DE69738709D1 - Herpes simplex virusstaemme - Google Patents
Herpes simplex virusstaemmeInfo
- Publication number
- DE69738709D1 DE69738709D1 DE69738709T DE69738709T DE69738709D1 DE 69738709 D1 DE69738709 D1 DE 69738709D1 DE 69738709 T DE69738709 T DE 69738709T DE 69738709 T DE69738709 T DE 69738709T DE 69738709 D1 DE69738709 D1 DE 69738709D1
- Authority
- DE
- Germany
- Prior art keywords
- icp27
- icp4
- icp0
- icp22
- cell lines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 241000700584 Simplexvirus Species 0.000 title abstract 6
- 101150027427 ICP4 gene Proteins 0.000 abstract 10
- 101710130522 mRNA export factor Proteins 0.000 abstract 10
- 101150090364 ICP0 gene Proteins 0.000 abstract 5
- 101001042049 Human herpesvirus 1 (strain 17) Transcriptional regulator ICP22 Proteins 0.000 abstract 4
- 101000999690 Human herpesvirus 2 (strain HG52) E3 ubiquitin ligase ICP22 Proteins 0.000 abstract 4
- 230000002950 deficient Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 108010007403 Immediate-Early Proteins Proteins 0.000 abstract 1
- 108091092356 cellular DNA Proteins 0.000 abstract 1
- 230000006801 homologous recombination Effects 0.000 abstract 1
- 238000002744 homologous recombination Methods 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16641—Use of virus, viral particle or viral elements as a vector
- C12N2710/16643—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16651—Methods of production or purification of viral material
- C12N2710/16652—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/651,419 US5804413A (en) | 1992-07-31 | 1996-05-22 | Herpes simplex virus strains for gene transfer |
PCT/US1997/008681 WO1998015637A1 (en) | 1996-05-22 | 1997-05-22 | Herpes simplex virus strains |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69738709D1 true DE69738709D1 (de) | 2008-07-03 |
Family
ID=24612790
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69738709T Expired - Lifetime DE69738709D1 (de) | 1996-05-22 | 1997-05-22 | Herpes simplex virusstaemme |
Country Status (8)
Country | Link |
---|---|
US (1) | US5804413A (de) |
EP (1) | EP0904395B2 (de) |
JP (1) | JP2001503611A (de) |
AT (1) | ATE396274T1 (de) |
AU (1) | AU733945B2 (de) |
CA (1) | CA2255939A1 (de) |
DE (1) | DE69738709D1 (de) |
WO (1) | WO1998015637A1 (de) |
Families Citing this family (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7223411B1 (en) * | 1992-07-31 | 2007-05-29 | Dana-Farber Cancer Institute | Herpesvirus replication defective mutants |
GB9415369D0 (en) | 1994-07-29 | 1994-09-21 | Lynxvale Ltd | Mutant virus |
US6261552B1 (en) * | 1997-05-22 | 2001-07-17 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Herpes simplex virus vectors |
GB9615794D0 (en) | 1996-07-26 | 1996-09-04 | Medical Res Council | Mutant herpes simplex virus strains and uses thereof |
US6458574B1 (en) * | 1996-09-12 | 2002-10-01 | Transkaryotic Therapies, Inc. | Treatment of a α-galactosidase a deficiency |
US6083725A (en) * | 1996-09-13 | 2000-07-04 | Transkaryotic Therapies, Inc. | Tranfected human cells expressing human α-galactosidase A protein |
