
WO2011153349A1 (en) 2010-06-02 2011-12-08 Alcon Research, Ltd. Ophthalmic compositions comprising pbo-peo-pbo block copolymers
KR101381903B1 (ko) * 2011-03-10 2014-04-10 주식회사 엘지생활건강 3-부톡시-1,2-프로판다이올을 함유하는 항균 또는 보존용 조성물
JP5989365B2 (ja) * 2012-03-19 2016-09-07 ロート製薬株式会社 コンタクトレンズ用眼科組成物
JP6592527B2 (ja) * 2015-11-30 2019-10-16 ロート製薬株式会社 眼科組成物
EP3876737A4 (de) 2018-11-08 2021-12-29 Hwang-Hsing Chen Tris-substituierte biguanidverbindungen und deren verwendungen

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3966905A (en) * 1973-05-29 1976-06-29 Barnes-Hind Pharmaceuticals, Inc. Stabilized catechol amine solutions
US4407791A (en) 1981-09-28 1983-10-04 Alcon Laboratories, Inc. Ophthalmic solutions
US4525346A (en) * 1981-09-28 1985-06-25 Alcon Laboratories, Inc. Aqueous antimicrobial ophthalmic solutions
AU565948B2 (en) 1982-02-03 1987-10-01 Baremek Pty. Ltd. Electrophoretic cleaner and sterilizer
FR2521856A1 (fr) 1982-02-19 1983-08-26 Pos Lab Medicament ophtalmique pour le traitement des glaucomes, a base d'ethers-oxydes ou d'ether-oximes de derives alcoylamines
ZA837627B (en) * 1982-10-15 1984-06-27 Procter & Gamble Storage stable topical pharmaceutical composition containing low dielectric solvents
US4758595A (en) 1984-12-11 1988-07-19 Bausch & Lomb Incorporated Disinfecting and preserving systems and methods of use
US4620979A (en) * 1985-08-02 1986-11-04 Schachar Ronald A Ophthalmological irrigating solution containing ascorbate
US4904359A (en) * 1985-10-31 1990-02-27 The Procter & Gamble Company Liquid detergent composition containing polymeric surfactant
DE3612538A1 (de) 1986-04-14 1987-10-15 Dispersa Ag Stabilisierung von quecksilberhaltigen konservierungsmitteln in augentropfen
DE3612537C1 (de) 1986-04-14 1987-07-16 Dispersa Ag Arzneimittel zur Behandlung von Entzuendungen im Auge
PH25150A (en) 1986-06-05 1991-03-13 Ciba Geigy Ag Novel pharmaceutical preparation for topical application
US4734475A (en) * 1986-12-15 1988-03-29 Ciba-Geigy Corporation Wettable surface modified contact lens fabricated from an oxirane containing hydrophobic polymer
JPH0662417B2 (ja) * 1987-12-25 1994-08-17 参天製薬株式会社 抗アレルギー点眼液
CA2009118C (en) * 1989-02-21 1996-02-27 Mary F. Mowrey-Mckee Method and composition for cleaning and disinfecting contact lenses
US5290774A (en) * 1989-08-03 1994-03-01 Eisai Co., Ltd. Photostabilizing method for ophthalmic solutions and the resulting ophthalmic solutions therefrom
US5171526A (en) 1990-01-05 1992-12-15 Allergan, Inc. Ophthalmic compositions and methods for preserving and using same
HU209538B (en) 1990-05-09 1994-07-28 Vepex Contractor Ltd Set and cleaning composition for treating contactlenses
JP3058656B2 (ja) * 1990-06-18 2000-07-04 トーメー産業株式会社 コンタクトレンズ用液剤組成物及びそれを用いたコンタクトレンズの洗浄若しくは保存方法
US5540864A (en) * 1990-12-21 1996-07-30 The Procter & Gamble Company Liquid hard surfce detergent compositions containing zwitterionic detergent surfactant and monoethanolamine and/or beta-aminoalkanol
US5422073A (en) 1990-12-27 1995-06-06 Allergan, Inc. Method and composition for disinfecting contact lenses
JPH0775620B2 (ja) 1991-04-08 1995-08-16 トーメー産業株式会社 含水性コンタクトレンズ用液剤組成物及び含水性コンタクトレンズの洗浄方法
JPH0558967A (ja) 1991-08-27 1993-03-09 Otsuka Pharmaceut Co Ltd アミノアルコール化合物塩及び消毒薬
ATE300936T1 (de) 1992-05-06 2005-08-15 Alcon Lab Inc Anwendung von boral-polyol-komplexen für ophthalmische arzneizusammensetzungen
US5505953A (en) 1992-05-06 1996-04-09 Alcon Laboratories, Inc. Use of borate-polyol complexes in ophthalmic compositions
TW203128B (en) 1992-06-17 1993-04-01 Ciba Geigy Ag The protection method for hard and soft contact lens
US5260021A (en) 1992-06-29 1993-11-09 Allergan, Inc. Hydrogen peroxide-containing gels and contact lens disinfecting using same
US5356555A (en) * 1992-09-14 1994-10-18 Allergan, Inc. Non-oxidative method and composition for simultaneously cleaning and disinfecting contact lenses using a protease with a disinfectant
AU6240294A (en) 1993-02-26 1994-09-14 Wesley-Jessen Corporation Method and composition for disinfecting contact lenses
JPH0776700A (ja) 1993-07-14 1995-03-20 Senju Pharmaceut Co Ltd コンタクトレンズ用剤の安定化方法
US5631005A (en) 1994-09-21 1997-05-20 Alcon Laboratories, Inc. Use of amidoamines in ophthalmic compositions
US5393491A (en) * 1993-09-22 1995-02-28 Alcon Laboratories, Inc. Use of amidoamines in ophthalmic compositions
US5573726A (en) 1993-09-22 1996-11-12 Alcon Laboratories, Inc. Use of amidoamines in ophthalmic compositions
AU7928294A (en) 1993-10-06 1995-05-01 Allergan, Inc. Compositions and methods for inhibiting and reducing lysozyme deposition on hydrophilic contact lenses
US5451237A (en) 1993-11-10 1995-09-19 Vehige; Joseph G. Compositions and methods for inhibiting and reducing lysozyme deposition on hydrophilic contact lenses using biocompatible colored compounds
FR2717075B1 (fr) * 1994-03-14 1996-04-05 Oreal Gel aqueux de maquillage à organopolysiloxane.
AU2277495A (en) 1994-04-05 1995-10-23 Allergan, Inc. Disposable disinfectant system for contact lenses
AU2825795A (en) 1994-06-23 1996-01-19 Allergan, Inc. Contact lens cleaning compositions with solubilized polymers
WO1996002624A1 (en) 1994-07-13 1996-02-01 So-Safe Specialty Products Pty. Ltd. A cleaning kit and a cleaning composition and methods of use
WO1996003158A1 (en) 1994-07-22 1996-02-08 Alcon Laboratories, Inc. Use of low molecular weight amino acids in ophthalmic compositions
IT1273742B (it) 1994-08-01 1997-07-09 Lifegroup Spa Composizioni ad elevata bioadesivita' e mucoadesivita' utili per il trattamento di epitali e mucose
US5820695A (en) * 1994-09-06 1998-10-13 S. C. Johnson & Son, Inc. Single-phase soap compositions
US5603929A (en) 1994-11-16 1997-02-18 Alcon Laboratories, Inc. Preserved ophthalmic drug compositions containing polymeric quaternary ammonium compounds
JPH08194192A (ja) 1995-01-13 1996-07-30 Senju Pharmaceut Co Ltd タンパク分解酵素含有凍結乾燥物の製造方法
US5558876A (en) * 1995-03-29 1996-09-24 Alcon Laboratories, Inc. Topical ophthalmic acidic drug formulations
JPH0930966A (ja) 1995-07-24 1997-02-04 Gakuzo Tamura 眼科用新規製剤
WO1998020912A1 (fr) 1996-11-13 1998-05-22 Tomey Technology Corporation Composition de traitement pour lentilles de contact et procede de traitement de lentilles de contact au moyen de ladite composition
PT1190718E (pt) * 1996-12-13 2006-08-31 Alcon Lab Inc Composicoes oftalmicas contendo aminoalcoois
US6331513B1 (en) * 1999-04-28 2001-12-18 Jacam Chemicals L.L.C. Compositions for dissolving metal sulfates
DK1692092T3 (da) * 2003-12-09 2009-06-22 Alcon Inc Anvendelse af bis-aminer til forstærkning af den antimikrobielle aktivitet af vandige sammensætninger

