DE69811886D1 - Biosensor mit ionendurchlässige kanäle aufweisender lipidmembran - Google Patents

Biosensor mit ionendurchlässige kanäle aufweisender lipidmembran

Info

Publication number
DE69811886D1
DE69811886D1 DE69811886T DE69811886T DE69811886D1 DE 69811886 D1 DE69811886 D1 DE 69811886D1 DE 69811886 T DE69811886 T DE 69811886T DE 69811886 T DE69811886 T DE 69811886T DE 69811886 D1 DE69811886 D1 DE 69811886D1
Authority
DE
Germany
Prior art keywords
lipid membrane
biosensor
pleasure
channels
ion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69811886T
Other languages
English (en)
Other versions
DE69811886T2 (de
Inventor
Robert Peterson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
COVENTRY UNIVERSITY COVENTRY
Original Assignee
COVENTRY UNIVERSITY COVENTRY
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by COVENTRY UNIVERSITY COVENTRY filed Critical COVENTRY UNIVERSITY COVENTRY
Application granted granted Critical
Publication of DE69811886D1 publication Critical patent/DE69811886D1/de
Publication of DE69811886T2 publication Critical patent/DE69811886T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/002—Electrode membranes
DE69811886T 1997-06-14 1998-06-15 Biosensor mit ionendurchlässige kanäle aufweisender lipidmembran Expired - Fee Related DE69811886T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9712386 1997-06-14
GBGB9712386.3A GB9712386D0 (en) 1997-06-14 1997-06-14 Biosensor
PCT/GB1998/001738 WO1998058248A1 (en) 1997-06-14 1998-06-15 Biosensor comprising a lipid membrane containing gated ion channels

Publications (2)

Publication Number Publication Date
DE69811886D1 true DE69811886D1 (de) 2003-04-10
DE69811886T2 DE69811886T2 (de) 2004-03-04

Family

ID=10814150

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69811886T Expired - Fee Related DE69811886T2 (de) 1997-06-14 1998-06-15 Biosensor mit ionendurchlässige kanäle aufweisender lipidmembran

Country Status (16)

Country Link
US (1) US6177000B1 (de)
EP (1) EP0988533B1 (de)
JP (1) JP2002505007A (de)
KR (1) KR100550404B1 (de)
CN (1) CN1161606C (de)
AT (1) ATE233897T1 (de)
AU (1) AU726398B2 (de)
CA (1) CA2293284A1 (de)
DE (1) DE69811886T2 (de)
DK (1) DK0988533T3 (de)
ES (1) ES2193535T3 (de)
GB (1) GB9712386D0 (de)
HK (1) HK1027623A1 (de)
NZ (1) NZ501640A (de)
PT (1) PT988533E (de)
WO (1) WO1998058248A1 (de)

Families Citing this family (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6036924A (en) 1997-12-04 2000-03-14 Hewlett-Packard Company Cassette of lancet cartridges for sampling blood
US20020144905A1 (en) 1997-12-17 2002-10-10 Christian Schmidt Sample positioning and analysis system
US7244349B2 (en) * 1997-12-17 2007-07-17 Molecular Devices Corporation Multiaperture sample positioning and analysis system
JP3486171B2 (ja) 1997-12-17 2004-01-13 エコル・ポリテクニック・フェデラル・ドゥ・ロザンヌ（エ・ペー・エフ・エル） ミクロ構造キャリア上における細胞単体および再構成膜系のポジショニングおよび電気生理学的特性決定
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
GB9812783D0 (en) 1998-06-12 1998-08-12 Cenes Ltd High throuoghput screen
US7204922B1 (en) * 1999-07-26 2007-04-17 Johan-Valentin Kahl Method and device for the electrophoretic separation of particles, especially of macromolecules, by electrophoresis
US6556001B1 (en) * 1999-10-12 2003-04-29 Gerald Wiegand Highly time resolved impedance spectroscopy
WO2001034764A2 (en) * 1999-11-08 2001-05-17 Cytion S.A. Apparatus and methods for positioning and analyzing biological membranous objects
KR100446468B1 (ko) * 2001-05-18 2004-09-01 주식회사 아이센스 시료도입의 능력을 향상시킨 크로마토그래피 기능의다공성 박막이 구비된 바이오센서
US7270730B2 (en) 2000-08-04 2007-09-18 Essen Instruments, Inc. High-throughput electrophysiological measurement system
US7067046B2 (en) * 2000-08-04 2006-06-27 Essen Instruments, Inc. System for rapid chemical activation in high-throughput electrophysiological measurements
DE10057832C1 (de) * 2000-11-21 2002-02-21 Hartmann Paul Ag Blutanalysegerät
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
US20050009004A1 (en) * 2002-05-04 2005-01-13 Jia Xu Apparatus including ion transport detecting structures and methods of use
CA2441366A1 (en) * 2001-03-24 2002-10-03 Aviva Biosciences Corporation Biochips including ion transport detecting structures and methods of use
US20060029955A1 (en) 2001-03-24 2006-02-09 Antonio Guia High-density ion transport measurement biochip devices and methods
US20040146849A1 (en) * 2002-01-24 2004-07-29 Mingxian Huang Biochips including ion transport detecting structures and methods of use
US20050196746A1 (en) * 2001-03-24 2005-09-08 Jia Xu High-density ion transport measurement biochip devices and methods
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
WO2002100461A2 (en) 2001-06-12 2002-12-19 Pelikan Technologies, Inc. Method and apparatus for improving success rate of blood yield from a fingerstick
US7033371B2 (en) * 2001-06-12 2006-04-25 Pelikan Technologies, Inc. Electric lancet actuator
US7344507B2 (en) 2002-04-19 2008-03-18 Pelikan Technologies, Inc. Method and apparatus for lancet actuation
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
AU2002312521A1 (en) 2001-06-12 2002-12-23 Pelikan Technologies, Inc. Blood sampling apparatus and method
US20070100255A1 (en) * 2002-04-19 2007-05-03 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
EP1404233B1 (de) * 2001-06-12 2009-12-02 Pelikan Technologies Inc. Selbstoptimierende lanzettenvorrichtung mit adaptationsmittel für zeitliche schwankungen von hauteigenschaften
WO2002100254A2 (en) * 2001-06-12 2002-12-19 Pelikan Technologies, Inc. Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
US9226699B2 (en) * 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
US7981056B2 (en) * 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US7025774B2 (en) * 2001-06-12 2006-04-11 Pelikan Technologies, Inc. Tissue penetration device
US8784335B2 (en) * 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US8267870B2 (en) * 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US20070142748A1 (en) * 2002-04-19 2007-06-21 Ajay Deshmukh Tissue penetration device
US7648468B2 (en) * 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7371247B2 (en) 2002-04-19 2008-05-13 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US9795334B2 (en) * 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7410468B2 (en) * 2002-04-19 2008-08-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7909778B2 (en) * 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7331931B2 (en) * 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7291117B2 (en) * 2002-04-19 2007-11-06 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US7892185B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7297122B2 (en) * 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8221334B2 (en) * 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7892183B2 (en) * 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7713214B2 (en) 2002-04-19 2010-05-11 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with optical analyte sensing
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8360992B2 (en) * 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7717863B2 (en) * 2002-04-19 2010-05-18 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7524293B2 (en) * 2002-04-19 2009-04-28 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7244265B2 (en) * 2002-04-19 2007-07-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
WO2003093494A2 (en) * 2002-05-04 2003-11-13 Aviva Biosciences Corporation Apparatus including ion transport detecting structures and methods of use
EP1504114B1 (de) * 2002-05-10 2017-07-12 The Texas A & M University System Stochastische bestimmung von analyten mittels kovalenten wechselwirkungen
US20040067481A1 (en) * 2002-06-12 2004-04-08 Leslie Leonard Thermal sensor for fluid detection
EP1578286A4 (de) * 2002-12-13 2009-01-14 Pelikan Technologies Inc Verfahren und vorrichtung zum messen von analyten
US7265881B2 (en) * 2002-12-20 2007-09-04 Hewlett-Packard Development Company, L.P. Method and apparatus for measuring assembly and alignment errors in sensor assemblies
US8574895B2 (en) * 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
DE602004028463D1 (de) 2003-05-30 2010-09-16 Pelikan Technologies Inc Verfahren und vorrichtung zur injektion von flüssigkeit
US7850621B2 (en) 2003-06-06 2010-12-14 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
US8282576B2 (en) * 2003-09-29 2012-10-09 Sanofi-Aventis Deutschland Gmbh Method and apparatus for an improved sample capture device
EP1680014A4 (de) 2003-10-14 2009-01-21 Pelikan Technologies Inc Verfahren und gerät für eine variable anwenderschnittstelle
EP1706026B1 (de) 2003-12-31 2017-03-01 Sanofi-Aventis Deutschland GmbH Verfahren und vorrichtung zur verbesserung der fluidströmung und der probennahme
US7822454B1 (en) * 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
EP1751546A2 (de) * 2004-05-20 2007-02-14 Albatros Technologies GmbH & Co. KG Bedruckbares wassergel für biosensoren
EP1765194A4 (de) 2004-06-03 2010-09-29 Pelikan Technologies Inc Verfahren und gerät für eine flüssigkeitsentnahmenvorrichtung
US9775553B2 (en) * 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
WO2006030523A1 (ja) 2004-09-17 2006-03-23 Japan Science And Technology Agency 人工脂質二重膜における脂質置換方法、その脂質置換方法を用いて得られる人工脂質二重膜、その人工脂質二重膜を製造する装置、および、イオン透過測定装置
US20080214917A1 (en) * 2004-12-30 2008-09-04 Dirk Boecker Method and apparatus for analyte measurement test time
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
US20060184065A1 (en) * 2005-02-10 2006-08-17 Ajay Deshmukh Method and apparatus for storing an analyte sampling and measurement device
GB0505971D0 (en) * 2005-03-23 2005-04-27 Isis Innovation Delivery of molecules to a lipid bilayer
US20070276290A1 (en) * 2005-10-04 2007-11-29 Dirk Boecker Tissue Penetrating Apparatus
US20070191736A1 (en) * 2005-10-04 2007-08-16 Don Alden Method for loading penetrating members in a collection device
GB2447043A (en) * 2007-02-20 2008-09-03 Oxford Nanolabs Ltd Lipid bilayer sensor system
US20110121840A1 (en) 2007-02-20 2011-05-26 Gurdial Singh Sanghera Lipid Bilayer Sensor System
GB0724736D0 (en) * 2007-12-19 2008-01-30 Oxford Nanolabs Ltd Formation of layers of amphiphilic molecules
WO2009126900A1 (en) 2008-04-11 2009-10-15 Pelikan Technologies, Inc. Method and apparatus for analyte detecting device
US20100187132A1 (en) * 2008-12-29 2010-07-29 Don Alden Determination of the real electrochemical surface areas of screen printed electrodes
US9375169B2 (en) * 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
JP4958941B2 (ja) * 2009-05-08 2012-06-20 株式会社日立製作所 分析用素子
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
GB201202519D0 (en) 2012-02-13 2012-03-28 Oxford Nanopore Tech Ltd Apparatus for supporting an array of layers of amphiphilic molecules and method of forming an array of layers of amphiphilic molecules
JP5985739B2 (ja) 2012-04-19 2016-09-06 アイトゥ バイオサイエンス インコーポレイテッドＡｙｔｕ ＢｉｏＳｃｉｅｎｃｅ，Ｉｎｃ． 多層ゲル
SG11201401110WA (en) 2012-10-23 2014-06-27 Luoxis Diagnostics Inc Methods and systems for measuring and using the oxidation-reduction potential of a biological sample
GB201313121D0 (en) 2013-07-23 2013-09-04 Oxford Nanopore Tech Ltd Array of volumes of polar medium
KR101490584B1 (ko) 2013-03-08 2015-02-05 (주) 더바이오 액체/젤 계면을 이용한 전류법 기반의 퍼클로레이트 이온 검출용 칩 센서와 이를 포함하는 검출장치
GB201418512D0 (en) 2014-10-17 2014-12-03 Oxford Nanopore Tech Ltd Electrical device with detachable components
GB201611770D0 (en) 2016-07-06 2016-08-17 Oxford Nanopore Tech Microfluidic device
EP3938779A1 (de) 2019-03-12 2022-01-19 Oxford Nanopore Technologies Limited Nanoporenerfassungsvorrichtung und verfahren zu deren betrieb und deren herstellung

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0382736B1 (de) 1987-07-27 1994-11-02 Commonwealth Scientific And Industrial Research Organisation Rezeptormembranen
US5766960A (en) 1987-07-27 1998-06-16 Australian Membrane And Biotechnology Research Institute Receptor membranes
US5111221A (en) 1988-05-13 1992-05-05 United States Of America As Represented By The Secretary Of The Navy Receptor-based sensor
AU666113B2 (en) * 1991-03-27 1996-02-01 Ambri Limited Ionic reservoir at electrode surface
EP0637384B1 (de) 1992-04-22 1996-10-02 Ecole Polytechnique Federale De Lausanne Lipidmembranen fur biosensoranwendungen
WO1995008637A1 (en) * 1993-09-21 1995-03-30 Washington State University Research Foundation Immunoassay comprising ligand-conjugated, ion channel receptor immobilized in lipid film

Also Published As

Publication number Publication date
HK1027623A1 (en) 2001-01-19
NZ501640A (en) 2001-11-30
US6177000B1 (en) 2001-01-23
ATE233897T1 (de) 2003-03-15
DE69811886T2 (de) 2004-03-04
AU7926698A (en) 1999-01-04
PT988533E (pt) 2003-06-30
CA2293284A1 (en) 1998-12-23
GB9712386D0 (en) 1997-08-13
KR20010013583A (ko) 2001-02-26
EP0988533A1 (de) 2000-03-29
AU726398B2 (en) 2000-11-09
CN1301343A (zh) 2001-06-27
WO1998058248A1 (en) 1998-12-23
JP2002505007A (ja) 2002-02-12
CN1161606C (zh) 2004-08-11
DK0988533T3 (da) 2003-07-07
ES2193535T3 (es) 2003-11-01
KR100550404B1 (ko) 2006-02-09
EP0988533B1 (de) 2003-03-05

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8370 Indication related to discontinuation of the patent is to be deleted
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8339 Ceased/non-payment of the annual fee