DE69808695T2 - Stabile Insulinformulierungen - Google Patents

Stabile Insulinformulierungen

Info

Publication number
DE69808695T2
DE69808695T2 DE69808695T DE69808695T DE69808695T2 DE 69808695 T2 DE69808695 T2 DE 69808695T2 DE 69808695 T DE69808695 T DE 69808695T DE 69808695 T DE69808695 T DE 69808695T DE 69808695 T2 DE69808695 T2 DE 69808695T2
Authority
DE
Germany
Prior art keywords
insulin formulations
stable insulin
stable
formulations
insulin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69808695T
Other languages
English (en)
Other versions
DE69808695D1 (de
Inventor
Michael Rosario Defilippis
Michael Allen Dobbins
Bruce Hill Frank
Shun Li
Dawn Marie Rebhun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of DE69808695D1 publication Critical patent/DE69808695D1/de
Publication of DE69808695T2 publication Critical patent/DE69808695T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
DE69808695T 1997-06-13 1998-06-12 Stabile Insulinformulierungen Expired - Lifetime DE69808695T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5308997P 1997-06-13 1997-06-13

Publications (2)

Publication Number Publication Date
DE69808695D1 DE69808695D1 (de) 2002-11-21
DE69808695T2 true DE69808695T2 (de) 2003-06-12

Family

ID=21981869

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69834956T Expired - Lifetime DE69834956T2 (de) 1997-06-13 1998-06-12 Stabile Insulinformulierungen
DE69808695T Expired - Lifetime DE69808695T2 (de) 1997-06-13 1998-06-12 Stabile Insulinformulierungen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69834956T Expired - Lifetime DE69834956T2 (de) 1997-06-13 1998-06-12 Stabile Insulinformulierungen

Country Status (31)

Country Link
US (3) US6034054A (de)
EP (1) EP0884053B1 (de)
JP (1) JP2002504908A (de)
KR (1) KR100597500B1 (de)
CN (1) CN1293916C (de)
AR (1) AR012894A1 (de)
AT (2) ATE226088T1 (de)
AU (1) AU734781B2 (de)
BR (1) BR9810116B1 (de)
CA (1) CA2295140C (de)
CO (1) CO4750643A1 (de)
CZ (1) CZ299637B6 (de)
DE (2) DE69834956T2 (de)
DK (1) DK0884053T3 (de)
EA (1) EA002880B1 (de)
ES (2) ES2185113T3 (de)
HK (1) HK1030747A1 (de)
HU (1) HUP0002877A3 (de)
ID (1) ID24310A (de)
IL (1) IL133348A0 (de)
NO (1) NO996131L (de)
NZ (1) NZ501382A (de)
PE (1) PE79099A1 (de)
PL (1) PL194244B1 (de)
PT (2) PT1283051E (de)
SV (1) SV1998000065A (de)
TR (1) TR199903036T2 (de)
TW (1) TW577753B (de)
UA (1) UA61109C2 (de)
WO (1) WO1998056406A1 (de)
ZA (1) ZA984697B (de)

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