DE69929244D1 - Dibenzo a,g] quinolizinium derivate und ihre salze - Google Patents

Dibenzo a,g] quinolizinium derivate und ihre salze

Info

Publication number
DE69929244D1
DE69929244D1 DE69929244T DE69929244T DE69929244D1 DE 69929244 D1 DE69929244 D1 DE 69929244D1 DE 69929244 T DE69929244 T DE 69929244T DE 69929244 T DE69929244 T DE 69929244T DE 69929244 D1 DE69929244 D1 DE 69929244D1
Authority
DE
Germany
Prior art keywords
group
carbons
represent
formula
different
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69929244T
Other languages
English (en)
Other versions
DE69929244T2 (de
Inventor
Ho Kim
Neung Jhong
Ki Paik
Seo Park
Deok Kim
Suk Lee
Un Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hanwha Chemical Corp
Original Assignee
Hanwha Chemical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanwha Chemical Corp filed Critical Hanwha Chemical Corp
Publication of DE69929244D1 publication Critical patent/DE69929244D1/de
Application granted granted Critical
Publication of DE69929244T2 publication Critical patent/DE69929244T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DE69929244T 1998-12-21 1999-01-19 DIBENZO[a,g] QUINOLIZINIUM DERIVATE UND IHRE SALZE Expired - Fee Related DE69929244T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR9858722 1998-12-21
KR1019980058722A KR20000042507A (ko) 1998-12-21 1998-12-21 콜레스테롤 생합성 저해효과를 나타내는 디벤조[a,g]퀴놀리지늄 유도체
PCT/KR1999/000030 WO2000037468A1 (en) 1998-12-21 1999-01-19 DIBENZO[a,g]QUINOLIZINIUM DERIVATIVES AND THE SALTS THEREOF

Publications (2)

Publication Number Publication Date
DE69929244D1 true DE69929244D1 (de) 2006-02-02
DE69929244T2 DE69929244T2 (de) 2006-09-14

Family

ID=36676726

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69929244T Expired - Fee Related DE69929244T2 (de) 1998-12-21 1999-01-19 DIBENZO[a,g] QUINOLIZINIUM DERIVATE UND IHRE SALZE

Country Status (14)

Country Link
US (2) US6030979A (de)
EP (1) EP1140930B1 (de)
JP (1) JP2000191662A (de)
KR (1) KR20000042507A (de)
CN (1) CN1216884C (de)
AT (1) ATE314369T1 (de)
AU (1) AU777377B2 (de)
BR (1) BR9916431A (de)
CA (1) CA2355469A1 (de)
DE (1) DE69929244T2 (de)
ES (1) ES2257027T3 (de)
IL (1) IL143754A0 (de)
RU (1) RU2223962C2 (de)
WO (1) WO2000037468A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20000021073A (ko) 1998-09-25 2000-04-15 박원배 콜레스테롤 생합성 저해제
CN1759834B (zh) * 2004-09-17 2010-06-23 中国医学科学院医药生物技术研究所 黄连素或其与辛伐他汀联合在制备用于预防或治疗与血脂有关疾病或症状的产品中用途
KR100706309B1 (ko) * 2006-02-14 2007-04-12 한국생명공학연구원 항진균 활성이 우수한 베르베루빈 유도체
CN101153039B (zh) * 2006-09-30 2010-12-01 中国科学院上海药物研究所 13，13a-二氢小檗碱衍生物及其药物组合物和用途
WO2009002873A1 (en) * 2007-06-22 2008-12-31 Cvi Pharmaceuticals Limited Compounds, compositions and methods for reducing lipid levels
WO2009035598A1 (en) * 2007-09-10 2009-03-19 Concert Pharmaceuticals, Inc. Deuterated pirfenidone
JP5551711B2 (ja) * 2008-12-23 2014-07-16 シーブイアイ ファーマシューティカルズ リミテッド 脂質レベルを減少させるための化合物、組成物および方法
WO2011006000A1 (en) * 2009-07-08 2011-01-13 Haiyan Liu Berberine derivatives useful for modulating lipid levels and their methods of synthesis
KR101155753B1 (ko) 2010-09-29 2012-06-12 동아제약주식회사 퀴놀린 유도체 화합물을 포함하는 약학 조성물
CA2970561C (en) * 2015-01-07 2019-07-23 Changzhou Deze Medical Science Co., Ltd Mangiferin-6-o-berberine salt and preparation method and use thereof
MA53246A (fr) 2016-07-27 2021-07-28 Univ Case Western Reserve Composés et procédés pour favoriser la myélinisation
CN107722000A (zh) * 2017-11-03 2018-02-23 中国药科大学 9位－取代的小檗碱衍生物的制备及其医药用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1265627A (de) * 1970-08-26 1972-03-01
DE2043218A1 (de) * 1970-09-01 1972-03-02 Dainippon Pharmaceutical Co , Ltd, Osaka (Japan) Pharmazeutische Zubereitungen zur Behandlung von Magengeschwüren
JPS4942700A (de) * 1972-08-25 1974-04-22
JPS4972298A (de) * 1972-11-16 1974-07-12
US3835140A (en) * 1973-01-30 1974-09-10 Us Health Process for the preparation of dehydroberbinium salts
JPS5231360B2 (de) * 1973-05-11 1977-08-13
US4042592A (en) * 1974-05-08 1977-08-16 Kanebo, Ltd. Novel dibenzo[a,g]quinolizinium compounds
DE2527941A1 (de) * 1975-06-23 1977-01-20 Kanebo Ltd Neue berbinderivate, verfahren zu ihrer herstellung und sie enthaltende mittel
US4033966A (en) * 1975-06-24 1977-07-05 Kanebo, Ltd. Novel berbine derivatives
JPS5248696A (en) * 1975-10-14 1977-04-18 Tetsuo Ikegawa Preparation of 9-substituted-tetrahdropyranyl berberines
US4200629A (en) * 1975-11-26 1980-04-29 Junichi Nakamura Anti-fungal substance and preparing method thereof
US4087426A (en) * 1976-08-16 1978-05-02 Research Corporation Oxybisberberine and a process for its production
US4980344A (en) * 1982-05-14 1990-12-25 Maroko Peter R Compositions for improving circulatory performance
US4761417A (en) * 1982-05-14 1988-08-02 Maroko Peter R Compounds, compositions and method of treatments for improving circulatory performance
JPS61130289A (ja) * 1984-11-29 1986-06-18 Ss Pharmaceut Co Ltd １３−プロピルベルベリンの塩
JPH0814787B2 (ja) * 1987-07-15 1996-02-14 三菱電機株式会社 デ−タ伝送装置
EP0307489A1 (de) * 1987-09-15 1989-03-22 S O "Pharmachim" Antiglaukommittel

Also Published As

Publication number Publication date
AU2077699A (en) 2000-07-12
AU777377B2 (en) 2004-10-14
US6030979A (en) 2000-02-29
ATE314369T1 (de) 2006-01-15
CA2355469A1 (en) 2000-06-29
CN1330650A (zh) 2002-01-09
KR20000042507A (ko) 2000-07-15
JP2000191662A (ja) 2000-07-11
IL143754A0 (en) 2002-04-21
DE69929244T2 (de) 2006-09-14
WO2000037468A1 (en) 2000-06-29
US6028197A (en) 2000-02-22
EP1140930B1 (de) 2005-12-28
RU2223962C2 (ru) 2004-02-20
EP1140930A1 (de) 2001-10-10
CN1216884C (zh) 2005-08-31
ES2257027T3 (es) 2006-07-16
BR9916431A (pt) 2001-09-04

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: HOESSLE PATENTANWAELTE PARTNERSCHAFT, 70173 STUTTG

8339 Ceased/non-payment of the annual fee