DE69931112D1 - Chimäre Adenoviren - Google Patents
Chimäre AdenovirenInfo
- Publication number
- DE69931112D1 DE69931112D1 DE69931112T DE69931112T DE69931112D1 DE 69931112 D1 DE69931112 D1 DE 69931112D1 DE 69931112 T DE69931112 T DE 69931112T DE 69931112 T DE69931112 T DE 69931112T DE 69931112 D1 DE69931112 D1 DE 69931112D1
- Authority
- DE
- Germany
- Prior art keywords
- adenoviruses
- gene therapy
- chimaeric
- decreased
- hybrid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10344—Chimeric viral vector comprising heterologous viral elements for production of another viral vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/20011—Rhabdoviridae
- C12N2760/20111—Lyssavirus, e.g. rabies virus
- C12N2760/20134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98202297 | 1998-07-08 | ||
EP98202297 | 1998-07-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69931112D1 true DE69931112D1 (de) | 2006-06-08 |
DE69931112T2 DE69931112T2 (de) | 2006-12-07 |
Family
ID=8233905
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69931112T Expired - Lifetime DE69931112T2 (de) | 1998-07-08 | 1999-07-08 | Chimäre Adenoviren |
Country Status (10)
Country | Link |
---|---|
US (3) | US20030017138A1 (de) |
EP (1) | EP0978566B1 (de) |
JP (1) | JP4472178B2 (de) |
AT (1) | ATE325200T1 (de) |
AU (1) | AU765276B2 (de) |
CA (1) | CA2303477C (de) |
DE (1) | DE69931112T2 (de) |
ES (1) | ES2263250T3 (de) |
NZ (1) | NZ503018A (de) |
WO (1) | WO2000003029A2 (de) |
Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69638058D1 (de) | 1995-06-15 | 2009-11-26 | Crucell Holland Bv | Verpackungssysteme für humane rekombinante Adenoviren zur Gentherapie |
US20030017138A1 (en) | 1998-07-08 | 2003-01-23 | Menzo Havenga | Chimeric adenoviruses |
US6929946B1 (en) | 1998-11-20 | 2005-08-16 | Crucell Holland B.V. | Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells |
WO2000052186A1 (en) * | 1999-03-04 | 2000-09-08 | Introgene B.V. | Means and methods for fibroblast-like or macrophage-like cell transduction |
US6869936B1 (en) | 1999-03-04 | 2005-03-22 | Crucell Holland B.V. | Means and methods for fibroblast-like or macrophage-like cell transduction |
US6913922B1 (en) | 1999-05-18 | 2005-07-05 | Crucell Holland B.V. | Serotype of adenovirus and uses thereof |
US20050232900A1 (en) * | 1999-05-18 | 2005-10-20 | Crucell Holland B.V. | Serotype of adenovirus and uses thereof |
US6492169B1 (en) | 1999-05-18 | 2002-12-10 | Crucell Holland, B.V. | Complementing cell lines |
EP1067188A1 (de) * | 1999-07-08 | 2001-01-10 | Introgene B.V. | Infektion mit chimärischen Adenoviren der Zellen die für den Adenoviren Serotyp 5 Coxsacki Adenoviren Rezeptor (CAR) negativ sind |
DE19956763A1 (de) * | 1999-11-25 | 2001-06-13 | Guenter Cichon | Rekombinante Adenoviren mit reduzierter Affinität zu humanen Erythrozyten zur Anwendung in der Gentherapie |
US6867022B1 (en) | 2000-01-21 | 2005-03-15 | Regents Of The University Of Michigan | Replication deficient adenovirus vectors and methods of making and using them |
