DE69737684D1 - Präzise wirksamkeitsbestimmungsmethode für wirkstoffe einschliesslich chemotherapeutika - Google Patents
Präzise wirksamkeitsbestimmungsmethode für wirkstoffe einschliesslich chemotherapeutikaInfo
- Publication number
- DE69737684D1 DE69737684D1 DE69737684T DE69737684T DE69737684D1 DE 69737684 D1 DE69737684 D1 DE 69737684D1 DE 69737684 T DE69737684 T DE 69737684T DE 69737684 T DE69737684 T DE 69737684T DE 69737684 D1 DE69737684 D1 DE 69737684D1
- Authority
- DE
- Germany
- Prior art keywords
- active substances
- determination method
- substances including
- efficacy determination
- including chemotherapeutics
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/679,056 US5728541A (en) | 1996-07-12 | 1996-07-12 | Method for preparing cell cultures from biologial specimens for chemotherapeutic and other assays |
US679056 | 1996-07-12 | ||
PCT/US1997/011595 WO1998002038A1 (en) | 1996-07-12 | 1997-07-10 | Precise efficacy assay methods for active agents including chemotherapeutic agents |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69737684D1 true DE69737684D1 (de) | 2007-06-14 |
DE69737684T2 DE69737684T2 (de) | 2008-01-31 |
Family
ID=24725407
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69737684T Expired - Lifetime DE69737684T2 (de) | 1996-07-12 | 1997-07-10 | Präzise wirksamkeitsbestimmungsmethode für wirkstoffe einschliesslich chemotherapeutika |
Country Status (13)
Country | Link |
---|---|
US (13) | US5728541A (de) |
EP (1) | EP0912085B1 (de) |
JP (1) | JP4108128B2 (de) |
CN (1) | CN1143618C (de) |
AT (1) | ATE360989T1 (de) |
AU (1) | AU712302B2 (de) |
BR (1) | BR9710348A (de) |
CA (1) | CA2259984C (de) |
DE (1) | DE69737684T2 (de) |
ES (1) | ES2283022T3 (de) |
IL (1) | IL127964A (de) |
NZ (1) | NZ333830A (de) |
WO (1) | WO1998002038A1 (de) |
Families Citing this family (70)
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US20040023375A1 (en) * | 2002-07-30 | 2004-02-05 | Precision Therapeutics, Inc. | Method for preparing cell cultures from biological specimens for chemotherapeutic and other assays |
US20040072722A1 (en) * | 2002-10-10 | 2004-04-15 | Kornblith Paul L. | Methods for assessing efficacy of chemotherapeutic agents |
US6171780B1 (en) | 1997-06-02 | 2001-01-09 | Aurora Biosciences Corporation | Low fluorescence assay platforms and related methods for drug discovery |
US6517781B1 (en) * | 1997-06-02 | 2003-02-11 | Aurora Biosciences Corporation | Low fluorescence assay platforms and related methods for drug discovery |
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DE19912798C1 (de) * | 1999-03-10 | 2000-02-17 | Andreas Jordan | Verfahren zur Kultivierung von Krebszellen aus Humangewebe und Vorrichtung zur Aufbereitung von Gewebeproben |
US20040086888A1 (en) * | 2001-10-18 | 2004-05-06 | Kornblith Paul L | Method for tandem genomic/proteomic analysis of proliferating cells |
US7276351B2 (en) * | 2003-09-10 | 2007-10-02 | Seahorse Bioscience | Method and device for measuring multiple physiological properties of cells |
US8658349B2 (en) * | 2006-07-13 | 2014-02-25 | Seahorse Bioscience | Cell analysis apparatus and method |
US20070087401A1 (en) * | 2003-10-17 | 2007-04-19 | Andy Neilson | Analysis of metabolic activity in cells using extracellular flux rate measurements |
WO2005114178A1 (de) * | 2004-05-21 | 2005-12-01 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Multizelluläre testsysteme |
EP1929306A4 (de) * | 2005-09-01 | 2009-11-11 | Precision Therapeutics Inc | Chemosensible assays, die tumorzellen mit persistenten phänotypischen merkmalen |
WO2011008990A1 (en) | 2009-07-15 | 2011-01-20 | Prometheus Laboratories Inc. | Drug selection for gastric cancer therapy using antibody-based arrays |
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WO2008150496A2 (en) * | 2007-05-31 | 2008-12-11 | Genelux Corporation | Assay for sensitivity to chemotherapeutic agents |
EP2207892A4 (de) * | 2007-10-15 | 2010-12-08 | Precision Therapeutics Inc | Verfahren zur selektion aktiver agentien für die krebsbehandlung |
EP2212696B1 (de) * | 2007-10-25 | 2013-12-04 | Genelux Corporation | Systeme und verfahren für die virustherapie |
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EP2281027A4 (de) * | 2008-05-14 | 2011-07-27 | Precision Therapeutics Inc | Verfahren zur vorhersage der reaktion eines patienten auf egfr-hemmer |
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EP3266453A1 (de) | 2008-07-03 | 2018-01-10 | Mayo Foundation for Medical Education and Research | Krebsbehandlung |
US8202702B2 (en) * | 2008-10-14 | 2012-06-19 | Seahorse Bioscience | Method and device for measuring extracellular acidification and oxygen consumption rate with higher precision |
US20110238322A1 (en) * | 2008-11-03 | 2011-09-29 | Precision Therapeutics, Inc. | Methods of simulating chemotherapy for a patient |
US8657841B2 (en) * | 2008-12-16 | 2014-02-25 | Nico Corporation | Tissue removal device for neurosurgical and spinal surgery applications |
US20100152762A1 (en) * | 2008-12-16 | 2010-06-17 | Mark Joseph L | Tissue removal system with multi-directional foot actuator assembly for neurosurgical and spinal surgery applications |
US8702738B2 (en) * | 2008-12-16 | 2014-04-22 | Nico Corporation | Tissue removal device for neurosurgical and spinal surgery applications |
US8430825B2 (en) * | 2008-12-16 | 2013-04-30 | Nico Corporation | Tissue removal device for neurosurgical and spinal surgery applications |
US9820480B2 (en) | 2008-12-16 | 2017-11-21 | Nico Corporation | System for collecting and preserving tissue cores |
US9504247B2 (en) | 2008-12-16 | 2016-11-29 | Nico Corporation | System for collecting and preserving tissue cores |
US9931105B2 (en) | 2008-12-16 | 2018-04-03 | Nico Corporation | System and method of taking and collecting tissue cores for treatment |
US9279751B2 (en) | 2008-12-16 | 2016-03-08 | Nico Corporation | System and method of taking and collecting tissue cores for treatment |
US8496599B2 (en) * | 2008-12-16 | 2013-07-30 | Nico Corporation | Tissue removal device for neurosurgical and spinal surgery applications |
US10080578B2 (en) | 2008-12-16 | 2018-09-25 | Nico Corporation | Tissue removal device with adjustable delivery sleeve for neurosurgical and spinal surgery applications |
US9655639B2 (en) * | 2008-12-16 | 2017-05-23 | Nico Corporation | Tissue removal device for use with imaging devices in neurosurgical and spinal surgery applications |
US8357175B2 (en) * | 2008-12-16 | 2013-01-22 | Nico Corporation | Positioning system for tissue removal device |
US8460327B2 (en) * | 2008-12-16 | 2013-06-11 | Nico Corporation | Tissue removal device for neurosurgical and spinal surgery applications |
US10368890B2 (en) | 2008-12-16 | 2019-08-06 | Nico Corporation | Multi-functional surgical device for neurosurgical and spinal surgery applications |
US9216031B2 (en) * | 2008-12-16 | 2015-12-22 | Nico Corporation | Tissue removal device with adjustable fluid supply sleeve for neurosurgical and spinal surgery applications |
US20110014644A1 (en) | 2009-06-22 | 2011-01-20 | Precision Therapeutics, Inc. | Methods for predicting a cancer patient's response to antifolate chemotherapy |
US20110097748A1 (en) * | 2009-10-28 | 2011-04-28 | Warsaw Orthopedic, Inc. | Use of cell lines to determine levels of efficacy of pharmaceutical formulations |
JP5847733B2 (ja) | 2010-01-28 | 2016-01-27 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 懸滴用アレイプレート |
US9427477B2 (en) | 2011-05-09 | 2016-08-30 | Mayo Foundation For Medical Education And Research | Cancer treatments |
US9963481B2 (en) | 2011-09-07 | 2018-05-08 | The Scripps Research Institute | Chiral oligomeric pentenoate amides as bio-oligomer mimetics |
KR20140114808A (ko) | 2012-01-17 | 2014-09-29 | 니코 코포레이션 | 조직 코어들의 수집 및 보존 시스템 |
SG11201408453PA (en) * | 2012-07-05 | 2015-01-29 | Caldera Health Ltd | Methods for determining personalized treatment compositions for prostate cancer and breast cancer |
ES2899643T3 (es) | 2012-10-01 | 2022-03-14 | Mayo Found Medical Education & Res | Tratamientos para el cáncer |
US9494577B2 (en) | 2012-11-13 | 2016-11-15 | Seahorse Biosciences | Apparatus and methods for three-dimensional tissue measurements based on controlled media flow |
