DE69914770D1 - Mitochondriale, als tumormarker geeignete mutationen, die nur ein basenpaar betreffen - Google Patents

Mitochondriale, als tumormarker geeignete mutationen, die nur ein basenpaar betreffen

Info

Publication number
DE69914770D1
DE69914770D1 DE69914770T DE69914770T DE69914770D1 DE 69914770 D1 DE69914770 D1 DE 69914770D1 DE 69914770 T DE69914770 T DE 69914770T DE 69914770 T DE69914770 T DE 69914770T DE 69914770 D1 DE69914770 D1 DE 69914770D1
Authority
DE
Germany
Prior art keywords
tumors
affect
base pair
mitochondrial mutations
mutations suitable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69914770T
Other languages
English (en)
Other versions
DE69914770T2 (de
Inventor
Bert Vogelstein
W Kinzler
Kornelia Polyak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johns Hopkins University
School of Medicine of Johns Hopkins University
Original Assignee
Johns Hopkins University
School of Medicine of Johns Hopkins University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johns Hopkins University, School of Medicine of Johns Hopkins University filed Critical Johns Hopkins University
Application granted granted Critical
Publication of DE69914770D1 publication Critical patent/DE69914770D1/de
Publication of DE69914770T2 publication Critical patent/DE69914770T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
DE69914770T 1998-08-20 1999-08-20 Mitochondriale, als tumormarker geeignete mutationen, die nur ein basenpaar betreffen Expired - Lifetime DE69914770T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9730798P 1998-08-20 1998-08-20
US97307P 1998-08-20
PCT/US1999/018775 WO2000011219A1 (en) 1998-08-20 1999-08-20 Subtle mitochondrial mutations as tumor markers

Publications (2)

Publication Number Publication Date
DE69914770D1 true DE69914770D1 (de) 2004-03-18
DE69914770T2 DE69914770T2 (de) 2005-05-12

Family

ID=22262720

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69914770T Expired - Lifetime DE69914770T2 (de) 1998-08-20 1999-08-20 Mitochondriale, als tumormarker geeignete mutationen, die nur ein basenpaar betreffen

Country Status (9)