GB9816856D0 (en) * | 1998-08-03 | 1998-09-30 | Univ London | Cell lines for virus growth |
US6764675B1 (en) * | 1999-06-08 | 2004-07-20 | The Uab Research Foundation | Herpes simplex virus expressing foreign genes and method for treating cancers therewith |
IL131212A0 (en) * | 1999-08-03 | 2001-01-28 | Yissum Res Dev Co | Recombinant virus and live-virus vaccines |
WO2001010903A2 (en) * | 1999-08-09 | 2001-02-15 | Incyte Genomics, Inc. | Proteases and protease inhibitors |
CA2384650A1 (en) * | 1999-09-10 | 2001-03-15 | Incyte Genomics, Inc. | Apoptosis proteins |
US6660259B2 (en) * | 1999-12-08 | 2003-12-09 | Onyx Pharmaceuticals, Inc. | Herpes simplex virus for treating unwanted hyperproliferative cell growth |
GB0001476D0 (en) * | 2000-01-21 | 2000-03-15 | Neurovex Ltd | Herpes virus strains |
WO2001066742A2 (en) * | 2000-03-03 | 2001-09-13 | Incyte Genomics, Inc. | G-protein coupled receptors |
US20040086877A1 (en) | 2000-06-16 | 2004-05-06 | Lal Preeti G. | Multi-mode directi memory access controller and method |
US7608704B2 (en) | 2000-11-08 | 2009-10-27 | Incyte Corporation | Secreted proteins |
EP1346036B1 (de) * | 2000-11-29 | 2010-04-28 | University of Rochester | Helfervirus-freie herpesvirus-amplifikatpartikel und deren verwendungen |
US8092791B2 (en) | 2001-05-23 | 2012-01-10 | University Of Rochester | Method of producing herpes simplex virus amplicons, resulting amplicons, and their use |
WO2003006658A1 (en) * | 2001-07-13 | 2003-01-23 | The General Hospital Corporation | Mutant herpes simplex virus that expresses yeast cytosine deaminase |
US7378492B2 (en) * | 2002-02-20 | 2008-05-27 | Incyte Corporation | CD40-related receptor that binds CD40L |
ATE514430T1 (de) * | 2002-04-25 | 2011-07-15 | Shire Human Genetic Therapies | Behandlung des alpha-galactosidase a mangels |
WO2004015396A2 (en) * | 2002-08-13 | 2004-02-19 | Incyte Corporation | Cell adhesion and extracellular matrix proteins |
US20070219353A1 (en) * | 2002-09-03 | 2007-09-20 | Incyte Corporation | Immune Response Associated Proteins |
WO2004033636A2 (en) * | 2002-10-04 | 2004-04-22 | Incyte Corporation | Protein modification and maintenance molecules |
US20050164275A1 (en) * | 2002-10-18 | 2005-07-28 | Incyte Corporation | Phosphodiesterases |
WO2004044166A2 (en) * | 2002-11-12 | 2004-05-27 | Incyte Corporation | Carbohydrate-associated proteins |
AU2003295462A1 (en) * | 2002-11-13 | 2004-06-03 | Incyte Corporation | Lipid-associated proteins |
US20070009516A1 (en) * | 2002-11-26 | 2007-01-11 | Tran Uyen K | Immune response-associated proteins |
US20040166091A1 (en) * | 2003-02-24 | 2004-08-26 | Genvec, Inc. | Materials and methods for treating disorders of the ear |
US7829682B1 (en) | 2003-04-30 | 2010-11-09 | Incyte Corporation | Human β-adrenergic receptor kinase nucleic acid molecule |
EP2377882A1 (de) | 2004-10-28 | 2011-10-19 | University of Pittsburgh of the Commonwealth System of Higher Education | Peripher verabreichte Gentherapie mit Glutaminsäure-Decarboxylase gegen Schmerzen aufgrund einer Rückenmarksverletzung |
