DE69735998D1 - Zusammensetzungen zur behandlung und wiederherstellung von knorpeldefekten mit funktioneller sperrschicht - Google Patents
Zusammensetzungen zur behandlung und wiederherstellung von knorpeldefekten mit funktioneller sperrschichtInfo
- Publication number
- DE69735998D1 DE69735998D1 DE69735998T DE69735998T DE69735998D1 DE 69735998 D1 DE69735998 D1 DE 69735998D1 DE 69735998 T DE69735998 T DE 69735998T DE 69735998 T DE69735998 T DE 69735998T DE 69735998 D1 DE69735998 D1 DE 69735998D1
- Authority
- DE
- Germany
- Prior art keywords
- cartilage
- bone
- matrix
- defect
- compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/108—Specific proteins or polypeptides not covered by groups A61L24/102 - A61L24/106
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/51—Lyases (4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0015—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/106—Fibrin; Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0028—Polypeptides; Proteins; Degradation products thereof
- A61L26/0047—Specific proteins or polypeptides not covered by groups A61L26/0033 - A61L26/0042
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30756—Cartilage endoprostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/672,618 US5853746A (en) | 1991-01-31 | 1996-06-28 | Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone using functional barrier |
US672618 | 1996-06-28 | ||
PCT/US1997/011208 WO1998000183A2 (en) | 1996-06-28 | 1997-06-24 | Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone using functional barrier |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69735998D1 true DE69735998D1 (de) | 2006-07-06 |
DE69735998T2 DE69735998T2 (de) | 2007-03-15 |
Family
ID=24699317
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69735998T Expired - Fee Related DE69735998T2 (de) | 1996-06-28 | 1997-06-24 | Zusammensetzungen zur behandlung und wiederherstellung von knorpeldefekten mit funktioneller sperrschicht |
Country Status (16)
Country | Link |
---|---|
US (1) | US5853746A (de) |
EP (1) | EP0912204B1 (de) |
JP (1) | JP2000513721A (de) |
KR (1) | KR20000022182A (de) |
CN (1) | CN1321681C (de) |
AT (1) | ATE327781T1 (de) |
AU (1) | AU731172B2 (de) |
BR (1) | BR9710088A (de) |
DE (1) | DE69735998T2 (de) |
ES (1) | ES2267145T3 (de) |
HK (1) | HK1017276A1 (de) |
IL (1) | IL127550A (de) |
NO (1) | NO320089B1 (de) |
NZ (1) | NZ333452A (de) |
WO (1) | WO1998000183A2 (de) |
ZA (1) | ZA975711B (de) |
Families Citing this family (98)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5989269A (en) * | 1996-08-30 | 1999-11-23 | Vts Holdings L.L.C. | Method, instruments and kit for autologous transplantation |
US20020173806A1 (en) * | 1996-08-30 | 2002-11-21 | Verigen Transplantation Service International (Vtsi) Ag | Method for autologous transplantation |
US6569172B2 (en) | 1996-08-30 | 2003-05-27 | Verigen Transplantation Service International (Vtsi) | Method, instruments, and kit for autologous transplantation |
US8882847B2 (en) | 2001-05-25 | 2014-11-11 | Conformis, Inc. | Patient selectable knee joint arthroplasty devices |
US9603711B2 (en) | 2001-05-25 | 2017-03-28 | Conformis, Inc. | Patient-adapted and improved articular implants, designs and related guide tools |
US8480754B2 (en) | 2001-05-25 | 2013-07-09 | Conformis, Inc. | Patient-adapted and improved articular implants, designs and related guide tools |
US8735773B2 (en) | 2007-02-14 | 2014-05-27 | Conformis, Inc. | Implant device and method for manufacture |
US7618451B2 (en) | 2001-05-25 | 2009-11-17 | Conformis, Inc. | Patient selectable joint arthroplasty devices and surgical tools facilitating increased accuracy, speed and simplicity in performing total and partial joint arthroplasty |