Country Link
US (2) US6344322B1 (de)
EP (1) EP1104492B1 (de)
JP (1) JP2002523061A (de)
AT (1) ATE259425T1 (de)
AU (1) AU773956B2 (de)
CA (1) CA2340175A1 (de)
DE (1) DE69914770T2 (de)
NO (1) NO20010843L (de)
WO (1) WO2000011219A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
EP1104492B1 (de) * 1998-08-20 2004-02-11 The Johns Hopkins University School Of Medicine Mitochondriale, als tumormarker geeignete mutationen, die nur ein basenpaar betreffen
US6605433B1 (en) 1998-08-20 2003-08-12 The Johns Hopkins University Mitochondrial dosimeter
US6759196B2 (en) * 2000-02-23 2004-07-06 Childrens Hospital Los Angeles Method of detecting mitochondrial dysfunction
AU2001262943A1 (en) * 2000-04-14 2001-10-30 Metabolon, Inc. Methods for drug discovery, disease treatment, and diagnosis using metabolomics
US7329489B2 (en) * 2000-04-14 2008-02-12 Matabolon, Inc. Methods for drug discovery, disease treatment, and diagnosis using metabolomics
US20070190534A1 (en) * 2001-06-11 2007-08-16 Genesis Genomics Inc. Mitochondrial sites and genes associated with prostate cancer
WO2005056573A1 (en) * 2002-06-10 2005-06-23 1304854 Ontario Ltd. Complete mitochondrial genome sequences as a diagnostic tool for the health sciences
CA2356540A1 (en) * 2001-08-30 2003-02-28 Emory University Expressed dna sequences involved in mitochondrial functions
JP2003116576A (ja) * 2001-10-17 2003-04-22 Gifu International Institute Of Biotechnology ヒトミトコンドリアｄｎａを用いた遺伝子検出方法
US7255993B1 (en) 2002-11-06 2007-08-14 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Detection of mutational frequency and related methods
US20080268433A1 (en) * 2004-04-27 2008-10-30 Flinders Technologies Pty. Ltd Use of Mitochondrial Point Mutations as Sensitive Clonal Markers
EP1652935A1 (de) * 2004-10-29 2006-05-03 PrimaGen Holding B.V. Verfahren zur Bestimmung des Gesundheitsstatus eines Individuums durch die Verwendung von mitochondrialen Nukleinsäuren
WO2006062389A2 (en) 2004-10-29 2006-06-15 Primagen Holding B.V. Methods using mitochondrial nucleic acid for determining a health status of an individual
WO2006076153A2 (en) * 2005-01-10 2006-07-20 Emory University Inherited mitochondrial dna mutations in cancer
DE602006017534D1 (de) 2005-04-18 2010-11-25 Mitomics Inc Mitochondriale mutationen und umlagerungen als diagnostisches werkzeug zum nachweis von sonneneinstrahlung, prostatakrebs und anderen krebserkrankungen
US20130022979A1 (en) 2005-04-18 2013-01-24 Genesis Genomics Inc. 3.4kb MITOCHONDRIAL DNA DELETION FOR USE IN THE DETECTION OF CANCER
US8849577B2 (en) * 2006-09-15 2014-09-30 Metabolon, Inc. Methods of identifying biochemical pathways
KR100789475B1 (ko) 2006-11-20 2008-01-02 전남대학교산학협력단 실시간중합효소연쇄반응 및 유전자 스캔을 이용한미토콘드리아 ＤＮＡ 4977 ｂｐ 거대결손의 정량적검출방법, 시발체 및 키트
EP2873799B1 (de) 2013-11-18 2017-06-14 Sandvik Intellectual Property AB Bohrhammer-Hammerbohrmeißelanordnung
WO2017049180A1 (en) 2015-09-18 2017-03-23 Agena Bioscience, Inc. Methods and compositions for the quantitation of mitochondrial nucleic acid

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3919293A (en) * 1992-03-27 1993-11-08 University Of Maryland At Baltimore Detection of gene mutations with mismatch repair enzymes
US6025127A (en) * 1994-01-14 2000-02-15 The Johns Hopkins University School Of Medicine Nucleic acid mutation detection in histologic tissue
EP0779935A4 (de) * 1994-08-31 2006-07-19 Univ Johns Hopkins Med Die bestimmung von schnell mutierenden nukleinsäuresequenzen im gewebe
US5879890A (en) * 1997-01-31 1999-03-09 The Johns Hopkins University APC mutation associated with familial colorectal cancer in Ashkenazi jews
EP1104492B1 (de) * 1998-08-20 2004-02-11 The Johns Hopkins University School Of Medicine Mitochondriale, als tumormarker geeignete mutationen, die nur ein basenpaar betreffen

Also Published As

Publication number Publication date
DE69914770T2 (de) 2005-05-12
ATE259425T1 (de) 2004-02-15
AU5677899A (en) 2000-03-14
US6344322B1 (en) 2002-02-05
US20020164622A1 (en) 2002-11-07
EP1104492B1 (de) 2004-02-11
US6750021B2 (en) 2004-06-15
WO2000011219A9 (en) 2001-04-26
NO20010843D0 (no) 2001-02-19
JP2002523061A (ja) 2002-07-30
CA2340175A1 (en) 2000-03-02
EP1104492A1 (de) 2001-06-06
NO20010843L (no) 2001-04-18
WO2000011219A1 (en) 2000-03-02
AU773956B2 (en) 2004-06-10

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Legal Events

Date Code Title Description
8332 No legal effect for de
8370 Indication related to discontinuation of the patent is to be deleted
8364 No opposition during term of opposition