DE69807747D1 - Tablette mit instant- und verzögerte freisetzung von einen oder mehrere wirkstoffe - Google Patents

Tablette mit instant- und verzögerte freisetzung von einen oder mehrere wirkstoffe

Info

Publication number
DE69807747D1
DE69807747D1 DE69807747T DE69807747T DE69807747D1 DE 69807747 D1 DE69807747 D1 DE 69807747D1 DE 69807747 T DE69807747 T DE 69807747T DE 69807747 T DE69807747 T DE 69807747T DE 69807747 D1 DE69807747 D1 DE 69807747D1
Authority
DE
Germany
Prior art keywords
instant
tablet
active substances
delayed release
delayed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69807747T
Other languages
English (en)
Other versions
DE69807747T2 (de
Inventor
Olivier Saslawski
Laurence Orlando
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Application granted granted Critical
Publication of DE69807747D1 publication Critical patent/DE69807747D1/de
Publication of DE69807747T2 publication Critical patent/DE69807747T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
DE69807747T 1997-12-23 1998-12-11 Tablette mit instant- und verzögerte freisetzung von einen oder mehrere wirkstoffe Expired - Lifetime DE69807747T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9716402A FR2772615B1 (fr) 1997-12-23 1997-12-23 Comprime multicouche pour la liberation instantanee puis prolongee de substances actives
PCT/EP1998/008100 WO1999033448A1 (en) 1997-12-23 1998-12-11 Tablet for instant and prolonged release of one or more active substances

Publications (2)

Publication Number Publication Date
DE69807747D1 true DE69807747D1 (de) 2002-10-10
DE69807747T2 DE69807747T2 (de) 2003-06-12

Family

ID=9515042

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69807747T Expired - Lifetime DE69807747T2 (de) 1997-12-23 1998-12-11 Tablette mit instant- und verzögerte freisetzung von einen oder mehrere wirkstoffe

Country Status (24)

Country Link
US (1) US6372255B1 (de)
EP (1) EP1041972B1 (de)
JP (1) JP4451563B2 (de)
KR (1) KR100574207B1 (de)
CN (1) CN1163220C (de)
AR (1) AR017897A1 (de)
AT (1) ATE223207T1 (de)
AU (1) AU743195B2 (de)
BR (1) BR9814345A (de)
CA (1) CA2316277C (de)
CZ (1) CZ291884B6 (de)
DE (1) DE69807747T2 (de)
DK (1) DK1041972T3 (de)
ES (1) ES2182397T3 (de)
FR (1) FR2772615B1 (de)
HU (1) HU226069B1 (de)
ID (1) ID26313A (de)
NO (1) NO20003289L (de)
PT (1) PT1041972E (de)
RU (1) RU2212885C2 (de)
SK (1) SK283236B6 (de)
UA (1) UA55503C2 (de)
WO (1) WO1999033448A1 (de)
ZA (1) ZA9811799B (de)