US8234097B2 (en) | 2001-05-25 | 2012-07-31 | Conformis, Inc. | Automated systems for manufacturing patient-specific orthopedic implants and instrumentation |
US8083745B2 (en) | 2001-05-25 | 2011-12-27 | Conformis, Inc. | Surgical tools for arthroplasty |
US7534263B2 (en) | 2001-05-25 | 2009-05-19 | Conformis, Inc. | Surgical tools facilitating increased accuracy, speed and simplicity in performing joint arthroplasty |
US7799077B2 (en) | 2002-10-07 | 2010-09-21 | Conformis, Inc. | Minimally invasive joint implant with 3-dimensional geometry matching the articular surfaces |
US8556983B2 (en) | 2001-05-25 | 2013-10-15 | Conformis, Inc. | Patient-adapted and improved orthopedic implants, designs and related tools |
US7468075B2 (en) | 2001-05-25 | 2008-12-23 | Conformis, Inc. | Methods and compositions for articular repair |
US8545569B2 (en) | 2001-05-25 | 2013-10-01 | Conformis, Inc. | Patient selectable knee arthroplasty devices |
US8771365B2 (en) | 2009-02-25 | 2014-07-08 | Conformis, Inc. | Patient-adapted and improved orthopedic implants, designs, and related tools |
EP2332564A1 (de) * | 1997-02-07 | 2011-06-15 | Stryker Corporation | Matrixlose osteogene Vorrichtungen und Implantate und Verfahren zu deren Verwendung |
US20010016646A1 (en) * | 1998-03-20 | 2001-08-23 | David C. Rueger | Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects |
US7041641B2 (en) * | 1997-03-20 | 2006-05-09 | Stryker Corporation | Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects |
DE19752900A1 (de) * | 1997-11-28 | 1999-06-02 | Biotechnolog Forschung Gmbh | Knochenmatrix und/oder osteogene Zellen, deren Verwendung, therapeutische Zubereitung und Kit |
US6123731A (en) * | 1998-02-06 | 2000-09-26 | Osteotech, Inc. | Osteoimplant and method for its manufacture |
JP2002510646A (ja) * | 1998-04-03 | 2002-04-09 | カイロン コーポレイション | 関節軟骨障害を処置するためのigfiの使用 |
EP1104313A2 (de) * | 1998-08-14 | 2001-06-06 | Verigen Transplantation Service International (VTSI) AG | Instrumente und werkstoffe für knorpelzellen-transplantation |
US7184814B2 (en) | 1998-09-14 | 2007-02-27 | The Board Of Trustees Of The Leland Stanford Junior University | Assessing the condition of a joint and assessing cartilage loss |
AU772012B2 (en) | 1998-09-14 | 2004-04-08 | Board Of Trustees Of The Leland Stanford Junior University | Assessing the condition of a joint and preventing damage |
US7239908B1 (en) | 1998-09-14 | 2007-07-03 | The Board Of Trustees Of The Leland Stanford Junior University | Assessing the condition of a joint and devising treatment |
US6727224B1 (en) | 1999-02-01 | 2004-04-27 | Genetics Institute, Llc. | Methods and compositions for healing and repair of articular cartilage |
ATE376433T1 (de) | 1999-03-25 | 2007-11-15 | Metabolix Inc | Medizinische vorrichtungen und verwendungen von polyhydroxyalkanoatpolymeren |
EP1441028A3 (de) * | 1999-07-28 | 2005-01-05 | Interface Biotech A/S | Zellkultivierungsverfahren zur Herstellung von Knorpelzellen/Knorpelbildungszellen |
US20020116063A1 (en) * | 1999-08-02 | 2002-08-22 | Bruno Giannetti | Kit for chondrocyte cell transplantation |
DE19957388A1 (de) * | 1999-11-24 | 2001-06-13 | Michael Sittinger | Chondroinduktive und implantierbare Substrate zur Knorpelheilung und -protektion |
EP1237511B1 (de) | 1999-12-15 | 2004-09-01 | Sulzer Orthopedics Ltd. | Präparat für die reparatur von knorpel- oder knorpel/knochen-defekten in menschlichen oder tierischen gelenken |
US20030095993A1 (en) * | 2000-01-28 | 2003-05-22 | Hanne Bentz | Gel-infused sponges for tissue repair and augmentation |
US9387094B2 (en) | 2000-07-19 | 2016-07-12 | Warsaw Orthopedic, Inc. | Osteoimplant and method of making same |
