DE69738984D1 - Mutierte nicht aktivierende igg2 domäne und diese sequenz enthaltende anti-cd3 antikörper - Google Patents

Mutierte nicht aktivierende igg2 domäne und diese sequenz enthaltende anti-cd3 antikörper

Info

Publication number
DE69738984D1
DE69738984D1 DE69738984T DE69738984T DE69738984D1 DE 69738984 D1 DE69738984 D1 DE 69738984D1 DE 69738984 T DE69738984 T DE 69738984T DE 69738984 T DE69738984 T DE 69738984T DE 69738984 D1 DE69738984 D1 DE 69738984D1
Authority
DE
Germany
Prior art keywords
antibodies
mutaten
activating
sequence
antibodies containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69738984T
Other languages
English (en)
Inventor
J Yun Tso
Michael S Cole
Claudio Anasetti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AbbVie Biotherapeutics Inc
Fred Hutchinson Cancer Center
Original Assignee
Fred Hutchinson Cancer Research Center
PDL Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fred Hutchinson Cancer Research Center, PDL Biopharma Inc filed Critical Fred Hutchinson Cancer Research Center
Application granted granted Critical
Publication of DE69738984D1 publication Critical patent/DE69738984D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
DE69738984T 1996-05-20 1997-05-19 Mutierte nicht aktivierende igg2 domäne und diese sequenz enthaltende anti-cd3 antikörper Expired - Lifetime DE69738984D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US65041096A 1996-05-20 1996-05-20
US08/656,586 US5834597A (en) 1996-05-20 1996-05-31 Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same
PCT/US1997/008576 WO1997044362A1 (en) 1996-05-20 1997-05-19 MUTATED NONACTIVATING IgG2 DOMAINS AND ANTI-CD3 ANTIBODIES INCORPORATING THE SAME

Publications (1)

Publication Number Publication Date
DE69738984D1 true DE69738984D1 (de) 2008-10-23

Family

ID=27095860

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69738984T Expired - Lifetime DE69738984D1 (de) 1996-05-20 1997-05-19 Mutierte nicht aktivierende igg2 domäne und diese sequenz enthaltende anti-cd3 antikörper

Country Status (11)

Country Link
US (1) US5834597A (de)
EP (1) EP0966485B1 (de)
JP (2) JP3947570B2 (de)
CN (1) CN100549031C (de)
AT (1) ATE407952T1 (de)
AU (1) AU725821B2 (de)
CA (1) CA2255826C (de)
DE (1) DE69738984D1 (de)
ES (1) ES2313736T3 (de)
PT (1) PT966485E (de)
WO (1) WO1997044362A1 (de)

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CN100549031C (zh) 2009-10-14
EP0966485B1 (de) 2008-09-10
JP3947570B2 (ja) 2007-07-25
CA2255826C (en) 2002-10-01
WO1997044362A1 (en) 1997-11-27
ES2313736T3 (es) 2009-03-01
CN1222162A (zh) 1999-07-07
ATE407952T1 (de) 2008-09-15
AU3208397A (en) 1997-12-09
US5834597A (en) 1998-11-10
PT966485E (pt) 2008-12-10
JP2002506420A (ja) 2002-02-26
AU725821B2 (en) 2000-10-19
EP0966485A4 (de) 2005-01-19
CA2255826A1 (en) 1997-11-27
JP2007106771A (ja) 2007-04-26
EP0966485A1 (de) 1999-12-29

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