DE69841028D1 - Vorrichtung zur okularen Iontophorese zur Verabreichung mehrerer Wirkstoffe - Google Patents
Vorrichtung zur okularen Iontophorese zur Verabreichung mehrerer WirkstoffeInfo
- Publication number
- DE69841028D1 DE69841028D1 DE69841028T DE69841028T DE69841028D1 DE 69841028 D1 DE69841028 D1 DE 69841028D1 DE 69841028 T DE69841028 T DE 69841028T DE 69841028 T DE69841028 T DE 69841028T DE 69841028 D1 DE69841028 D1 DE 69841028D1
- Authority
- DE
- Germany
- Prior art keywords
- reservoir
- administration
- electrode
- multiple drugs
- medication
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0432—Anode and cathode
- A61N1/044—Shape of the electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0448—Drug reservoir
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9800009A FR2773320B1 (fr) | 1998-01-05 | 1998-01-05 | Dispositif pour le transfert intraoculaire de produits actifs par iontophorese |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69841028D1 true DE69841028D1 (de) | 2009-09-10 |
Family
ID=9521510
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69841028T Expired - Lifetime DE69841028D1 (de) | 1998-01-05 | 1998-12-17 | Vorrichtung zur okularen Iontophorese zur Verabreichung mehrerer Wirkstoffe |
DE69829637T Expired - Lifetime DE69829637T2 (de) | 1998-01-05 | 1998-12-17 | Vorrichtung zur intraokularen Übertragung von aktiven Wirkstoffen durch Iontophorese |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69829637T Expired - Lifetime DE69829637T2 (de) | 1998-01-05 | 1998-12-17 | Vorrichtung zur intraokularen Übertragung von aktiven Wirkstoffen durch Iontophorese |
Country Status (13)
Country | Link |
---|---|
US (1) | US6154671A (de) |
EP (2) | EP0927560B1 (de) |
JP (1) | JP4308353B2 (de) |
KR (1) | KR100551706B1 (de) |
AT (2) | ATE437672T1 (de) |
BR (1) | BR9900009A (de) |
CA (1) | CA2257749C (de) |
DE (2) | DE69841028D1 (de) |
DK (1) | DK0927560T3 (de) |
ES (2) | ES2327636T3 (de) |
FR (1) | FR2773320B1 (de) |
IL (1) | IL127711A (de) |
PT (1) | PT927560E (de) |
Families Citing this family (80)
Publication number | Priority date | Publication date | Assignee | Title |
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US6101411A (en) * | 1998-09-24 | 2000-08-08 | Newsome; David A. | Dilation enhancer |
US7346389B1 (en) * | 1998-09-24 | 2008-03-18 | Newsome David A | Dilation enhancer with pre-medicated contact lenses |
US7252655B2 (en) | 1999-05-25 | 2007-08-07 | Iomed, Inc. | Ocular iontophoretic apparatus handle |
US6728573B1 (en) | 2000-02-23 | 2004-04-27 | Iomed, Inc. | Ocular iontophoretic apparatus handle |
US6319240B1 (en) * | 1999-05-25 | 2001-11-20 | Iomed, Inc. | Methods and apparatus for ocular iontophoresis |
US6539251B2 (en) | 1999-05-25 | 2003-03-25 | Iomed, Inc. | Ocular iontophoretic apparatus |
US6546283B1 (en) | 2000-10-18 | 2003-04-08 | Iomed, Inc. | High current density iontophoretic device and method of use thereof |
US20030045830A1 (en) * | 2001-04-17 | 2003-03-06 | De Bizemont Therese | Gene therapy with chimeric oligonucleotides delivered by a method comprising a step of iontophoresis |
US7031776B2 (en) * | 2001-06-29 | 2006-04-18 | Optobionics | Methods for improving damaged retinal cell function |
US20050004625A1 (en) * | 2001-06-29 | 2005-01-06 | Chow Alan Y. | Treatment of degenerative retinal disease via electrical stimulation of surface structures |
US20040106965A1 (en) * | 2001-06-29 | 2004-06-03 | Chow Alan Y. | Methods and apparatus for treatment of degenerative retinal disease via indirect electrical stimulation |
US20050033202A1 (en) * | 2001-06-29 | 2005-02-10 | Chow Alan Y. | Mechanically activated objects for treatment of degenerative retinal disease |
DE60219189T2 (de) * | 2001-07-20 | 2008-01-03 | Iomed, Inc., Salt Lake City | Iontophoretische okularvorrichtung zur abgabe von medikamenten auf methotrexat-basis und deren verwendung zur behandlung von neoplastischen, angiogenen, fibroplastischen und/oder immunsuppressiven augenunregelmässigkeiten |
AU2002316724A1 (en) * | 2001-07-20 | 2003-03-03 | Iomed, Inc. | Ophthalmic use of 5 fluorourcil |
FR2830766B1 (fr) | 2001-10-12 | 2004-03-12 | Optis France Sa | Dispositif de delivrance de medicaments par iontophorese transpalpebrale |
FR2830767B1 (fr) * | 2001-10-12 | 2004-03-12 | Optis France Sa | Dispositif de delivrance de medicaments par iontophorese ou electroporation introculaire |
FR2836832B1 (fr) | 2002-03-08 | 2005-02-04 | Optis France Sa | Ensemble de connexion a usage medical pour le transfert de fluides |
WO2003096991A2 (en) | 2002-05-17 | 2003-11-27 | Othera Pharmaceuticals, Inc. | Amelioration of the development of cataracts and other opthalmic diseases |
FR2851912B1 (fr) | 2003-03-03 | 2005-05-13 | Optis France Sa | Connecteur d'alimentation uniforme pour des dispositifs de delivrance de principes actifs |
US7825134B2 (en) * | 2003-05-19 | 2010-11-02 | Othera Holding, Inc. | Amelioration of cataracts, macular degeneration and other ophthalmic diseases |
US7589107B2 (en) | 2003-05-19 | 2009-09-15 | Othera Holding, Inc. | Amelioration of vitrectomy-induced cataracts |
FR2855761B1 (fr) * | 2003-06-03 | 2006-02-24 | Optis France Sa | Dispositif oculaire de delivrance variable de principes actifs par iontophorese |
EP2052720A3 (de) | 2003-11-20 | 2009-05-06 | Othera Holding, Inc. | Verwendung von mindestens einer Hydroxylamin-Verbindung zur Behandlung einer Augenkrankheit |
JP2007521124A (ja) * | 2004-02-06 | 2007-08-02 | シフィックス リミテッド ライアビリティ カンパニー | 電気エネルギー、光エネルギー、および音響エネルギーのうち少なくともいずれか1つを用いる視覚障害の治療 |
BRPI0509334A (pt) | 2004-04-30 | 2007-10-16 | Eyegate Pharma S A | dispositivo de iontoforese ocular, que diminui as irritações |
FR2869531B1 (fr) * | 2004-04-30 | 2006-07-14 | Optis France Sa Sa | Dispositif de iontophorese oculaire diminuant les irritations |
CN1964711A (zh) * | 2004-05-25 | 2007-05-16 | 奥特拉药物公司 | 眼睛选择性药物及前体药物 |
US8246949B2 (en) * | 2004-10-27 | 2012-08-21 | Aciont, Inc. | Methods and devices for sustained in-vivo release of an active agent |
WO2006058189A2 (en) * | 2004-11-23 | 2006-06-01 | Wong Jr Edward K | Medical device for temperature control and treatment of the eye and surrounding tissues |
US8262715B2 (en) * | 2004-11-23 | 2012-09-11 | Eye Delivery System, Llc | Medical device and method for temperature control and treatment of the eye and surrounding tissues via magnetic drug therapy |
US20070282282A1 (en) * | 2004-11-23 | 2007-12-06 | Wong Edward K Jr | Medical device and method for temperature control and treatment of the eye and surrounding tissues |
WO2006072887A1 (en) * | 2005-01-05 | 2006-07-13 | Eyegate Pharma Sa | Ocular iontophoresis device for delivering sirna and aptamers |
JP5000638B2 (ja) * | 2005-04-18 | 2012-08-15 | アンスティテュー・ナシオナル・ドゥ・ラ・サンテ・エ・ドゥ・ラ・ルシェルシュ・メディカル・(イ・エヌ・エス・ウ・エール・エム) | 対象の眼球に対して治療用生成物を送達するための改良型方法及び装置 |
WO2006127592A2 (en) * | 2005-05-26 | 2006-11-30 | Othera Pharmaceuticals, Inc. | Use of hydroxylamine derivates for inhibiting vitrectomy-induced cataracts |
US20070260171A1 (en) * | 2005-09-27 | 2007-11-08 | Higuchi John W | Intraocular iontophoretic device and associated methods |
US8755880B2 (en) * | 2005-10-24 | 2014-06-17 | Aciont, Inc. | Intraocular iontophoretic device and associated methods |
US8634907B2 (en) | 2005-10-24 | 2014-01-21 | Aciont, Inc. | Intraocular iontophoretic device and associated methods |
EP1940507A4 (de) * | 2005-10-24 | 2011-04-20 | Aciont Inc | Intraokulare iontophoretische vorrichtung und relevante verfahren |
FR2893852B1 (fr) * | 2005-11-29 | 2010-09-03 | Eyegate Pharma Sa | Dispositif d'iontophorese oculaire |
US8099162B2 (en) | 2005-11-29 | 2012-01-17 | Eyegate Pharma, S.A.S. | Ocular iontophoresis device |
US20070203190A1 (en) * | 2006-02-22 | 2007-08-30 | Ghanshyam Patil | Hydroxylamines and derivatives for the inhibition of complement activation |
US20070202186A1 (en) | 2006-02-22 | 2007-08-30 | Iscience Interventional Corporation | Apparatus and formulations for suprachoroidal drug delivery |
JPWO2007123142A1 (ja) * | 2006-04-20 | 2009-09-03 | Tti・エルビュー株式会社 | イオントフォレーシス装置 |
US20070299386A1 (en) * | 2006-06-23 | 2007-12-27 | Minu, L.L.C. | Delivery of an ocular agent using iontophoresis |
WO2008013913A2 (en) * | 2006-07-26 | 2008-01-31 | Aciont, Inc. | Method and device for minimally invasive site specific ocular drug delivery |
US8923961B2 (en) | 2006-10-18 | 2014-12-30 | The Cleveland Clinic Foundation | Electrode assembly for delivering a therapeutic agent into ocular tissue |
CA2679066A1 (en) | 2007-02-22 | 2008-08-28 | Othera Holding, Inc. | Hydroxylamine compounds and methods of their use |
US9125807B2 (en) | 2007-07-09 | 2015-09-08 | Incept Llc | Adhesive hydrogels for ophthalmic drug delivery |
US8480638B2 (en) * | 2007-10-04 | 2013-07-09 | Aciont, Inc. | Intraocular iontophoretic device and associated methods |
WO2009076220A1 (en) * | 2007-12-05 | 2009-06-18 | Eyegate Pharma S.A.S. | Methods for delivering sirna via iontophoresis |
WO2009108626A2 (en) * | 2008-02-25 | 2009-09-03 | Eyegate Pharma S.A.S. | Enhanced delivery of a therapeutic to ocular tissues through iontophoresis |
FR2928536B1 (fr) | 2008-03-14 | 2012-04-27 | Inst Nat Sante Rech Med | Dispositif d'injection dans l'oeil |
MX2011006925A (es) * | 2008-12-31 | 2011-07-28 | Eyegate Pharma S A S | Sistema y metodo de iontoforesis ocular con amortiguacion. |
JP5890182B2 (ja) | 2009-02-12 | 2016-03-22 | インセプト エルエルシー | ヒドロゲルプラグによる薬物送達 |
US10413506B2 (en) | 2010-04-03 | 2019-09-17 | Praful Doshi | Medical devices including medicaments and methods of making and using same including enhancing comfort, enhancing drug penetration, and treatment of myopia |
CA2794956C (en) | 2010-04-03 | 2017-05-02 | Praful Doshi | Medical devices including medicaments and methods of making and using same |
CA2803923A1 (en) | 2010-06-25 | 2011-12-29 | Ignacio R. Rodriguez | Methods of treatment using sterculic acid |
US8961501B2 (en) | 2010-09-17 | 2015-02-24 | Incept, Llc | Method for applying flowable hydrogels to a cornea |
EP2648663B1 (de) | 2011-01-12 | 2015-03-25 | Sooft Italia Spa | Vorrichtung für die abgabe von riboflavin mittels iontophorese zur behandlung von keratokonus |
WO2012162459A1 (en) * | 2011-05-26 | 2012-11-29 | Pepose Jay | Device and method for administering eye medications |
US10226417B2 (en) | 2011-09-16 | 2019-03-12 | Peter Jarrett | Drug delivery systems and applications |
KR20190090048A (ko) | 2011-12-05 | 2019-07-31 | 인셉트, 엘엘씨 | 의료용 유기젤 방법 및 조성물 |
CA2940513C (en) | 2013-03-11 | 2023-08-15 | University Of Florida Research Foundation, Inc. | Delivery of card protein as therapy for ocular inflammation |
BR112015027762A2 (pt) | 2013-05-03 | 2017-08-29 | Clearside Biomedical Inc | Aparelho e métodos para injeção ocular |
ITVE20130043A1 (it) * | 2013-07-31 | 2015-02-01 | I A C E R S R L | Dispositivo perfezionato oftalmologico per il trattamento di malattie corneali quali il cheratocono. |
ES2672327T3 (es) * | 2014-01-27 | 2018-06-13 | Opia Technologies | Dispositivo de iontoforesis ocular |
JP5828535B1 (ja) * | 2014-10-10 | 2015-12-09 | 石根 三井 | 矯正角膜クロスリンキング用コンタクトレンズ |
CN104353183B (zh) * | 2014-10-31 | 2016-12-07 | 厦门微科格瑞生物科技有限公司 | 电解液位置固定的可佩戴智能药物导入结构 |
CA2973595A1 (en) * | 2015-01-22 | 2016-07-28 | Eyegate Pharmaceuticals, Inc. | Iontophoretic contact lens |
US10206814B2 (en) * | 2016-01-06 | 2019-02-19 | David R. Hardten | System and method for the delivery of medications or fluids to the eye |
CA3062845A1 (en) | 2016-05-02 | 2017-11-09 | Clearside Biomedical, Inc. | Systems and methods for ocular drug delivery |
WO2018175654A1 (en) | 2017-03-23 | 2018-09-27 | Doheny Eye Institute | Systems, methods, and devices for optical coherence tomgraphy multiple enface angiography averaging |
EP3860703A1 (de) | 2018-10-01 | 2021-08-11 | Biovisics Medical, Inc. | System und verfahren zur gesteuerten elektrischen modulation für sehtherapie |
US11305118B2 (en) | 2018-11-30 | 2022-04-19 | Biovisics Medical, Inc. | Head worn apparatuses for vision therapy |
WO2020146358A1 (en) | 2019-01-09 | 2020-07-16 | Verily Life Sciences Llc | Programmable therapeutic agent delivery from eye mounted device |
US11399976B2 (en) | 2019-01-09 | 2022-08-02 | Twenty Twenty Therapeutics Llc | Eye mounted device for therapeutic agent release |
WO2020210471A1 (en) | 2019-04-10 | 2020-10-15 | Biovisics Medical, Inc. | Systems and interfaces for ocular therapy |
US11511112B2 (en) | 2019-06-14 | 2022-11-29 | Biovisics Medical, Inc. | Wearable medical device |
CN110547907A (zh) * | 2019-08-15 | 2019-12-10 | 中南大学湘雅二医院 | 一种用于眼内手术的双环虹膜扩张器 |
WO2024009535A1 (ja) * | 2022-07-08 | 2024-01-11 | テルモ株式会社 | 眼内薬物投与装置、薬剤リザーバ及び眼内薬物投与装置の動作方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US551880A (en) * | 1895-12-24 | Theodore b | ||
US2525381A (en) * | 1947-09-25 | 1950-10-10 | Tower Paul | Contact-type electrode holder |
US3122137A (en) * | 1961-10-30 | 1964-02-25 | Erlanger Gustav | Device for facilitating iontophoresis treatment of eyes |
SU995783T (en) | 1980-07-21 | 1983-02-15 | Omskij G Med I | A device for drug electrophoresis in ocular tissue |
US4678466A (en) * | 1981-06-25 | 1987-07-07 | Rosenwald Peter L | Internal medication delivery method and vehicle |
US4564016A (en) | 1982-05-24 | 1986-01-14 | The Board Of Trustees Of The Leland Stanford Junior University | Apparatus for introducing ionized drugs into the posterior segment of the eye and method |
US5053000A (en) * | 1985-11-13 | 1991-10-01 | Imperial Chemical Industries Plc | Ocular treatment |
IL86076A (en) * | 1988-04-14 | 1992-12-01 | Inventor S Funding Corp Ltd | Transdermal drug delivery device |
US4955378A (en) * | 1988-05-02 | 1990-09-11 | University Of South Florida | Apparatus and methods for performing electrofusion at specific anatomical sites |
EP0464138A1 (de) * | 1989-03-17 | 1992-01-08 | Candela Laser Corporation | Lasertherapiestrahlgerät für glaukombehandlung |
US5174304A (en) * | 1990-02-16 | 1992-12-29 | Latina Mark A | Electrocycloablation apparatus and method |
US5472436A (en) * | 1994-07-26 | 1995-12-05 | Fremstad; Daria A. | Ocular appliance for delivering medication |
US5522864A (en) * | 1994-10-25 | 1996-06-04 | Wallace; Larry B. | Apparatus and method for ocular treatment |
AUPM982694A0 (en) * | 1994-12-02 | 1995-01-05 | University Of Queensland, The | Iontophoresis method and apparatus |
US5676648A (en) * | 1996-05-08 | 1997-10-14 | The Aps Organization, Llp | Iontophoretic drug delivery apparatus and method for use |
-
1998
- 1998-01-05 FR FR9800009A patent/FR2773320B1/fr not_active Expired - Lifetime
- 1998-12-17 ES ES04011635T patent/ES2327636T3/es not_active Expired - Lifetime
- 1998-12-17 ES ES98403189T patent/ES2236880T3/es not_active Expired - Lifetime
- 1998-12-17 DK DK98403189T patent/DK0927560T3/da active
- 1998-12-17 EP EP98403189A patent/EP0927560B1/de not_active Expired - Lifetime
- 1998-12-17 PT PT98403189T patent/PT927560E/pt unknown
- 1998-12-17 DE DE69841028T patent/DE69841028D1/de not_active Expired - Lifetime
- 1998-12-17 EP EP04011635A patent/EP1452203B1/de not_active Expired - Lifetime
- 1998-12-17 DE DE69829637T patent/DE69829637T2/de not_active Expired - Lifetime
- 1998-12-17 AT AT04011635T patent/ATE437672T1/de not_active IP Right Cessation
- 1998-12-17 AT AT98403189T patent/ATE292493T1/de not_active IP Right Cessation
- 1998-12-23 IL IL12771198A patent/IL127711A/en not_active IP Right Cessation
- 1998-12-28 JP JP37384898A patent/JP4308353B2/ja not_active Expired - Lifetime
- 1998-12-28 KR KR1019980059369A patent/KR100551706B1/ko active IP Right Grant
-
1999
- 1999-01-04 BR BR9900009-1A patent/BR9900009A/pt not_active IP Right Cessation
- 1999-01-04 CA CA002257749A patent/CA2257749C/en not_active Expired - Lifetime
- 1999-01-04 US US09/225,206 patent/US6154671A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DK0927560T3 (da) | 2005-08-15 |
JPH11244323A (ja) | 1999-09-14 |
IL127711A0 (en) | 1999-10-28 |
ATE437672T1 (de) | 2009-08-15 |
IL127711A (en) | 2004-06-20 |
ES2327636T3 (es) | 2009-11-02 |
US6154671A (en) | 2000-11-28 |
EP0927560A1 (de) | 1999-07-07 |
KR100551706B1 (ko) | 2006-07-06 |
PT927560E (pt) | 2005-07-29 |
CA2257749A1 (en) | 1999-07-05 |
ATE292493T1 (de) | 2005-04-15 |
DE69829637T2 (de) | 2006-03-09 |
KR19990066875A (ko) | 1999-08-16 |
DE69829637D1 (de) | 2005-05-12 |
BR9900009A (pt) | 2001-03-20 |
EP1452203B1 (de) | 2009-07-29 |
EP1452203A2 (de) | 2004-09-01 |
FR2773320B1 (fr) | 2000-03-03 |
EP1452203A3 (de) | 2004-09-08 |
FR2773320A1 (fr) | 1999-07-09 |
JP4308353B2 (ja) | 2009-08-05 |
EP0927560B1 (de) | 2005-04-06 |
ES2236880T3 (es) | 2005-07-16 |
CA2257749C (en) | 2009-03-24 |
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