DE69828193D1 - Hyaluronan synthase gen und seine verwendung - Google Patents

Hyaluronan synthase gen und seine verwendung

Info

Publication number
DE69828193D1
DE69828193D1 DE69828193T DE69828193T DE69828193D1 DE 69828193 D1 DE69828193 D1 DE 69828193D1 DE 69828193 T DE69828193 T DE 69828193T DE 69828193 T DE69828193 T DE 69828193T DE 69828193 D1 DE69828193 D1 DE 69828193D1
Authority
DE
Germany
Prior art keywords
nucleic acid
hyaluronan synthase
synthase gene
hyaluronan
synthase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69828193T
Other languages
English (en)
Other versions
DE69828193T2 (de
Inventor
H Weigel
Kshama Kumari
Paul Deangelis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Oklahoma
Original Assignee
University of Oklahoma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Oklahoma filed Critical University of Oklahoma
Publication of DE69828193D1 publication Critical patent/DE69828193D1/de
Application granted granted Critical
Publication of DE69828193T2 publication Critical patent/DE69828193T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/832—Bacillus
    • Y10S435/836—Bacillus licheniformis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/832—Bacillus
    • Y10S435/839—Bacillus subtilis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/848—Escherichia
DE69828193T 1997-10-31 1998-10-30 Hyaluronan synthase gen und seine verwendung Expired - Lifetime DE69828193T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6443597P 1997-10-31 1997-10-31
US64435P 1997-10-31
US17885198A 1998-10-26 1998-10-26
US178851 1998-10-26
PCT/US1998/023153 WO1999023227A2 (en) 1997-10-31 1998-10-30 Hyaluronan synthase gene and uses thereof

Publications (2)

Publication Number Publication Date
DE69828193D1 true DE69828193D1 (de) 2005-01-20
DE69828193T2 DE69828193T2 (de) 2005-12-01

Family

ID=26744517

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69828193T Expired - Lifetime DE69828193T2 (de) 1997-10-31 1998-10-30 Hyaluronan synthase gen und seine verwendung

Country Status (13)

Country Link
US (10) US6833264B1 (de)
EP (2) EP1522579A3 (de)
JP (1) JP4731013B2 (de)
KR (1) KR20010031682A (de)
CN (1) CN1322121C (de)
AT (1) ATE284954T1 (de)
AU (2) AU762036B2 (de)
BR (1) BR9814834B1 (de)
CA (1) CA2307842C (de)
DE (1) DE69828193T2 (de)
DK (1) DK1025211T3 (de)
ES (1) ES2235378T3 (de)
WO (1) WO1999023227A2 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7091008B1 (en) 1994-07-01 2006-08-15 The Board Of Regents Of The University Of Oklahoma Hyaluronan synthase genes and expression thereof in Bacillus hosts
ES2235378T3 (es) * 1997-10-31 2005-07-01 The Board Of Regents Of The University Of Oklahoma Gen de la hialuronan sintasa y usos del mismo.
US7060469B2 (en) * 1998-04-02 2006-06-13 The Board Of Regents Of The University Of Oklahoma Polymer grafting by polysaccharide synthases
IL138803A0 (en) * 1998-04-02 2001-10-31 Univ Oklahoma Nucleic acid encoding hyaluronan synthase
US7534589B2 (en) * 1999-11-10 2009-05-19 The Board Of Regents Of The University Of Oklahoma Polymer grafting by polysaccharide synthases
US20070020737A1 (en) * 2001-12-03 2007-01-25 Pummill Philip E Hyaluronan synthases and methods of making and using same
PL399352A1 (pl) 2001-12-21 2012-10-08 Novozymes Biopharma Dk A/S Sposoby wytwarzania hialuronanu w rekombinowanej komórce gospodarzu
AU2008200910C1 (en) * 2001-12-21 2012-11-22 Novozymes A/S Methods for producing hyaluronan in a recombinant host cell
US9733625B2 (en) * 2006-03-20 2017-08-15 General Electric Company Trip optimization system and method for a train
WO2004001054A2 (en) * 2002-06-20 2003-12-31 Novozymes Biopolymer A/S Flocculation with divalent salt
CA2533925C (en) * 2003-07-31 2012-07-10 Toyo Boseki Kabushiki Kaisha Plants producing hyaluronic acid
PT1805312E (pt) 2004-09-23 2009-09-28 Bayer Cropscience Ag Processos e meios para produzir hialurano
EP1640457A1 (de) * 2004-09-23 2006-03-29 Bayer CropScience GmbH Verfahren und Mittel zur Herstellung von Hyaluronan
JP2008526693A (ja) * 2005-01-03 2008-07-24 ノボザイムス バイオポリマー アクティーゼルスカブ 保湿及び抗−しわ性質を有するヒアルロン酸画分
JP2006204260A (ja) * 2005-01-31 2006-08-10 Toyobo Co Ltd ヒアルロン酸合成酵素及びその遺伝子
US8003851B2 (en) 2005-08-25 2011-08-23 Toyo Boseki Kabushiki Kaisha Plant producing hyaluronic acid
JP2009509555A (ja) * 2005-10-05 2009-03-12 バイエル・クロップサイエンス・アーゲー ヒアルロン酸の産生が増大した植物ｉｉ
EP1772052A1 (de) * 2005-10-05 2007-04-11 Bayer CropScience GmbH Verbesserte Verfahren und Mittel zur Herstellung von Hyaluronan
JP2009509556A (ja) * 2005-10-05 2009-03-12 バイエル・クロップサイエンス・アーゲー ヒアルロナンｉｉの生産が増加している植物
WO2007039316A1 (en) * 2005-10-05 2007-04-12 Bayer Cropscience Ag Improved methods and means for producings hyaluronan
JP2007174957A (ja) * 2005-12-27 2007-07-12 Toyobo Co Ltd ヒアルロン酸生産酵母
CA2657823A1 (en) 2006-08-04 2008-02-07 Novozymes Biopolymer A/S Branched hyaluronic acid and method of manufacture
NZ580623A (en) * 2007-03-29 2012-04-27 Futuragene Israel Ltd Transgenic plants containing soluble cell wall polysaccharides
AU2008291695A1 (en) * 2007-08-31 2009-03-05 Sugar Industry Innovation Pty Ltd Production of hyaluronic acid
JP5523338B2 (ja) 2007-12-19 2014-06-18 エヴォニク ゴールドシュミット ゲーエムベーハー エマルジョン中の架橋ヒアルロン酸
US20140155347A1 (en) 2011-05-30 2014-06-05 Novozymes Biopharma Dk A/S Spray Drying of High Molecular Weight Hyaluronic Acid
EP2750665A1 (de) 2011-09-02 2014-07-09 Novozymes Biopharma DK A/S Orale formulierungen mit hyaluronsäure für verzögerte wirkstofffreisetzung
WO2014100837A1 (en) 2012-12-17 2014-06-26 Bui The Duy Computer aided implantation of body implants
AU2014228022B9 (en) * 2013-03-15 2016-11-03 NuTech Medical, Inc. Preparations derived from placental materials of making and using same
KR102135044B1 (ko) * 2018-12-10 2020-07-17 대화제약 주식회사 히알루론산 합성효소 변이 단백질 및 이를 이용한 히알루론산 생산 방법
RU2719140C1 (ru) 2019-07-26 2020-04-17 Общество с ограниченной ответственностью "ЦЕНТР ТРАНСФЕРА БИОТЕХНОЛОГИЙ ОКА-Биотех" Бактерия рода bacillus, продуцирующая гиалуроновую кислоту, и способ получения гиалуроновой кислоты с использованием указанной бактерии

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH624011A5 (de) 1977-08-05 1981-07-15 Battelle Memorial Institute
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
ZA811368B (en) 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
EP0038776B1 (de) 1980-04-17 1983-09-21 Ciba-Geigy Ag Phenylharnstoffe
US4517295A (en) 1983-02-18 1985-05-14 Diagnostic, Inc. Hyaluronic acid from bacterial culture
CA1167797A (en) 1983-06-30 1984-05-22 Herbert E. Gladish Air conveyor components
JPS6060177A (ja) 1983-09-12 1985-04-06 Hiroyuki Yugawa 冷却用寒剤
US4511478A (en) 1983-11-10 1985-04-16 Genetic Systems Corporation Polymerizable compounds and methods for preparing synthetic polymers that integrally contain polypeptides
AU565354B2 (en) 1983-11-14 1987-09-10 Bio-Mimetics Inc. Bioadhesive compositions and methods of treatment therewith
US4983392A (en) 1983-11-14 1991-01-08 Bio-Mimetics, Inc. Bioadhesive compositions and methods of treatment therewith
NO161573C (no) 1983-11-25 1989-08-30 Miles Inc Fremgangsmaate til fremstilling av hyaluronsyre.
US4708861A (en) 1984-02-15 1987-11-24 The Liposome Company, Inc. Liposome-gel compositions
JPS60251898A (ja) 1984-05-25 1985-12-12 Shiseido Co Ltd 醗酵法によるヒアルロン酸の製造方法
FR2569724B1 (fr) 1984-09-04 1991-02-08 Chisso Corp Procede pour la preparation d'acide hyaluronique
JPS6163294A (ja) * 1984-09-05 1986-04-01 Chisso Corp 発酵法によるヒアルロン酸の製造法
US5171689A (en) 1984-11-08 1992-12-15 Matsushita Electric Industrial Co., Ltd. Solid state bio-sensor
US4784990A (en) * 1985-01-18 1988-11-15 Bio-Technology General Corporation High molecular weight sodium hyaluronate
US4780414A (en) 1985-01-18 1988-10-25 Bio-Technology General Corp. Method of producing high molecular weight sodium hyallronate by fermentation of streptococcus
IT1208514B (it) 1985-03-19 1989-07-10 Eniricerche Spa Vettori plasmidici ad espressione in escherichia coli e/o bacillussubtilis.
JPS61267189A (ja) 1985-05-22 1986-11-26 株式会社東芝 結束装置付入金集計機
JPS6232893A (ja) 1985-08-01 1987-02-12 Kyowa Hakko Kogyo Co Ltd ヒアルロン酸の製造法
US5023175A (en) 1986-05-01 1991-06-11 Kabushiki Kaisha Yakult Honsha Novel production process of hyaluronic acid and bacterium strain therefor
JPS6394988A (ja) 1986-10-08 1988-04-26 Meiji Seika Kaisha Ltd ヒアルロン酸の製造法
JPH072117B2 (ja) 1986-10-09 1995-01-18 三菱レイヨン株式会社 ヒアルロン酸の製造法
EP0265578A1 (de) 1986-10-30 1988-05-04 Jan-Olof Eriksson Zusammensetzung eines nicht abschleifenden Polier- und Reinigungsmittels und Verfahren zu ihrer Herstellung
US4822867A (en) 1987-02-02 1989-04-18 Semih Erhan Protein polymer grafts
JPH02193818A (ja) 1989-01-23 1990-07-31 Okura Yusoki Co Ltd パレット荷積み装置
US5015577A (en) 1989-08-29 1991-05-14 Board Of Regents, The University Of Texas System DNA encoding hyaluronate synthase
FR2652736A1 (fr) 1989-10-06 1991-04-12 Neftel Frederic Dispositif implantable d'evaluation du taux de glucose.
JP2986519B2 (ja) 1990-07-24 1999-12-06 生化学工業株式会社 燐脂質結合グリコサミノグリカン
JPH04124854A (ja) 1990-09-17 1992-04-24 Nikko Kyodo Co Ltd 半導体装置の製造方法
CA2061703C (en) * 1992-02-20 2002-07-02 Rudolf E. Falk Formulations containing hyaluronic acid
JPH04134854A (ja) 1990-09-26 1992-05-08 Shimadzu Corp Ｉｃチップ間配線方法
JPH04158798A (ja) 1990-10-19 1992-06-01 Tdk Corp 酵素活性の測定方法
JPH0630605B2 (ja) 1990-10-23 1994-04-27 チッソ株式会社 ヒアルロン酸ナトリウム水溶液の製造法
IT1250421B (it) 1991-05-30 1995-04-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato con proprieta' bio-adesive.
US5217743A (en) 1992-02-07 1993-06-08 Paradigm Biotechnologies Partnership Biomaterials of enhanced biocompatibility
US5621089A (en) 1992-05-27 1997-04-15 Novo Nordisk Biotech, Inc. Nucleic acid constructs for the production of a Bacillus alkaline protease
IT1260153B (it) * 1992-06-19 1996-03-28 Michael O'regan Individuazione di un frammento di dna codificante l'enzima acido ialuronico sintetasi (has) e della sua sequenza nucleotidica
JP3591837B2 (ja) 1994-02-17 2004-11-24 ニューヨーク・ブラッド・センター・インコーポレイテッド フィブリン膠およびリポソームを含有する生物学的生体接着剤組成物、その製造方法および使用