EP1191105A1 (de) * | 2000-09-25 | 2002-03-27 | Galapagos Genomics B.V. | Gentransfervektoren mit einer Gewebsspezifität für T-Lymphozyten |
EP1157999A1 (de) * | 2000-05-24 | 2001-11-28 | Introgene B.V. | Verfahren und Mitteln zur Verbesserung der Haut-Transplantation mittels Genabgabe-Vehikel mit Tropismus für primären Fibroblasten, sowie andere Verwendungsmöglichkeiten für diesen |
AU2001263689B2 (en) * | 2000-05-31 | 2007-03-22 | University Of Saskatchewan | Modified bovine adenovirus having altered tropism |
US7754201B2 (en) * | 2000-06-02 | 2010-07-13 | GenPhar, Inc | Method of vaccination through serotype rotation |
WO2002012523A2 (en) * | 2000-08-10 | 2002-02-14 | Crucell Holland B.V. | Transduction of chondrocytes using adenoviral vectors |
US7235233B2 (en) | 2000-09-26 | 2007-06-26 | Crucell Holland B.V. | Serotype 5 adenoviral vectors with chimeric fibers for gene delivery in skeletal muscle cells or myoblasts |
EP1195440A1 (de) * | 2000-10-06 | 2002-04-10 | Introgene B.V. | Genverabreichung-Vektoren für Stammzellen |
WO2002029073A2 (en) * | 2000-10-06 | 2002-04-11 | Crucell Holland B.V. | Gene delivery vectors for stem cells |
US6635466B2 (en) * | 2001-01-09 | 2003-10-21 | University Of Iowa Research Foundation | Adenovirus serotype 30 (Ad30) |
AU2002314705A1 (en) * | 2001-01-09 | 2002-10-28 | Beverly L. Davidson | Adenovirus serotype 30 (ad30) fiber protein and uses thereof |
EP1377672A2 (de) | 2001-02-23 | 2004-01-07 | Novartis AG | Vektorkonstrukte |
JP2002325573A (ja) * | 2001-04-27 | 2002-11-12 | Japan Science & Technology Corp | ベクター |
EP1256803A1 (de) | 2001-05-07 | 2002-11-13 | Crucell Holland B.V. | Verfahren zur Identifizierung von antiviralen Verbindungen |
ATE530672T1 (de) | 2001-06-22 | 2011-11-15 | Univ Pennsylvania | Rekombinante adenoviren mit affen-adenovirus proteinen und verwendung davon. |
AU2007201747B2 (en) * | 2001-11-21 | 2010-06-03 | The Trustees Of The University Of Pennsylvania | Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use |
SG2013034475A (en) * | 2001-11-21 | 2016-10-28 | Univ Pennsylvania | Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use |
EP1944043A1 (de) * | 2001-11-21 | 2008-07-16 | The Trustees of the University of Pennsylvania | Nukleinsäure- und Aminosäuresequenzen von Affen-Adenoviren, hergeleitete Vektoren und Verwendungsverfahren. |
EP1516055A4 (de) * | 2002-01-24 | 2007-08-08 | Scripps Research Inst | Faserschaftmodifikationen für effizientes zielen |
CN100374574C (zh) | 2002-04-25 | 2008-03-12 | 克鲁塞尔荷兰公司 | 稳定的腺病毒载体及其增殖方法 |
EA010828B1 (ru) | 2002-04-25 | 2008-12-30 | Круселл Холланд Б.В. | Рекомбинантный аденовирусный вектор и способы его получения и применения |
WO2004027073A1 (en) * | 2002-09-20 | 2004-04-01 | Crucell Holland B.V. | Modified adenoviral vectors for use in vaccines and gene therapy |
US20080153083A1 (en) | 2003-10-23 | 2008-06-26 | Crucell Holland B.V. | Settings for recombinant adenoviral-based vaccines |
WO2004037294A2 (en) | 2002-10-23 | 2004-05-06 | Crucell Holland B.V. | New settings for recombinant adenoviral-based vaccines |
