DE69925624D1 - Nukleinsäure-markierungsverbindungen - Google Patents
Nukleinsäure-markierungsverbindungenInfo
- Publication number
- DE69925624D1 DE69925624D1 DE69925624T DE69925624T DE69925624D1 DE 69925624 D1 DE69925624 D1 DE 69925624D1 DE 69925624 T DE69925624 T DE 69925624T DE 69925624 T DE69925624 T DE 69925624T DE 69925624 D1 DE69925624 D1 DE 69925624D1
- Authority
- DE
- Germany
- Prior art keywords
- nucleic acid
- acid marking
- marking connections
- connections
- heterocyclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/12—Triazine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/126,645 US20010018514A1 (en) | 1998-07-31 | 1998-07-31 | Nucleic acid labeling compounds |
US126645 | 1998-07-31 | ||
PCT/US1999/012390 WO2000006771A2 (en) | 1998-07-31 | 1999-07-20 | Nucleic acid labeling compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69925624D1 true DE69925624D1 (de) | 2005-07-07 |
DE69925624T2 DE69925624T2 (de) | 2006-04-27 |
Family
ID=22425958
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69925624T Expired - Lifetime DE69925624T2 (de) | 1998-07-31 | 1999-07-20 | Nukleinsäure-markierungsverbindungen |
Country Status (8)
Country | Link |
---|---|
US (5) | US20010018514A1 (de) |
EP (2) | EP1124838B1 (de) |
JP (2) | JP2002521495A (de) |
AT (1) | ATE296833T1 (de) |
AU (1) | AU5203599A (de) |
CA (1) | CA2339016A1 (de) |
DE (1) | DE69925624T2 (de) |
WO (1) | WO2000006771A2 (de) |
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6864059B2 (en) | 1996-01-23 | 2005-03-08 | Affymetrix, Inc. | Biotin containing C-glycoside nucleic acid labeling compounds |
US7282327B2 (en) | 1996-01-23 | 2007-10-16 | Affymetrix, Inc. | Nucleic acid labeling compounds |
US20010018514A1 (en) | 1998-07-31 | 2001-08-30 | Mcgall Glenn H. | Nucleic acid labeling compounds |
US6965020B2 (en) | 1996-01-23 | 2005-11-15 | Affymetrix, Inc. | Nucleic acid labeling compounds |
US7423143B2 (en) | 1996-01-23 | 2008-09-09 | Affymetrix. Inc. | Nucleic acid labeling compounds |
US7291463B2 (en) * | 1996-01-23 | 2007-11-06 | Affymetrix, Inc. | Nucleic acid labeling compounds |
CA2255599C (en) | 1996-04-25 | 2006-09-05 | Bioarray Solutions, Llc | Light-controlled electrokinetic assembly of particles near surfaces |
US6582921B2 (en) * | 1996-07-29 | 2003-06-24 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses thereof |
US7715989B2 (en) | 1998-04-03 | 2010-05-11 | Elitech Holding B.V. | Systems and methods for predicting oligonucleotide melting temperature (TmS) |
US7045610B2 (en) | 1998-04-03 | 2006-05-16 | Epoch Biosciences, Inc. | Modified oligonucleotides for mismatch discrimination |
US6949367B1 (en) | 1998-04-03 | 2005-09-27 | Epoch Pharmaceuticals, Inc. | Modified oligonucleotides for mismatch discrimination |
US6683173B2 (en) | 1998-04-03 | 2004-01-27 | Epoch Biosciences, Inc. | Tm leveling methods |
US7875440B2 (en) | 1998-05-01 | 2011-01-25 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and DNA molecules |
US6780591B2 (en) | 1998-05-01 | 2004-08-24 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and DNA molecules |
US20030096321A1 (en) * | 1999-05-19 | 2003-05-22 | Jose Remacle | Method for the identification and/or the quantification of a target compound obtained from a biological sample upon chips |
US6660845B1 (en) * | 1999-11-23 | 2003-12-09 | Epoch Biosciences, Inc. | Non-aggregating, non-quenching oligomers comprising nucleotide analogues; methods of synthesis and use thereof |
US6727356B1 (en) | 1999-12-08 | 2004-04-27 | Epoch Pharmaceuticals, Inc. | Fluorescent quenching detection reagents and methods |
US6800439B1 (en) | 2000-01-06 | 2004-10-05 | Affymetrix, Inc. | Methods for improved array preparation |
JP2003525292A (ja) * | 2000-03-01 | 2003-08-26 | エポック・バイオサイエンシーズ・インコーポレイテッド | ミスマッチ識別のための修飾オリゴヌクレオチド |
EP1944310A3 (de) * | 2000-03-01 | 2008-08-06 | Epoch Biosciences, Inc. | Modifizierte Oligonukleotide zur Erkennung von Fehlanpassungen |
US6806361B1 (en) | 2000-03-17 | 2004-10-19 | Affymetrix, Inc. | Methods of enhancing functional performance of nucleic acid arrays |
US6833450B1 (en) | 2000-03-17 | 2004-12-21 | Affymetrix, Inc. | Phosphite ester oxidation in nucleic acid array preparation |
US7005259B1 (en) | 2000-06-01 | 2006-02-28 | Affymetrix, Inc. | Methods for array preparation using substrate rotation |
US9709559B2 (en) | 2000-06-21 | 2017-07-18 | Bioarray Solutions, Ltd. | Multianalyte molecular analysis using application-specific random particle arrays |
DE60117556T2 (de) | 2000-06-21 | 2006-11-02 | Bioarray Solutions Ltd. | Multianalytische molekularanalyse durch verwendung anwendungsspezifischer zufallspartikelarrays |
JP4331476B2 (ja) | 2000-08-03 | 2009-09-16 | エフ.ホフマン−ラ ロシュ アーゲー | プリン−2,6−ジアミンのピラゾロ[3,4−d]ピリミジンアナローグを含有する核酸結合性化合物およびそれらの使用 |
AU2002258502A1 (en) | 2001-03-12 | 2002-09-24 | Affymetrix, Inc. | Nucleic acid labeling compounds |
US7262063B2 (en) * | 2001-06-21 | 2007-08-28 | Bio Array Solutions, Ltd. | Directed assembly of functional heterostructures |
WO2003000187A2 (en) * | 2001-06-21 | 2003-01-03 | Ariad Pharmaceuticals, Inc. | Novel pyrazolo-and pyrrolo-pyrimidines and uses thereof |
US7439346B2 (en) * | 2001-10-12 | 2008-10-21 | Perkinelmer Las Inc. | Nucleic acids arrays and methods of use therefor |
NZ532947A (en) | 2001-10-15 | 2006-01-27 | Bioarray Solutions Ltd | Multiplexed analysis of polymorphic loci by concurrent interrogation and enzyme-mediated detection |
AU2003298655A1 (en) | 2002-11-15 | 2004-06-15 | Bioarray Solutions, Ltd. | Analysis, secure access to, and transmission of array images |
EP1565480B1 (de) * | 2002-11-22 | 2018-08-22 | Roche Diagnostics GmbH | Markierte nukleosidanaloge und ihre anwendung |
JP4804340B2 (ja) | 2003-01-17 | 2011-11-02 | ダニスコ エイ/エス | 脂質アシルトランスフェラーゼの使用 |
CA2463719A1 (en) | 2003-04-05 | 2004-10-05 | F. Hoffmann-La Roche Ag | Nucleotide analogs with six membered rings |
US9394565B2 (en) | 2003-09-05 | 2016-07-19 | Agena Bioscience, Inc. | Allele-specific sequence variation analysis |
US7927796B2 (en) | 2003-09-18 | 2011-04-19 | Bioarray Solutions, Ltd. | Number coding for identification of subtypes of coded types of solid phase carriers |
CN1882699A (zh) | 2003-09-22 | 2006-12-20 | 佰尔瑞溶液有限公司 | 带有多个能共价结合生物分子的官能基团的表面固定化多电解质 |
US7563569B2 (en) | 2003-10-28 | 2009-07-21 | Michael Seul | Optimization of gene expression analysis using immobilized capture probes |
ES2533876T3 (es) | 2003-10-29 | 2015-04-15 | Bioarray Solutions Ltd | Análisis multiplexado de ácidos nucleicos mediante fragmentación de ADN bicatenario |
US7169560B2 (en) | 2003-11-12 | 2007-01-30 | Helicos Biosciences Corporation | Short cycle methods for sequencing polynucleotides |
US7439341B2 (en) | 2003-11-14 | 2008-10-21 | Integrated Dna Technologies, Inc. | Fluorescence quenching azo dyes, their methods of preparation and use |
EP1716254B1 (de) | 2004-02-19 | 2010-04-07 | Helicos Biosciences Corporation | Verfahren zur analyse von polynukleotidsequenzen |
JP5149622B2 (ja) * | 2004-05-20 | 2013-02-20 | クエスト ダイアグノスティックス インヴェストメンツ インコーポレイテッド | 単一標識比較ハイブリダイゼーション |
DE602005009693D1 (de) * | 2004-06-02 | 2008-10-23 | Asm Scient Inc | 2"-nitrobenzyl-modifizierte ribonukleotide |
US7848889B2 (en) | 2004-08-02 | 2010-12-07 | Bioarray Solutions, Ltd. | Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification |
DE602006018861D1 (de) * | 2005-01-27 | 2011-01-27 | Quest Diagnostics Invest Inc | Schnelle komparative genomhybridisierung |
US8486629B2 (en) | 2005-06-01 | 2013-07-16 | Bioarray Solutions, Ltd. | Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation |
US20060292576A1 (en) * | 2005-06-23 | 2006-12-28 | Quest Diagnostics Investments Incorporated | Non-in situ hybridization method for detecting chromosomal abnormalities |
US7977108B2 (en) * | 2005-07-25 | 2011-07-12 | Roche Molecular Systems, Inc. | Method for detecting a mutation in a repetitive nucleic acid sequence |
US7666593B2 (en) | 2005-08-26 | 2010-02-23 | Helicos Biosciences Corporation | Single molecule sequencing of captured nucleic acids |
US8076074B2 (en) | 2005-11-29 | 2011-12-13 | Quest Diagnostics Investments Incorporated | Balanced translocation in comparative hybridization |
US7807359B2 (en) * | 2006-12-01 | 2010-10-05 | Quest Diagnostics Investments Incorporated | Methods of detecting TPMT mutations |
US7507539B2 (en) * | 2007-07-30 | 2009-03-24 | Quest Diagnostics Investments Incorporated | Substractive single label comparative hybridization |
US8093063B2 (en) * | 2007-11-29 | 2012-01-10 | Quest Diagnostics Investments Incorporated | Assay for detecting genetic abnormalities in genomic nucleic acids |
US8039794B2 (en) * | 2008-12-16 | 2011-10-18 | Quest Diagnostics Investments Incorporated | Mass spectrometry assay for thiopurine-S-methyl transferase activity and products generated thereby |
JP5441479B2 (ja) * | 2009-04-08 | 2014-03-12 | 国立大学法人北陸先端科学技術大学院大学 | アザピリミジン骨格を有する光応答性核酸類 |
CA2774116A1 (en) * | 2009-09-25 | 2011-03-31 | Signature Genomics Laboratories Llc | Multiplex (+/-) stranded arrays and assays for detecting chromosomal abnormalities associated with cancer and other diseases |
WO2011120049A1 (en) | 2010-03-26 | 2011-09-29 | Integrated Dna Technologies, Inc. | Methods for enhancing nucleic acid hybridization |
US9506057B2 (en) | 2010-03-26 | 2016-11-29 | Integrated Dna Technologies, Inc. | Modifications for antisense compounds |
US8536323B2 (en) | 2010-04-21 | 2013-09-17 | Pierce Biotechnology, Inc. | Modified nucleotides |
US9206216B2 (en) | 2010-04-21 | 2015-12-08 | Pierce Biotechnology, Inc. | Modified nucleotides methods and kits |
WO2012033848A1 (en) | 2010-09-07 | 2012-03-15 | Integrated Dna Technologies, Inc. | Modifications for antisense compounds |
US20120153139A1 (en) * | 2010-12-16 | 2012-06-21 | Exxonmobil Research And Engineering Company | Generation of model-of-composition of petroleum by high resolution mass spectrometry and associated analytics |
JP6491486B2 (ja) * | 2015-01-29 | 2019-03-27 | 学校法人日本大学 | 8−アザ−3,7−ジデアザアデニンヌクレオシド誘導体、8−アザ−3,7−ジデアザアデニンヌクレオチド誘導体及びポリヌクレオチド誘導体ならびにプローブ |
Family Cites Families (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US389162A (en) | 1888-09-04 | George a | ||
GB721016A (en) | 1952-07-08 | 1954-12-29 | Gen Motors Corp | Improved refrigerator |
US3352849A (en) * | 1965-10-24 | 1967-11-14 | Merck & Co Inc | 6-aza-2'-deoxyuridines |
NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
DE2122991C2 (de) * | 1971-05-04 | 1982-06-09 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von Cytosin- und 6-Azacytosinnucleosiden |
US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
US4427633A (en) | 1980-07-03 | 1984-01-24 | Beckman Instruments, Inc. | Gas mixing apparatus for metastable transfer emission spectroscopy |
US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
US4711955A (en) * | 1981-04-17 | 1987-12-08 | Yale University | Modified nucleotides and methods of preparing and using same |
US4594339A (en) * | 1982-04-06 | 1986-06-10 | Sloan-Kettering Institute For Cancer Research | Anti-herpes virus compositions containing 5-substituted 1-2'(deoxy-2-'-substituted-β-d-arabinofuranosyl)pyrimedene nucleosides |
US4948882A (en) * | 1983-02-22 | 1990-08-14 | Syngene, Inc. | Single-stranded labelled oligonucleotides, reactive monomers and methods of synthesis |
JPS6010174A (ja) | 1983-06-29 | 1985-01-19 | Fuji Photo Film Co Ltd | オ−トラジオグラフイ−による遺伝子のスクリ−ニング方法 |
FR2552164B1 (fr) * | 1983-09-21 | 1986-12-26 | Snecma | Disque de compresseur avec accelerateur centripete integre pour l'aspiration d'air dans un dispositif de refroidissement d'une turbine a gaz |
CA1260372A (en) | 1984-04-27 | 1989-09-26 | Elazar Rabbani | Hybridization method for the detection of genetic materials |
JPS61109797A (ja) | 1984-11-01 | 1986-05-28 | Yuki Gosei Yakuhin Kogyo Kk | 標識化ヌクレオチドおよび標識化ポリヌクレオチド |
US4981783A (en) | 1986-04-16 | 1991-01-01 | Montefiore Medical Center | Method for detecting pathological conditions |
US5151507A (en) | 1986-07-02 | 1992-09-29 | E. I. Du Pont De Nemours And Company | Alkynylamino-nucleotides |
CA1340806C (en) | 1986-07-02 | 1999-11-02 | James Merrill Prober | Method, system and reagents for dna sequencing |
US5242796A (en) | 1986-07-02 | 1993-09-07 | E. I. Du Pont De Nemours And Company | Method, system and reagents for DNA sequencing |
US4987066A (en) | 1986-11-07 | 1991-01-22 | Max Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Process for the detection of restriction fragment length polymorphisms in eukaryotic genomes |
US5202231A (en) | 1987-04-01 | 1993-04-13 | Drmanac Radoje T | Method of sequencing of genomes by hybridization of oligonucleotide probes |
US6211158B1 (en) | 1987-04-10 | 2001-04-03 | Roche Diagnostics Gmbh | Desazapurine-nucleotide derivatives, processes for the preparation thereof, pharmaceutical compositions containing them and the use thereof for nucleic acid sequencing and as antiviral agents |
AU622426B2 (en) | 1987-12-11 | 1992-04-09 | Abbott Laboratories | Assay using template-dependent nucleic acid probe reorganization |
EP0322311B1 (de) | 1987-12-21 | 1994-03-23 | Applied Biosystems, Inc. | Verfahren und Testsatz zum Nachweis einer Nukleinsäure-Sequenz |
GB8810400D0 (en) | 1988-05-03 | 1988-06-08 | Southern E | Analysing polynucleotide sequences |
CA1341584C (en) | 1988-04-06 | 2008-11-18 | Bruce Wallace | Method of amplifying and detecting nucleic acid sequences |
US5002867A (en) | 1988-04-25 | 1991-03-26 | Macevicz Stephen C | Nucleic acid sequence determination by multiple mixed oligonucleotide probes |
AU3869289A (en) | 1988-07-14 | 1990-02-05 | Baylor College Of Medicine | Solid phase assembly and reconstruction of biopolymers |
US4997928A (en) | 1988-09-15 | 1991-03-05 | E. I. Du Pont De Nemours And Company | Fluorescent reagents for the preparation of 5'-tagged oligonucleotides |
US5262536A (en) | 1988-09-15 | 1993-11-16 | E. I. Du Pont De Nemours And Company | Reagents for the preparation of 5'-tagged oligonucleotides |
WO1990003370A1 (en) | 1988-09-28 | 1990-04-05 | Microprobe Corporation | DERIVATIVES OF PYRAZOLO[3,4-d]PYRIMIDINE |
US6040138A (en) | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
US5424186A (en) | 1989-06-07 | 1995-06-13 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis |
US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
DE69126530T2 (de) * | 1990-07-27 | 1998-02-05 | Isis Pharmaceuticals Inc | Nuklease resistente, pyrimidin modifizierte oligonukleotide, die die gen-expression detektieren und modulieren |
US5173260A (en) | 1990-09-17 | 1992-12-22 | Eastman Kodak Company | Beads fused to a test device support |
ES2155822T3 (es) | 1990-12-06 | 2001-06-01 | Affymetrix Inc | Compuestos y su utilizacion en una estrategia de sintesis binaria. |
EP0834576B1 (de) | 1990-12-06 | 2002-01-16 | Affymetrix, Inc. (a Delaware Corporation) | Detektion von Nukleinsäuresequenzen |
RU1794088C (ru) | 1991-03-18 | 1993-02-07 | Институт Молекулярной Биологии Ан@ Ссср | Способ определени нуклеотидной последовательности ДНК и устройство дл его осуществлени |
US5342796A (en) * | 1991-05-28 | 1994-08-30 | Sharp Kabushiki Kaisha | Method for controlling gate size for semiconduction process |
US5422241A (en) | 1991-07-03 | 1995-06-06 | Ambion, Inc. | Methods for the recovery of nucleic acids from reaction mixtures |
US5324633A (en) | 1991-11-22 | 1994-06-28 | Affymax Technologies N.V. | Method and apparatus for measuring binding affinity |
JPH07504087A (ja) | 1992-02-12 | 1995-05-11 | クロマジェン インク | 蛍光性n−ヌクレオシド及び蛍光性n−ヌクレオシド構造類似体の応用 |
CA2130562A1 (en) | 1992-02-19 | 1993-09-02 | Alexander B. Chetverin | Novel oligonucleotide arrays and their use for sorting, isolating, sequencing, and manipulating nucleic acids |
US5543292A (en) | 1992-06-16 | 1996-08-06 | Hitachi, Ltd. | Process for the measurement of nucleic acids |
US6114114A (en) | 1992-07-17 | 2000-09-05 | Incyte Pharmaceuticals, Inc. | Comparative gene transcript analysis |
WO1995011995A1 (en) | 1993-10-26 | 1995-05-04 | Affymax Technologies N.V. | Arrays of nucleic acid probes on biological chips |
EP0705271B1 (de) | 1993-06-25 | 2002-11-13 | Affymetrix, Inc. (a Delaware Corporation) | Hybridisierung und sequenzierung von nukleinsäuren |
RU2041262C1 (ru) | 1993-08-11 | 1995-08-09 | Институт молекулярной биологии им.В.А.Энгельгардта РАН | Способ иммобилизации водорастворимых биоорганических соединений на капиллярно-пористый носитель |
RU2041263C1 (ru) | 1993-08-11 | 1995-08-09 | Геннадий Моисеевич Ершов | Способ микродозирования водных растворов веществ на носитель и устройство для его осуществления |
RU2041261C1 (ru) | 1993-08-11 | 1995-08-09 | Институт молекулярной биологии им.В.А.Энгельгардта РАН | Способ изготовления матрицы для детектирования мисматчей |
AU2360195A (en) | 1994-05-05 | 1995-11-29 | Beckman Instruments, Inc. | Oligonucleotide repeat arrays |
US5571639A (en) | 1994-05-24 | 1996-11-05 | Affymax Technologies N.V. | Computer-aided engineering system for design of sequence arrays and lithographic masks |
US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
US5795716A (en) | 1994-10-21 | 1998-08-18 | Chee; Mark S. | Computer-aided visualization and analysis system for sequence evaluation |