Families Citing this family (158)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9407386D0 (en) 1994-04-14 1994-06-08 Smithkline Beecham Plc Pharmaceutical formulation
US20030109503A1 (en) * 1995-06-06 2003-06-12 Smithkline Beecham P.L.C. Pharmaceutical formulations comprising clavulanic acid alone or in combination with other beta-lactam antibiotics
US8022095B2 (en) * 1996-08-16 2011-09-20 Pozen, Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
DE19821625C1 (de) * 1998-05-15 2000-01-05 Merck Patent Gmbh Pharmazeutische Zubereitung
EP1005863A1 (de) * 1998-12-04 2000-06-07 Synthelabo Dosisformen mit gesteuerter Wirkstofffreigabe enthaltend ein kurzer wirkung Hypnotikum oder einem Salz davon
US7250176B1 (en) * 1999-04-13 2007-07-31 Beecham Pharmaceuticals (Pte) Limited Method of treating a bacterial infection
US6294199B1 (en) 1999-04-13 2001-09-25 Beecham Pharmaceuticals (Pte) Limited Method of treating a bacterial infection comprising administering amoxycillin
US6878386B1 (en) 1999-04-13 2005-04-12 Beecham Pharmaceuticals (Pte) Limited Method of treating a bacterial infection comprising amoxycillin and potassium clavulanate
EP1064937A1 (de) * 1999-06-28 2001-01-03 Sanofi-Synthelabo Pharmazeutische Zusammensetzungen mit kontrollierten Freigabe enthaltend ein Hypnotikum mit kurzer Wirkung oder deren Salze
EP1210079A2 (de) * 1999-08-20 2002-06-05 Ferrosan A/S Anordordung zur verabreichung von medikamenten ehthaltend vitamin c und vitamin e und verwendung einer kombination von vitamin c und vitamin e zur behandlung oder zur vorbeugung von oxidatriven stresszuständer
AU783656B2 (en) * 1999-09-02 2005-11-24 Nostrum Pharmaceuticals, Inc. Controlled release oral dosage suitable for oral administration
WO2001022791A2 (en) * 1999-09-28 2001-04-05 Panacea Biotec Limited Controlled release compositions comprising nimesulide
EP1138330A1 (de) * 1999-12-23 2001-10-04 Warner-Lambert Company Kombinationsarzneimittel enthaltend Trimebutin und ein Opiatanalgetikum
BR0007360A (pt) * 1999-12-23 2001-08-14 Johnson & Johnson Composição de liberação controlada
ATE340563T1 (de) 2000-02-04 2006-10-15 Depomed Inc DOSIERUNGSFORM DES TYPS ßHÜLLE UND KERNß MIT EINER WIRKSTOFFFREISETZUNG, DIE SICH DER NULLTEN ORDNUNG ANNÄHERT
US20070141107A1 (en) * 2000-03-15 2007-06-21 Orbusneich Medical, Inc. Progenitor Endothelial Cell Capturing with a Drug Eluting Implantable Medical Device
US8088060B2 (en) 2000-03-15 2012-01-03 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
US9522217B2 (en) 2000-03-15 2016-12-20 Orbusneich Medical, Inc. Medical device with coating for capturing genetically-altered cells and methods for using same
US6372252B1 (en) * 2000-04-28 2002-04-16 Adams Laboratories, Inc. Guaifenesin sustained release formulation and tablets
EP1330236A2 (de) 2000-10-12 2003-07-30 Beecham Pharmaceuticals (Pte) Limited Amoxicillinhaltige arzneizusammensetzungen
US6756057B2 (en) 2000-10-12 2004-06-29 Beecham Pharmaceuticals (Pte) Limited Amoxicillin and potassium clavulanate dosage form
ES2220789T3 (es) * 2000-10-30 2004-12-16 Lupin Limited Composicion de cefuroxima axetilo de liberacion lenta que se desintegra rapidamente.
KR100778835B1 (ko) * 2000-12-28 2007-11-22 엘지.필립스 엘시디 주식회사 액정표시장치의 제조방법
KR100685945B1 (ko) 2000-12-29 2007-02-23 엘지.필립스 엘시디 주식회사 액정표시장치 및 그 제조방법
US20030224047A1 (en) * 2001-02-15 2003-12-04 Franz G. Andrew Levothyroxine compositions and methods
US20030032675A1 (en) * 2001-02-15 2003-02-13 Franz G. Andrew Manufacture of thyroid hormone tablets having consistent active moiety amounts
US7067148B2 (en) * 2001-02-15 2006-06-27 King Pharmaceutical Research & Development, Inc. Stabilized pharmaceutical and thyroid hormone compositions and method of preparation
US6555581B1 (en) 2001-02-15 2003-04-29 Jones Pharma, Inc. Levothyroxine compositions and methods
AU2002256092C1 (en) * 2001-04-05 2009-10-15 Collagenex Pharmaceuticals, Inc. Controlled delivery of tetracycline compounds and tetracycline derivatives
CA2343949A1 (en) * 2001-04-12 2002-10-12 Bernard Charles Sherman Benazepril hydrochloride tablet formulations
SE0101379D0 (sv) 2001-04-18 2001-04-18 Diabact Ab Komposition som hämmar utsöndring av magsyra
US20030035839A1 (en) * 2001-05-15 2003-02-20 Peirce Management, Llc Pharmaceutical composition for both intraoral and oral administration
US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
GB0114069D0 (en) * 2001-06-08 2001-08-01 Smithkline Beecham Plc Composition
US20030190349A1 (en) * 2001-08-10 2003-10-09 Franz G. Andrew Methods of stabilizing pharmaceutical compositions
US20030180353A1 (en) * 2001-08-10 2003-09-25 Franz G. Andrew Stabilized pharmaceutical compositions
US20030198671A1 (en) * 2001-08-10 2003-10-23 Franz G. Andrew Levothyroxine compositions having unique plasma AUC properties
US20030198667A1 (en) * 2001-08-10 2003-10-23 Franz Andrew G. Methods of producing dispersible pharmaceutical compositions
US20030203967A1 (en) * 2001-08-14 2003-10-30 Franz G. Andrew Levothyroxine compositions having unique Tmax properties
US20030199586A1 (en) * 2001-08-14 2003-10-23 Franz G. Andrew Unique levothyroxine aqueous materials
US20030199587A1 (en) * 2001-08-14 2003-10-23 Franz G. Andrew Levothyroxine compositions having unique Cmax properties
US20030195253A1 (en) * 2001-08-14 2003-10-16 Franz G. Andrew Unadsorbed levothyroxine pharmaceutical compositions, methods of making and methods of administration
US20030198672A1 (en) * 2001-08-14 2003-10-23 Franz G. Andrew Levothyroxine compositions having unique triidothyronine plasma AUC properties
US20040043066A1 (en) * 2001-10-29 2004-03-04 Franz G. Andrew Levothyroxine compositions having unique triiodothyronine Tmax properties
US6645526B2 (en) * 2001-11-13 2003-11-11 Mylan Pharmaceuticals, Inc. Storage stable thyroxine active drug formulations and methods for their production
US20030099699A1 (en) * 2001-11-13 2003-05-29 Hanshew Dwight D. Storage stable thyroxine active drug formulations and methods for their production
US6863901B2 (en) 2001-11-30 2005-03-08 Collegium Pharmaceutical, Inc. Pharmaceutical composition for compressed annular tablet with molded triturate tablet for both intraoral and oral administration
US6827946B2 (en) 2001-12-05 2004-12-07 Collegium Pharmaceutical, Inc. Compositions containing both sedative and non-sedative antihistamines
US6682759B2 (en) 2002-02-01 2004-01-27 Depomed, Inc. Manufacture of oral dosage forms delivering both immediate-release and sustained-release drugs
US7229644B2 (en) * 2002-05-23 2007-06-12 Cephalon, Inc. Pharmaceutical formulations of modafinil
EP1515701B1 (de) 2002-06-17 2014-09-17 Inventia Healthcare Private Limited Verfahren zur herstellung von mehrschichtigen tabletten die thiazolidinedione und biguanide enthalten
AR040682A1 (es) 2002-07-25 2005-04-13 Pharmacia Corp Forma de dosificacion una vez al dia de pramipexol
AR040588A1 (es) * 2002-07-26 2005-04-13 Schering Corp Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa
US20040116532A1 (en) * 2002-09-13 2004-06-17 Craig Heacock Pharmaceutical formulations of modafinil
KR101363679B1 (ko) * 2002-09-20 2014-02-14 안드렉스 랩스 엘엘씨 약제학적 정제
SE0203065D0 (sv) * 2002-10-16 2002-10-16 Diabact Ab Gastric acid secretion inhibiting composition
US8487002B2 (en) * 2002-10-25 2013-07-16 Paladin Labs Inc. Controlled-release compositions
TWI319713B (en) * 2002-10-25 2010-01-21 Sustained-release tramadol formulations with 24-hour efficacy
MXPA02010828A (es) * 2002-11-04 2004-07-16 Leopoldo Espinosa Abdala Composicion farmaceutica en capsulas que comprende un antiinflamatorio no esteroideo y un analgesico opiaceo para el manejo del dolor.
US20040115265A1 (en) * 2002-12-11 2004-06-17 Loutfy Benkerrour Multilayered tablet containing pravastatin and aspirin and method
US20040253311A1 (en) * 2002-12-18 2004-12-16 Roger Berlin Multi-layer tablet comprising non-steroidal anti-inflammatory drugs, decongestants and non-sedating antihist amines
AU2003303631B2 (en) * 2002-12-26 2008-05-29 Nuvo Pharmaceuticals (Ireland) Designated Activity Company Multilayer Dosage Forms Containing NSAIDs and Triptans
TWI355276B (en) * 2003-01-14 2012-01-01 Akira Tsuji Gastrointestinal absorption enhancer mediated by p
WO2004064815A1 (en) * 2003-01-21 2004-08-05 Smartrix Technologies Inc. Oral dosage formulation
DE602004015246D1 (de) * 2003-02-11 2008-09-04 Alza Corp Verfahren und dosierformen mit modifizierter schichtgeometrie
FR2851734B1 (fr) * 2003-02-28 2006-06-09 Galenix Innovations Procede pour la fabrication d'une composition pharmaceutique sous la forme de comprimes contenant un fibrate et comprimes obtenus selon le procede
AU2004222339A1 (en) * 2003-03-14 2004-09-30 Nirmal Mulye A process for preparing sustained release tablets
US20040192781A1 (en) * 2003-03-31 2004-09-30 Haley Eugene T. Method of administration for metoclopramide and pharmaceutical formulation therefor
PL1615622T3 (pl) 2003-04-07 2012-12-31 Supernus Pharmaceuticals Inc Preparaty doksycyklin do jednorazowego dziennego podawania
US20050013863A1 (en) * 2003-07-18 2005-01-20 Depomed, Inc., A Corporation Of The State Of California Dual drug dosage forms with improved separation of drugs
US6863830B1 (en) * 2003-08-21 2005-03-08 Biolab Services, Inc. Dual layer tablet, method of making and use thereof
US7390503B1 (en) 2003-08-22 2008-06-24 Barr Laboratories, Inc. Ondansetron orally disintegrating tablets
US20050118267A1 (en) * 2003-09-19 2005-06-02 Penwest Pharmaceuticals Co. Chronotherapeutic dosage forms
MXPA06003453A (es) * 2003-09-26 2006-08-31 Johnson & Johnson Barra de empuje oros para el suministro controlado de agentes activos.
NZ546148A (en) 2003-09-26 2009-05-31 Alza Corp Drug coating providing high drug loading and methods for providing the same
US20060172006A1 (en) * 2003-10-10 2006-08-03 Vincent Lenaerts Sustained-release tramadol formulations with 24-hour clinical efficacy
US20050084531A1 (en) * 2003-10-16 2005-04-21 Jatin Desai Tablet with aqueous-based sustained release coating
RS20060413A (en) * 2004-01-06 2008-11-28 Panacea Biotec Ltd., Non-disintegrating oral solid composition of high dose of water soluble drugs
US20050226929A1 (en) * 2004-04-12 2005-10-13 Jianbo Xie Controlled release opioid analgesic formulation
WO2005099672A1 (en) * 2004-04-13 2005-10-27 Ranbaxy Laboratories Limited A modified release pharmaceutical formulation comprising amoxicillin and clavulanate
SI1591109T1 (sl) * 2004-04-30 2008-10-31 Topotarget Germany Ag Formulacija, ki obsega inhibitor histon-deacetilaze in izkazuje dvofazno sproščanje
FR2873113B1 (fr) * 2004-07-19 2007-06-15 Eurotab Sa Produit solide compacte bicouche de purification d'eau
US20060020007A1 (en) * 2004-07-26 2006-01-26 Roger Berlin Compositions containing policosanol and biotin and their pharmaceutical uses
JP4785847B2 (ja) * 2004-08-13 2011-10-05 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング プラミペキソール又はその医薬品として許容される塩を含む放出が延長された錠剤調合物、その製造方法及びその使用
AU2005282784B2 (en) 2004-09-01 2008-06-19 Euro-Celtique S.A. Opioid dosage forms having dose proportional steady state Cave and AUC and less than dose proportional single dose Cmax
US20070129402A1 (en) * 2004-12-27 2007-06-07 Eisai Research Institute Sustained release formulations
US20060280789A1 (en) * 2004-12-27 2006-12-14 Eisai Research Institute Sustained release formulations
NZ555693A (en) 2004-12-27 2010-10-29 Eisai R&D Man Co Ltd Matrix type sustained-release preparation containing donepezil
US20090208579A1 (en) * 2004-12-27 2009-08-20 Eisai R & D Management Co., Ltd. Matrix Type Sustained-Release Preparation Containing Basic Drug or Salt Thereof, and Method for Manufacturing the Same
WO2006081347A2 (en) * 2005-01-26 2006-08-03 Elan Pharma International Limited Controlled release compositions comprising an antipsychotic agent
DE102005019458A1 (de) 2005-04-25 2006-10-26 Grünenthal GmbH Darreichungsform mit verbesserter Freisetzung von Cefuroximaxetil
CA2604617C (en) * 2005-04-28 2014-06-17 Eisai R&D Management Co., Ltd. Composition containing anti-dementia drug
ATE480229T1 (de) * 2005-05-24 2010-09-15 Flamel Tech Sa Orale pharmazeutische zusammensetzung zur behandlung einer cox-2-vermittelten erkrankung
US20070020333A1 (en) * 2005-07-20 2007-01-25 Chin-Chih Chiang Controlled release of hypnotic agents
