DE69906445D1 - Dihydro- und Tetrahydrochinolinderivate als medizinisches Antioxydans - Google Patents
Dihydro- und Tetrahydrochinolinderivate als medizinisches AntioxydansInfo
- Publication number
- DE69906445D1 DE69906445D1 DE69906445T DE69906445T DE69906445D1 DE 69906445 D1 DE69906445 D1 DE 69906445D1 DE 69906445 T DE69906445 T DE 69906445T DE 69906445 T DE69906445 T DE 69906445T DE 69906445 D1 DE69906445 D1 DE 69906445D1
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- optionally substituted
- cycloalkyl
- aryl
- heterocycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
- C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9813306A FR2784988B1 (fr) | 1998-10-23 | 1998-10-23 | Nouveaux composes dihydro et tetrahydroquinoleiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR9813306 | 1998-10-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69906445D1 true DE69906445D1 (de) | 2003-05-08 |
| DE69906445T2 DE69906445T2 (de) | 2004-04-08 |
Family
ID=9531911
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69906445T Expired - Fee Related DE69906445T2 (de) | 1998-10-23 | 1999-10-22 | Dihydro- und Tetrahydrochinolinderivate als medizinisches Antioxydans |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6350759B1 (de) |
| EP (1) | EP0995743B1 (de) |
| JP (1) | JP3159971B2 (de) |
| KR (1) | KR100421074B1 (de) |
| CN (1) | CN1255493A (de) |
| AT (1) | ATE236129T1 (de) |
| AU (1) | AU753044B2 (de) |
| BR (1) | BR9905587A (de) |
| CA (1) | CA2287046C (de) |
| DE (1) | DE69906445T2 (de) |
| DK (1) | DK0995743T3 (de) |
| EA (1) | EA003272B1 (de) |
| ES (1) | ES2196742T3 (de) |
| FR (1) | FR2784988B1 (de) |
| NO (1) | NO313590B1 (de) |
| NZ (1) | NZ500574A (de) |
| PL (1) | PL336139A1 (de) |
| PT (1) | PT995743E (de) |
| SI (1) | SI0995743T1 (de) |
| ZA (1) | ZA996667B (de) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6703384B2 (en) | 1998-09-23 | 2004-03-09 | Research Development Foundation | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof |
| IL151108A0 (en) * | 2000-02-11 | 2003-04-10 | Res Dev Foundation | Tocopherols, tocotrienols, other chroman and chain derivatives and uses thereof |
| AU2002243228B2 (en) * | 2000-11-16 | 2007-08-02 | The Regents Of The University Of California | Marine actinomycete taxon for drug and fermentation product discovery |
| KR100488444B1 (ko) * | 2001-12-31 | 2005-05-11 | 한국과학기술연구원 | 퀴놀론 유도체 및 그 제조 방법 |
| US7176232B2 (en) | 2002-06-24 | 2007-02-13 | The Regents Of The University Of California | Salinosporamides and methods for use thereof |
| US7919497B2 (en) | 2002-08-02 | 2011-04-05 | Nereus Pharmaceuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
| US7935704B2 (en) * | 2003-08-01 | 2011-05-03 | Nereus Pharmaceuticals, Inc. | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof |
| ES2295695T3 (es) * | 2002-08-02 | 2008-04-16 | Nereus Pharmaceuticals, Inc. | Deshidrofenilahistinas y sus analogos y la sintesis de deshidrofenilahistinas y sus analogos. |
| US7112581B2 (en) * | 2002-09-27 | 2006-09-26 | Nereus Pharmaceuticals, Inc. | Macrocyclic lactams |
| US20070037848A1 (en) * | 2003-04-03 | 2007-02-15 | Masters Colin L | Treatment of neurological conditions |
| CN1823070A (zh) * | 2003-06-20 | 2006-08-23 | 加利福尼亚大学董事会 | 盐孢菌酰胺及其使用方法 |
| KR20060026052A (ko) * | 2003-06-20 | 2006-03-22 | 니리어스 파마슈티컬즈, 인코퍼레이션 | 암, 염증 및 감염성 질환의 치료를 위한 [3.2.0]헤테로사이클릭 화합물 및 그 유사체의 사용방법 |
| BRPI0506535A (pt) | 2004-01-23 | 2007-02-27 | Nereus Pharmaceuticals Inc | pirroles bis-indole úteis como agentes anti-microbiais |
| BRPI0509824A (pt) * | 2004-04-30 | 2007-10-09 | Nereus Pharmaceuticals Inc | compostos heterocìclicos [3.2.0] e métodos de uso dos mesmos |
| US7579371B2 (en) | 2004-04-30 | 2009-08-25 | Nereus Pharmaceuticals, Inc. | Methods of using [3.2.0] heterocyclic compounds and analogs thereof |
| BRPI0517135B1 (pt) | 2004-12-03 | 2022-04-19 | Triphase Research And Development I Corp | Composições e métodos para tratar doenças neoplásticas |
| BRPI0519013A2 (pt) * | 2004-12-13 | 2009-11-03 | Lilly Co Eli | composto ou esteroisÈmeros únicos, misturas de esteroisÈmeros, sais, tautÈmeros ou pró-drogas destes farmaceuticamente aceitáveis, composição farmacêutica, e, uso de um composto |
| WO2007117591A2 (en) | 2006-04-06 | 2007-10-18 | Nereus Pharmaceuticals, Inc. | Total synthesis of salinosporamide a and analogs thereof |
| US8129527B2 (en) * | 2006-11-03 | 2012-03-06 | Nereus Pharmacuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
| WO2008095195A2 (en) * | 2007-02-02 | 2008-08-07 | Nereus Pharmaceuticals, Inc. | Lyophilized formulations of salinosporamide a |
| TWI366565B (en) * | 2007-06-06 | 2012-06-21 | Otsuka Pharma Co Ltd | Quinolone compound and pharmaceutical composition |
| US8394816B2 (en) * | 2007-12-07 | 2013-03-12 | Irene Ghobrial | Methods of using [3.2.0] heterocyclic compounds and analogs thereof in treating Waldenstrom's Macroglobulinemia |
| CA2723465A1 (en) | 2008-05-12 | 2009-11-19 | Nereus Pharmaceuticals, Inc. | Proteasome inhibitors |
| JP5247667B2 (ja) * | 2008-12-05 | 2013-07-24 | 大塚製薬株式会社 | 医薬 |
| KR101053329B1 (ko) | 2009-07-09 | 2011-08-01 | 삼성전기주식회사 | 세라믹 전자부품 |
| CN102958919A (zh) * | 2010-07-02 | 2013-03-06 | 霍夫曼-拉罗奇有限公司 | 新的四氢喹啉衍生物 |
| CN103159676B (zh) * | 2011-12-16 | 2015-07-15 | 卢忠林 | 一种式i化合物的制备方法 |
| US8835643B2 (en) | 2012-02-23 | 2014-09-16 | Empire Technology Development Llc | Molecules, compositions, and methods for light absorption |
| JP2017531033A (ja) | 2014-09-14 | 2017-10-19 | アヴェニール ファーマシューティカルズ， インコーポレイテッド | 認知症における激越の処置のためのデキストロメトルファン化合物およびキニジンを含む医薬組成物 |
| MY194341A (en) | 2015-03-06 | 2022-11-29 | Beyondspring Pharmaceuticals Inc | Method of treating a brain tumor |
| AU2016229294B2 (en) | 2015-03-06 | 2021-11-04 | Beyondspring Pharmaceuticals, Inc. | Method of treating cancer associated with a RAS mutation |
| US10155748B2 (en) | 2015-07-13 | 2018-12-18 | Beyondspring Pharmaceuticals, Inc. | Plinabulin compositions |
| RU2753543C1 (ru) | 2016-02-08 | 2021-08-17 | Бейондспринг Фармасьютикалс, Инк. | Композиции, содержащие тукаресол или его аналоги |
| CN107304184A (zh) * | 2016-04-18 | 2017-10-31 | 诺华丝国际股份有限公司 | 用于从取代的1,2‑二氢喹啉除去污染物的方法 |
| JP7025416B2 (ja) | 2016-06-06 | 2022-02-24 | ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド | 好中球減少症を低減させるための組成物および方法 |
| US11633393B2 (en) | 2017-01-06 | 2023-04-25 | Beyondspring Pharmaceuticals, Inc. | Tubulin binding compounds and therapeutic use thereof |
| WO2018144764A1 (en) | 2017-02-01 | 2018-08-09 | Beyondspring Pharmaceuticals, Inc. | Method of reducing neutropenia |
| CN109553575B (zh) * | 2017-09-27 | 2022-06-03 | 泰兴瑞泰化工有限公司 | 一种高纯乙氧基喹啉的吸附除杂方法 |