WO2006130806A2 (en) * | 2005-06-01 | 2006-12-07 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Assay for agonists and antagonists of ion channels and for regulators of genetic expression |
WO2006132925A2 (en) * | 2005-06-01 | 2006-12-14 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Method of amidated peptide biosynthesis and delivery in vivo: endomorphin-2 for pain therapy |
US20100008944A1 (en) * | 2005-07-29 | 2010-01-14 | President And Fellows Of Harvard College | Herpes simplex virus mutant and uses therefore |
EP1783210A1 (de) * | 2005-11-08 | 2007-05-09 | ProBioGen AG | Proteinfaktoren zur Erhöhung der Produktivität, neue Zelllinien und deren Verwendungen |
US20080289058A1 (en) * | 2007-05-14 | 2008-11-20 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Targeted delivery of glycine receptors to excitable cells |
US8889622B2 (en) * | 2007-07-25 | 2014-11-18 | Washington University | Methods of inhibiting seizure in a subject |
US20120219583A1 (en) | 2009-10-16 | 2012-08-30 | Los Alamos National Security, Llc | Nucleic acid sequences encoding expandable hiv mosaic proteins |
EP3284821B1 (de) | 2010-03-23 | 2022-01-05 | Precigen, Inc. | Vektoren zur bedingten expression therapeutischer proteine, wirtszellen mit diesen vektoren und verwendungen davon |
WO2011130749A2 (en) | 2010-04-16 | 2011-10-20 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Identification of mutations in herpes simplex virus envelope glycoproteins that enable or enhance vector retargeting to novel non-hsv receptors |
EP3450568A3 (de) | 2011-03-04 | 2019-04-24 | Intrexon Corporation | Vektoren für bedingte proteinexpression |
RU2020105656A (ru) * | 2013-07-17 | 2021-01-27 | Юниверсити Оф Питтсбург- Оф Дзе Коммонвелт Систем Оф Хайер Эдьюкейшн | Нетоксичные векторы на основе впг для применений в эффективной доставке генов и комплементирующие клетки для их продуцирования |
KR102490462B1 (ko) | 2013-10-28 | 2023-01-19 | 유니버시티 오브 피츠버그-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 | 종양분해성 hsv 벡터 |
US9580699B2 (en) | 2014-04-17 | 2017-02-28 | University of Pittsburgh—of the Commonwealth System of Higher Education | TRPV1 modulatory gene product that affects TRPV1-specific pain behavioral responses identified in a functional screen of an HSV-based cDNA library |
CN107073091A (zh) | 2014-09-07 | 2017-08-18 | 西莱克塔生物科技公司 | 用于减弱外显子跳读抗病毒转移载体免疫应答的方法和组合物 |
TWI710635B (zh) | 2014-10-09 | 2020-11-21 | 美商珍維克公司 | 編碼人類無調同源物-1(hath1)之腺病毒載體 |
CA2985649A1 (en) * | 2015-05-13 | 2016-11-17 | Sanofi Pasteur Biologics, Llc | Icp0-mediated enhanced expression system |
ES2919953T3 (es) | 2016-01-27 | 2022-07-29 | Oncorus Inc | Vectores víricos oncolíticos y usos de los mismos |
EP3432912B1 (de) * | 2016-03-25 | 2022-12-21 | PeriphaGen, Inc. | Hochumformende hsv-vektoren |
US10799560B2 (en) | 2016-03-25 | 2020-10-13 | Periphagen, Inc. | HSV vectors for delivery of NT3 and treatment of CIPN |
EP3478321A4 (de) | 2016-06-30 | 2020-04-22 | Oncorus, Inc. | Pseudotypisierte onkolytische virale verabreichung von therapeutischen polypeptiden |
CA3034094A1 (en) | 2016-08-16 | 2018-02-22 | Bluebird Bio, Inc. | Il-10 receptor alpha homing endonuclease variants, compositions, and methods of use |