BR112015024780A2 (pt) * | 2013-03-28 | 2017-10-10 | Ct Hospitalier Universitaire Montpellier | metodo para determinar radiosensibilidade |
EP2796873A1 (de) * | 2013-04-25 | 2014-10-29 | QGel SA | Verfahren zur zellbasierten Arzneimitteluntersuchungsprüfung und Verwendung davon |
DE102013010528B3 (de) * | 2013-06-25 | 2014-02-20 | FLACOD GmbH | Verfahren zur Erstellung einer Datenbank für die Vorabschätzung der Wirksamkeit von Wirkstoffen in der Tumortherapie |
CN106999926A (zh) | 2014-06-02 | 2017-08-01 | 安捷伦科技有限公司 | 用于分析生物样本的单列微板系统和载体 |
EP3154595A4 (de) | 2014-06-16 | 2018-01-24 | Mayo Foundation for Medical Education and Research | Behandlung von myelomen |
EP3158487A1 (de) * | 2014-06-20 | 2017-04-26 | Connecticut Children's Medical Center | Automatisiertes zellkultursystem und entsprechendes verfahren |
US9446148B2 (en) | 2014-10-06 | 2016-09-20 | Mayo Foundation For Medical Education And Research | Carrier-antibody compositions and methods of making and using the same |
TW201707725A (zh) | 2015-08-18 | 2017-03-01 | 美國馬友醫藥教育研究基金會 | 載體-抗體組合物及其製造及使用方法 |
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EP3399861A4 (de) | 2016-01-07 | 2019-08-07 | Mayo Foundation for Medical Education and Research | Verfahren zur behandlung von krebs mit interferon |
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KR20190053203A (ko) | 2016-09-01 | 2019-05-17 | 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 | T-세포 암을 표적화하는 방법 및 조성물 |
KR20230011473A (ko) | 2016-09-06 | 2023-01-20 | 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 | Pd-l1 발현 암의 치료 방법 |
EP3509635A1 (de) | 2016-09-06 | 2019-07-17 | Vavotar Life Sciences LLC | Verfahren zur behandlung von dreifach negativem brustkrebs unter verwendung von zusammensetzungen aus antikörpern und trägerproteinen |
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-
1996
- 1996-07-12 US US08/679,056 patent/US5728541A/en not_active Expired - Lifetime
-
1997
- 1997-07-10 AU AU36493/97A patent/AU712302B2/en not_active Ceased
- 1997-07-10 JP JP50606998A patent/JP4108128B2/ja not_active Expired - Fee Related
- 1997-07-10 DE DE69737684T patent/DE69737684T2/de not_active Expired - Lifetime
- 1997-07-10 NZ NZ333830A patent/NZ333830A/xx unknown
- 1997-07-10 ES ES97933267T patent/ES2283022T3/es not_active Expired - Lifetime
- 1997-07-10 CA CA002259984A patent/CA2259984C/en not_active Expired - Lifetime
- 1997-07-10 CN CNB971961433A patent/CN1143618C/zh not_active Expired - Fee Related
- 1997-07-10 WO PCT/US1997/011595 patent/WO1998002038A1/en active IP Right Grant
- 1997-07-10 EP EP97933267A patent/EP0912085B1/de not_active Expired - Lifetime
- 1997-07-10 AT AT97933267T patent/ATE360989T1/de not_active IP Right Cessation
- 1997-07-10 IL IL12796497A patent/IL127964A/en not_active IP Right Cessation
- 1997-07-10 BR BR9710348-9A patent/BR9710348A/pt not_active Application Discontinuation
-
1998
- 1998-03-16 US US09/039,957 patent/US6933129B1/en not_active Expired - Lifetime
- 1998-03-17 US US09/040,161 patent/US6900027B1/en not_active Expired - Lifetime
-
2002
- 2002-07-26 US US10/205,887 patent/US6887680B2/en not_active Expired - Lifetime
-
2005
- 2005-03-08 US US11/073,931 patent/US7112415B2/en not_active Expired - Lifetime
- 2005-03-17 US US11/081,827 patent/US7314731B2/en not_active Expired - Fee Related
-
2006
- 2006-08-15 US US11/504,098 patent/US7563593B2/en not_active Expired - Fee Related
-
2007
- 2007-11-26 US US11/944,884 patent/US7501260B2/en not_active Expired - Fee Related
-
2008
- 2008-09-10 US US12/208,076 patent/US7678552B2/en not_active Expired - Fee Related
- 2008-10-02 US US12/244,463 patent/US7771963B2/en not_active Expired - Fee Related
-
2010
- 2010-01-20 US US12/690,529 patent/US8183009B2/en not_active Expired - Fee Related
- 2010-07-01 US US12/828,665 patent/US8058025B2/en not_active Expired - Fee Related
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2011
- 2011-10-06 US US13/267,581 patent/US20120088264A1/en not_active Abandoned
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