AU2003298361B2 (en) | 2002-12-17 | 2009-05-14 | Crucell Holland B.V. | Recombinant viral-based malaria vaccines |
JP2007525166A (ja) * | 2003-03-28 | 2007-09-06 | ザ・スクリップス・リサーチ・インスティテュート | 樹状細胞に対する感染性が増大したアデノウイルス粒子と、肝細胞に対する感染性が低下した粒子 |
US20070003923A1 (en) * | 2003-06-11 | 2007-01-04 | Scripps Research Institute, The | Modified fiber proteins for efficient receptor binding |
JP4754480B2 (ja) * | 2003-06-20 | 2011-08-24 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | キメラアデノウイルスの作成法およびそのようなキメラアデノウイルスの使用 |
US7291498B2 (en) | 2003-06-20 | 2007-11-06 | The Trustees Of The University Of Pennsylvania | Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses |
CN1922308A (zh) | 2004-02-23 | 2007-02-28 | 克鲁塞尔荷兰公司 | 病毒纯化方法 |
BR122013008865B8 (pt) | 2004-05-26 | 2021-05-25 | Psioxus Therapeutics Ltd | adenovírus oncolítico de replicação competente |
AP2351A (en) * | 2004-10-13 | 2012-01-25 | Crucell Holland Bv | Improved adenoviral vectors and uses thereof. |
ATE412737T1 (de) | 2005-04-11 | 2008-11-15 | Crucell Holland Bv | Virusreinigung mit ultrafiltration |
AU2005337612A1 (en) * | 2005-10-28 | 2007-05-03 | David T. Curiel | Conditionally replicating viruses and methods for cancer virotherapy |
EP1998804B1 (de) * | 2006-03-27 | 2014-04-16 | Crucell Holland B.V. | Zusammensetzungen, die einen rekombinanten adenovirus und ein adjuvans umfassen |
CA2742474C (en) | 2008-11-03 | 2016-05-31 | Crucell Holland B.V. | Method for the production of adenoviral vectors |
CN102791852B (zh) | 2009-10-15 | 2014-05-07 | 克鲁塞尔荷兰公司 | 纯化腺病毒颗粒的方法 |
DK2488635T3 (en) | 2009-10-15 | 2014-02-24 | Crucell Holland Bv | A method for purifying adenovirus of cultures with high cell density |
KR101721725B1 (ko) * | 2010-08-16 | 2017-03-31 | 더 솔크 인스티튜트 포 바이올로지칼 스터디즈 | 아데노바이러스 조립 방법 |
US8771709B2 (en) | 2010-09-20 | 2014-07-08 | Crucell Holland B.V. | Therapeutic vaccination against active Tuberculosis |
BR112014012681A8 (pt) | 2011-11-28 | 2017-06-20 | Crucell Holland Bv | polipeptídeo, métido para proporcionar um polipeptídeo, ácido nucleico, e, composição imunogênica |
EP2855669B1 (de) | 2012-05-29 | 2018-10-10 | GenVec, Inc. | Modifizierte serotyp-28-adenovirusvektoren |
KR102089121B1 (ko) | 2013-03-14 | 2020-03-13 | 더 솔크 인스티튜트 포 바이올로지칼 스터디즈 | 종양살상형 아데노바이러스 조성물 |
US9974737B2 (en) | 2013-09-19 | 2018-05-22 | Janssen Vaccines & Prevention B.V. | Adenovirus formulations |
SG10201804030WA (en) | 2013-10-25 | 2018-07-30 | Psioxus Therapeutics Ltd | Oncolytic adenoviruses armed with heterologous genes |
BR122018004815A2 (pt) | 2015-04-30 | 2019-09-10 | Psioxus Therapeutics Ltd | adenovírus oncolítico que codifica proteína b7 |
US20170067028A1 (en) * | 2015-05-15 | 2017-03-09 | Douglas J. Ballon | Radiolabeling of adeno associated virus |
US20180280519A1 (en) | 2015-10-06 | 2018-10-04 | Janssen Vaccines & Prevention B.V. | Methods for preventing plastic-induced degradation of biologicals |
JP7064437B2 (ja) | 2015-12-17 | 2022-05-10 | サイオクサス セラピューティクス リミテッド | 抗tcr複合体抗体又は断片をコードするb群アデノウイルス |