EP3504335A4 (de) | 2016-08-23 | 2020-04-15 | Bluebird Bio, Inc. | Tim3-homing-endonuklease-varianten, zusammensetzungen und verfahren zur verwendung |
KR102622910B1 (ko) | 2016-09-08 | 2024-01-10 | 2세븐티 바이오, 인코포레이티드 | Pd-1 호밍 엔도뉴클레아제 변이체, 조성물 및 사용 방법 |
US11530395B2 (en) | 2016-10-17 | 2022-12-20 | 2Seventy Bio, Inc. | TGFBetaR2 endonuclease variants, compositions, and methods of use |
AU2017362484B2 (en) | 2016-11-17 | 2021-12-16 | 2Seventy Bio, Inc. | TGFβ signal convertor |
KR20240015743A (ko) | 2017-01-07 | 2024-02-05 | 셀렉타 바이오사이언시즈, 인크. | 합성 나노담체에 커플링된 면역억제제의 패턴화된 투여 |
WO2018152325A1 (en) | 2017-02-15 | 2018-08-23 | Bluebird Bio, Inc. | Donor repair templates multiplex genome editing |
WO2018176103A1 (en) | 2017-03-30 | 2018-10-04 | The University Of Queensland | "chimeric molecules and uses thereof" |
JP7191042B2 (ja) | 2017-05-25 | 2022-12-16 | 2セブンティ バイオ インコーポレイテッド | Cblbエンドヌクレアーゼバリアント、組成物、および使用方法 |
US11612625B2 (en) | 2017-07-26 | 2023-03-28 | Oncorus, Inc. | Oncolytic viral vectors and uses thereof |
WO2019070974A1 (en) | 2017-10-04 | 2019-04-11 | Bluebird Bio, Inc. | PCSK9 ENDONUCLEASE VARIANTS, COMPOSITIONS AND METHODS OF USE |
US20190142974A1 (en) | 2017-10-13 | 2019-05-16 | Selecta Biosciences, Inc. | Methods and compositions for attenuating anti-viral transfer vector igm responses |
WO2019133847A1 (en) | 2017-12-29 | 2019-07-04 | Oncorus, Inc. | Oncolytic viral delivery of therapeutic polypeptides |
EP3758682A4 (de) | 2018-02-26 | 2021-12-15 | Antolrx, Inc. | Tolerogene liposome und verfahren zur verwendung davon |
KR20210021522A (ko) | 2018-06-14 | 2021-02-26 | 블루버드 바이오, 인코포레이티드. | Cd79a 키메라 항원 수용체 |
EP3856761A1 (de) * | 2018-09-24 | 2021-08-04 | Krystal Biotech, Inc. | Zusammensetzungen und verfahren zur behandlung des netherton-syndroms |
WO2020072059A1 (en) | 2018-10-04 | 2020-04-09 | Bluebird Bio, Inc. | Cblb endonuclease variants, compositions, and methods of use |
US20200291428A1 (en) * | 2019-03-14 | 2020-09-17 | Massachusetts Institute Of Technology | Engineered herpes simplex virus-1 (hsv-1) vectors and uses thereof |
US20200360453A1 (en) | 2019-04-28 | 2020-11-19 | Selecta Biosciences, Inc. | Methods for treatment of subjects with preexisting immunity to viral transfer vectors |
CN114206396A (zh) | 2019-05-28 | 2022-03-18 | 西莱克塔生物科技公司 | 用于减弱抗病毒转移载体免疫应答的方法和组合物 |
US20220380735A1 (en) | 2019-10-10 | 2022-12-01 | Oncorus, Inc. | Dual viruses and dual oncolytic viruses and methods of treatment |
KR20220167324A (ko) | 2020-04-10 | 2022-12-20 | 솔라 바이오사이언시즈 엘엘씨 | 단백질 응집 장애의 치료를 위한 조성물 및 방법 |
KR20230025659A (ko) | 2020-04-28 | 2023-02-22 | 솔라 바이오사이언시즈 엘엘씨 | Tdp-43 단백질병증의 치료를 위한 조성물 및 방법 |
US20230234997A1 (en) | 2020-06-05 | 2023-07-27 | Sola Biosciences Llc | Compositions and Methods for the Treatment of Synucleinopathies |
JP2023529892A (ja) | 2020-06-09 | 2023-07-12 | イノザイム ファーマ インク. | 可溶性enpp1又はenpp3タンパク質及びその使用 |
TW202233655A (zh) | 2020-10-26 | 2022-09-01 | 美商碩拿生物科學有限責任公司 | 用於治療阿茲海默症之組合物及方法 |