IT1268954B1 (it) 1994-03-11 1997-03-18 Fidia Advanced Biopolymers Srl Processo per la preparazione di acido ialuronico mediante sintesienzimatica e relative composizioni farmaceutiche
US5473034A (en) 1994-03-18 1995-12-05 Hyogo Prefectural Government Method for producing protein-synthetic polymer conjugate and said conjugate produced thereby
EP0804582A1 (de) 1994-05-16 1997-11-05 The Uab Research Foundation $i(STREPTOCOCCUS PNEUMONIAE) KAPSULÄRE POLYSACCHARIDGENEN UND FLANKIERENDE REGIONEN
SE9401806D0 (sv) 1994-05-26 1994-05-26 Pharmacia Ab Method and means for the production of hyaluronic acid
US7091008B1 (en) * 1994-07-01 2006-08-15 The Board Of Regents Of The University Of Oklahoma Hyaluronan synthase genes and expression thereof in Bacillus hosts
US6455304B1 (en) * 1994-07-01 2002-09-24 The Board Of Regents Of The University Of Oklahoma Hyaluronate synthase gene and uses thereof
US6951743B2 (en) * 1997-10-31 2005-10-04 University Of Oklahoma Board Of Regents Hyaluronan synthase genes and expression thereof in bacillus hosts
JPH0838336A (ja) 1994-08-01 1996-02-13 Matsushita Electric Ind Co Ltd 電気カーペット用カバー
CN1161060A (zh) * 1994-09-12 1997-10-01 M·G·伯杰龙 用于微生物学实验室日常诊断中迅速检测和鉴别临床样品中普通细菌病原体和抗生素抗性基因之特异性和通用性探针及扩增引物
US5831057A (en) * 1995-10-05 1998-11-03 Cold Spring Harbor Laboratory Associative learning and the linotte gene
EA199800475A1 (ru) 1995-11-28 1998-12-24 Дженвек, Инк. Векторы и способы для переноса генов в клетки
SE9504304D0 (sv) 1995-11-30 1995-11-30 Sandvik Ab Coated milling insert
WO1997020061A1 (en) * 1995-11-30 1997-06-05 The Scripps Research Institute Synthesis of hyaluronic acid
US6423514B1 (en) 1996-04-22 2002-07-23 Millennium Pharmaceuticals, Inc. Mammalian hyaluronan synthases, nucleic acids and uses thereof
US5610241A (en) 1996-05-07 1997-03-11 Cornell Research Foundation, Inc. Reactive graft polymer with biodegradable polymer backbone and method for preparing reactive biodegradable polymers
US6602693B1 (en) * 1996-07-03 2003-08-05 Clear Solutions Biotech, Inc. Gene encoding hyaluronan synthase
US6492150B1 (en) * 1996-07-03 2002-12-10 Clear Colutions Biotech, Inc. Gene encoding hyaluronan synthase
CN101113436B (zh) * 1997-10-31 2013-02-06 俄克拉何马大学董事会 透明质酸合酶基因及其应用
ES2235378T3 (es) * 1997-10-31 2005-07-01 The Board Of Regents Of The University Of Oklahoma Gen de la hialuronan sintasa y usos del mismo.
US7223571B2 (en) * 1998-04-02 2007-05-29 The Board Of Regents Of The Universtiy Of Oklahoma Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US7060469B2 (en) * 1998-04-02 2006-06-13 The Board Of Regents Of The University Of Oklahoma Polymer grafting by polysaccharide synthases
US20080108110A1 (en) * 1998-04-02 2008-05-08 Deangelis Paul L Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US20060188966A1 (en) 1998-04-02 2006-08-24 Deangelis Paul L Natural, chimeric and hybrid glycosaminoglycan polymers and methods of making and using same
US6987023B2 (en) * 1998-04-02 2006-01-17 The Board Of Regents Of The University Of Oklahoma DNA encoding hyaluronan synthase from Pasteurella multocida and methods of use
US7094581B2 (en) 1998-10-26 2006-08-22 The Board Of Regents Of The University Of Oklahoma Hyaluronan synthases and methods of making and using same
US20060105431A1 (en) * 1998-11-11 2006-05-18 Deangelis Paul L Polymer grafting by polysaccharide synthases using artificial sugar acceptors
JP2002529064A (ja) * 1998-11-11 2002-09-10 ザ ボード オブ リージェンツ オブ ザ ユニヴァーシティー オブ オクラホマ 多糖類シンターゼによるポリマーグラフティング
US7534589B2 (en) * 1999-11-10 2009-05-19 The Board Of Regents Of The University Of Oklahoma Polymer grafting by polysaccharide synthases
PL399352A1 (pl) * 2001-12-21 2012-10-08 Novozymes Biopharma Dk A/S Sposoby wytwarzania hialuronanu w rekombinowanej komórce gospodarzu
AU2005287397A1 (en) * 2004-06-30 2006-03-30 Paul L. Deangelis Methods of selectively treating diseases with specific glycosaminoglycan polymers

Also Published As

Publication number Publication date
ATE284954T1 (de) 2005-01-15
WO1999023227A3 (en) 1999-08-19
US7060466B2 (en) 2006-06-13
US20030082780A1 (en) 2003-05-01
KR20010031682A (ko) 2001-04-16
CA2307842A1 (en) 1999-05-14
EP1522579A3 (de) 2007-11-07
CN1322121C (zh) 2007-06-20
US6833264B1 (en) 2004-12-21
JP4731013B2 (ja) 2011-07-20
AU762036B2 (en) 2003-06-19
US20060216808A1 (en) 2006-09-28
BR9814834B1 (pt) 2011-08-23
US20060216794A1 (en) 2006-09-28
US20050202540A1 (en) 2005-09-15
CN1283224A (zh) 2001-02-07
DE69828193T2 (de) 2005-12-01
EP1522579A2 (de) 2005-04-13
US7166450B2 (en) 2007-01-23
US6991921B2 (en) 2006-01-31
US7115405B2 (en) 2006-10-03
DK1025211T3 (da) 2005-04-04
WO1999023227A2 (en) 1999-05-14
US20070087416A1 (en) 2007-04-19
CA2307842C (en) 2010-10-19
ES2235378T3 (es) 2005-07-01
US20060216793A1 (en) 2006-09-28
EP1025211B1 (de) 2004-12-15
AU1370699A (en) 1999-05-24
JP2001521741A (ja) 2001-11-13
US7504246B2 (en) 2009-03-17
US20060018924A1 (en) 2006-01-26
US20060013829A1 (en) 2006-01-19
BR9814834A (pt) 2001-07-17
US20030073221A1 (en) 2003-04-17
US7087413B2 (en) 2006-08-08
EP1025211A2 (de) 2000-08-09
US7153677B2 (en) 2006-12-26
AU2003248204A1 (en) 2003-10-30
US7109011B2 (en) 2006-09-19
US7141409B2 (en) 2006-11-28
WO1999023227A9 (en) 2000-07-13

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