US6974666B1 (en) | 1994-10-21 | 2005-12-13 | Appymetric, Inc. | Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA |
DE19509038A1 (de) | 1995-03-14 | 1996-09-19 | Boehringer Mannheim Gmbh | C-Nukleosid-Derivate und deren Verwendung in der Detektion von Nukleinsäuren |
US6174998B1 (en) | 1996-03-12 | 2001-01-16 | Roche Diagnostics Gmbh | C-nucleoside derivatives and their use in the detection of nucleic acids |
US5684142A (en) * | 1995-06-07 | 1997-11-04 | Oncor, Inc. | Modified nucleotides for nucleic acid labeling |
US6965020B2 (en) * | 1996-01-23 | 2005-11-15 | Affymetrix, Inc. | Nucleic acid labeling compounds |
AU2253397A (en) * | 1996-01-23 | 1997-08-20 | Affymetrix, Inc. | Nucleic acid analysis techniques |
US20010018514A1 (en) * | 1998-07-31 | 2001-08-30 | Mcgall Glenn H. | Nucleic acid labeling compounds |
US6864059B2 (en) * | 1996-01-23 | 2005-03-08 | Affymetrix, Inc. | Biotin containing C-glycoside nucleic acid labeling compounds |
GB9602028D0 (en) * | 1996-02-01 | 1996-04-03 | Amersham Int Plc | Nucleoside analogues |
US6228575B1 (en) | 1996-02-08 | 2001-05-08 | Affymetrix, Inc. | Chip-based species identification and phenotypic characterization of microorganisms |
CA2251945A1 (en) * | 1996-04-17 | 1997-10-23 | Aronex Pharmaceuticals, Inc. | Antisense inhibitors of vascular endothelial growth factor (vefg/vpf) expression |
DE19637042A1 (de) | 1996-09-12 | 1998-03-19 | Boehringer Mannheim Gmbh | Heterocyclische Verbindungen und deren Verwendung in der Detektion von Nucleinsäuren |
-
1998
- 1998-07-31 US US09/126,645 patent/US20010018514A1/en not_active Abandoned
-
1999
- 1999-07-20 EP EP99937150A patent/EP1124838B1/de not_active Expired - Lifetime
- 1999-07-20 EP EP05011696A patent/EP1589025A3/de not_active Withdrawn
- 1999-07-20 JP JP2000562553A patent/JP2002521495A/ja active Pending
- 1999-07-20 AU AU52035/99A patent/AU5203599A/en not_active Abandoned
- 1999-07-20 AT AT99937150T patent/ATE296833T1/de not_active IP Right Cessation
- 1999-07-20 DE DE69925624T patent/DE69925624T2/de not_active Expired - Lifetime
- 1999-07-20 WO PCT/US1999/012390 patent/WO2000006771A2/en active IP Right Grant
- 1999-07-20 CA CA002339016A patent/CA2339016A1/en not_active Abandoned
-
2001
- 2001-02-09 US US09/780,574 patent/US6596856B2/en not_active Expired - Lifetime
-
2003
- 2003-06-02 US US10/452,375 patent/US6844433B2/en not_active Expired - Lifetime
- 2003-06-02 US US10/452,519 patent/US7179905B2/en not_active Expired - Lifetime
-
2005
- 2005-01-18 US US11/037,065 patent/US7491818B2/en not_active Expired - Fee Related
-
2006
- 2006-03-20 JP JP2006077729A patent/JP2006258818A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US6596856B2 (en) | 2003-07-22 |
EP1124838B1 (de) | 2005-06-01 |
WO2000006771A3 (en) | 2001-06-21 |
US20050164268A1 (en) | 2005-07-28 |
JP2002521495A (ja) | 2002-07-16 |
CA2339016A1 (en) | 2000-02-10 |
JP2006258818A (ja) | 2006-09-28 |
EP1124838A2 (de) | 2001-08-22 |
US20010018514A1 (en) | 2001-08-30 |
DE69925624T2 (de) | 2006-04-27 |
AU5203599A (en) | 2000-02-21 |
WO2000006771A9 (en) | 2002-08-22 |
US6844433B2 (en) | 2005-01-18 |
US7491818B2 (en) | 2009-02-17 |
US7179905B2 (en) | 2007-02-20 |
US20040002595A1 (en) | 2004-01-01 |
EP1589025A2 (de) | 2005-10-26 |
US20030232979A1 (en) | 2003-12-18 |
ATE296833T1 (de) | 2005-06-15 |
WO2000006771A2 (en) | 2000-02-10 |
EP1589025A3 (de) | 2006-04-19 |
US20010044531A1 (en) | 2001-11-22 |
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