WO2002022014A1 (en) | 2000-09-14 | 2002-03-21 | The Board Of Trustees Of The Leland Stanford Junior University | Assessing the condition of a joint and devising treatment |
DE60136549D1 (de) | 2000-09-14 | 2008-12-24 | Univ R | Verfahren zur manipulation medizinischer bilder |
JP4246994B2 (ja) * | 2001-01-30 | 2009-04-02 | オーソジーン, インコーポレイテッド | 滑膜由来の組織または細胞を使用する関節軟骨における欠陥または病変の処置および修復のための組成物および方法 |
CA2447694A1 (en) | 2001-05-25 | 2002-12-05 | Imaging Therapeutics, Inc. | Methods and compositions for articular resurfacing |
US8439926B2 (en) | 2001-05-25 | 2013-05-14 | Conformis, Inc. | Patient selectable joint arthroplasty devices and surgical tools |
US8951260B2 (en) | 2001-05-25 | 2015-02-10 | Conformis, Inc. | Surgical cutting guide |
US20030166274A1 (en) * | 2001-11-15 | 2003-09-04 | Hewitt Charles W. | Three-dimensional matrix for producing living tissue equivalents |
US7381426B2 (en) * | 2002-01-24 | 2008-06-03 | Southwest Research Institute | Targeted delivery of bioactive factors to the systemic skeleton |
CN103182092A (zh) * | 2002-03-28 | 2013-07-03 | 组织基因股份有限公司 | 通过基因治疗的骨生成 |
US20040136968A1 (en) * | 2002-09-27 | 2004-07-15 | Verigen Ag | Autologous cells on a support matrix for tissue repair |
AU2003290757A1 (en) | 2002-11-07 | 2004-06-03 | Conformis, Inc. | Methods for determing meniscal size and shape and for devising treatment |
CA2504287A1 (en) | 2002-11-26 | 2004-06-10 | Nobex Corporation | Natriuretic compounds, conjugates, and uses thereof |
US7067123B2 (en) | 2003-04-29 | 2006-06-27 | Musculoskeletal Transplant Foundation | Glue for cartilage repair |
US7488348B2 (en) | 2003-05-16 | 2009-02-10 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
US7901457B2 (en) | 2003-05-16 | 2011-03-08 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
NZ544050A (en) | 2003-06-11 | 2009-03-31 | Osteotech Inc | Osteoimplants and methods for their manufacture |
US20050202067A1 (en) * | 2003-10-28 | 2005-09-15 | Gkss Forschungszentrum | Matrix structure and hybrid matrix system for inducing a neofacia, their use and method for generating a neofacia |
ES2403357T3 (es) | 2003-12-11 | 2013-05-17 | Isto Technologies Inc. | Sistema de cartílago particulado |
EP1773417A1 (de) * | 2004-06-23 | 2007-04-18 | Angiotech Pharmaceuticals (US), Inc. | Verfahren und vernetzte polymer-zusammensetzungen für die knorpelreparatur |
US8512730B2 (en) | 2004-07-12 | 2013-08-20 | Isto Technologies, Inc. | Methods of tissue repair and compositions therefor |
US7837740B2 (en) | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
US7799754B2 (en) * | 2004-10-14 | 2010-09-21 | Biomimetic Therapeutics, Inc. | Compositions and methods for treating bone |
US7473678B2 (en) | 2004-10-14 | 2009-01-06 | Biomimetic Therapeutics, Inc. | Platelet-derived growth factor compositions and methods of use thereof |
US20060111778A1 (en) * | 2004-10-29 | 2006-05-25 | Michalow Alexander E | Methods of promoting healing of cartilage defects and method of causing stem cells to differentiate by the articular chondrocyte pathway |
US7270655B2 (en) * | 2005-01-14 | 2007-09-18 | Haidukewych George J | Autologous material delivery apparatus and method |
US7825083B2 (en) * | 2005-02-10 | 2010-11-02 | Spine Wave, Inc. | Synovial fluid barrier |
US7815926B2 (en) | 2005-07-11 | 2010-10-19 | Musculoskeletal Transplant Foundation | Implant for articular cartilage repair |
EP1916964A4 (de) | 2005-08-26 | 2015-11-04 | Zimmer Inc | Implantate und verfahren zur behebung, ersetzung und behandlung von gelenkkrankheiten |
AU2006292224B2 (en) | 2005-09-19 | 2013-08-01 | Histogenics Corporation | Cell-support matrix and a method for preparation thereof |
NZ571113A (en) | 2005-11-17 | 2012-02-24 | Biomimetic Therapeutics Inc | Maxillofacial bone augmentation using rhpdgf-bb and a biocompatible matrix |
