DE69812983D1 - Verfahren zur herstellung von phosphodiestern - Google Patents

Verfahren zur herstellung von phosphodiestern

Info

Publication number
DE69812983D1
DE69812983D1 DE69812983T DE69812983T DE69812983D1 DE 69812983 D1 DE69812983 D1 DE 69812983D1 DE 69812983 T DE69812983 T DE 69812983T DE 69812983 T DE69812983 T DE 69812983T DE 69812983 D1 DE69812983 D1 DE 69812983D1
Authority
DE
Germany
Prior art keywords
alcohol
reaction
phosphodia
star
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69812983T
Other languages
English (en)
Other versions
DE69812983T2 (de
Inventor
C Amedio
J Bernard
Mark Fountain
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Epix Pharmaceuticals Inc
Original Assignee
Epix Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epix Pharmaceuticals Inc filed Critical Epix Pharmaceuticals Inc
Publication of DE69812983D1 publication Critical patent/DE69812983D1/de
Application granted granted Critical
Publication of DE69812983T2 publication Critical patent/DE69812983T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
DE69812983T 1997-04-11 1998-01-27 Verfahren zur herstellung von phosphodiestern Expired - Lifetime DE69812983T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/833,745 US5919967A (en) 1997-04-11 1997-04-11 Process for synthesizing phosphodiesters
PCT/US1998/001473 WO1998046612A1 (en) 1997-04-11 1998-01-27 Process for synthesizing phosphodiesters
US833745 2010-07-09

Publications (2)

Publication Number Publication Date
DE69812983D1 true DE69812983D1 (de) 2003-05-08
DE69812983T2 DE69812983T2 (de) 2004-01-08

Family

ID=25265165

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69812983T Expired - Lifetime DE69812983T2 (de) 1997-04-11 1998-01-27 Verfahren zur herstellung von phosphodiestern

Country Status (21)

Country Link
US (1) US5919967A (de)
EP (1) EP1021452B1 (de)
JP (2) JP4014231B2 (de)
KR (2) KR20060066122A (de)
AT (1) ATE236171T1 (de)
AU (1) AU728902B2 (de)
BR (1) BR9809084B1 (de)
CA (1) CA2285417C (de)
CZ (1) CZ294469B6 (de)
DE (1) DE69812983T2 (de)
DK (1) DK1021452T3 (de)
ES (1) ES2195315T3 (de)
HU (1) HU224257B1 (de)
IL (1) IL131964A (de)
IS (1) IS1994B (de)
NO (1) NO325619B1 (de)
NZ (1) NZ337921A (de)
PL (1) PL188258B1 (de)
PT (1) PT1021452E (de)
SK (1) SK283832B6 (de)
WO (1) WO1998046612A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9812716A (pt) * 1997-10-02 2000-08-22 Epix Medical Inc Métodos para formação de imagem para diagnóstico de contraste intensificado para monitorar terapias interventivas
US6559330B1 (en) * 1999-09-09 2003-05-06 Schering Aktiengesellschaft Calcium complex of [[(4r)-4-[bis{carboxy-.kappa.o)methyl]amino-.kappa.n]-6,9-bis[(carboxy.kappa.o)methyl]-1-[(4,4-diphenylcyclohexyl)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-ylic-acid-.kappa.n6,.kappa.n9,.kappa.011]1-oxidato(6-)]-, hexahydrogen, its salts, pharmaceutical agents that contain these complexes, their use in treatment and as additives in diagnosis, as well as processes for the production of the complexes and agents
DE19964224B4 (de) * 1999-09-09 2005-09-01 Schering Ag Pharmazeutische Mittel enthaltend Calcium-Komplex von [[(4R)-4-[bis[(carboxy-.kappa.O)methyl]amino-.kappa.N]-6,9-bis[(carboxy-.kappa.O)methyl]-1-[(4,4-diphenylcyclohexyl)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-yl-säure-.kappa.N6,.kappa.N9,.kappa.011]1-oxidato(6-)]-, tetrahydrogen (MS-325) und dessen Salze sowie Verfahren zur Herstellung der Mittel
US20030203879A1 (en) * 1999-09-09 2003-10-30 Schering Ag Calcium complex of [[(4R)-4-[bis[(carboxy-.kappa.O)methyl]amino-.kappa.n]-6,9-bis[(carboxy.kappa.O)methyl]-1-[(4,4-diphenylcyclohexy)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-ylic-acid-.kappa.N6,.Kappa.N9,.Kappa 011]1-oxidato(6-)]-, hexahydrogen, its salts, pharmaceutical agents that contain these complexes, their use in treatment and as additives in diagnosis, as well as processes for the production of the complexes and agents
WO2003029257A1 (de) * 2001-09-27 2003-04-10 Schering Aktiengesellschaft (ethylen)-(propylen/butylen)-phosphodiester-triaminpentaessigsäure-derivate
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US20050100963A1 (en) 2002-03-01 2005-05-12 Dyax Corporation KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
AU2003213730A1 (en) 2002-03-01 2003-09-16 Bracco International B.V. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
WO2004078778A2 (en) 2003-03-03 2004-09-16 Dyax Corp. PEPTIDES THAT SPECIFICALLY BIND HGF RECEPTOR (cMet) AND USES THEREOF
KR100585219B1 (ko) * 2004-05-07 2006-06-01 주식회사 태평양 포스페이트 유도체 및 이의 제조방법
CN100487093C (zh) * 2006-03-15 2009-05-13 中国石油化工股份有限公司 一种亚磷酰胺酯类极压抗磨剂及其制备和应用
WO2010121133A2 (en) 2009-04-17 2010-10-21 The General Hospital Corporation Multimodal imaging of fibrin
CN102356087A (zh) 2009-03-19 2012-02-15 惠氏有限责任公司 [2-(8,9-二氧代-2,6-二氮杂双环[5.2.0]壬-1(7)-烯-2-基)乙基]膦酸及其前体的制备方法
TW201514188A (zh) * 2013-03-13 2015-04-16 Lantheus Medical Imaging Inc 製備釓磷維塞三鈉單水合物之方法
US20150344523A1 (en) 2014-05-05 2015-12-03 California Institute Of Technology Mutant akt-specific capture agents, compositions, and methods of using and making
WO2015196208A2 (en) 2014-06-20 2015-12-23 The General Hospital Corporation Collagen targeted imaging probes
CN107624115B (zh) 2015-03-16 2021-10-26 加州理工学院 肉毒神经毒素特异性捕获剂、组合物、使用方法和制造方法
US10598671B2 (en) 2015-07-15 2020-03-24 Indi Molecular, Inc. IL-17F-specific capture agents, compositions, and methods of using and making
WO2018064597A1 (en) 2016-09-29 2018-04-05 Indi Molecular, Inc. Compositions for detection, inhibition and imaging of indoleamine 2,3-dioxygenase 1 (ido1) and methods of making and using same
EP3535278A4 (de) 2016-11-01 2020-06-24 Ohio State Innovation Foundation Verfahren zur jodierung von biomolekülen
EP3638687A1 (de) 2017-06-15 2020-04-22 Indi Molecular, Inc. Il-17f- und il-17a-spezifische fänger, zusammensetzungen und verfahren zur verwendung und herstellung davon
US11919972B2 (en) 2018-11-02 2024-03-05 Regeneron Pharmaceuticals, Inc. Peptide libraries with non-canonical amino acids
US11638764B2 (en) 2018-11-08 2023-05-02 Indi Molecular, Inc. Theranostic capture agents, compositions, and methods of using and making
US11414460B2 (en) 2019-07-19 2022-08-16 Institute For Systems Biology KRAS-specific capture agents, compositions, and methods of making and using
WO2022098743A1 (en) 2020-11-03 2022-05-12 Indi Molecular, Inc. Compositions, imaging, and therapeutic methods targeting folate receptor 1 (folr1)
WO2022098745A1 (en) 2020-11-03 2022-05-12 Indi Molecular, Inc. Compositions, delivery systems, and methods useful in tumor therapy
CN116917301A (zh) * 2021-03-03 2023-10-20 国立大学法人东京工业大学 非对称型磷酸三酯的制造方法、对称型磷酸三酯的制造方法、磷酸酯的制造方法、以及有机磷化合物的制造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US4880008A (en) * 1985-05-08 1989-11-14 The General Hospital Corporation Vivo enhancement of NMR relaxivity
TW319763B (de) * 1995-02-01 1997-11-11 Epix Medical Inc
EP0827406A1 (de) * 1995-03-08 1998-03-11 The Scripps Research Institute Carbopeptoide und carbonukleotoide

Also Published As

Publication number Publication date
CZ294469B6 (cs) 2005-01-12
KR100593650B1 (ko) 2006-07-03
AU728902B2 (en) 2001-01-18
EP1021452B1 (de) 2003-04-02
NZ337921A (en) 2000-09-29
CZ355999A3 (cs) 2000-01-12
EP1021452A1 (de) 2000-07-26
JP2002511060A (ja) 2002-04-09
PL337423A1 (en) 2000-08-14
DK1021452T3 (da) 2003-08-18
ES2195315T3 (es) 2003-12-01
IS1994B (is) 2005-03-15
BR9809084A (pt) 2000-08-01
IL131964A (en) 2004-01-04
ATE236171T1 (de) 2003-04-15
AU6042598A (en) 1998-11-11
PL188258B1 (pl) 2005-01-31
DE69812983T2 (de) 2004-01-08
BR9809084B1 (pt) 2010-12-14
NO994919L (no) 1999-10-08
NO994919D0 (no) 1999-10-08
CA2285417A1 (en) 1998-10-22
KR20060066122A (ko) 2006-06-15
SK283832B6 (sk) 2004-02-03
HU224257B1 (hu) 2005-07-28
SK138299A3 (en) 2000-05-16
CA2285417C (en) 2006-01-24
JP4014231B2 (ja) 2007-11-28
IS5193A (is) 1999-09-24
JP2005206605A (ja) 2005-08-04
WO1998046612A1 (en) 1998-10-22
KR20010006177A (ko) 2001-01-26
IL131964A0 (en) 2001-03-19
US5919967A (en) 1999-07-06
NO325619B1 (no) 2008-06-30
PT1021452E (pt) 2003-08-29
HUP0004239A2 (en) 2001-03-28
HUP0004239A3 (en) 2001-11-28

Similar Documents

Publication Publication Date Title
DE69812983D1 (de) Verfahren zur herstellung von phosphodiestern
DE69806470T2 (de) Verfahren zur herstellung von 4-amino-1-hydroxybutyliden-1,1-biphosphonsäure
DE69113325D1 (de) Verbessertes Verfahren zur Herstellung von Salzen der 4-Amino-1-hydroxybutyliden-1,1-bisphosphonsäure.
DE3780145D1 (de) Verfahren zur herstellung hochkonzentrierter phosphorsaeure.
DE59600209D1 (de) Verfahren zur Herstellung von 4,6-Dichlorpyrimidinen
ATE327219T1 (de) Verfahren zur herstellung von hydroxymethylthiobuttersäure
DE69505532T2 (de) Verfahren zur herstellung von n-phosphonomethylamino carboxylsäuren
EP0675076A3 (de) Phosphorylierungsreagens, Verfahren und Verwendung.
ATE155789T1 (de) Verfahren zur herstellung von aminomethanphosphonsäure
PT87916A (pt) Processo para a preparacao de fosfono-alquil-fosfinatos de aminometileno
ATE360087T1 (de) Verfahren zur racematspaltung von arylalkylcarbonsäureestern
DE69005309T2 (de) Verfahren zur herstellung von peroxykarbonsäuren unter verwendung eines enzymkatalysators.
DE59807664D1 (de) Verfahren zur herstellung von 3-cyano-2,4-dihalogen-5-fluor-benzoesäuren
DE50113691D1 (de) Verfahren zur Herstellung von Ethylen-1,2-diphosphonsäuren
DE50003163D1 (de) Verfahren zur Herstellung von Alkylphosphonigsäureestern
ES2127876T3 (es) Acidos fosforicos sustituidos.
DE59009231D1 (de) Verfahren zur Herstellung von Tris(2,4-di-tert-butyl-phenyl)phosphit.
ATE217316T1 (de) Verfahren zur herstellung von diphosphonat- derivaten
ATE256689T1 (de) Verfahren zur herstellung von ascorbinsaüre-2- monophosphat salz
ATE135692T1 (de) Verfahren zur herstellung von dichlormethylpyridinen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: EPIX PHARMACEUTICALS,INC.(N.D.GES.D.STAATES DELAWA

8327 Change in the person/name/address of the patent owner

Owner name: EPIX PHARMACEUTICALS, INC., LEXINGTON, MASS., US