DE69817484D1 - Verfahren zur isolierung bestimmter biologischer stoffe mittels magnetischer silika-partikel - Google Patents

Verfahren zur isolierung bestimmter biologischer stoffe mittels magnetischer silika-partikel

Info

Publication number
DE69817484D1
DE69817484D1 DE69817484T DE69817484T DE69817484D1 DE 69817484 D1 DE69817484 D1 DE 69817484D1 DE 69817484 T DE69817484 T DE 69817484T DE 69817484 T DE69817484 T DE 69817484T DE 69817484 D1 DE69817484 D1 DE 69817484D1
Authority
DE
Germany
Prior art keywords
silica particles
specific biological
biological substances
magnetic silica
insulating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69817484T
Other languages
English (en)
Other versions
DE69817484T2 (de
Inventor
E Smith
K York
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Promega Corp
Original Assignee
Promega Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25134438&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69817484(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Promega Corp filed Critical Promega Corp
Application granted granted Critical
Publication of DE69817484D1 publication Critical patent/DE69817484D1/de
Publication of DE69817484T2 publication Critical patent/DE69817484T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
    • C12N15/1013—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers by using magnetic beads
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/832—Nanostructure having specified property, e.g. lattice-constant, thermal expansion coefficient
    • Y10S977/838—Magnetic property of nanomaterial
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915—Therapeutic or pharmaceutical composition
    • Y10S977/916—Gene therapy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/92—Detection of biochemical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/924—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis using nanostructure as support of dna analysis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/932—Specified use of nanostructure for electronic or optoelectronic application
    • Y10S977/953—Detector using nanostructure
    • Y10S977/96—Of magnetic property
DE69817484T 1997-01-21 1998-01-21 Verfahren zur isolierung bestimmter biologischer stoffe mittels magnetischer silika-partikel Expired - Lifetime DE69817484T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/785,097 US6027945A (en) 1997-01-21 1997-01-21 Methods of isolating biological target materials using silica magnetic particles
US785097 1997-01-21
PCT/US1998/001149 WO1998031840A1 (en) 1997-01-21 1998-01-21 Methods of isolating biological target materials using silica magnetic particles

Publications (2)

Publication Number Publication Date
DE69817484D1 true DE69817484D1 (de) 2003-10-02
DE69817484T2 DE69817484T2 (de) 2004-06-17

Family

ID=25134438

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69817484T Expired - Lifetime DE69817484T2 (de) 1997-01-21 1998-01-21 Verfahren zur isolierung bestimmter biologischer stoffe mittels magnetischer silika-partikel
DE0895546T Pending DE895546T1 (de) 1997-01-21 1998-01-21 Verfahren zur isolierung bestimmter biologischer stoffe mittels magnetischer silika-partikel
DE69841555T Expired - Lifetime DE69841555D1 (de) 1997-01-21 1998-01-21 Verfahren zur Isolierung bestimmter biologischer Stoffe mittels magnetischer Silika-Partikel

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE0895546T Pending DE895546T1 (de) 1997-01-21 1998-01-21 Verfahren zur isolierung bestimmter biologischer stoffe mittels magnetischer silika-partikel
DE69841555T Expired - Lifetime DE69841555D1 (de) 1997-01-21 1998-01-21 Verfahren zur Isolierung bestimmter biologischer Stoffe mittels magnetischer Silika-Partikel

Country Status (9)

Country Link
US (5) US6027945A (de)
EP (2) EP0895546B1 (de)
JP (1) JP3253638B2 (de)
AU (1) AU732756B2 (de)
BR (1) BR9805897A (de)
CA (1) CA2249393A1 (de)
DE (3) DE69817484T2 (de)
DK (1) DK1367137T3 (de)
WO (1) WO1998031840A1 (de)

Families Citing this family (259)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9425138D0 (en) 1994-12-12 1995-02-08 Dynal As Isolation of nucleic acid
KR100463475B1 (ko) 1995-06-08 2005-06-22 로셰 디아그노스틱스 게엠베하 자기성피그먼트
DE19520398B4 (de) * 1995-06-08 2009-04-16 Roche Diagnostics Gmbh Magnetisches Pigment
JP2965131B2 (ja) * 1995-07-07 1999-10-18 東洋紡績株式会社 核酸結合用磁性担体およびそれを用いる核酸単離方法
CA2255599C (en) 1996-04-25 2006-09-05 Bioarray Solutions, Llc Light-controlled electrokinetic assembly of particles near surfaces
KR100464870B1 (ko) 1997-01-21 2005-01-05 더블유.알. 그레이스 앤드 캄파니-콘. 자성 물질상의 실리카 흡착제
US6027945A (en) * 1997-01-21 2000-02-22 Promega Corporation Methods of isolating biological target materials using silica magnetic particles
US20050287583A1 (en) * 1997-01-21 2005-12-29 Promega Corporation Methods and kits for isolating biological target materials using silica magnetic particles
US6130043A (en) * 1997-05-02 2000-10-10 Abbott Laboratories Reagents and methods useful for detecting diseases of the prostate
DE19743518A1 (de) * 1997-10-01 1999-04-15 Roche Diagnostics Gmbh Automatisierbare universell anwendbare Probenvorbereitungsmethode
US20080064108A1 (en) * 1997-12-10 2008-03-13 Tony Baker Urine Preservation System
US7569342B2 (en) * 1997-12-10 2009-08-04 Sierra Molecular Corp. Removal of molecular assay interferences
EP0937497B9 (de) * 1997-12-25 2003-10-29 Tosoh Corporation Magnetischer Träger, seine Herstellung, und Verfahren zum Extrahieren von Nukleinsäuren
US7078224B1 (en) * 1999-05-14 2006-07-18 Promega Corporation Cell concentration and lysate clearance using paramagnetic particles
US6534262B1 (en) 1998-05-14 2003-03-18 Whitehead Institute For Biomedical Research Solid phase technique for selectively isolating nucleic acids
EP0969090A1 (de) * 1998-05-27 2000-01-05 QIAGEN GmbH Schnelles und einfaches Verfahren zur Isolierung von zirkulären Nucleinsäuren
US6368866B1 (en) 1998-08-03 2002-04-09 Reference Diagnostics, Inc. Rapid separation assay for total iron binding capacity
US6703228B1 (en) * 1998-09-25 2004-03-09 Massachusetts Institute Of Technology Methods and products related to genotyping and DNA analysis
EP1124990B1 (de) * 1998-10-27 2006-01-18 Affymetrix, Inc. Komplexitätsmanagement und analyse genomischer dna
US5973138A (en) * 1998-10-30 1999-10-26 Becton Dickinson And Company Method for purification and manipulation of nucleic acids using paramagnetic particles
JP3561235B2 (ja) * 1998-11-30 2004-09-02 ロシュ ダイアグノスティクス ゲゼルシャフト ミット ベシュレンクテル ハフツング 核酸を精製するための磁性粒子
EP1162444A4 (de) * 1999-01-18 2007-02-21 Prec System Science Co Ltd Gerät zur konzentrationssteigerung mit hilfe magnetischer partikeln und verfahren hierfür
FI990082A0 (fi) * 1999-01-18 1999-01-18 Labsystems Oy Puhdistusprosessi magneettipartikkeleita käyttäen
AU2731700A (en) * 1999-01-20 2000-08-07 Reference Diagnostics, Inc. Magnetically responsive gel particle
US6310199B1 (en) 1999-05-14 2001-10-30 Promega Corporation pH dependent ion exchange matrix and method of use in the isolation of nucleic acids
CA2372485A1 (en) * 1999-05-14 2000-11-23 Rex M. Bitner Cell concentration and lysate clearance using paramagnetic particles
EP1621618B1 (de) 1999-05-14 2011-10-26 Promega Corporation Zell Konzentration und lysat Klärung mittels paramagnetischen Partikeln
US6270970B1 (en) 1999-05-14 2001-08-07 Promega Corporation Mixed-bed solid phase and its use in the isolation of nucleic acids
ES2258429T3 (es) * 1999-07-15 2006-09-01 Qiagen Gmbh Metodos para separar sustratos en particulas de una solucion, al tiempo que se minimiza la perdida de particulas.
DE19937607A1 (de) * 1999-08-09 2001-02-15 Bilatec Ges Zur Entwicklung Bi Reagenzienkit zur Isolierung von Nukleinsäuren
CA2379503A1 (en) * 1999-08-20 2001-03-01 Promega Corporation Simultaneous isolation and quantitation of dna
EP1510578A3 (de) * 1999-08-20 2005-03-16 Promega Corporation Simultane Isolierung und Quantifizierung von DNA
US6503761B1 (en) * 1999-10-19 2003-01-07 Kimberly-Clark Worldwide, Inc. Selective removal of contaminants from a surface using articles having magnets
US6841393B2 (en) 1999-10-19 2005-01-11 Kimberly-Clark Worldwide, Inc. Selective removal of contaminants from a surface using colored particles and articles having magnets
US6958225B2 (en) 1999-10-27 2005-10-25 Affymetrix, Inc. Complexity management of genomic DNA
WO2001037291A1 (en) * 1999-11-17 2001-05-25 Roche Diagnostics Gmbh Magnetic glass particles, method for their preparation and uses thereof
US6936414B2 (en) * 1999-12-22 2005-08-30 Abbott Laboratories Nucleic acid isolation method and kit
AU6380001A (en) * 2000-03-24 2001-10-03 Qiagen Gmbh Porous ferro- or ferrimagnetic glass particles for isolating molecules
US6672458B2 (en) * 2000-05-19 2004-01-06 Becton, Dickinson And Company System and method for manipulating magnetically responsive particles fluid samples to collect DNA or RNA from a sample
EP1282469B1 (de) * 2000-05-19 2009-01-07 Becton, Dickinson and Company System und verfahren zur behandlung von magnetpartikeln in test-flüssigkeiten zum sammeln von dna und rna
GB0013658D0 (en) * 2000-06-05 2000-07-26 Dynal Asa Nucleic acid isolation
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
DE60117556T2 (de) * 2000-06-21 2006-11-02 Bioarray Solutions Ltd. Multianalytische molekularanalyse durch verwendung anwendungsspezifischer zufallspartikelarrays
WO2002000342A2 (en) * 2000-06-23 2002-01-03 Irm, Llc Method and apparatus for performing an assay
WO2002020842A1 (en) * 2000-09-06 2002-03-14 Transnetyx, Inc. System, method and apparatus for transgenic and targeted mutagenesis screening
US20030082605A1 (en) * 2000-09-06 2003-05-01 Hodge Timothy A. Genomic DNA detection method and system thereof
US20050272085A1 (en) * 2000-09-06 2005-12-08 Hodge Timothy A Methods for forensic and congenic screening
JP2004508057A (ja) * 2000-09-06 2004-03-18 ホッジ　ティモシー　エイ トランスジェニック変異および標的特定変異をスクリ−ニングするためのシステム、方法並びに装置
US20030087286A1 (en) * 2000-09-06 2003-05-08 Hodge Timothy A. Isolation of eukaryotic genomic DNA using magnetically responsive solid functionalized particles
US20050239125A1 (en) * 2000-09-06 2005-10-27 Hodge Timothy A Methods for genotype screening
US7011943B2 (en) * 2000-09-06 2006-03-14 Transnetyx, Inc. Method for detecting a designated genetic sequence in murine genomic DNA
US7494817B2 (en) * 2000-09-06 2009-02-24 Transnet Yx, Inc. Methods for genotype screening using magnetic particles
US20050266494A1 (en) * 2000-09-06 2005-12-01 Hodge Timothy A System and method for computer network ordering of biological testing
US20030207289A1 (en) * 2001-09-04 2003-11-06 Hodge Timothy A. Detection of genetic sequences using a bipartite probe
AU2002225942B2 (en) * 2000-11-13 2007-05-10 Promega Corporation Lysate clearance and nucleic acid isolation using silanized silica matrices
EP1339876A2 (de) * 2000-11-28 2003-09-03 Promega Corporation Aufreinigung von dna sequenzierungreaktionen unter verwendung magnetischer silika-partikel
US6607667B2 (en) * 2000-11-28 2003-08-19 W. R. Grace & Co.-Conn. Method for adsorbing substances using silica adsorbent on magnetic substrate
US6794141B2 (en) * 2000-12-22 2004-09-21 Arcturus Bioscience, Inc. Nucleic acid amplification
ATE309344T1 (de) * 2001-01-19 2005-11-15 Mueller Drm Ag Verfahren zur aufbereitung von biomasse zur herstellung von plasmid dna haltigem zelllysat
ATE422542T1 (de) 2001-02-16 2009-02-15 Cortex Biochem Inc Magnetische isolierung und reinigung von nukleinsäuren
US6855499B1 (en) 2001-02-16 2005-02-15 Cortex Biochem, Inc. Magnetic isolation and purification of nucleic acids
US20030022203A1 (en) * 2001-04-23 2003-01-30 Rajan Kumar Cellular Arrays
US6849186B2 (en) * 2001-05-02 2005-02-01 Phillips Plastic Corporation Composite particles
US6656587B2 (en) 2001-05-02 2003-12-02 Phillips Plastics Corporation Composite particles
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
WO2003033740A2 (en) * 2001-07-10 2003-04-24 Massachusetts Institute Of Technology Apparatus and method for isolating a nucleic acid
US7285412B2 (en) * 2001-07-27 2007-10-23 Surface Logix Inc. Device for magnetic immobilization of cells
US7169578B2 (en) * 2001-07-27 2007-01-30 Surface Logix, Inc. Cell isolation and screening device and method of using same
US7169577B2 (en) * 2001-07-27 2007-01-30 Surface Logix, Inc. Cell isolation and screening device and method of using same
US20030040129A1 (en) * 2001-08-20 2003-02-27 Shah Haresh P. Binding assays using magnetically immobilized arrays
US20060014186A1 (en) * 2001-09-04 2006-01-19 Hodge Timothy A Methods for genotype screening of a strain disposed on an adsorbent carrier
US20040137449A1 (en) * 2001-10-05 2004-07-15 Nargessi R D Magnetic isolation and purification of nucleic acids
NZ532947A (en) 2001-10-15 2006-01-27 Bioarray Solutions Ltd Multiplexed analysis of polymorphic loci by concurrent interrogation and enzyme-mediated detection
ATE420165T1 (de) 2001-11-06 2009-01-15 Cortex Biochem Inc Isolierung und aufreinigung von nukleinsäuren
AU2003202026A1 (en) 2002-01-16 2003-09-02 Dynal Biotech Asa Method for isolating nucleic acids and protein from a single sample
US20060258856A1 (en) * 2002-02-13 2006-11-16 Medimolecular Pty. Ltd. Method of isolating nucleic acids from stool samples
US20060246434A1 (en) * 2002-03-15 2006-11-02 Erlander Mark G Nucleic acid amplification
US7214427B2 (en) * 2002-03-21 2007-05-08 Aviva Biosciences Corporation Composite beads comprising magnetizable substance and electro-conductive substance
GB0207975D0 (en) * 2002-04-05 2002-05-15 Genovision As Isolating nucleic acid
GB0210766D0 (en) * 2002-05-10 2002-06-19 Genovision As Isolating nucleic acid
DE60316748T2 (de) * 2002-06-27 2008-02-07 Toyo Boseki K.K. Magnetischer Träger für biologische Substanzen, Verfahren zur seiner Produktion und seiner Verwendung zur Isolierung dieser biologischen Substanzen
GB0215185D0 (en) 2002-07-01 2002-08-07 Genovision As Binding a target substance
EP1552005A4 (de) * 2002-07-10 2010-12-15 Massachusetts Inst Technology Vorrichtung und verfahren zur isolierung einer nukleinsäure aus einer probe
WO2004013633A2 (en) * 2002-07-29 2004-02-12 Axxima Pharmaceuticals Ag Method for isolating atp binding proteins by means of immobolized protein inhibitors
US7183104B1 (en) 2002-08-23 2007-02-27 Duane Morris Llp Separator and particle detection system
US7176036B2 (en) * 2002-09-20 2007-02-13 Arrowhead Center, Inc. Electroactive microspheres and methods
AU2003298655A1 (en) 2002-11-15 2004-06-15 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
GB0229287D0 (en) * 2002-12-16 2003-01-22 Dna Res Innovations Ltd Polyfunctional reagents
US20040157219A1 (en) * 2003-02-06 2004-08-12 Jianrong Lou Chemical treatment of biological samples for nucleic acid extraction and kits therefor
US7601491B2 (en) * 2003-02-06 2009-10-13 Becton, Dickinson And Company Pretreatment method for extraction of nucleic acid from biological samples and kits therefor
JP2004000922A (ja) * 2003-03-26 2004-01-08 Toyobo Co Ltd 核酸またはタンパク質抽出用シリカ粒子組成物
ES2355899T3 (es) 2003-05-19 2011-04-01 Brandeis University Procedimientos, kits y dispositivos de tratamiento de ácidos nucleicos.
JP4612789B2 (ja) * 2003-05-29 2011-01-12 キヤノン株式会社 Ｄｎａハイブリッド及びｄｎａハイブリッドを用いた環境浄化システム
WO2004108925A1 (en) * 2003-06-04 2004-12-16 Qiagen As Method for sequentially isolating dna and rna from the same nucleic acid-containing sample
US20050042660A1 (en) * 2003-07-31 2005-02-24 Hall Gerald Edward Devices and methods for isolating RNA
GB0319671D0 (en) * 2003-08-21 2003-09-24 Secr Defence Apparatus for processing a fluid sample
EP1510577A1 (de) * 2003-08-29 2005-03-02 Qiagen GmbH Verfahren zur Magnetische Kügelchem Isolierung von Nukleinsäuren
US7927796B2 (en) * 2003-09-18 2011-04-19 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
CN1882699A (zh) * 2003-09-22 2006-12-20 佰尔瑞溶液有限公司 带有多个能共价结合生物分子的官能基团的表面固定化多电解质
WO2005045059A2 (en) * 2003-10-28 2005-05-19 Bioarray Solutions Ltd. Allele assignment and probe selection in multiplexed assays of polymorphic targets
US7563569B2 (en) 2003-10-28 2009-07-21 Michael Seul Optimization of gene expression analysis using immobilized capture probes
ES2533876T3 (es) 2003-10-29 2015-04-15 Bioarray Solutions Ltd Análisis multiplexado de ácidos nucleicos mediante fragmentación de ADN bicatenario
US20050106602A1 (en) * 2003-11-17 2005-05-19 Hashem Akhavan-Tafti Simplified methods for isolating nucleic acids from cellular materials
US20050106589A1 (en) * 2003-11-17 2005-05-19 Hashem Akhavan-Tafti Compositions and methods for releasing nucleic acids from solid phase binding materials
US20050136477A1 (en) * 2003-11-17 2005-06-23 Hashem Akhavan-Tafti Methods for isolating nucleic acids from biological and cellular materials
US20050106577A1 (en) * 2003-11-17 2005-05-19 Hashem Akhavan-Tafti Cleavable solid phases for isolating nucleic acids
US20050106576A1 (en) * 2003-11-17 2005-05-19 Hashem Akhavan-Tafti Methods of using cleavable solid phases for isolating nucleic acids
DE10358137A1 (de) * 2003-12-12 2005-07-07 Merck Patent Gmbh Verfahren und Kit zur Isolierung von RNA
JP2007516729A (ja) * 2003-12-30 2007-06-28 シグマ−アルドリッチ・カンパニー 酵素消化による核酸の迅速な調製
WO2005079984A1 (en) * 2004-02-18 2005-09-01 Applera Corporation Polyelectrolyte-coated size-exclusion ion-exchange particles
US8426126B2 (en) * 2004-03-18 2013-04-23 Applied Biosystems, Llc Modified surfaces as solid supports for nucleic acid purification
US20050239091A1 (en) * 2004-04-23 2005-10-27 Collis Matthew P Extraction of nucleic acids using small diameter magnetically-responsive particles
US20050236299A1 (en) * 2004-04-27 2005-10-27 Mark Weber Folded material containment packages and related methods of packaging folded material products
NL1026271C2 (nl) * 2004-05-26 2005-11-30 Keygene Nv Werkwijze en inrichting voor het isoleren van nucleïnezuur uit nucleïnezuur bevattend materiaal.
US20060024712A1 (en) * 2004-06-25 2006-02-02 Invitrogen Corporation Separation of nucleic acid
JP4476050B2 (ja) * 2004-06-30 2010-06-09 株式会社ニデック 視野計
US7363170B2 (en) * 2004-07-09 2008-04-22 Bio Array Solutions Ltd. Transfusion registry network providing real-time interaction between users and providers of genetically characterized blood products
JP4798971B2 (ja) * 2004-07-30 2011-10-19 キヤノン株式会社 磁性粒子集合体およびそれを用いた標的核酸の抽出装置および抽出方法
JP2008510456A (ja) 2004-07-30 2008-04-10 アジェンコート バイオサイエンス コーポレーション 多官能基コート化固相担体を用いる核酸の単離方法
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
CA2839092C (en) * 2004-08-03 2018-04-03 Becton, Dickinson And Company Use of magnetic material to direct isolation of compounds and fractionation of multipart samples
CA2575784A1 (en) * 2004-08-03 2006-02-16 Becton, Dickinson And Company Use of magnetic material to fractionate samples
WO2006015374A2 (en) 2004-08-03 2006-02-09 Novartis Vaccines And Diagnostics Inc. Compositions and methods for preparation of nucleic acids from microbial samples
EP1623996A1 (de) * 2004-08-06 2006-02-08 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Verbessertes Verfahren zur Auswahl eines Proteins von einer Bibliothek
US20060099605A1 (en) * 2004-11-11 2006-05-11 Hall Gerald E Jr Devices and methods for isolating RNA
US7320891B2 (en) * 2004-09-10 2008-01-22 Promega Corporation Methods and kits for isolating sperm cells
US7166680B2 (en) * 2004-10-06 2007-01-23 Advanced Cardiovascular Systems, Inc. Blends of poly(ester amide) polymers
EP1650297B1 (de) * 2004-10-19 2011-04-13 Samsung Electronics Co., Ltd. Verfahren und Apparatur zur schnellen Zerstörung von Zellen und Viren durch die Verwendung von mikro magnet Kügelchen und Laser
DE102005002343A1 (de) 2005-01-18 2006-07-27 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur spezifischen oder unspezifischen Separation von Zellen und/oder Viren aus flüssigen Medien und dessen Verwendung
US7964380B2 (en) * 2005-01-21 2011-06-21 Argylia Technologies Nanoparticles for manipulation of biopolymers and methods of thereof
US20060166223A1 (en) * 2005-01-26 2006-07-27 Reed Michael W DNA purification and analysis on nanoengineered surfaces
EP1690938A1 (de) 2005-02-11 2006-08-16 Qiagen GmbH Verfahren zur Isolierung von Nukleinsäuren, wobei die Nukleinsäuren bei erhöhter Temperatur an einer Matrix immobilisiert werden
ITRM20050067A1 (it) 2005-02-17 2006-08-18 Istituto Naz Per Le Malattie I Metodo per la rivelazione di acidi nucleici virali o di origine virale nelle urine.
US7914982B2 (en) * 2005-02-17 2011-03-29 Trovagene, Inc. Methods for detecting pathogen specific nucleic acids in urine
ITRM20050068A1 (it) * 2005-02-17 2006-08-18 Istituto Naz Per Le Malattie I Metodo per la rivelazione di acidi nucleici di agenti patogeni batterici o di parassiti nelle urine.
US20060223071A1 (en) * 2005-04-01 2006-10-05 Wisniewski Michele E Methods, compositions, and kits for detecting nucleic acids in a single vessel
US8632970B2 (en) 2005-05-09 2014-01-21 Affymetrix, Inc. Multiplex capture of nucleic acids
US8628918B2 (en) * 2005-05-09 2014-01-14 Affymetrix, Inc. Multiplex capture of nucleic acids
WO2006124771A2 (en) * 2005-05-12 2006-11-23 Panomics, Inc. Multiplex branched-chain dna assays
US20060270843A1 (en) * 2005-05-26 2006-11-30 Hall Gerald E Jr Methods for isolation of nucleic acids
US20060269929A1 (en) * 2005-05-26 2006-11-30 Hall Gerald E Jr Methods and kits for DNA purification on polymeric membranes at low ionic strength
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
WO2007001986A2 (en) * 2005-06-20 2007-01-04 Yuling Luo Methods of detecting nucleic acids in individual cells and of identifying rare cells from large heterogeneous cell populations
JP2009500019A (ja) * 2005-07-01 2009-01-08 プロメガ・コーポレーション 生体分子の精製のための浮遊性粒子のネットワーク、及び生体分子の精製のための浮遊性粒子又は浮遊性粒子のネットワークの使用
US20070072195A1 (en) * 2005-09-29 2007-03-29 Constantine Haralambopoulos Bio-commemorative article incorporating amplified genetic material
US7927798B2 (en) * 2005-10-05 2011-04-19 Panomics, Inc. Detection of nucleic acids from whole blood
US7727473B2 (en) 2005-10-19 2010-06-01 Progentech Limited Cassette for sample preparation
US7754148B2 (en) 2006-12-27 2010-07-13 Progentech Limited Instrument for cassette for sample preparation
US20070092403A1 (en) * 2005-10-21 2007-04-26 Alan Wirbisky Compact apparatus, compositions and methods for purifying nucleic acids
EP1963526A4 (de) 2005-12-09 2009-11-18 Promega Corp Nukleinsäurereinigung mittels bindungsmatrix
KR101066179B1 (ko) * 2006-02-15 2011-09-21 토소가부시키가이샤 생물재료로부터의 핵산 추출법
US20070254284A1 (en) * 2006-05-01 2007-11-01 Biwei Zhao A nucleic acid detection method
US8163535B2 (en) * 2006-06-26 2012-04-24 Blood Cell Storage, Inc. Devices and processes for nucleic acid extraction
US7608399B2 (en) * 2006-06-26 2009-10-27 Blood Cell Storage, Inc. Device and method for extraction and analysis of nucleic acids from biological samples
WO2008127356A2 (en) * 2006-10-06 2008-10-23 Promega Corporation Methods and kits for isolating cells
EP1911844A1 (de) * 2006-10-10 2008-04-16 Qiagen GmbH Verfahren und Zusammenstellung zur Isolierung von Nukleinsäure
JP5638806B2 (ja) 2006-11-03 2014-12-10 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドＳｉｅｍｅｎｓ Ｈｅａｌｔｈｃａｒｅ Ｄｉａｇｎｏｓｔｉｃｓ Ｉｎｃ． ポリメラーゼ連鎖反応試験のためのランダムアクセスシステムおよび方法
EP2094846B8 (de) * 2006-12-13 2013-10-16 Roche Diagnostics GmbH Verwendung von tde zur isolation von nukleinsäuren
DE602007010986D1 (de) * 2006-12-13 2011-01-13 Roche Diagnostics Gmbh Verwendung von acetalen zur isolation von nukleinsäuren
EP2066709B1 (de) * 2006-12-21 2012-04-11 Invitrogen Dynal AS Partikel und ihre verwendung in einem verfahren zur nukleinsäureisolierung oder einem verfahren zur phosphorproteinisolierung
US8993292B2 (en) * 2007-01-16 2015-03-31 Applied Biosystems Llc Methods and systems for differential extraction
US7960180B2 (en) * 2007-02-20 2011-06-14 University Of Notre Dame Du Lac Methods and apparatus to capture and release microbe particles using amino-functionalized silica
WO2008134470A2 (en) * 2007-04-25 2008-11-06 3M Innovative Properties Company Methods for nucleic acid amplification
ES2665280T3 (es) * 2007-06-29 2018-04-25 Becton, Dickinson And Company Métodos para la extracción y purificación de componentes de muestras biológicas
US7868145B2 (en) * 2007-07-11 2011-01-11 Industrial Technology Research Institute Magnetic particles containing a copolymer core, magnetic layer and silicon layer
US8969044B2 (en) 2007-07-23 2015-03-03 Life Technologies Corporation Method for recovering sperm nucleic acid from a forensic sample
US8486626B2 (en) * 2007-08-22 2013-07-16 Trovagene, Inc. Methods of detecting cell-free miRNA in urine and blood
CN101363045B (zh) * 2007-09-10 2012-10-17 厦门致善生物科技有限公司 一种用超微磁颗粒分离纯化生物靶物质的方法
US9388457B2 (en) * 2007-09-14 2016-07-12 Affymetrix, Inc. Locus specific amplification using array probes
US8357296B2 (en) 2007-09-24 2013-01-22 Emd Millipore Corporation Centrifugal filter
JP2011504591A (ja) * 2007-11-26 2011-02-10 アトノミックス アクティーゼルスカブ 信号対ノイズ比を増すための手段および方法を備える、統合型分離および検出カートリッジ
EP2240603A4 (de) 2008-01-03 2011-07-20 Univ Johns Hopkins Zusammensetzungen und verfahren für polynukleotidextraktion und methylierungsnachweis
KR101053023B1 (ko) * 2008-02-14 2011-08-01 (주)바이오니아 구형 실리카 자성입자 및 이의 제조방법
US9074244B2 (en) 2008-03-11 2015-07-07 Affymetrix, Inc. Array-based translocation and rearrangement assays
EP2265942B1 (de) 2008-03-12 2017-10-18 University Of Virginia Patent Foundation Nachweis polymerer analyten
US20120149587A1 (en) * 2008-03-12 2012-06-14 University Of Virginia Patent Foundation Method for detecting nucleated cells
DE102008029356A1 (de) * 2008-06-20 2009-12-24 Siemens Healthcare Diagnostics Gmbh Verfahren zur Aufreinigung von Nukleinsäuren, insbesondere aus fixiertem Gewebe
EP2147981A1 (de) * 2008-07-25 2010-01-27 Biotype AG Kit und Verfahren zur Auswertung der Detektionseigenschaften bei Verstärkungsreaktionen
US20100062518A1 (en) * 2008-09-09 2010-03-11 Sukanta Banerjee Concentrating White Blood Cells for DNA Extraction from a Leukodepleted Blood Sample
US8632671B2 (en) * 2008-10-03 2014-01-21 Board Of Regents, University Of Texas System Method for measuring carbon nanotubes taken-up by a plurality of living cells
JP2012508015A (ja) * 2008-11-04 2012-04-05 ブラッド・セル・ストレイジ，インコーポレイテッド 湾曲したガラス表面上での核酸抽出
US8846878B1 (en) 2009-01-23 2014-09-30 Cubrc Corporation Method and device for isolating a protein sample
EP2391725A4 (de) * 2009-01-30 2013-01-02 Us Health Verfahren und systeme zur reinigung von übertragenden und/oder manipulierenden nukleinsäuren
DE102009001864A1 (de) * 2009-03-25 2010-09-30 Qiagen Gmbh Überschichtung zur Partikelabtrennung
DE102009022512A1 (de) * 2009-05-25 2010-12-02 Qiagen Gmbh Verfahren zur Reaktivierung von Silikaoberflächen zur Isolierung von Nukleinsäuren
US8039613B2 (en) 2009-08-28 2011-10-18 Promega Corporation Methods of purifying a nucleic acid and formulation and kit for use in performing such methods
US8222397B2 (en) 2009-08-28 2012-07-17 Promega Corporation Methods of optimal purification of nucleic acids and kit for use in performing such methods
CA2772020A1 (en) * 2009-08-31 2011-03-03 Mbio Diagnostics, Inc. Integrated sample preparation and analyte detection
US11096345B2 (en) 2009-09-01 2021-08-24 Basf Se Method for treating post-emergent rice
TW201113377A (en) 2009-09-01 2011-04-16 Basf Agrochemical Products Bv Herbicide-tolerant plants
TWI407994B (zh) 2009-10-22 2013-09-11 Ind Tech Res Inst 分離核酸的方法、試劑及套組
WO2011077333A1 (en) * 2009-12-23 2011-06-30 Koninklijke Philips Electronics N.V. Analyte measurement apparatus and method
EP2345719A1 (de) 2010-01-18 2011-07-20 Qiagen GmbH Verfahren zur Isolierung kleiner RNA
JP6154137B2 (ja) 2010-02-23 2017-06-28 ルミネックス コーポレーション 一体化された試料調製、反応、及び検出のための装置及び方法
US20110223588A1 (en) * 2010-03-09 2011-09-15 Biosample Llc Solid Phase Nucleic Acid Extraction From Small Sample Volumes, and Release of Controlled Quantities
EP2407540A1 (de) 2010-07-15 2012-01-18 Qiagen GmbH Verfahren zur Reinigung von Nukleinsäure
DE102010036111B4 (de) 2010-09-01 2013-08-29 Bundesrepublik Deutschland (Bundesamt für Ausrüstung, Informationstechnik und Nutzung der Bundeswehr) Vorbehandlungsverfahren zur Isolierung und Aufkonzentrierung von Nukleinsäuren aus einer Umweltprobe
CN104849472A (zh) 2010-10-21 2015-08-19 领先细胞医疗诊断有限公司 用于原位检测核酸的超灵敏方法
EP3239296A1 (de) 2010-11-30 2017-11-01 Life Technologies Corporation Alkylenglykole sowie polymere und copolymere daraus zur direkten isolierung von nukleinsäuren aus eingebetteten proben
JP6334169B2 (ja) 2010-12-16 2018-05-30 ビーエーエスエフ アグロ ベー．ブイ． 除草剤耐性の増大した植物
EP2465934A1 (de) 2010-12-20 2012-06-20 Steffen Mergemeier Extraktion von Nukleinsäuren
US9051563B2 (en) 2011-01-14 2015-06-09 Zymo Research Corporation Nucleic acid purification
AU2012250619B2 (en) 2011-05-04 2015-11-26 Luminex Corporation Apparatus and methods for integrated sample preparation, reaction and detection
US8629264B2 (en) 2011-05-19 2014-01-14 Blood Cell Storage, Inc. Gravity flow fluidic device for nucleic acid extraction
US9304070B2 (en) 2011-07-13 2016-04-05 Emd Millipore Corporation All-in-one sample preparation device and method
DE102011054474B4 (de) 2011-07-20 2014-02-13 Stratec Biomedical Ag System zur Stabilisierung, Aufbewahrung und Lagerung einer Nukleinsäure
DK2742152T3 (en) 2011-08-12 2017-07-31 Qiagen Gmbh PROCEDURE FOR ISOLATING NUCLEIC ACIDS
WO2013116375A1 (en) 2012-01-30 2013-08-08 Exact Sciences Corporation Modification of dna on magnetic beads
EP2634254A1 (de) 2012-02-29 2013-09-04 QIAGEN GmbH Verfahren zur Isolierung von Nukleinsäuren aus Nahrungsmittelproben
AR091489A1 (es) 2012-06-19 2015-02-11 Basf Se Plantas que tienen una mayor tolerancia a herbicidas inhibidores de la protoporfirinogeno oxidasa (ppo)
US10041087B2 (en) 2012-06-19 2018-08-07 BASF Agro B.V. Plants having increased tolerance to herbicides
JP6382188B2 (ja) * 2012-06-25 2018-08-29 ザ ジェネラル ホスピタル コーポレイション 高勾配磁場を使用する粒子選別法
EP2770056B1 (de) 2012-07-18 2017-05-31 Zymo Research Corporation Nukleinsäurereinigung
FR2994184B1 (fr) 2012-08-02 2017-12-08 Biomerieux Sa Procedes de fonctionalisation et reactifs utilises dans de tels procedes utilisant un anhydride aza-isatoique ou un de ses derives, molecules biologiques ainsi traitees et kits
WO2014029792A1 (en) 2012-08-21 2014-02-27 Qiagen Gmbh Virus particle stabilisation and method for isolating viral nucleic acids
US20150225712A1 (en) 2012-08-21 2015-08-13 Qiagen Gmbh Method for isolating nucleic acids from a formaldehyde releaser stabilized sample
US10329553B2 (en) 2012-09-03 2019-06-25 Qiagen Gmbh Method for isolating RNA including small RNA with high yield
AU2013330344B2 (en) 2012-09-17 2018-07-05 W. R. Grace & Co.-Conn. Chromatography media and devices
GB201217405D0 (en) * 2012-09-28 2012-11-14 Fermentas Uab Protein removal agent
US10745686B2 (en) 2013-02-08 2020-08-18 Qiagen Gmbh Method for separating DNA by size
CN105190312B (zh) 2013-03-01 2017-12-12 斯彼诺米克斯公司 基于磁性粒子的分离和测定方法
EP2971169A4 (de) * 2013-03-13 2016-10-26 Abbott Molecular Inc Systeme und verfahren zur isolierung von nukleinsäuren
US9670479B2 (en) 2013-03-15 2017-06-06 F Cubed, LLC Sample preparation device and methods of use
JP5802237B2 (ja) * 2013-04-18 2015-10-28 三洋化成工業株式会社 磁性粒子及びその製造方法
AU2014307664A1 (en) 2013-08-12 2016-02-18 BASF Agro B.V. Plants having increased tolerance to herbicides (PPO)
UA123757C2 (uk) 2013-08-12 2021-06-02 Басф Агро Б. В. Мутована протопорфіриногеноксидаза, що надає рослинам стійкості до ппо-інгібуючого гербіциду
DE202014002379U1 (de) 2014-03-15 2014-08-19 Ruprecht-Karls-Universität Heidelberg DNA Stabilisierungssystem
WO2015150465A2 (en) 2014-04-03 2015-10-08 Basf Se Plants having increased tolerance to herbicides
JP6914189B2 (ja) 2014-05-02 2021-08-04 ダブリュー・アール・グレース・アンド・カンパニー−コーンＷ Ｒ Ｇｒａｃｅ ＆ Ｃｏ−Ｃｏｎｎ 官能化担体材料並びに官能化担体材料を作製及び使用する方法
KR102344395B1 (ko) * 2014-06-24 2021-12-29 (주)바이오니아 자성 입자를 이용한 핵산 분리 방법
US10000750B2 (en) 2014-10-09 2018-06-19 Promega Corporation Method of isolating nucleic acid
JP2017539080A (ja) 2014-10-23 2017-12-28 コーニング インコーポレイテッド 高分子被包磁性ナノ粒子
JP6773402B2 (ja) * 2014-11-04 2020-10-21 三洋化成工業株式会社 磁性シリカ粒子を用いた対象物質の分離方法
EP3059312A1 (de) 2015-02-20 2016-08-24 QIAGEN GmbH Nukleinsäureextraktionsverfahren
US9422596B1 (en) 2015-04-27 2016-08-23 Norgen Biotek Corp. Methods and columns for nucleic acid purification
KR101646610B1 (ko) 2015-05-28 2016-08-09 (주)바이오니아 생체 물질 정제용 고활성 실리카 자성나노입자 및 이의 제조 방법
EP3303582A1 (de) 2015-06-01 2018-04-11 Qiagen GmbH Elektrophoreseunterstütztes verfahren und vorrichtung zur reinigung eines geladenen zielmoleküls aus einer probe
WO2016193282A1 (en) 2015-06-01 2016-12-08 Qiagen Gmbh Electrophoresis assisted method for purifying a target nucleic acid using a delayed elution approach
JP7007197B2 (ja) 2015-06-05 2022-01-24 キアゲン ゲーエムベーハー サイズによってｄｎａを分離する方法
WO2016196906A1 (en) 2015-06-05 2016-12-08 W. R. Grace & Co.-Conn. Adsorbent bioprocessing clarification agents and methods of making and using the same
JP2018526021A (ja) * 2015-09-11 2018-09-13 コーニング インコーポレイテッド 血液試料からの核酸精製のための組成物及び方法
US11078528B2 (en) 2015-10-12 2021-08-03 Advanced Cell Diagnostics, Inc. In situ detection of nucleotide variants in high noise samples, and compositions and methods related thereto
JP7184648B2 (ja) 2016-04-29 2022-12-06 ビーエーエスエフ プラント サイエンス カンパニー ゲーエムベーハー 標的核酸の改変のための改善された方法
TR201606310A2 (tr) 2016-05-12 2017-11-21 Akdeniz Ueniversitesi Genomik dna izolasyon yöntemi ve kiti.
KR101913163B1 (ko) 2016-06-30 2018-11-01 주식회사 바이오이즈 이중가닥 핵산 신호 프로브 및 이를 이용한 표적분자의 검출방법
CA3032014A1 (en) 2016-07-27 2018-02-01 BASF Agro B.V. Plants having increased tolerance to herbicides
US10077465B2 (en) * 2016-09-13 2018-09-18 The United States Of America, As Represented By The Secretary Of The Navy Sorbents for extraction and stabilization of nucleic acids
US11185863B2 (en) 2016-09-30 2021-11-30 Koninklijke Philips N.V. System for applying a reagent to a sample
CN110225980B (zh) 2016-11-21 2023-01-06 纳米线科技公司 化学组合物及其使用方法
CN110382702A (zh) 2016-12-20 2019-10-25 巴斯夫农业公司 具有增加的除草剂耐性的植物
US11891599B2 (en) * 2017-05-22 2024-02-06 Qiagen Healthcare Biotechnologies Systems Gmbh Recovery of nucleic acids from solid supports
WO2019063071A1 (en) 2017-09-27 2019-04-04 Qiagen Gmbh METHOD FOR HIGH-PERFORMANCE RNA ISOLATION
CN112703255A (zh) 2018-05-14 2021-04-23 纳米线科技公司 化学组合物及其使用方法
JP7428657B2 (ja) * 2018-10-26 2024-02-06 テルモ株式会社 標的物質の分離方法および定量方法
EP3968029A4 (de) * 2019-05-08 2023-01-18 Hitachi High-Tech Corporation Vorbehandlungsverfahren einer automatischen analysevorrichtung
US11807909B1 (en) 2019-09-12 2023-11-07 Zymo Research Corporation Methods for species-level resolution of microorganisms
WO2021100801A1 (ja) * 2019-11-20 2021-05-27 東レ株式会社 核酸の分離方法、検出方法、核酸精製カラム及びその製造方法
EP4163397A1 (de) 2020-06-05 2023-04-12 Seegene, Inc. Probentransportkit zum nachweis von atemwegspathogenen und verfahren zum nachweis von atemwegspathogenen damit
KR20220075978A (ko) 2020-11-30 2022-06-08 (주)바이오니아 중저 비유전율을 가진 화합물을 포함한 핵산 결합 완충액을 이용한 핵산 분리방법

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4233169A (en) * 1979-04-13 1980-11-11 Corning Glass Works Porous magnetic glass structure
US4395271A (en) * 1979-04-13 1983-07-26 Corning Glass Works Method for making porous magnetic glass and crystal-containing structures
US4297337A (en) * 1979-04-13 1981-10-27 Corning Glass Works Solid-phase immunoassays using magnetic glass
DE3211309A1 (de) 1982-03-26 1983-09-29 Metin Dipl.-Ing. 6100 Darmstadt Colpan Chromatographisches verfahren zur isolierung von makromolekuelen
US5482834A (en) 1982-05-17 1996-01-09 Hahnemann University Evaluation of nucleic acids in a biological sample hybridization in a solution of chaotrophic salt solubilized cells
US4695393A (en) * 1983-05-12 1987-09-22 Advanced Magnetics Inc. Magnetic particles for use in separations
US4554088A (en) * 1983-05-12 1985-11-19 Advanced Magnetics Inc. Magnetic particles for use in separations
US4672040A (en) 1983-05-12 1987-06-09 Advanced Magnetics, Inc. Magnetic particles for use in separations
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5076950A (en) * 1985-12-20 1991-12-31 Syntex (U.S.A.) Inc. Magnetic composition for particle separation
US6027750A (en) * 1986-09-04 2000-02-22 Gautsch; James Systems and methods for the rapid isolation of nucleic acids
DE3639949A1 (de) 1986-11-22 1988-06-09 Diagen Inst Molekularbio Verfahren zur trennung von langkettigen nukleinsaeuren
US4767670A (en) 1987-01-21 1988-08-30 E. I. Du Pont De Nemours And Company Chromatographic supports for separation of oligonucleotides
ATE117829T1 (de) * 1988-05-24 1995-02-15 Anagen Uk Ltd Magnetisch anziehbare teilchen und herstellungsverfahren.
US5512439A (en) * 1988-11-21 1996-04-30 Dynal As Oligonucleotide-linked magnetic particles and uses thereof
US5075430A (en) * 1988-12-12 1991-12-24 Bio-Rad Laboratories, Inc. Process for the purification of DNA on diatomaceous earth
US5234809A (en) 1989-03-23 1993-08-10 Akzo N.V. Process for isolating nucleic acid
US5523231A (en) 1990-02-13 1996-06-04 Amersham International Plc Method to isolate macromolecules using magnetically attractable beads which do not specifically bind the macromolecules
US5243037A (en) * 1990-09-21 1993-09-07 E. I. Du Pont De Nemours And Company Poly(fluoroalkyl) sugar reagents for surface modification of supports
EP0620761A1 (de) 1991-01-04 1994-10-26 Perseptive Biosystems, Inc. Durch sulfonamide gebundener hydrophiler überzug
US5155018A (en) * 1991-07-10 1992-10-13 Hahnemann University Process and kit for isolating and purifying RNA from biological sources
US5395498A (en) * 1991-11-06 1995-03-07 Gombinsky; Moshe Method for separating biological macromolecules and means therfor
US5734020A (en) 1991-11-20 1998-03-31 Cpg, Inc. Production and use of magnetic porous inorganic materials
US5610274A (en) * 1991-11-20 1997-03-11 Cpg, Inc. Production and use of magnetic porous inorganic materials
US5346994A (en) * 1992-01-28 1994-09-13 Piotr Chomczynski Shelf-stable product and process for isolating RNA, DNA and proteins
DE69324716T2 (de) 1992-02-13 1999-09-09 Becton Dickinson Co Celithydrat und Reinigung von DNS
CA2137563C (en) * 1992-06-08 2005-06-28 Thomas B. Ryder Preparation of nucleic acid from mononuclear cells
US5316680A (en) 1992-10-21 1994-05-31 Cornell Research Foundation, Inc. Multimodal chromatographic separation media and process for using same
WO1994018156A1 (en) 1993-02-01 1994-08-18 University Of Iowa Research Foundation Quartenary amine surfactants and methods of using same in isolation of rna
DE4307262A1 (de) * 1993-03-02 1994-09-08 Christian Bergemann Magnetisches polymeres Siliciumdioxid
EP0723549B1 (de) * 1993-08-30 2003-12-17 Promega Corporation Zusammensetzungen und verfahren zur reinigung von nukleinsäuren
JP4113580B2 (ja) 1994-02-07 2008-07-09 キアゲン ゲゼルシャフト ミット ベシュレンクテル ハフツング エンドトキシンを減量又は除去する方法
US5990301A (en) 1994-02-07 1999-11-23 Qiagen Gmbh Process for the separation and purification of nucleic acids from biological sources
DE4420732A1 (de) * 1994-06-15 1995-12-21 Boehringer Mannheim Gmbh Vorrichtung zur Behandlung von Nukleinsäuren aus einer Probe
EP0772776B1 (de) * 1994-07-27 2000-03-22 Herbert Dr. Pilgrimm Superparamagnetische teilchen, verfahren zur herstellung und deren verwendung
US5582988A (en) 1994-09-15 1996-12-10 Johnson & Johnson Clinical Diagnostics, Inc. Methods for capture and selective release of nucleic acids using weakly basic polymer and amplification of same
US5652348A (en) 1994-09-23 1997-07-29 Massey University Chromatographic resins and methods for using same
US5660984A (en) * 1994-12-09 1997-08-26 Davis; Thomas E. DNA isolating apparatus comprising a non-porous DNA binding, anion exchange resin and methods of use thereof
DE19520398B4 (de) 1995-06-08 2009-04-16 Roche Diagnostics Gmbh Magnetisches Pigment
JP2965131B2 (ja) * 1995-07-07 1999-10-18 東洋紡績株式会社 核酸結合用磁性担体およびそれを用いる核酸単離方法
US5783686A (en) * 1995-09-15 1998-07-21 Beckman Instruments, Inc. Method for purifying nucleic acids from heterogenous mixtures
SE9600590D0 (sv) 1996-02-19 1996-02-19 Pharmacia Biotech Ab Sätt för kromatografisk separation av peptider och nukleinsyra samt ny högaffin jonbytesmatris
US5904848A (en) 1996-02-21 1999-05-18 Cpg, Inc. Controlled pore glass-synthetic resin membrane
EP0929694A4 (de) * 1996-03-15 2002-05-02 Penn State Res Found Nachweis von extrazellulärer tumor-assoziierter nukleinsäuren im blutplasma oder -serum mittels eines nukleinsäure-amplifizierungsverfahren
JPH09327291A (ja) * 1996-06-11 1997-12-22 Toyobo Co Ltd Ｒｎａの抽出精製方法
JP3940935B2 (ja) * 1996-06-11 2007-07-04 東洋紡績株式会社 プラスミドｄｎａの抽出精製方法
US6027945A (en) 1997-01-21 2000-02-22 Promega Corporation Methods of isolating biological target materials using silica magnetic particles
KR100464870B1 (ko) 1997-01-21 2005-01-05 더블유.알. 그레이스 앤드 캄파니-콘. 자성 물질상의 실리카 흡착제
JP4196227B2 (ja) 1997-05-20 2008-12-17 東洋紡績株式会社 核酸またはタンパク質抽出用シリカ粒子組成物
WO2000050564A2 (en) * 1999-02-26 2000-08-31 Myriad Genetics, Inc. Method for extracting dna from dried specimens

Also Published As

Publication number Publication date
EP0895546A1 (de) 1999-02-10
CA2249393A1 (en) 1998-07-23
US6673631B1 (en) 2004-01-06
AU732756B2 (en) 2001-04-26
DE69817484T2 (de) 2004-06-17
US6027945A (en) 2000-02-22
DK1367137T3 (da) 2010-07-12
JP3253638B2 (ja) 2002-02-04
EP0895546A4 (de) 2002-03-20
US20040086930A1 (en) 2004-05-06
US20020086326A1 (en) 2002-07-04
WO1998031840A1 (en) 1998-07-23
BR9805897A (pt) 1999-08-24
AU6647598A (en) 1998-08-07
US6368800B1 (en) 2002-04-09
DE895546T1 (de) 2002-10-17
JPH11509742A (ja) 1999-08-31
EP0895546B1 (de) 2003-08-27
DE69841555D1 (de) 2010-04-22
EP1367137B1 (de) 2010-03-10
EP1367137A1 (de) 2003-12-03

Similar Documents

Publication Publication Date Title
DE69817484D1 (de) Verfahren zur isolierung bestimmter biologischer stoffe mittels magnetischer silika-partikel
DE60037268D1 (de) Verfahren zur durchführung magnetischer chromatographischer assays
DE69626564D1 (de) Verfahren zur Gastrennung mittels Adsorption
DE59609524D1 (de) Verfahren zur Genexpressionsanalyse
DE69839294D1 (de) Gerät zur Abscheidung magnetischer Teilchen
DE69634036D1 (de) System und verfahren zur entdeckung von schmuggelware mittels kernquadrupolresonanz
DE69933186D1 (de) Methode zur Reinigung und Manipulation von Nukleinsäure mittels paramagnetischen Partikeln
DE69937910D1 (de) Gerät und Verfahren zur Probenuntersuchung mittels Ladungsträgerstrahlen
DE69511229D1 (de) Verfahren zur Analyse von gleichmässig erregten mechanischen Schwingungen
ATE272613T1 (de) Verfahren zur synthese von cox-2 inhibitoren
DE69810361T2 (de) Verfahren und Vorrichtung zur mehrkanaligen akustischen Signalkodierung und -dekodierung
DE69636967D1 (de) Verfahren zur Analyse mittels Lichtstreuung
EP1109610A4 (de) Vorrichtung und verfahren zur magnetischen abtrennung von biologischen molekülen
DE69905425T2 (de) Verfahren und vorrichtung zur trennung von bioorganischen molekülen mittels elektrophorese
DE60034693D1 (de) Modul-aptamer und verfahren zur detektion von zielproteinen durch anwendung desselben
DE69523702T2 (de) Verfahren zur modell-prädiktiven Regelung eines Lufttrennungssystemes
DE69938441D1 (de) Verfahren und Vorrichtung zur Abtastratenumsetzung von Audiosignalen
DE69841482D1 (de) Verfahren zur Verarbeitung einer Probe mittels Ionenaustauscheherharzen
DE69500118D1 (de) Verfahren zur dauerhaften Verformung der keratinischen Substanzen
DE69841476D1 (de) Gerät und verfahren zur bildformung eines objektes durch magnetische resonanz
DE69420750D1 (de) Verfahren zur Probenanalyse mittels Kapillarelektroforese
DE69815562D1 (de) Verfahren und Vorrichtung zur Signalverarbeitung mittels logischer Sprachgrenzen
DE59708724D1 (de) Verfahren zur verbesserung des regelverhaltens eines abs in der kurve
DE69535284D1 (de) Verfahren zur Präparation von Nukleinsäuren zur Analyse und Kits dafür
DE59702410D1 (de) Verfahren zur verbesserung des regelverhaltens eines abs

Legal Events

Date Code Title Description
8380 Miscellaneous part iii

Free format text: DER VERTRETER WURDE AM 10.08.04 GEAENDERT IN: HOFFMANN & EITLE, IN MUENCHEN