TWI584796B (zh) | 2006-02-06 | 2017-06-01 | 康福美斯公司 | 患者可選擇式關節置換術裝置及外科工具 |
US8623026B2 (en) | 2006-02-06 | 2014-01-07 | Conformis, Inc. | Patient selectable joint arthroplasty devices and surgical tools incorporating anatomical relief |
AU2007269712B2 (en) | 2006-06-30 | 2013-02-07 | Biomimetic Therapeutics, Llc | PDGF-biomatrix compositions and methods for treating rotator cuff injuries |
US9161967B2 (en) | 2006-06-30 | 2015-10-20 | Biomimetic Therapeutics, Llc | Compositions and methods for treating the vertebral column |
AU2007333425B2 (en) | 2006-11-03 | 2014-03-27 | Biomimetic Therapeutics, Llc | Compositions and methods for arthrodetic procedures |
US8163549B2 (en) | 2006-12-20 | 2012-04-24 | Zimmer Orthobiologics, Inc. | Method of obtaining viable small tissue particles and use for tissue repair |
US8870871B2 (en) | 2007-01-17 | 2014-10-28 | University Of Massachusetts Lowell | Biodegradable bone plates and bonding systems |
AU2008209473B2 (en) * | 2007-01-22 | 2012-10-25 | Orthotrophix, Inc. | A peptide composition and a method of promoting cartilage formation |
EP2591756A1 (de) | 2007-02-14 | 2013-05-15 | Conformis, Inc. | Implantat und Herstellungsverfahren |
US8435551B2 (en) | 2007-03-06 | 2013-05-07 | Musculoskeletal Transplant Foundation | Cancellous construct with support ring for repair of osteochondral defects |
US20090012629A1 (en) | 2007-04-12 | 2009-01-08 | Isto Technologies, Inc. | Compositions and methods for tissue repair |
CN102014977B (zh) | 2008-02-07 | 2015-09-02 | 生物模拟治疗有限责任公司 | 用于牵引成骨术的组合物和方法 |
CA2717725A1 (en) | 2008-03-05 | 2009-09-11 | Musculoskeletal Transplant Foundation | Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles |
WO2009111626A2 (en) | 2008-03-05 | 2009-09-11 | Conformis, Inc. | Implants for altering wear patterns of articular surfaces |
AU2009246474B2 (en) | 2008-05-12 | 2015-04-16 | Conformis, Inc. | Devices and methods for treatment of facet and other joints |
EP2341951A2 (de) | 2008-09-09 | 2011-07-13 | BioMimetic Therapeutics, Inc. | Aus thrombozyten stammende wachstumsfaktor-zusammensetzungen und verfahren zur behandlung von sehnen- und bänderverletzungen |
US8808297B2 (en) | 2009-02-24 | 2014-08-19 | Microport Orthopedics Holdings Inc. | Orthopedic surgical guide |
US8808303B2 (en) | 2009-02-24 | 2014-08-19 | Microport Orthopedics Holdings Inc. | Orthopedic surgical guide |
US9017334B2 (en) | 2009-02-24 | 2015-04-28 | Microport Orthopedics Holdings Inc. | Patient specific surgical guide locator and mount |
BRPI1014917A2 (pt) | 2009-04-16 | 2016-04-19 | Conformis Inc | "dispositivos de artroplastia de junta específica para páciente para reparo de ligamento" |
CA2782137A1 (en) | 2009-12-11 | 2011-06-16 | Conformis, Inc. | Patient-specific and patient-engineered orthopedic implants |
JP6144049B2 (ja) | 2010-02-22 | 2017-06-07 | バイオミメティック セラピューティクス,リミテッド ライアビリティ カンパニー | 腱障害を処置するための血小板由来成長因子組成物及び方法 |
US8435305B2 (en) | 2010-08-31 | 2013-05-07 | Zimmer, Inc. | Osteochondral graft delivery device and uses thereof |
US9717779B2 (en) | 2011-01-31 | 2017-08-01 | Warsaw Orthopedic, Inc. | Implantable matrix having optimum ligand concentrations |
WO2012112694A2 (en) | 2011-02-15 | 2012-08-23 | Conformis, Inc. | Medeling, analyzing and using anatomical data for patient-adapted implants. designs, tools and surgical procedures |
US9486226B2 (en) | 2012-04-18 | 2016-11-08 | Conformis, Inc. | Tibial guides, tools, and techniques for resecting the tibial plateau |
US9675471B2 (en) | 2012-06-11 | 2017-06-13 | Conformis, Inc. | Devices, techniques and methods for assessing joint spacing, balancing soft tissues and obtaining desired kinematics for joint implant components |
KR20150048114A (ko) * | 2012-07-11 | 2015-05-06 | 오시리스 쎄라퓨틱스, 인크. | 공극형성된 연골 제품 |
US10245306B2 (en) | 2012-11-16 | 2019-04-02 | Isto Technologies Ii, Llc | Flexible tissue matrix and methods for joint repair |
US20140178343A1 (en) | 2012-12-21 | 2014-06-26 | Jian Q. Yao | Supports and methods for promoting integration of cartilage tissue explants |
US10179191B2 (en) | 2014-10-09 | 2019-01-15 | Isto Technologies Ii, Llc | Flexible tissue matrix and methods for joint repair |
US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
EP3242934B1 (de) * | 2015-01-08 | 2021-08-18 | The Board of Trustees of the Leland Stanford Junior University | Faktoren und zellen zur bereitstellung der induktion von knochen, knochenmark und knorpel |
CN114984298A (zh) * | 2022-07-18 | 2022-09-02 | 重庆大学 | 一类软骨组织粘合剂及其制备方法和用途 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5001116A (en) * | 1982-12-20 | 1991-03-19 | The Children's Medical Center Corporation | Inhibition of angiogenesis |
US4994443A (en) * | 1982-12-20 | 1991-02-19 | The Children's Medical Center Corporation | Inhibition of angiogenesis |
IL68218A (en) * | 1983-03-23 | 1985-12-31 | Univ Ramot | Compositions for cartilage repair comprising embryonal chondrocytes |
US4609551A (en) * | 1984-03-20 | 1986-09-02 | Arnold Caplan | Process of and material for stimulating growth of cartilage and bony tissue at anatomical sites |
US4563350A (en) * | 1984-10-24 | 1986-01-07 | Collagen Corporation | Inductive collagen based bone repair preparations |
EP0213180B1 (de) * | 1985-02-26 | 1992-10-07 | The Johns Hopkins University | Neovaskularisierungsinhibitoren und deren herstellung |
US5041138A (en) * | 1986-11-20 | 1991-08-20 | Massachusetts Institute Of Technology | Neomorphogenesis of cartilage in vivo from cell culture |
US4846835A (en) * | 1987-06-15 | 1989-07-11 | Grande Daniel A | Technique for healing lesions in cartilage |
US5306311A (en) * | 1987-07-20 | 1994-04-26 | Regen Corporation | Prosthetic articular cartilage |
US4904259A (en) * | 1988-04-29 | 1990-02-27 | Samuel Itay | Compositions and methods for repair of cartilage and bone |
US4950483A (en) * | 1988-06-30 | 1990-08-21 | Collagen Corporation | Collagen wound healing matrices and process for their production |
US5236456A (en) * | 1989-11-09 | 1993-08-17 | Osteotech, Inc. | Osteogenic composition and implant containing same |
AU652744B2 (en) * | 1990-01-25 | 1994-09-08 | Children's Medical Center Corporation | Method and compositions for inhibiting angiogenesis |
DE4006609A1 (de) * | 1990-03-02 | 1991-09-26 | Max Planck Gesellschaft | Inhibitor der proliferation von endothelzellen |
US5268384A (en) * | 1990-11-21 | 1993-12-07 | Galardy Richard E | Inhibition of angiogenesis by synthetic matrix metalloprotease inhibitors |
WO1992010210A1 (en) * | 1990-12-14 | 1992-06-25 | E.I. Du Pont De Nemours And Company | Inhibition of angiogenesis by il-1 |
US5206023A (en) * | 1991-01-31 | 1993-04-27 | Robert F. Shaw | Method and compositions for the treatment and repair of defects or lesions in cartilage |
US5270300A (en) * | 1991-09-06 | 1993-12-14 | Robert Francis Shaw | Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone |
US5382514A (en) * | 1992-03-31 | 1995-01-17 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | In vivo angiogenesis assay |
US5368051A (en) * | 1993-06-30 | 1994-11-29 | Dunn; Allan R. | Method of regenerating articular cartilage |
DK0797988T3 (da) * | 1993-07-19 | 2009-05-11 | Univ British Columbia | Anti-angiogene præparater og fremgangsmåder til anvendelse deraf |
EP0637450A3 (de) * | 1993-08-04 | 1995-04-05 | Collagen Corp | Verfahren und Zusammensetzung zur Wiederbelebung von Nerbgewebe. |
WO1995013830A1 (en) * | 1993-11-17 | 1995-05-26 | Massachusetts Institute Of Technology | Method for inhibiting angiogenesis using heparinase |
ATE241340T1 (de) * | 1994-02-17 | 2003-06-15 | New York Blood Ct Inc | Biologische bioadhäsive präparate, die fibrinkleber und liposomen enthalten, verfahren für ihre herstellung und verwendung |
-
1996
- 1996-06-28 US US08/672,618 patent/US5853746A/en not_active Expired - Lifetime
-
1997
- 1997-06-24 AU AU35815/97A patent/AU731172B2/en not_active Ceased
- 1997-06-24 DE DE69735998T patent/DE69735998T2/de not_active Expired - Fee Related
- 1997-06-24 WO PCT/US1997/011208 patent/WO1998000183A2/en active IP Right Grant
- 1997-06-24 NZ NZ333452A patent/NZ333452A/xx unknown
- 1997-06-24 EP EP97932329A patent/EP0912204B1/de not_active Expired - Lifetime
- 1997-06-24 ES ES97932329T patent/ES2267145T3/es not_active Expired - Lifetime
- 1997-06-24 IL IL12755097A patent/IL127550A/en not_active IP Right Cessation
- 1997-06-24 KR KR1019980710600A patent/KR20000022182A/ko not_active Application Discontinuation
- 1997-06-24 CN CNB97196887XA patent/CN1321681C/zh not_active Expired - Fee Related
- 1997-06-24 BR BR9710088A patent/BR9710088A/pt not_active Application Discontinuation
- 1997-06-24 AT AT97932329T patent/ATE327781T1/de not_active IP Right Cessation
- 1997-06-24 JP JP10504318A patent/JP2000513721A/ja not_active Ceased
- 1997-06-26 ZA ZA9705711A patent/ZA975711B/xx unknown
-
1998
- 1998-12-23 NO NO19986083A patent/NO320089B1/no not_active IP Right Cessation
-
1999
- 1999-05-13 HK HK99102149A patent/HK1017276A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ES2267145T3 (es) | 2007-03-01 |
IL127550A (en) | 2004-06-01 |
NO986083D0 (no) | 1998-12-23 |
BR9710088A (pt) | 1999-08-10 |
CN1321681C (zh) | 2007-06-20 |
EP0912204A2 (de) | 1999-05-06 |
NO320089B1 (no) | 2005-10-24 |
WO1998000183A2 (en) | 1998-01-08 |
EP0912204B1 (de) | 2006-05-31 |
DE69735998T2 (de) | 2007-03-15 |
NZ333452A (en) | 2000-04-28 |
JP2000513721A (ja) | 2000-10-17 |
AU3581597A (en) | 1998-01-21 |
WO1998000183A3 (en) | 1998-02-12 |
HK1017276A1 (en) | 1999-11-19 |
NO986083L (no) | 1999-03-01 |
KR20000022182A (ko) | 2000-04-25 |
IL127550A0 (en) | 1999-10-28 |
CN1226839A (zh) | 1999-08-25 |
ATE327781T1 (de) | 2006-06-15 |
ZA975711B (en) | 1998-01-26 |
AU731172B2 (en) | 2001-03-22 |
US5853746A (en) | 1998-12-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69735998D1 (de) | Zusammensetzungen zur behandlung und wiederherstellung von knorpeldefekten mit funktioneller sperrschicht | |
KR100278905B1 (ko) | 연골또는뼈의결손또는병변을치료하고치유시키기위한방법및조성물 | |
DK0569541T3 (da) | Vækstfaktor indholdende matriks til behandling af brusklæsioner | |
ATE447419T1 (de) | Methoden und zusammensetzungen zur heilung und reparatur von gelenkknorpeln | |
JP2002531193A (ja) | 生きた組織を再生するための方法および物品 | |
Zubery et al. | Ossification of a collagen membrane cross‐linked by sugar: a human case series | |
ATE255920T1 (de) | Methoden und zusammensetzungen zur heilung und reparatur von gelenkknorpeln | |
Guarnieri et al. | Histologic evaluation of bone healing of adjacent alveolar sockets grafted with bovine-and porcine-derived bone: a comparative case report in humans | |
CA2258601A1 (en) | Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone using functional barrier | |
Schaberg | COMPARISON OF FRESH AUTOLOGOUS AND FREEZE-DRIED ALLOGENEIC FREE VASCULARIZED RIB GRAFTS IN DOG RADIAL DISCONTINUITY DEFECTS (MICROVASCULAR, HISTOMORPHOMETRY, LYOPHILIZATION, MAXILLOFACIAL WOUNDS) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8327 | Change in the person/name/address of the patent owner |
Owner name: SHAW, ROBERT FRANCIS, GREENBRAE, CALIF., US |
|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |