DE69736515D1 - Neue ortho-naphthochinonderivate, neue synthesen zu ihrer herstellung und ihre anwendung in der inhibierung von neoplastischem zellwachstum - Google Patents

Neue ortho-naphthochinonderivate, neue synthesen zu ihrer herstellung und ihre anwendung in der inhibierung von neoplastischem zellwachstum

Info

Publication number
DE69736515D1
DE69736515D1 DE69736515T DE69736515T DE69736515D1 DE 69736515 D1 DE69736515 D1 DE 69736515D1 DE 69736515 T DE69736515 T DE 69736515T DE 69736515 T DE69736515 T DE 69736515T DE 69736515 D1 DE69736515 D1 DE 69736515D1
Authority
DE
Germany
Prior art keywords
new
naphthochinone
inhibition
derivatives
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69736515T
Other languages
English (en)
Inventor
J Frydman
T Witiak
J Marton
Karen Neder
M Dolan
H Geiser
Shunneng Sun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/604,131 external-priority patent/US5824700A/en
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Application granted granted Critical
Publication of DE69736515D1 publication Critical patent/DE69736515D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92—Naphthofurans; Hydrogenated naphthofurans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
    • C07C50/32—Quinones containing groups having oxygen atoms singly bound to carbon atoms the quinoid structure being part of a condensed ring system having two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
DE69736515T 1996-02-20 1997-02-20 Neue ortho-naphthochinonderivate, neue synthesen zu ihrer herstellung und ihre anwendung in der inhibierung von neoplastischem zellwachstum Expired - Lifetime DE69736515D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/604,131 US5824700A (en) 1996-02-20 1996-02-20 Ortho-quinone derivatives novel synthesis therefor and their use in the inhibition of neoplastic cell growth
US08/744,631 US5883270A (en) 1996-02-20 1996-11-06 4-substituted-1, 2-naphthoquinones and their use in the inhibition of neoplastic cell growth
PCT/US1997/002955 WO1997031936A2 (en) 1996-02-20 1997-02-20 Novel ortho-naphthoquinone derivatives, novel synthesis therefor, and their use in the inhibition of neoplastic cell growth

Publications (1)

Publication Number Publication Date
DE69736515D1 true DE69736515D1 (de) 2006-09-28

Family

ID=27084594

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69736515T Expired - Lifetime DE69736515D1 (de) 1996-02-20 1997-02-20 Neue ortho-naphthochinonderivate, neue synthesen zu ihrer herstellung und ihre anwendung in der inhibierung von neoplastischem zellwachstum

Country Status (7)

Country Link
US (2) US5883270A (de)
EP (1) EP0888326B1 (de)
JP (1) JP2000506841A (de)
AT (1) ATE336488T1 (de)
AU (1) AU1975497A (de)
DE (1) DE69736515D1 (de)
WO (1) WO1997031936A2 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
EP1173223A2 (de) * 1999-04-30 2002-01-23 Slil Biomedical Corporation Konjugate fur therapie von krebs und prostaterkrankungen
US6482943B1 (en) 1999-04-30 2002-11-19 Slil Biomedical Corporation Quinones as disease therapies
US7312244B2 (en) * 1999-04-30 2007-12-25 Cellgate, Inc. Polyamine analog-amino acid conjugates useful as anticancer agents
WO2000066528A2 (en) * 1999-04-30 2000-11-09 Slil Biomedical Corporation Quinones for treatment of diseases
US6649587B1 (en) 1999-04-30 2003-11-18 Slil Biomedical Corporation Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
EP1574507A3 (de) * 1999-04-30 2005-10-26 SLIL Biomedical Corporation Furo- und Pyrano-Naphthochinone und ihre Verwendung gegen Krebs
ATE308512T1 (de) * 1999-12-21 2005-11-15 Cd45 inhibitoren
US6939896B2 (en) * 1999-12-21 2005-09-06 Astrazeneca Ab Cd45 inhibitors
US7070797B2 (en) 2000-11-07 2006-07-04 Dana Farber Cancer Institute, Inc. Method of treating hematologic tumors and cancers
JP4244141B2 (ja) * 2000-11-07 2009-03-25 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド 血液腫瘍および血液癌を処置する方法
US7074824B2 (en) 2001-07-31 2006-07-11 Arqule, Inc. Pharmaceutical compositions containing beta-lapachone, or derivatives or analogs thereof, and methods of using same
US6962944B2 (en) 2001-07-31 2005-11-08 Arqule, Inc. Pharmaceutical compositions containing beta-lapachone, or derivatives or analogs thereof, and methods of using same
KR100455458B1 (ko) * 2001-10-18 2004-11-08 (주)바이오니아 1,2-나프토퀴논유도체 및 약학적으로 허용되는 이들의염과 그 제조방법
US6890950B2 (en) 2002-04-23 2005-05-10 Case Western Reserve University Lapachone delivery systems, compositions and uses related thereto
BR0316296A (pt) * 2002-11-18 2005-12-13 Arqule Inc Compostos lapacone e seus métodos de uso
EP1722776A2 (de) * 2004-02-20 2006-11-22 Arqule, Inc. Verwendung von beta-lapachone als anti-krebsmitter mit breitem wirkungsspektrum
WO2014018919A1 (en) * 2012-07-27 2014-01-30 The Regents Of The University Of California Seriniquinones, melanoma-specific anticancer agents
CN105130936B (zh) * 2015-09-01 2017-09-26 中国药科大学 一类邻萘醌化合物、其制备方法和医药用途
US10829427B2 (en) 2015-12-18 2020-11-10 The Board Of Regents Of The University Of Texas System Naphthoquinones, pro-drugs, and methods of use thereof
KR102171818B1 (ko) 2018-01-18 2020-10-29 (주)나디안바이오 듀니온을 유효성분으로 포함하는 탈모의 예방 또는 개선용 조성물

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4879243A (en) * 1987-05-26 1989-11-07 Eastman Kodak Company Use of substituted ortho-quinones as electron transfer agents in analytical determinations
US4882339A (en) * 1987-07-10 1989-11-21 Ciba-Geigy Corporation 4-Amino-substituted 1,2-dihydroxynaphthalene derivatives useful in inhibiting 5-lipoxygenase activity in mammals
LU87403A1 (fr) * 1988-12-06 1990-07-10 Oreal Procede de teinture de fibres keratiniques avec un hydroxyindole,associe a un derive quinonique
DE3926747A1 (de) * 1989-08-12 1991-02-14 Basf Ag 1,2-napthochinone enthaltende fungizide mittel
GB9216859D0 (en) * 1992-08-07 1992-09-23 Wellcome Found Medicaments
EP0659190A1 (de) * 1992-11-09 1995-06-28 Biochem Pharma Inc Antineoplastic heteronaphtochinone
WO1995012588A1 (en) * 1993-11-05 1995-05-11 Biochem Pharma Inc. Antineoplastic heteronaphthoquinones
US5763625A (en) * 1995-04-25 1998-06-09 Wisconsin Alumni Research Foundation Synthesis and use of β-lapachone analogs

Also Published As

Publication number Publication date
ATE336488T1 (de) 2006-09-15
AU1975497A (en) 1997-09-16
US5883270A (en) 1999-03-16
JP2000506841A (ja) 2000-06-06
EP0888326B1 (de) 2006-08-16
EP0888326A2 (de) 1999-01-07
WO1997031936A3 (en) 1998-01-08
WO1997031936A2 (en) 1997-09-04
US5977187A (en) 1999-11-02

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