DE69828193D1 - Hyaluronan synthase gen und seine verwendung - Google Patents

Hyaluronan synthase gen und seine verwendung

Info

Publication number
DE69828193D1
DE69828193D1 DE69828193T DE69828193T DE69828193D1 DE 69828193 D1 DE69828193 D1 DE 69828193D1 DE 69828193 T DE69828193 T DE 69828193T DE 69828193 T DE69828193 T DE 69828193T DE 69828193 D1 DE69828193 D1 DE 69828193D1
Authority
DE
Germany
Prior art keywords
nucleic acid
hyaluronan synthase
synthase gene
hyaluronan
synthase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69828193T
Other languages
English (en)
Other versions
DE69828193T2 (de
Inventor
H Weigel
Kshama Kumari
Paul Deangelis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Oklahoma
Original Assignee
University of Oklahoma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Oklahoma filed Critical University of Oklahoma
Publication of DE69828193D1 publication Critical patent/DE69828193D1/de
Application granted granted Critical
Publication of DE69828193T2 publication Critical patent/DE69828193T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/832—Bacillus
    • Y10S435/836—Bacillus licheniformis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/832—Bacillus
    • Y10S435/839—Bacillus subtilis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/848—Escherichia
DE69828193T 1997-10-31 1998-10-30 Hyaluronan synthase gen und seine verwendung Expired - Lifetime DE69828193T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6443597P 1997-10-31 1997-10-31
US64435P 1997-10-31
US17885198A 1998-10-26 1998-10-26
US178851 1998-10-26
PCT/US1998/023153 WO1999023227A2 (en) 1997-10-31 1998-10-30 Hyaluronan synthase gene and uses thereof

Publications (2)

Publication Number Publication Date
DE69828193D1 true DE69828193D1 (de) 2005-01-20
DE69828193T2 DE69828193T2 (de) 2005-12-01

Family

ID=26744517

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69828193T Expired - Lifetime DE69828193T2 (de) 1997-10-31 1998-10-30 Hyaluronan synthase gen und seine verwendung

Country Status (13)

Country Link
US (10) US6833264B1 (de)
EP (2) EP1025211B1 (de)
JP (1) JP4731013B2 (de)
KR (1) KR20010031682A (de)
CN (1) CN1322121C (de)
AT (1) ATE284954T1 (de)
AU (2) AU762036B2 (de)
BR (1) BR9814834B1 (de)
CA (1) CA2307842C (de)
DE (1) DE69828193T2 (de)
DK (1) DK1025211T3 (de)
ES (1) ES2235378T3 (de)
WO (1) WO1999023227A2 (de)

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US7060469B2 (en) * 1998-04-02 2006-06-13 The Board Of Regents Of The University Of Oklahoma Polymer grafting by polysaccharide synthases
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US7534589B2 (en) * 1999-11-10 2009-05-19 The Board Of Regents Of The University Of Oklahoma Polymer grafting by polysaccharide synthases
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KR20140058581A (ko) 2011-09-02 2014-05-14 노보자임스 바이오파마 디케이 에이/에스 지연된 약물 방출용 히알루론산 함유 경구 제형
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JP6123018B2 (ja) * 2013-03-15 2017-04-26 ニューテック メディカル インコーポレイテッド 胎盤物質由来の製剤並びにその製造方法及び使用方法
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US7534589B2 (en) 1999-11-10 2009-05-19 The Board Of Regents Of The University Of Oklahoma Polymer grafting by polysaccharide synthases
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Publication number Publication date
EP1522579A2 (de) 2005-04-13
AU762036B2 (en) 2003-06-19
ES2235378T3 (es) 2005-07-01
WO1999023227A3 (en) 1999-08-19
KR20010031682A (ko) 2001-04-16
US7109011B2 (en) 2006-09-19
US7141409B2 (en) 2006-11-28
US7153677B2 (en) 2006-12-26
JP4731013B2 (ja) 2011-07-20
DK1025211T3 (da) 2005-04-04
US20030082780A1 (en) 2003-05-01
EP1025211A2 (de) 2000-08-09
JP2001521741A (ja) 2001-11-13
US7060466B2 (en) 2006-06-13
CN1322121C (zh) 2007-06-20
US20050202540A1 (en) 2005-09-15
US20070087416A1 (en) 2007-04-19
US20060216794A1 (en) 2006-09-28
DE69828193T2 (de) 2005-12-01
EP1522579A3 (de) 2007-11-07
US20060013829A1 (en) 2006-01-19
EP1025211B1 (de) 2004-12-15
AU2003248204A1 (en) 2003-10-30
CN1283224A (zh) 2001-02-07
CA2307842C (en) 2010-10-19
US7115405B2 (en) 2006-10-03
US7166450B2 (en) 2007-01-23
BR9814834A (pt) 2001-07-17
US20060216793A1 (en) 2006-09-28
WO1999023227A2 (en) 1999-05-14
WO1999023227A9 (en) 2000-07-13
US6833264B1 (en) 2004-12-21
US7504246B2 (en) 2009-03-17
ATE284954T1 (de) 2005-01-15
US6991921B2 (en) 2006-01-31
US20060018924A1 (en) 2006-01-26
CA2307842A1 (en) 1999-05-14
US20030073221A1 (en) 2003-04-17
BR9814834B1 (pt) 2011-08-23
AU1370699A (en) 1999-05-24
US7087413B2 (en) 2006-08-08
US20060216808A1 (en) 2006-09-28

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