EP3390645B1 (de) | 2016-02-23 | 2022-09-14 | Salk Institute for Biological Studies | Exogene genexpression eines therapeutischen adenovirus mit geringem einfluss auf die virale kinetik |
AU2017222568B2 (en) | 2016-02-23 | 2020-09-10 | Salk Institute For Biological Studies | High throughput assay for measuring adenovirus replication kinetics |
GB201713765D0 (en) | 2017-08-28 | 2017-10-11 | Psioxus Therapeutics Ltd | Modified adenovirus |
CA3045892A1 (en) | 2016-12-12 | 2018-06-21 | Salk Institute For Biological Studies | Tumor-targeting synthetic adenoviruses and uses thereof |
JP7260173B2 (ja) | 2017-04-21 | 2023-04-18 | ベイラー カレッジ オブ メディスン | 腫瘍溶解性ウイルス療法および免疫療法 |
AU2018272095A1 (en) | 2017-05-26 | 2020-01-02 | Epicentrx, Inc. | Recombinant adenoviruses carrying transgenes |
GB202013940D0 (en) | 2020-09-04 | 2020-10-21 | Synpromics Ltd | Regulatory nucleic acid sequences |
US20230374542A1 (en) | 2020-10-07 | 2023-11-23 | Asklepios Biopharmaceutical, Inc. | Therapeutic adeno-associated virus delivery of fukutin related protein (fkrp) for treating dystroglycanopathy. disorders including limb girdle 21 (lgmd21) |
EP4338727A1 (de) | 2022-09-14 | 2024-03-20 | Roquette Freres | Adenovirus-formulierungen |
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-
1999
- 1999-07-07 US US09/348,354 patent/US20030017138A1/en not_active Abandoned
- 1999-07-08 CA CA2303477A patent/CA2303477C/en not_active Expired - Fee Related
- 1999-07-08 AU AU49356/99A patent/AU765276B2/en not_active Ceased
- 1999-07-08 WO PCT/NL1999/000436 patent/WO2000003029A2/en active IP Right Grant
- 1999-07-08 JP JP2000559250A patent/JP4472178B2/ja not_active Expired - Fee Related
- 1999-07-08 NZ NZ503018A patent/NZ503018A/xx not_active IP Right Cessation
- 1999-07-08 DE DE69931112T patent/DE69931112T2/de not_active Expired - Lifetime
- 1999-07-08 EP EP99202233A patent/EP0978566B1/de not_active Expired - Lifetime
- 1999-07-08 ES ES99202233T patent/ES2263250T3/es not_active Expired - Lifetime
- 1999-07-08 AT AT99202233T patent/ATE325200T1/de not_active IP Right Cessation
-
2001
- 2001-09-14 US US09/953,280 patent/US20030073072A1/en not_active Abandoned
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2005
- 2005-08-18 US US11/207,626 patent/US7749493B2/en not_active Expired - Fee Related
Also Published As
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DE69931112T2 (de) | 2006-12-07 |
EP0978566B1 (de) | 2006-05-03 |
ATE325200T1 (de) | 2006-06-15 |
WO2000003029A2 (en) | 2000-01-20 |
CA2303477A1 (en) | 2000-01-20 |
US20060014276A1 (en) | 2006-01-19 |
US20030017138A1 (en) | 2003-01-23 |
EP0978566A3 (de) | 2000-04-19 |
AU765276B2 (en) | 2003-09-11 |
CA2303477C (en) | 2010-04-06 |
US20030073072A1 (en) | 2003-04-17 |
ES2263250T3 (es) | 2006-12-01 |
WO2000003029A3 (en) | 2000-03-16 |
US7749493B2 (en) | 2010-07-06 |
AU4935699A (en) | 2000-02-01 |
EP0978566A2 (de) | 2000-02-09 |
JP4472178B2 (ja) | 2010-06-02 |
JP2002520026A (ja) | 2002-07-09 |
NZ503018A (en) | 2003-06-30 |
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