GB0516604D0 (en) * 2005-08-12 2005-09-21 Sandoz Ag Rapidly dispersing/disintegrating compositions
KR101655455B1 (ko) * 2005-09-09 2016-09-07 안젤리니 라보팜 엘엘씨 일일 1회 투여를 위한 트라조돈 조성물
AU2005336956A1 (en) * 2005-09-28 2007-04-12 Teva Pharmaceutical Industries Ltd. Stable combinations of amlodipine besylate and benazepril hydrochloride
DE102005048293A1 (de) * 2005-10-08 2007-04-12 Sanofi-Aventis Deutschland Gmbh Retardformulierung für Pralnacasan
WO2007065559A1 (en) * 2005-11-18 2007-06-14 Synthon B.V. Zolpidem tablets
DE602006018529D1 (de) 2005-12-29 2011-01-05 Osmotica Kereskedelmi Es Szolgaltato Kft Mehrschichtige tablette mit dreifacher freisetzungskombination
CZ300698B6 (cs) * 2006-06-16 2009-07-22 Zentiva, A. S. Tableta s obsahem metforminu
FR2906801B1 (fr) * 2006-10-05 2008-12-12 Eurotab Sa Produit solide compacte bicouche de potabilisaton d'eau et procede de preparation.
US8642083B2 (en) 2006-10-30 2014-02-04 Hanall Biopharma Co., Ltd. Controlled release complex composition comprising angiotensin-II-receptor blockers and HMG-CoA reductase inhibitors
US8394845B2 (en) 2006-10-30 2013-03-12 Hanall Biopharma Co., Ltd. Method of using combination preparation comprising angiotensin-II-receptor blocker and HMG-CoA reductase inhibitor
EP2120945A1 (de) * 2007-02-28 2009-11-25 Collegium Pharmaceutical, Inc. Antihistamin-kombination
US20100098757A1 (en) * 2007-03-15 2010-04-22 Toyo Boseki Kabushiki Kaisha Process for production of buprenorphine pharmaceutical preparation to be applied to mouth mucosa
WO2008142627A2 (en) * 2007-05-17 2008-11-27 Ranbaxy Laboratories Limited Multilayered modified release formulation comprising amoxicillin and clavulanate
US20100172991A1 (en) * 2007-06-08 2010-07-08 Henry Joseph Horacek Extended Release Formulation and Methods of Treating Adrenergic Dysregulation
MX2009013384A (es) * 2007-06-08 2010-01-25 Addrenex Pharmaceuticals Inc Formulacion de liberacion extendida, y metodo para tratar disregulacion adrenergica.
US8404275B2 (en) * 2007-07-01 2013-03-26 Vitalis Llc Combination tablet with chewable outer layer
WO2009024858A1 (en) * 2007-08-22 2009-02-26 Aurobindo Pharma Limited Controlled release dosage form of galantamine
AU2008314454A1 (en) * 2007-10-16 2009-04-23 Labopharm (Barbados) Limited Bilayer composition for the sustained release of acetaminophen and tramadol
JP5651818B2 (ja) 2007-12-17 2015-01-14 パラディン ラブス インコーポレーテッド 誤用を防止するための放出制御製剤
FR2927965B1 (fr) * 2008-02-22 2010-06-04 Valeo Materiaux De Friction Sa Procede de fabrication d'un materiau de friction et notamment d'une couronne de friction d'embrayage.
WO2009154810A2 (en) * 2008-02-25 2009-12-23 Dr. Reddy's Laboratories Ltd. Delivery systems for multiple active agents
WO2009118764A1 (en) * 2008-03-28 2009-10-01 Panacea Biotec Limited Pharmaceutical composition comprising diclofenac and paracetamol
JP2009256237A (ja) * 2008-04-16 2009-11-05 Daiichi Sankyo Healthcare Co Ltd 固形製剤
MX340249B (es) 2008-08-15 2016-07-01 Depomed Inc Composiciones farmacéuticas retentivas gástricas para tratamiento y prevención de transtornos del sistema nervioso central (cns).
EP2344139A1 (de) 2008-09-09 2011-07-20 AstraZeneca AB Verfahren zur abgabe einer pharmazeutischen zusammensetzung an einen patienten, der diese benötigt
WO2010045656A2 (en) * 2008-10-17 2010-04-22 Nectid, Inc. Novel sglt2 inhibitor dosage forms
CN102245171A (zh) * 2008-11-10 2011-11-16 株式会社爱茉莉太平洋 缓释微粒及其制备方法
CA2746888C (en) 2008-12-16 2015-05-12 Labopharm (Barbados) Limited Misuse preventative, controlled release formulation
PL2389166T3 (pl) * 2009-01-23 2013-04-30 Hoffmann La Roche Kompozycja farmaceutyczna zawierająca aleglitazar
KR101050076B1 (ko) * 2009-02-04 2011-07-19 한국유나이티드제약 주식회사 제어 방출성 아세클로페낙을 함유하는 경구 제제의 조성물 및 그의 제조방법
WO2010138441A1 (en) * 2009-05-28 2010-12-02 Aptapharma, Inc. Multilayer oral tablets containing a non-steroidal anti-inflammatory drug and/or acetaminophen
AU2010266026B2 (en) * 2009-06-25 2014-08-07 Nuvo Pharmaceuticals (Ireland) Designated Activity Company Method for treating a patient in need of aspirin therapy
EP2445499A4 (de) 2009-06-25 2013-02-27 Astrazeneca Ab Verfahren zur behandlung eines patienten mit risiko der entwicklung eines nsaid-assoziierten geschwürs
CN102883601A (zh) 2009-12-02 2013-01-16 阿达玛斯医药公司 金刚烷胺组合物及其使用方法
WO2011080716A2 (en) 2010-01-04 2011-07-07 Wockhardt Limited Pharmaceutical composition for modified delivery of actives
US20110274751A1 (en) * 2010-05-04 2011-11-10 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Trimetazidine formulation with different release profiles
AR084698A1 (es) * 2010-06-22 2013-06-05 Twi Pharmaceuticals Inc Composiciones de liberacion controlada con reducido efecto de alimentos, reducida interaccion entre farmaco y los alimentos
CN102727496A (zh) * 2011-04-12 2012-10-17 上海双健现代药物技术咨询有限公司 一种复方抗结核药口服固体制剂及其制备方法
WO2013063078A1 (en) 2011-10-28 2013-05-02 Vitalis Llc Anti-flush compositions
BR112014016085A8 (pt) 2011-12-28 2017-07-04 Pozen Inc composições aprimoradas e métodos para distribuição de omeprazol mais ácido acetilsalicílico
PL2809305T3 (pl) * 2012-01-31 2016-03-31 Sanovel Ilac Sanayi Ve Ticaret As Formulacje tabletek dwuwarstwowych flurbiprofenu i glukozaminy
EP2817001A1 (de) * 2012-02-20 2014-12-31 Lupin Limited Doppelschichttablette aus dronedaron
BR112014020186A8 (pt) 2012-02-22 2017-07-11 Duchesnay Inc Formulação de doxilamina e piridoxina e/ou seus metabólitos ou sais
US20140072671A1 (en) * 2012-06-29 2014-03-13 Adam Auerbach Multi-component oral delivery systems and uses thereof
WO2014075155A1 (pt) * 2012-11-14 2014-05-22 Diffucap Chemobras Química E Farmacêutica Ltda Combinação farmacêutica contendo agente analgésico e agente antiespasmódico
KR102237799B1 (ko) 2012-11-14 2021-04-08 더블유.알. 그레이스 앤드 캄파니-콘. 생물학적 활성 물질 및 비-정렬된 무기 산화물을 함유하는 조성물
RU2521572C1 (ru) * 2012-12-21 2014-06-27 Федеральное государственное бюджетное учреждение науки Институт химии растворов им. Г.А. Крестова Российской академии наук (ИХР РАН) Сокристаллическая форма фенбуфена
KR20150126383A (ko) * 2013-03-12 2015-11-11 바이오히트 오와이제이 위장관 내의 알데하이드에 결합하는 경구 투여용 조성물
KR101778106B1 (ko) 2013-04-29 2017-09-13 끌라리앙 프로딕숑 (프랑스) 에스.아.에스. 용기용 마개
US10154971B2 (en) 2013-06-17 2018-12-18 Adamas Pharma, Llc Methods of administering amantadine
US9452181B2 (en) 2013-07-22 2016-09-27 Duchesnay Inc. Composition for the management of nausea and vomiting
MX366760B (es) 2013-07-22 2019-07-23 Duchesnay Inc Composición para la gestión de las náuseas y los vómitos.
WO2015027303A1 (pt) * 2013-08-28 2015-03-05 Diffucap Chemobras Quimica E Farmaceutica Ltda Procedimento. de fabricação de combinação farmacêutica contendo agente analgésico e agente antiespasmódico e combinação farmacêutica
WO2015063669A1 (en) 2013-10-30 2015-05-07 Wockhardt Limited Pharmaceutical compositions comprising combination of roflumilast and acebrophylline or pharmaceutically acceptable salts thereof
US9526703B2 (en) 2014-08-29 2016-12-27 Duchesnay Inc. Plurimodal release formulation of doxylamine and pyridoxine and/or metabolites or salts thereof
ES2674996T3 (es) * 2014-08-29 2018-07-05 Duchesnay Inc. Formulación de liberación plurimodal de doxilamina y piridoxina y/o metabolitos o sales de los mismos
US9132096B1 (en) 2014-09-12 2015-09-15 Alkermes Pharma Ireland Limited Abuse resistant pharmaceutical compositions
CA2936741C (en) * 2014-10-31 2018-11-06 Purdue Pharma Methods and compositions particularly for treatment of attention deficit disorder
US10413403B2 (en) * 2015-07-14 2019-09-17 Boston Scientific Scimed, Inc. Prosthetic heart valve including self-reinforced composite leaflets
MX2018000939A (es) * 2015-07-23 2018-06-07 Athena Drug Delivery Solutions Pvt Ltd Composicion de zolpidem y proceso para preparar la misma.
AU2018320946A1 (en) 2017-08-24 2020-04-16 Adamas Pharma, Llc Amantadine compositions, preparations thereof, and methods of use
US11819482B2 (en) 2017-08-29 2023-11-21 Conrig Pharma Aps Composition comprising suplatast tosilate
US20230040902A1 (en) * 2019-12-19 2023-02-09 Celltrion Inc. Pharmaceutical Formulation Comprising Cibenzoline or Salt Thereof
CN114432300B (zh) * 2022-02-16 2023-08-01 平顶山市第二人民医院 含有比索洛尔和依那普利的药物组合物及其工艺

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5911563B2 (ja) * 1980-02-27 1984-03-16 日本原子力研究所 多層構造の徐放性複合体を製造する方法
IT1206166B (it) * 1984-07-26 1989-04-14 Sigma Tau Ind Farmaceuti Dispositivo per rilasciare una sostanza in un fluido di dissoluzione con cinetica di ordine zero e procedimento per la sua preparazione
US4752479A (en) * 1986-05-27 1988-06-21 Ciba-Geigy Corporaton Multi vitamin and mineral dietary supplement with controlled release bioavailable iron
FR2645152B1 (fr) * 1989-03-30 1991-05-31 Lipha 3h-pteridinones-4, procedes de preparation et medicaments les contenant
JP5170723B2 (ja) * 1997-01-10 2013-03-27 アボット・ラボラトリーズ 活性薬剤の制御放出用錠剤

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AR017897A1 (es) 2001-10-24
FR2772615B1 (fr) 2002-06-14
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EP1041972A1 (de) 2000-10-11
ATE223207T1 (de) 2002-09-15
CN1283110A (zh) 2001-02-07
KR100574207B1 (ko) 2006-04-27
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HU226069B1 (en) 2008-04-28
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AU2160699A (en) 1999-07-19
FR2772615A1 (fr) 1999-06-25
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JP4451563B2 (ja) 2010-04-14
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UA55503C2 (uk) 2003-04-15
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