DE69912262D1 - Retinolhaltiges arzneimittel kompatibel mit weichgelatinekapseln - Google Patents

Retinolhaltiges arzneimittel kompatibel mit weichgelatinekapseln

Info

Publication number
DE69912262D1
DE69912262D1 DE69912262T DE69912262T DE69912262D1 DE 69912262 D1 DE69912262 D1 DE 69912262D1 DE 69912262 T DE69912262 T DE 69912262T DE 69912262 T DE69912262 T DE 69912262T DE 69912262 D1 DE69912262 D1 DE 69912262D1
Authority
DE
Germany
Prior art keywords
retinoled
compatible
soft gel
gel capsules
medicine compatible
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69912262T
Other languages
English (en)
Other versions
DE69912262T2 (de
Inventor
A Rinaldi
C Tutschek
J Saxena
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RP Scherer Technologies LLC
Original Assignee
RP Scherer Technologies LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/062,138 external-priority patent/US5891470A/en
Application filed by RP Scherer Technologies LLC filed Critical RP Scherer Technologies LLC
Publication of DE69912262D1 publication Critical patent/DE69912262D1/de
Application granted granted Critical
Publication of DE69912262T2 publication Critical patent/DE69912262T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
DE69912262T 1998-04-17 1999-04-16 Retinolhaltiges arzneimittel kompatibel mit weichgelatinekapseln Expired - Lifetime DE69912262T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US62138 1998-04-17
US09/062,138 US5891470A (en) 1998-04-17 1998-04-17 Softgel formulation containing retinol
US09/272,893 US6228894B1 (en) 1998-04-17 1999-03-19 Softgel-compatible composition containing retinol
US272893 1999-03-19
PCT/US1999/008559 WO1999053904A2 (en) 1998-04-17 1999-04-16 Softgel-compatible composition containing retinol

Publications (2)

Publication Number Publication Date
DE69912262D1 true DE69912262D1 (de) 2003-11-27
DE69912262T2 DE69912262T2 (de) 2004-08-26

Family

ID=26741915

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69912262T Expired - Lifetime DE69912262T2 (de) 1998-04-17 1999-04-16 Retinolhaltiges arzneimittel kompatibel mit weichgelatinekapseln

Country Status (11)

Country Link
US (1) US6228894B1 (de)
EP (1) EP1071404B1 (de)
JP (1) JP4338894B2 (de)
AT (1) ATE252376T1 (de)
AU (1) AU765268B2 (de)
BR (1) BR9910129A (de)
CA (1) CA2328945C (de)
DE (1) DE69912262T2 (de)
ES (1) ES2211075T3 (de)
MX (1) MXPA00010116A (de)
WO (1) WO1999053904A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9803936A (pt) * 1998-09-08 2000-04-04 Cosmeticos Natural Ind Com Processo e composição para aumentar a ação de vitamina a na atividade celular de um indivìduo e uso de vitamina c.
US6468516B1 (en) * 1999-03-19 2002-10-22 Warner-Lambert Company Composition and manufacture of topical pharmaceutical and cosmetic semi-solid post-foaming dosage forms in a pouch
AU2001257534A1 (en) * 2000-05-05 2001-11-20 R.P. Scherer Technologies, Inc. Oil-in-water emulsion formulation containing hydroquinone and retinol
EP1269994A3 (de) * 2001-06-22 2003-02-12 Pfizer Products Inc. Pharmazeutische Zusammensetzungen die ein Arzneimittel und die Konzentration verbesserende Polymere enthalten
JP2003104827A (ja) * 2001-09-28 2003-04-09 Kose Corp 化粧料
US20030232091A1 (en) * 2002-06-17 2003-12-18 Adi Shefer Stabilized retinol for cosmetic dermatological, and pharmaceutical compositions, and use thereof
AU2002358337A1 (en) * 2002-12-18 2004-07-09 Coreana Cosmetics Co., Ltd. Novel retinol derivative and cosmetic composition comprising the same
US20050031699A1 (en) 2003-06-26 2005-02-10 L'oreal Porous particles loaded with cosmetically or pharmaceutically active compounds
US8920918B2 (en) * 2005-10-31 2014-12-30 Kee Action Sports Technology Holdings, Llc Oil and polyethylene glycol fill material for use in paintball shells
PE20081482A1 (es) * 2006-12-20 2008-12-23 Novartis Ag Capsulas de gelatina que contienen un acido
MX2010008287A (es) * 2008-02-01 2010-08-31 Amcol International Corp Composicion mejorada, aclaradora de la piel.
FR2931662B1 (fr) * 2008-05-30 2010-07-30 Galderma Res & Dev Nouvelles compositions depigmentantes sous forme d'une composition anhydre sans vaseline et sans elastomere comprenant un derive phenolique solubilise.
FR2931661B1 (fr) * 2008-05-30 2010-07-30 Galderma Res & Dev Nouvelles compositions depigmentantes sous forme d'une composition anhydre sans vaseline et sans elastomere comprenant un derive phenolique solubilise et un retinoide.
EP2334286A1 (de) * 2008-09-12 2011-06-22 Amcol International Corporation Topische retinoidzusammensetzungen mit niedrigem ph-wert
US20100064927A1 (en) * 2008-09-17 2010-03-18 Aldo Perrone Starch-based paintball fill material
US9180112B2 (en) * 2010-03-23 2015-11-10 Ermis Labs, LLC Dermal compositions containing gorgonian extract
KR101080186B1 (ko) * 2010-06-21 2011-11-07 주식회사 필라이트솔루션 개량형 ｌｅｄ 조명등
WO2015115072A1 (ja) * 2014-01-31 2015-08-06 富士カプセル株式会社 カプセル製剤
DE102018201522A1 (de) * 2018-02-01 2019-08-01 Beiersdorf Ag Kosmetisches Produkt umfassend einen Spender und eine wasserfreie kosmetische Zubereitung

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4369180A (en) 1981-09-10 1983-01-18 Randolph C. Karrh Cosmetic facial preparation containing aloe vera
US4826828A (en) 1985-04-22 1989-05-02 Avon Products, Inc. Composition and method for reducing wrinkles
US4690825A (en) 1985-10-04 1987-09-01 Advanced Polymer Systems, Inc. Method for delivering an active ingredient by controlled time release utilizing a novel delivery vehicle which can be prepared by a process utilizing the active ingredient as a porogen
US5145675A (en) 1986-03-31 1992-09-08 Advanced Polymer Systems, Inc. Two step method for preparation of controlled release formulations
JP2622955B2 (ja) 1986-07-29 1997-06-25 エイボン プロダクツ インコ−ポレイテツド 無水化粧品
ZA886284B (en) * 1987-08-31 1990-04-25 Advanced Polymer Systems Inc Controlled release formulations
ZA892859B (en) 1988-04-22 1989-12-27 Advanced Polymer Systems Inc Porous particles in preparations involving immiscible phases
US4873091A (en) 1988-05-23 1989-10-10 Advanced Polymer Systems, Inc. Controlled release formulating employing resilient microbeads
US5055300A (en) 1988-06-17 1991-10-08 Basic Bio Systems, Inc. Time release protein
US5073365A (en) 1989-06-01 1991-12-17 Advanced Polymer Systems Clinical and personal care articles enhanced by lubricants and adjuvants
US5559149A (en) 1990-01-29 1996-09-24 Johnson & Johnson Consumer Products, Inc. Skin care compositions containing retinoids
AU639063B2 (en) 1990-01-29 1993-07-15 Johnson & Johnson Consumer Products, Inc. Skin care compositions
US5082661A (en) 1990-09-26 1992-01-21 Elizabeth Arden Co., Division Of Conopco, Inc. Odorless cosmetic compositions in gelatin capsules
BR9106891A (pt) 1991-06-27 1994-06-14 Johnson & Johnson Consumer Composiçoes para o tratamento da pele
GR1002207B (en) 1992-08-06 1996-03-27 Johnson & Johnson Consumer Skin care compositions containing imidazoles.
US5516793A (en) * 1993-04-26 1996-05-14 Avon Products, Inc. Use of ascorbic acid to reduce irritation of topically applied active ingredients
US5587149A (en) 1995-02-06 1996-12-24 R.P. Scherer Corporation Topical application emulsions
FR2737122B1 (fr) 1995-07-25 1997-09-12 Oreal Composition stable contenant de l'acide ascorbique
US5851538A (en) 1995-12-29 1998-12-22 Advanced Polymer Systems, Inc. Retinoid formulations in porous microspheres for reduced irritation and enhanced stability
US5750123A (en) 1996-06-28 1998-05-12 Chesebrough-Pond's Co., Division Of Conopco, Inc. Vitamin C delivery system
CA2270073A1 (en) 1997-09-16 1999-03-25 E-L Management Corp. Stable anhydrous formulation
US6017549A (en) 1997-09-30 2000-01-25 E-L Management Corp. Non-irritating cosmetic and pharmaceutical compositions
US6194452B1 (en) 1997-11-07 2001-02-27 Howard Murad Stable pharmaceutical compositions including ascorbic acid and methods of using same
US5891470A (en) * 1998-04-17 1999-04-06 Advanced Polymer Systems, Inc. Softgel formulation containing retinol

Also Published As

Publication number Publication date
JP4338894B2 (ja) 2009-10-07
AU3653299A (en) 1999-11-08
JP2002512184A (ja) 2002-04-23
WO1999053904A3 (en) 1999-12-23
ATE252376T1 (de) 2003-11-15
CA2328945C (en) 2007-07-03
EP1071404A2 (de) 2001-01-31
US6228894B1 (en) 2001-05-08
MXPA00010116A (es) 2002-08-06
WO1999053904A2 (en) 1999-10-28
CA2328945A1 (en) 1999-10-28
ES2211075T3 (es) 2004-07-01
BR9910129A (pt) 2001-01-09
AU765268B2 (en) 2003-09-11
DE69912262T2 (de) 2004-08-26
EP1071404B1 (de) 2003-10-22

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