DE69905176T2 - Verfahren zur herstellung von clarithromycinkristallen der form ii - Google Patents

Verfahren zur herstellung von clarithromycinkristallen der form ii

Info

Publication number
DE69905176T2
DE69905176T2 DE69905176T DE69905176T DE69905176T2 DE 69905176 T2 DE69905176 T2 DE 69905176T2 DE 69905176 T DE69905176 T DE 69905176T DE 69905176 T DE69905176 T DE 69905176T DE 69905176 T2 DE69905176 T2 DE 69905176T2
Authority
DE
Germany
Prior art keywords
crystals
clarithromycine
producing
water
clarithromycin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69905176T
Other languages
English (en)
Other versions
DE69905176D1 (de
Inventor
Suk Lee
Cheol Lee
Ik Lee
Sun Lee
Joo Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hanmi Pharmaceutical Co Ltd
Original Assignee
Hanmi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanmi Pharmaceutical Co Ltd filed Critical Hanmi Pharmaceutical Co Ltd
Publication of DE69905176D1 publication Critical patent/DE69905176D1/de
Application granted granted Critical
Publication of DE69905176T2 publication Critical patent/DE69905176T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
DE69905176T 1998-09-09 1999-09-08 Verfahren zur herstellung von clarithromycinkristallen der form ii Expired - Fee Related DE69905176T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-1998-0037181A KR100377159B1 (ko) 1998-09-09 1998-09-09 잔류 용매가 없는 클라리스로마이신의 결정형 2의 제조 방법
PCT/KR1999/000530 WO2000014099A1 (en) 1998-09-09 1999-09-08 Method of preparing form ii crystals of clarithromycin

Publications (2)

Publication Number Publication Date
DE69905176D1 DE69905176D1 (de) 2003-03-06
DE69905176T2 true DE69905176T2 (de) 2003-10-09

Family

ID=19550077

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69905176T Expired - Fee Related DE69905176T2 (de) 1998-09-09 1999-09-08 Verfahren zur herstellung von clarithromycinkristallen der form ii

Country Status (8)

Country Link
US (1) US6506886B1 (de)
EP (1) EP1112280B1 (de)
JP (1) JP3779155B2 (de)
KR (1) KR100377159B1 (de)
AT (1) ATE231879T1 (de)
DE (1) DE69905176T2 (de)
ES (1) ES2192072T3 (de)
WO (1) WO2000014099A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2245398C (en) 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
KR100377159B1 (ko) * 1998-09-09 2003-08-19 한미약품공업 주식회사 잔류 용매가 없는 클라리스로마이신의 결정형 2의 제조 방법
CZ20021999A3 (cs) 1999-12-16 2003-02-12 Teva Pharmaceutical Industries Ltd. Způsob přípravy klaritromycinových polymorfních forem a nového polymorfu IV
HUP0204252A3 (en) 2000-01-11 2003-04-28 Teva Pharma Process for preparing clarithromycin polymorphs and pharmaceutical compositions containing them
US6565882B2 (en) * 2000-02-24 2003-05-20 Advancis Pharmaceutical Corp Antibiotic composition with inhibitor
US6544555B2 (en) 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
HUP0302466A2 (hu) * 2000-02-29 2003-11-28 Teva Pharmaceutical Industries Ltd. Eljárások clarithromycin, clarithromycin intermedier, gyakorlatilag oximmentes clarithromycin és ezt tartalmazó gyógyszerkészítmény előállítására
US6541014B2 (en) * 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
US20020068078A1 (en) * 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
US20020197314A1 (en) * 2001-02-23 2002-12-26 Rudnic Edward M. Anti-fungal composition
KR100408848B1 (ko) * 2001-03-12 2003-12-06 주식회사 씨트리 클래리스로마이신의 정제방법
NZ539801A (en) 2001-05-22 2006-10-27 Pfizer Prod Inc Crystal forms of azithromycin
EP1652851A1 (de) * 2001-05-22 2006-05-03 Pfizer Products Inc. Neue Kristallforme von Azithromycin
US6861413B2 (en) 2001-05-22 2005-03-01 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
WO2005009368A2 (en) * 2003-07-21 2005-02-03 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
WO2005009364A2 (en) * 2003-07-21 2005-02-03 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
JP2006528189A (ja) * 2003-07-21 2006-12-14 アドバンシス ファーマスーティカル コーポレイション 抗生物質産物、その使用法および製剤
EP1653925A1 (de) * 2003-08-11 2006-05-10 Advancis Pharmaceutical Corporation Robustes pellet
CA2535398C (en) 2003-08-12 2013-11-12 Advancis Pharmaceuticals Corporation Antibiotic product, use and formulation thereof
US8246996B2 (en) * 2003-08-29 2012-08-21 Shionogi Inc. Antibiotic product, use and formulation thereof
CA2538064C (en) * 2003-09-15 2013-12-17 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
AU2004308419B2 (en) * 2003-12-24 2011-06-02 Victory Pharma, Inc. Enhanced absorption of modified release dosage forms
WO2006014427A1 (en) * 2004-07-02 2006-02-09 Advancis Pharmaceutical Corporation Tablet for pulsed delivery
EP1904041A2 (de) * 2005-07-07 2008-04-02 Elan Pharma International Limited Nanopartikuläre clarithromycinformulierung
US8357394B2 (en) 2005-12-08 2013-01-22 Shionogi Inc. Compositions and methods for improved efficacy of penicillin-type antibiotics
US8299052B2 (en) 2006-05-05 2012-10-30 Shionogi Inc. Pharmaceutical compositions and methods for improved bacterial eradication
CN103087130B (zh) * 2013-02-06 2015-12-23 浙江国邦药业有限公司 一种克拉霉素晶型转换方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5187140A (en) * 1989-10-18 1993-02-16 Union Carbide Chemicals & Plastics Technology Corporation Alkylene oxide catalysts containing high silver content
US5844105A (en) * 1996-07-29 1998-12-01 Abbott Laboratories Preparation of crystal form II of clarithromycin
US5858986A (en) * 1996-07-29 1999-01-12 Abbott Laboratories Crystal form I of clarithromycin
EP0915899B1 (de) * 1996-07-29 2004-08-04 Abbott Laboratories Herstellung von kristallinen form ii von clarithromycin
US5945405A (en) * 1997-01-17 1999-08-31 Abbott Laboratories Crystal form O of clarithromycin
KR100377159B1 (ko) * 1998-09-09 2003-08-19 한미약품공업 주식회사 잔류 용매가 없는 클라리스로마이신의 결정형 2의 제조 방법

Also Published As

Publication number Publication date
WO2000014099A1 (en) 2000-03-16
DE69905176D1 (de) 2003-03-06
EP1112280B1 (de) 2003-01-29
JP2002524465A (ja) 2002-08-06
ES2192072T3 (es) 2003-09-16
KR100377159B1 (ko) 2003-08-19
EP1112280A1 (de) 2001-07-04
KR20000019206A (ko) 2000-04-06
JP3779155B2 (ja) 2006-05-24
ATE231879T1 (de) 2003-02-15
US6506886B1 (en) 2003-01-14

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee