DE69739319D1 - Verfahren zur Expression von PDGF oder IGR Proteinen in Hefe - Google Patents
Verfahren zur Expression von PDGF oder IGR Proteinen in HefeInfo
- Publication number
- DE69739319D1 DE69739319D1 DE69739319T DE69739319T DE69739319D1 DE 69739319 D1 DE69739319 D1 DE 69739319D1 DE 69739319 T DE69739319 T DE 69739319T DE 69739319 T DE69739319 T DE 69739319T DE 69739319 D1 DE69739319 D1 DE 69739319D1
- Authority
- DE
- Germany
- Prior art keywords
- proteins
- isoforms
- pdgf
- clipped
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1858—Platelet-derived growth factor [PDGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/49—Platelet-derived growth factor [PDGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3272096P | 1996-12-13 | 1996-12-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69739319D1 true DE69739319D1 (de) | 2009-04-30 |
Family
ID=21866458
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69739319T Expired - Lifetime DE69739319D1 (de) | 1996-12-13 | 1997-12-12 | Verfahren zur Expression von PDGF oder IGR Proteinen in Hefe |
DE69725881T Expired - Lifetime DE69725881T2 (de) | 1996-12-13 | 1997-12-12 | Verfahren zur expression von heterologen proteinen in hefe |
DE69738768T Expired - Lifetime DE69738768D1 (de) | 1996-12-13 | 1997-12-12 | Analyse und separation von pdgf-proteinen |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69725881T Expired - Lifetime DE69725881T2 (de) | 1996-12-13 | 1997-12-12 | Verfahren zur expression von heterologen proteinen in hefe |
DE69738768T Expired - Lifetime DE69738768D1 (de) | 1996-12-13 | 1997-12-12 | Analyse und separation von pdgf-proteinen |
Country Status (9)
Country | Link |
---|---|
US (10) | US6083910A (de) |
EP (4) | EP1365028B1 (de) |
JP (4) | JP4275741B2 (de) |
AT (3) | ATE426030T1 (de) |
AU (2) | AU5465498A (de) |
DE (3) | DE69739319D1 (de) |
ES (1) | ES2306462T3 (de) |
PT (1) | PT948538E (de) |
WO (2) | WO1998025963A1 (de) |
Families Citing this family (62)
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ATE220101T1 (de) | 1983-04-25 | 2002-07-15 | Chiron Corp | Hybrid-dns-synthesis von reifen insulinähnlichen wachstumsfaktoren |
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US20040146918A1 (en) * | 2000-02-18 | 2004-07-29 | Weiner Michael L. | Hybrid nucleic acid assembly |
US7166712B2 (en) | 2000-07-12 | 2007-01-23 | Philadelphia, Health And Education Corporation | Mammalian MDM2 binding proteins and uses thereof |
US20080014594A1 (en) * | 2003-01-31 | 2008-01-17 | Kevin Hestir | Lung-Expressed Polypeptides |
EP2404931A1 (de) | 2003-07-02 | 2012-01-11 | Verenium Corporation | Glucanasen, Nukleinsäuren, die diese codieren, und Verfahren zu deren Herstellung und Verwendung |
DE10342794A1 (de) * | 2003-09-16 | 2005-04-21 | Basf Ag | Sekretion von Proteinen aus Hefen |
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AU2005211362B2 (en) | 2004-02-02 | 2008-03-13 | Ambrx, Inc. | Modified human interferon polypeptides and their uses |
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JP5425398B2 (ja) | 2004-12-22 | 2014-02-26 | アンブレツクス・インコーポレイテツド | 非天然アミノ酸及びポリペプチドを含む組成物、非天然アミノ酸及びポリペプチドに関連する方法並び非天然アミノ酸及びポリペプチドその使用 |
ATE529442T1 (de) * | 2005-06-03 | 2011-11-15 | Ambrx Inc | Verbesserte humane interferon-moleküle und ihre verwendungen |
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CN103103238B (zh) | 2005-08-18 | 2016-08-10 | Ambrx公司 | 一种在细胞中制造在特定位置处具有所选氨基酸的抗体或抗体片段多肽的方法 |
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EP1951890A4 (de) | 2005-11-16 | 2009-06-24 | Ambrx Inc | Verfahren und zusammensetzungen mit nichtnatürlichen aminosäuren |
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DK1968635T3 (en) * | 2005-12-14 | 2014-12-15 | Ambrx Inc | Compositions and Methods of, and uses of non-natural amino acids and polypeptides |
CA2641860C (en) * | 2006-02-09 | 2015-07-14 | Biomimetic Therapeutics, Inc. | Compositions and methods for treating bone |
JP5484047B2 (ja) | 2006-06-30 | 2014-05-07 | バイオミメティック セラピューティクス, エルエルシー | 回旋筋腱板傷害を処置するためのpdgf−生体マトリックス組成物および方法 |
US9161967B2 (en) | 2006-06-30 | 2015-10-20 | Biomimetic Therapeutics, Llc | Compositions and methods for treating the vertebral column |
EP2615108B1 (de) | 2006-09-08 | 2016-10-26 | Ambrx, Inc. | Modifiziertes humanes Plasmapolypeptid oder Fc-Gerüste und deren Verwendungen |
DK2061878T3 (da) | 2006-09-08 | 2014-04-07 | Ambrx Inc | Hybridsuppressor-trna for hvirveldyrceller |
MX2009002526A (es) * | 2006-09-08 | 2009-04-16 | Ambrx Inc | Transcripcion de tarn supresor en celulas de vertebrados. |
US8106008B2 (en) | 2006-11-03 | 2012-01-31 | Biomimetic Therapeutics, Inc. | Compositions and methods for arthrodetic procedures |
US9862956B2 (en) | 2006-12-10 | 2018-01-09 | Danisco Us Inc. | Expression and high-throughput screening of complex expressed DNA libraries in filamentous fungi |
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ATE554785T1 (de) | 2007-03-30 | 2012-05-15 | Ambrx Inc | Modifizierte fgf-21 polypeptide und ihre verwendung |
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CN102014977B (zh) | 2008-02-07 | 2015-09-02 | 生物模拟治疗有限责任公司 | 用于牵引成骨术的组合物和方法 |
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JP6144049B2 (ja) | 2010-02-22 | 2017-06-07 | バイオミメティック セラピューティクス,リミテッド ライアビリティ カンパニー | 腱障害を処置するための血小板由来成長因子組成物及び方法 |
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CN105085652B (zh) | 2014-05-16 | 2021-06-22 | 中国人民解放军军事医学科学院生物工程研究所 | 血小板衍生生长因子b突变体、其制备方法及用途 |
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CN106496302B (zh) * | 2015-09-08 | 2021-12-10 | 三生国健药业(上海)股份有限公司 | 一种用离子交换层析纯化蛋白质的方法 |
CN108239648B (zh) * | 2016-12-26 | 2023-04-07 | 丰益(上海)生物技术研发中心有限公司 | 高效表达米黑根毛霉脂肪酶的方法 |
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CN110590930B (zh) * | 2018-06-13 | 2023-03-31 | 四川好医生攀西药业有限责任公司 | 美洲大蠊生长因子pdgf在制备损伤修复药物中的应用 |
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US6248878B1 (en) * | 1996-12-24 | 2001-06-19 | Ribozyme Pharmaceuticals, Inc. | Nucleoside analogs |
US6001311A (en) * | 1997-02-05 | 1999-12-14 | Protogene Laboratories, Inc. | Apparatus for diverse chemical synthesis using two-dimensional array |
US6395713B1 (en) * | 1997-07-23 | 2002-05-28 | Ribozyme Pharmaceuticals, Inc. | Compositions for the delivery of negatively charged molecules |
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1997
- 1997-12-12 US US08/989,250 patent/US6083910A/en not_active Expired - Lifetime
- 1997-12-12 EP EP03012465A patent/EP1365028B1/de not_active Expired - Lifetime
- 1997-12-12 JP JP52698598A patent/JP4275741B2/ja not_active Expired - Lifetime
- 1997-12-12 DE DE69739319T patent/DE69739319D1/de not_active Expired - Lifetime
- 1997-12-12 AU AU54654/98A patent/AU5465498A/en not_active Abandoned
- 1997-12-12 EP EP97954073A patent/EP0946736B1/de not_active Expired - Lifetime
- 1997-12-12 DE DE69725881T patent/DE69725881T2/de not_active Expired - Lifetime
- 1997-12-12 WO PCT/US1997/022815 patent/WO1998025963A1/en active Application Filing
- 1997-12-12 AT AT03012465T patent/ATE426030T1/de not_active IP Right Cessation
- 1997-12-12 EP EP08006174A patent/EP1935901A1/de not_active Withdrawn
- 1997-12-12 JP JP52692698A patent/JP4341859B2/ja not_active Expired - Fee Related
- 1997-12-12 PT PT97948629T patent/PT948538E/pt unknown
- 1997-12-12 AT AT97948629T patent/ATE398139T1/de active
- 1997-12-12 AU AU57945/98A patent/AU5794598A/en not_active Abandoned
- 1997-12-12 US US08/989,251 patent/US6017731A/en not_active Expired - Fee Related
- 1997-12-12 WO PCT/US1997/022647 patent/WO1998026080A1/en active IP Right Grant
- 1997-12-12 AT AT97954073T patent/ATE253120T1/de not_active IP Right Cessation
- 1997-12-12 DE DE69738768T patent/DE69738768D1/de not_active Expired - Lifetime
- 1997-12-12 ES ES97948629T patent/ES2306462T3/es not_active Expired - Lifetime
- 1997-12-12 EP EP97948629A patent/EP0948538B1/de not_active Expired - Lifetime
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1999
- 1999-07-01 US US09/340,250 patent/US6083723A/en not_active Expired - Fee Related
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2000
- 2000-03-17 US US09/528,108 patent/US6312923B1/en not_active Expired - Fee Related
- 2000-04-14 US US09/549,290 patent/US6448382B1/en not_active Expired - Lifetime
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2001
- 2001-08-02 US US09/921,398 patent/US6706496B2/en not_active Expired - Fee Related
-
2002
- 2002-07-26 US US10/205,693 patent/US7084262B2/en not_active Expired - Fee Related
- 2002-10-25 US US10/280,826 patent/US6897043B2/en not_active Expired - Fee Related
-
2005
- 2005-01-28 US US11/046,099 patent/US7166446B2/en not_active Expired - Fee Related
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2006
- 2006-07-07 US US11/483,033 patent/US20060252695A1/en not_active Abandoned
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2007
- 2007-08-09 JP JP2007208669A patent/JP2008031173A/ja not_active Withdrawn
- 2007-12-27 JP JP2007338286A patent/JP2008119008A/ja not_active Withdrawn
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