WO2023288267A1 (en) | 2021-07-14 | 2023-01-19 | 2Seventy Bio, Inc. | Engineered t cell receptors fused to binding domains from antibodies |
WO2023060248A1 (en) | 2021-10-08 | 2023-04-13 | Sola Biosciences Llc | Compositions and methods for the treatment of p53-mediated cancers |
WO2023060221A2 (en) | 2021-10-08 | 2023-04-13 | Sola Biosciences Llc | Compositions and methods for the treatment of proteopathies |
WO2023064367A1 (en) | 2021-10-12 | 2023-04-20 | Selecta Biosciences, Inc. | Methods and compositions for attenuating anti-viral transfer vector igm responses |
WO2023172624A1 (en) | 2022-03-09 | 2023-09-14 | Selecta Biosciences, Inc. | Immunosuppressants in combination with anti-igm agents and related dosing |
WO2023196997A2 (en) | 2022-04-08 | 2023-10-12 | 2Seventy Bio, Inc. | Multipartite receptor and signaling complexes |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5026635A (en) * | 1987-05-19 | 1991-06-25 | Du Pont Merck Pharmaceutical | Stable human cell lines expressing an indicator gene product under virus-specific genetic controls |
US5674722A (en) * | 1987-12-11 | 1997-10-07 | Somatix Therapy Corporation | Genetic modification of endothelial cells |
US5672344A (en) * | 1987-12-30 | 1997-09-30 | The Regents Of The University Of Michigan | Viral-mediated gene transfer system |
US5124263A (en) * | 1989-01-12 | 1992-06-23 | Wisconsin Alumni Research Foundation | Recombination resistant retroviral helper cell and products produced thereby |
US5070010A (en) * | 1989-10-30 | 1991-12-03 | Hoffman-La Roche Inc. | Method for determining anti-viral transactivating activity |
CA2039921A1 (en) * | 1990-04-16 | 1991-10-17 | Xandra O. Breakefield | Transfer and expression of gene sequences into central nervous system cells using herpes simplex virus mutants with deletions in genes for viral replication |
AU1176095A (en) * | 1993-11-10 | 1995-05-29 | University Of British Columbia, The | Method of treatment using, process of preparing, and composition comprising a recombinant hsv-1 |
US5698431A (en) * | 1995-02-09 | 1997-12-16 | Washington University | Herpes simplex virus mutant UL41NHB |
-
1996
- 1996-05-22 US US08/651,419 patent/US5804413A/en not_active Expired - Lifetime
-
1997
- 1997-05-22 AU AU31379/97A patent/AU733945B2/en not_active Ceased
- 1997-05-22 AT AT97926668T patent/ATE396274T1/de not_active IP Right Cessation
- 1997-05-22 JP JP51203698A patent/JP2001503611A/ja active Pending
- 1997-05-22 CA CA002255939A patent/CA2255939A1/en not_active Abandoned
- 1997-05-22 DE DE69738709T patent/DE69738709D1/de not_active Expired - Lifetime
- 1997-05-22 EP EP97926668A patent/EP0904395B2/de not_active Expired - Lifetime
- 1997-05-22 WO PCT/US1997/008681 patent/WO1998015637A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
JP2001503611A (ja) | 2001-03-21 |
ATE396274T1 (de) | 2008-06-15 |
AU733945B2 (en) | 2001-05-31 |
US5804413A (en) | 1998-09-08 |
EP0904395A1 (de) | 1999-03-31 |
CA2255939A1 (en) | 1998-04-16 |
WO1998015637A1 (en) | 1998-04-16 |
EP0904395B1 (de) | 2008-05-21 |
AU3137997A (en) | 1998-05-05 |
EP0904395B2 (de) | 2011-07-27 |
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