Also Published As

Publication number Publication date
CA2272308A1 (en) 1998-06-18
JP4276139B2 (ja) 2009-06-10
ES2178786T3 (es) 2003-01-01
US20020106304A1 (en) 2002-08-08
DE69713388D1 (de) 2002-07-18
CN1157227C (zh) 2004-07-14
US20140056997A1 (en) 2014-02-27
CA2272308C (en) 2007-01-16
US20050239900A1 (en) 2005-10-27
US20060264516A1 (en) 2006-11-23
US6949218B2 (en) 2005-09-27
JP3724813B2 (ja) 2005-12-07
EP0948357B1 (de) 2002-06-12
JP2004262948A (ja) 2004-09-24
DE69735963T2 (de) 2007-01-25
ATE326983T1 (de) 2006-06-15
US8865776B2 (en) 2014-10-21
PT1190718E (pt) 2006-08-31
AU718199B2 (en) 2000-04-06
KR20000057524A (ko) 2000-09-25
HK1022089A1 (en) 2000-07-28
ES2262603T3 (es) 2006-12-01
DK0948357T3 (da) 2002-07-15
EP0948357A1 (de) 1999-10-13
ATE218887T1 (de) 2002-06-15
US8563011B2 (en) 2013-10-22
AU5257898A (en) 1998-07-03
US7045095B2 (en) 2006-05-16
JP2000513001A (ja) 2000-10-03
NZ336031A (en) 2000-05-26
US6319464B1 (en) 2001-11-20
WO1998025649A1 (en) 1998-06-18
CN1240361A (zh) 2000-01-05
KR100366676B1 (ko) 2003-01-14
PT948357E (pt) 2002-10-31
DE69713388T2 (de) 2002-10-31

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