DE69739319D1 - Verfahren zur Expression von PDGF oder IGR Proteinen in Hefe - Google Patents
Verfahren zur Expression von PDGF oder IGR Proteinen in HefeInfo
- Publication number
- DE69739319D1 DE69739319D1 DE69739319T DE69739319T DE69739319D1 DE 69739319 D1 DE69739319 D1 DE 69739319D1 DE 69739319 T DE69739319 T DE 69739319T DE 69739319 T DE69739319 T DE 69739319T DE 69739319 D1 DE69739319 D1 DE 69739319D1
- Authority
- DE
- Germany
- Prior art keywords
- proteins
- isoforms
- pdgf
- clipped
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1858—Platelet-derived growth factor [PDGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/49—Platelet-derived growth factor [PDGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3272096P | 1996-12-13 | 1996-12-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69739319D1 true DE69739319D1 (de) | 2009-04-30 |
Family
ID=21866458
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69738768T Expired - Lifetime DE69738768D1 (de) | 1996-12-13 | 1997-12-12 | Analyse und separation von pdgf-proteinen |
DE69725881T Expired - Lifetime DE69725881T2 (de) | 1996-12-13 | 1997-12-12 | Verfahren zur expression von heterologen proteinen in hefe |
DE69739319T Expired - Lifetime DE69739319D1 (de) | 1996-12-13 | 1997-12-12 | Verfahren zur Expression von PDGF oder IGR Proteinen in Hefe |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69738768T Expired - Lifetime DE69738768D1 (de) | 1996-12-13 | 1997-12-12 | Analyse und separation von pdgf-proteinen |
DE69725881T Expired - Lifetime DE69725881T2 (de) | 1996-12-13 | 1997-12-12 | Verfahren zur expression von heterologen proteinen in hefe |
Country Status (9)
Country | Link |
---|---|
US (10) | US6017731A (de) |
EP (4) | EP1365028B1 (de) |
JP (4) | JP4275741B2 (de) |
AT (3) | ATE426030T1 (de) |
AU (2) | AU5794598A (de) |
DE (3) | DE69738768D1 (de) |
ES (1) | ES2306462T3 (de) |
PT (1) | PT948538E (de) |
WO (2) | WO1998025963A1 (de) |
Families Citing this family (62)
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DE3486491T2 (de) | 1983-04-25 | 2003-01-16 | Chiron Corp | Hybrid-DNS-Synthesis von reifen insulinähnlichen Wachstumsfaktoren |
US5811381A (en) * | 1996-10-10 | 1998-09-22 | Mark A. Emalfarb | Cellulase compositions and methods of use |
US7883872B2 (en) * | 1996-10-10 | 2011-02-08 | Dyadic International (Usa), Inc. | Construction of highly efficient cellulase compositions for enzymatic hydrolysis of cellulose |
AU5794598A (en) * | 1996-12-13 | 1998-07-03 | Patricia Tekamp-Olson | Method for expression of heterologous proteins in yeast |
ES2237159T3 (es) * | 1998-10-06 | 2005-07-16 | Mark Aaron Emalfarb | Sistema de transformacion en el campo de los hongos micoticos filamentosos en chrysosporium. |
US20040146918A1 (en) * | 2000-02-18 | 2004-07-29 | Weiner Michael L. | Hybrid nucleic acid assembly |
US7166712B2 (en) * | 2000-07-12 | 2007-01-23 | Philadelphia, Health And Education Corporation | Mammalian MDM2 binding proteins and uses thereof |
US20080014594A1 (en) * | 2003-01-31 | 2008-01-17 | Kevin Hestir | Lung-Expressed Polypeptides |
JP2007529993A (ja) | 2003-07-02 | 2007-11-01 | シンジェンタ パーティシペーションズ アーゲー | グルカナーゼ、それらをコードする核酸並びにそれらを製造及び使用する方法 |
DE10342794A1 (de) * | 2003-09-16 | 2005-04-21 | Basf Ag | Sekretion von Proteinen aus Hefen |
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EP1771205B1 (de) * | 2004-06-18 | 2016-10-26 | Ambrx, Inc. | Neuartige antigen-bindende polypeptide und ihre verwendungen |
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EP1991282B1 (de) * | 2006-02-09 | 2013-06-19 | BioMimetic Therapeutics, LLC | Zusammensetzungen und verfahren zur behandlung von knochen |
US9161967B2 (en) | 2006-06-30 | 2015-10-20 | Biomimetic Therapeutics, Llc | Compositions and methods for treating the vertebral column |
ES2664229T3 (es) | 2006-06-30 | 2018-04-18 | Biomimetic Therapeutics, Llc | Composiciones y métodos de biomatriz-PDGF para el tratamiento de lesiones del manguito rotador |
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BRPI0809583B1 (pt) | 2007-03-30 | 2022-02-22 | Ambrx, Inc | Polipeptídeo fgf-21 modificado, composição compreendendo o mesmo, método para produzir o referido polipetídeo fgf-21 e célula compreendendo um polinucleotídeo |
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CA2736661A1 (en) * | 2007-09-07 | 2009-03-12 | Dyadic International, Inc. | Novel fungal enzymes |
US8946148B2 (en) | 2007-11-20 | 2015-02-03 | Ambrx, Inc. | Modified insulin polypeptides and their uses |
CN102014977B (zh) | 2008-02-07 | 2015-09-02 | 生物模拟治疗有限责任公司 | 用于牵引成骨术的组合物和方法 |
CN101939443B (zh) | 2008-02-08 | 2014-01-29 | Ambrx公司 | 经修饰瘦素多肽和其用途 |
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CN105085652B (zh) | 2014-05-16 | 2021-06-22 | 中国人民解放军军事医学科学院生物工程研究所 | 血小板衍生生长因子b突变体、其制备方法及用途 |
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CN106496302B (zh) * | 2015-09-08 | 2021-12-10 | 三生国健药业(上海)股份有限公司 | 一种用离子交换层析纯化蛋白质的方法 |
CN108239648B (zh) * | 2016-12-26 | 2023-04-07 | 丰益(上海)生物技术研发中心有限公司 | 高效表达米黑根毛霉脂肪酶的方法 |
TW201837051A (zh) | 2017-02-08 | 2018-10-16 | 美商必治妥美雅史谷比公司 | 包含藥物動力學增強劑之經修飾之鬆弛素(relaxin)多肽及其用途 |
CN110590930B (zh) * | 2018-06-13 | 2023-03-31 | 四川好医生攀西药业有限责任公司 | 美洲大蠊生长因子pdgf在制备损伤修复药物中的应用 |
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US5716824A (en) * | 1995-04-20 | 1998-02-10 | Ribozyme Pharmaceuticals, Inc. | 2'-O-alkylthioalkyl and 2-C-alkylthioalkyl-containing enzymatic nucleic acids (ribozymes) |
ZA9610456B (en) * | 1995-12-20 | 1997-06-20 | Novo Nordisk As | N-terminally extended proteins expressed in yeast |
US5998203A (en) * | 1996-04-16 | 1999-12-07 | Ribozyme Pharmaceuticals, Inc. | Enzymatic nucleic acids containing 5'-and/or 3'-cap structures |
AU5794598A (en) * | 1996-12-13 | 1998-07-03 | Patricia Tekamp-Olson | Method for expression of heterologous proteins in yeast |
US6248878B1 (en) * | 1996-12-24 | 2001-06-19 | Ribozyme Pharmaceuticals, Inc. | Nucleoside analogs |
US6001311A (en) * | 1997-02-05 | 1999-12-14 | Protogene Laboratories, Inc. | Apparatus for diverse chemical synthesis using two-dimensional array |
US6395713B1 (en) * | 1997-07-23 | 2002-05-28 | Ribozyme Pharmaceuticals, Inc. | Compositions for the delivery of negatively charged molecules |
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1997
- 1997-12-12 AU AU57945/98A patent/AU5794598A/en not_active Abandoned
- 1997-12-12 EP EP03012465A patent/EP1365028B1/de not_active Expired - Lifetime
- 1997-12-12 AU AU54654/98A patent/AU5465498A/en not_active Abandoned
- 1997-12-12 EP EP97954073A patent/EP0946736B1/de not_active Expired - Lifetime
- 1997-12-12 US US08/989,251 patent/US6017731A/en not_active Expired - Fee Related
- 1997-12-12 DE DE69738768T patent/DE69738768D1/de not_active Expired - Lifetime
- 1997-12-12 AT AT03012465T patent/ATE426030T1/de not_active IP Right Cessation
- 1997-12-12 DE DE69725881T patent/DE69725881T2/de not_active Expired - Lifetime
- 1997-12-12 EP EP97948629A patent/EP0948538B1/de not_active Expired - Lifetime
- 1997-12-12 JP JP52698598A patent/JP4275741B2/ja not_active Expired - Lifetime
- 1997-12-12 AT AT97954073T patent/ATE253120T1/de not_active IP Right Cessation
- 1997-12-12 PT PT97948629T patent/PT948538E/pt unknown
- 1997-12-12 AT AT97948629T patent/ATE398139T1/de active
- 1997-12-12 WO PCT/US1997/022815 patent/WO1998025963A1/en active Application Filing
- 1997-12-12 WO PCT/US1997/022647 patent/WO1998026080A1/en active IP Right Grant
- 1997-12-12 US US08/989,250 patent/US6083910A/en not_active Expired - Lifetime
- 1997-12-12 ES ES97948629T patent/ES2306462T3/es not_active Expired - Lifetime
- 1997-12-12 JP JP52692698A patent/JP4341859B2/ja not_active Expired - Fee Related
- 1997-12-12 DE DE69739319T patent/DE69739319D1/de not_active Expired - Lifetime
- 1997-12-12 EP EP08006174A patent/EP1935901A1/de not_active Withdrawn
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1999
- 1999-07-01 US US09/340,250 patent/US6083723A/en not_active Expired - Fee Related
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2000
- 2000-03-17 US US09/528,108 patent/US6312923B1/en not_active Expired - Fee Related
- 2000-04-14 US US09/549,290 patent/US6448382B1/en not_active Expired - Lifetime
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2001
- 2001-08-02 US US09/921,398 patent/US6706496B2/en not_active Expired - Fee Related
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2002
- 2002-07-26 US US10/205,693 patent/US7084262B2/en not_active Expired - Fee Related
- 2002-10-25 US US10/280,826 patent/US6897043B2/en not_active Expired - Fee Related
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2005
- 2005-01-28 US US11/046,099 patent/US7166446B2/en not_active Expired - Fee Related
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2006
- 2006-07-07 US US11/483,033 patent/US20060252695A1/en not_active Abandoned
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2007
- 2007-08-09 JP JP2007208669A patent/JP2008031173A/ja not_active Withdrawn
- 2007-12-27 JP JP2007338286A patent/JP2008119008A/ja not_active Withdrawn
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