| SG11202006985TA (en) | 2018-01-24 | 2020-08-28 | Beyondspring Pharmaceuticals Inc | Composition and method for reducing thrombocytopenia via the administration of plinabulin |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3331846A (en) * | 1963-08-28 | 1967-07-18 | Lilly Co Eli | Metal catalyst process for converting alpha-amino-acetylenes to dihydroquinoline |
| IL51342A (en) * | 1977-01-27 | 1980-11-30 | Abic Ltd | Ethoxyquin derivatives,their preparation and pharmaceutical and veterinary compositions comprising them |
| GB8816269D0 (en) * | 1988-07-08 | 1988-08-10 | Int Assn Of Fish Meal Manufact | Compounds for use as anti-oxidants in fish meal/fish oil |
| US5696127A (en) * | 1994-12-22 | 1997-12-09 | Ligand Pharmaceuticals Incorporated | Steroid receptor modulator compounds and methods |
| JPH09301953A (ja) * | 1996-03-12 | 1997-11-25 | Sanwa Kagaku Kenkyusho Co Ltd | マロン酸ジアミド誘導体及びその用途 |
-
1998
- 1998-10-23 FR FR9813306A patent/FR2784988B1/fr not_active Expired - Fee Related
-
1999
- 1999-10-20 CA CA002287046A patent/CA2287046C/fr not_active Expired - Fee Related
- 1999-10-21 JP JP29930399A patent/JP3159971B2/ja not_active Expired - Fee Related
- 1999-10-21 PL PL99336139A patent/PL336139A1/xx not_active Application Discontinuation
- 1999-10-22 DK DK99402624T patent/DK0995743T3/da active
- 1999-10-22 NZ NZ500574A patent/NZ500574A/en unknown
- 1999-10-22 AT AT99402624T patent/ATE236129T1/de not_active IP Right Cessation
- 1999-10-22 ES ES99402624T patent/ES2196742T3/es not_active Expired - Lifetime
- 1999-10-22 SI SI9930251T patent/SI0995743T1/xx unknown
- 1999-10-22 US US09/425,267 patent/US6350759B1/en not_active Expired - Fee Related
- 1999-10-22 CN CN99125591A patent/CN1255493A/zh active Pending
- 1999-10-22 EP EP99402624A patent/EP0995743B1/de not_active Expired - Lifetime
- 1999-10-22 PT PT99402624T patent/PT995743E/pt unknown
- 1999-10-22 BR BR9905587-2A patent/BR9905587A/pt not_active IP Right Cessation
- 1999-10-22 ZA ZA9906667A patent/ZA996667B/xx unknown
- 1999-10-22 AU AU56009/99A patent/AU753044B2/en not_active Ceased
- 1999-10-22 NO NO19995175A patent/NO313590B1/no not_active IP Right Cessation
- 1999-10-22 EA EA199900865A patent/EA003272B1/ru not_active IP Right Cessation
- 1999-10-22 DE DE69906445T patent/DE69906445T2/de not_active Expired - Fee Related
- 1999-10-23 KR KR10-1999-0046162A patent/KR100421074B1/ko not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO995175L (no) | 2000-04-25 |
| ATE236129T1 (de) | 2003-04-15 |
| NO995175D0 (no) | 1999-10-22 |
| EP0995743A1 (de) | 2000-04-26 |
| ES2196742T3 (es) | 2003-12-16 |
| KR100421074B1 (ko) | 2004-03-04 |
| BR9905587A (pt) | 2001-12-11 |
| NZ500574A (en) | 2000-08-25 |
| CN1255493A (zh) | 2000-06-07 |
| KR20000029268A (ko) | 2000-05-25 |
| NO313590B1 (no) | 2002-10-28 |
| CA2287046C (fr) | 2003-12-02 |
| ZA996667B (en) | 2000-05-02 |
| PT995743E (pt) | 2003-07-31 |
| FR2784988B1 (fr) | 2002-09-20 |
| FR2784988A1 (fr) | 2000-04-28 |
| US6350759B1 (en) | 2002-02-26 |
| CA2287046A1 (fr) | 2000-04-23 |
| JP2000128865A (ja) | 2000-05-09 |
| DK0995743T3 (da) | 2003-07-21 |
| AU5600999A (en) | 2000-05-04 |
| EA199900865A2 (ru) | 2000-04-24 |
| EP0995743B1 (de) | 2003-04-02 |
| SI0995743T1 (en) | 2003-08-31 |
| JP3159971B2 (ja) | 2001-04-23 |
| EA199900865A3 (ru) | 2000-10-30 |
| DE69906445T2 (de) | 2004-04-08 |
| AU753044B2 (en) | 2002-10-03 |
| PL336139A1 (en) | 2000-04-25 |
| EA003272B1 (ru) | 2003-02-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |