DE69931608D1 - Verfahren zur bestimmung von dna-längenpolymorphismen - Google Patents
Verfahren zur bestimmung von dna-längenpolymorphismenInfo
- Publication number
- DE69931608D1 DE69931608D1 DE69931608T DE69931608T DE69931608D1 DE 69931608 D1 DE69931608 D1 DE 69931608D1 DE 69931608 T DE69931608 T DE 69931608T DE 69931608 T DE69931608 T DE 69931608T DE 69931608 D1 DE69931608 D1 DE 69931608D1
- Authority
- DE
- Germany
- Prior art keywords
- repeat units
- sequence
- target
- hybridization complex
- reporter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 3
- 102000054765 polymorphisms of proteins Human genes 0.000 title 1
- 238000009396 hybridization Methods 0.000 abstract 4
- 239000000523 sample Substances 0.000 abstract 4
- 238000003556 assay Methods 0.000 abstract 3
- 238000012360 testing method Methods 0.000 abstract 3
- 230000000295 complement effect Effects 0.000 abstract 2
- 230000002068 genetic effect Effects 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 238000004458 analytical method Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 108091035233 repetitive DNA sequence Proteins 0.000 abstract 1
- 102000053632 repetitive DNA sequence Human genes 0.000 abstract 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
- H01L29/00—Semiconductor devices adapted for rectifying, amplifying, oscillating or switching, or capacitors or resistors with at least one potential-jump barrier or surface barrier, e.g. PN junction depletion layer or carrier concentration layer; Details of semiconductor bodies or of electrodes thereof ; Multistep manufacturing processes therefor
- H01L29/66—Types of semiconductor device ; Multistep manufacturing processes therefor
- H01L29/66007—Multistep manufacturing processes
- H01L29/66075—Multistep manufacturing processes of devices having semiconductor bodies comprising group 14 or group 13/15 materials
- H01L29/66227—Multistep manufacturing processes of devices having semiconductor bodies comprising group 14 or group 13/15 materials the devices being controllable only by the electric current supplied or the electric potential applied, to an electrode which does not carry the current to be rectified, amplified or switched, e.g. three-terminal devices
- H01L29/66409—Unipolar field-effect transistors
- H01L29/66477—Unipolar field-effect transistors with an insulated gate, i.e. MISFET
- H01L29/6656—Unipolar field-effect transistors with an insulated gate, i.e. MISFET using multiple spacer layers, e.g. multiple sidewall spacers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6825—Nucleic acid detection involving sensors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00653—Making arrays on substantially continuous surfaces the compounds being bound to electrodes embedded in or on the solid supports
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00603—Making arrays on substantially continuous surfaces
- B01J2219/00659—Two-dimensional arrays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/030,156 US6207373B1 (en) | 1998-02-25 | 1998-02-25 | Methods for determining nature of repeat units in DNA |
US30156 | 1998-02-25 | ||
PCT/US1999/003175 WO1999043853A1 (en) | 1998-02-25 | 1999-02-12 | Methods and apparatus for determination of length polymorphisms in dna |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69931608D1 true DE69931608D1 (de) | 2006-07-06 |
DE69931608T2 DE69931608T2 (de) | 2007-05-16 |
Family
ID=21852807
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69931608T Expired - Lifetime DE69931608T2 (de) | 1998-02-25 | 1999-02-12 | Verfahren zur bestimmung von dna-längenpolymorphismen |
Country Status (9)
Country | Link |
---|---|
US (3) | US6207373B1 (de) |
EP (1) | EP1056887B1 (de) |
JP (1) | JP2002519998A (de) |
CN (1) | CN1252282C (de) |
AT (1) | ATE328114T1 (de) |
AU (1) | AU2765399A (de) |
CA (1) | CA2322206A1 (de) |
DE (1) | DE69931608T2 (de) |
WO (1) | WO1999043853A1 (de) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994003624A1 (en) * | 1992-08-04 | 1994-02-17 | Auerbach Jeffrey I | Methods for the isothermal amplification of nucleic acid molecules |
US6261808B1 (en) * | 1992-08-04 | 2001-07-17 | Replicon, Inc. | Amplification of nucleic acid molecules via circular replicons |
US6207373B1 (en) * | 1998-02-25 | 2001-03-27 | Nanogen, Inc. | Methods for determining nature of repeat units in DNA |
US7582421B2 (en) * | 1993-11-01 | 2009-09-01 | Nanogen, Inc. | Methods for determination of single nucleic acid polymorphisms using a bioelectronic microchip |
US6468742B2 (en) | 1993-11-01 | 2002-10-22 | Nanogen, Inc. | Methods for determination of single nucleic acid polymorphisms using bioelectronic microchip |
US6379897B1 (en) | 2000-11-09 | 2002-04-30 | Nanogen, Inc. | Methods for gene expression monitoring on electronic microarrays |
US6207673B1 (en) * | 1997-03-12 | 2001-03-27 | The University Of North Carolina At Chapel Hill | Covalent conjugates of topoisomerase I and topoisomerase II inhibitors |
US6013459A (en) | 1997-06-12 | 2000-01-11 | Clinical Micro Sensors, Inc. | Detection of analytes using reorganization energy |
EP1124990B1 (de) | 1998-10-27 | 2006-01-18 | Affymetrix, Inc. | Komplexitätsmanagement und analyse genomischer dna |
EP1088101A4 (de) * | 1999-03-30 | 2004-10-20 | Nanogen Inc | Unterscheidung von einzelnukleotidpolymorphismen durch elektronische dot-blot versuche auf halbleitermikrochips |
WO2000061805A1 (en) * | 1999-04-12 | 2000-10-19 | Nanogen, Inc. | Methods for determination of single nucleic acid polymorphisms using a bioelectronic microchip |
US6958225B2 (en) | 1999-10-27 | 2005-10-25 | Affymetrix, Inc. | Complexity management of genomic DNA |
US6642046B1 (en) * | 1999-12-09 | 2003-11-04 | Motorola, Inc. | Method and apparatus for performing biological reactions on a substrate surface |
US6824669B1 (en) | 2000-02-17 | 2004-11-30 | Motorola, Inc. | Protein and peptide sensors using electrical detection methods |
US6602400B1 (en) | 2000-06-15 | 2003-08-05 | Motorola, Inc. | Method for enhanced bio-conjugation events |
KR100443569B1 (ko) * | 2000-12-15 | 2004-08-09 | 학교법인 인하학원 | 길이다형성 dna 염기서열을 이용한 다중 증폭중합효소연쇄반응 조건의 최적화에 의한 개인식별 및친자감별 방법 |
DE10122659A1 (de) * | 2001-05-10 | 2002-12-05 | Infineon Technologies Ag | Biochip-Anordnung |
US6893822B2 (en) | 2001-07-19 | 2005-05-17 | Nanogen Recognomics Gmbh | Enzymatic modification of a nucleic acid-synthetic binding unit conjugate |
EP2980222A1 (de) | 2001-09-24 | 2016-02-03 | One Lambda, Inc. | Diagnosesondendetektionssystem |
EP2390330B1 (de) | 2001-09-28 | 2018-04-25 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | MikroRNA-Moleküle |
AU2011253686C1 (en) * | 2001-09-28 | 2014-04-03 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. | Micro-RNA molecules |
US20030175947A1 (en) * | 2001-11-05 | 2003-09-18 | Liu Robin Hui | Enhanced mixing in microfluidic devices |
GB0205455D0 (en) | 2002-03-07 | 2002-04-24 | Molecular Sensing Plc | Nucleic acid probes, their synthesis and use |
US20040011650A1 (en) * | 2002-07-22 | 2004-01-22 | Frederic Zenhausern | Method and apparatus for manipulating polarizable analytes via dielectrophoresis |
US7601493B2 (en) * | 2002-07-26 | 2009-10-13 | Nanogen, Inc. | Methods and apparatus for screening and detecting multiple genetic mutations |
JP4657919B2 (ja) * | 2002-08-19 | 2011-03-23 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 進化する新しい分子機能 |
US7270952B2 (en) * | 2002-09-24 | 2007-09-18 | Intel Corporation | Detecting molecular binding by monitoring feedback controlled cantilever deflections |
US7125672B2 (en) * | 2003-05-07 | 2006-10-24 | E. I. Du Pont De Nemours And Company | Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts |
EP1687445A4 (de) * | 2003-09-23 | 2007-03-28 | Atom Sciences Inc | Polymere nukleinsäurehybridisierungssonden |
US20060008823A1 (en) * | 2004-05-12 | 2006-01-12 | Kemp Jennifer T | DNA profiling and SNP detection utilizing microarrays |
WO2007044071A2 (en) * | 2005-04-21 | 2007-04-19 | Exact Sciences Corporation | Analysis of heterogeneous nucleic acid samples |
US20070020671A1 (en) * | 2005-07-12 | 2007-01-25 | Radtkey Ray R | Method for detecting large mutations and duplications using control amplification comparisons to paralogous genes |
US9388457B2 (en) | 2007-09-14 | 2016-07-12 | Affymetrix, Inc. | Locus specific amplification using array probes |
ATE516371T1 (de) * | 2007-10-22 | 2011-07-15 | Lgc Ltd | Oligonukleotide und deren verwendungen |
US9074244B2 (en) | 2008-03-11 | 2015-07-07 | Affymetrix, Inc. | Array-based translocation and rearrangement assays |
US20130183666A1 (en) | 2012-01-18 | 2013-07-18 | Marc N. Feiglin | Partial genotyping by differential hybridization |
WO2014019099A1 (es) * | 2012-07-31 | 2014-02-06 | Juan Carlos Jaime | Procedimiento para obtener y detectar un marcador de objetos a identificar, el marcador, método para la autenticación y método para la verificación |
AU2021231104A1 (en) * | 2020-03-03 | 2022-07-21 | Universiteit Gent | Hydrolysis-based probe and method for STR genotyping |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
CA1323553C (en) | 1987-11-03 | 1993-10-26 | Timothy George Helentjaris | Method and device for improved restriction fragment length polymorphism analysis |
US4963663A (en) | 1988-12-23 | 1990-10-16 | University Of Utah | Genetic identification employing DNA probes of variable number tandem repeat loci |
DE3834636A1 (de) | 1988-10-11 | 1990-04-19 | Max Planck Gesellschaft | Verfahren zur analyse von laengenpolymorphismen in dna-bereichen |
GB8824531D0 (en) | 1988-10-20 | 1988-11-23 | Ici Plc | Polynucleotide probes |
GB2228086A (en) | 1988-11-25 | 1990-08-15 | Ici Plc | Characterisation of genomic DNA |
US5364759B2 (en) | 1991-01-31 | 1999-07-20 | Baylor College Medicine | Dna typing with short tandem repeat polymorphisms and identification of polymorphic short tandem repeats |
US5632957A (en) | 1993-11-01 | 1997-05-27 | Nanogen | Molecular biological diagnostic systems including electrodes |
US6051380A (en) * | 1993-11-01 | 2000-04-18 | Nanogen, Inc. | Methods and procedures for molecular biological analysis and diagnostics |
US5849486A (en) * | 1993-11-01 | 1998-12-15 | Nanogen, Inc. | Methods for hybridization analysis utilizing electrically controlled hybridization |
US6017696A (en) * | 1993-11-01 | 2000-01-25 | Nanogen, Inc. | Methods for electronic stringency control for molecular biological analysis and diagnostics |
US6048690A (en) * | 1991-11-07 | 2000-04-11 | Nanogen, Inc. | Methods for electronic fluorescent perturbation for analysis and electronic perturbation catalysis for synthesis |
US5605662A (en) * | 1993-11-01 | 1997-02-25 | Nanogen, Inc. | Active programmable electronic devices for molecular biological analysis and diagnostics |
US5403708A (en) | 1992-07-06 | 1995-04-04 | Brennan; Thomas M. | Methods and compositions for determining the sequence of nucleic acids |
EP0688366B1 (de) * | 1993-01-15 | 2002-05-22 | The Public Health Research Institute Of The City Of New York, Inc. | Empfindlicher nukleinsäure-sandwichhybridisierungs-assay und kits |
US6207373B1 (en) * | 1998-02-25 | 2001-03-27 | Nanogen, Inc. | Methods for determining nature of repeat units in DNA |
AU2360195A (en) | 1994-05-05 | 1995-11-29 | Beckman Instruments, Inc. | Oligonucleotide repeat arrays |
US5795716A (en) * | 1994-10-21 | 1998-08-18 | Chee; Mark S. | Computer-aided visualization and analysis system for sequence evaluation |
GB9507238D0 (en) * | 1995-04-07 | 1995-05-31 | Isis Innovation | Detecting dna sequence variations |
US5753439A (en) | 1995-05-19 | 1998-05-19 | Trustees Of Boston University | Nucleic acid detection methods |
US5908745A (en) | 1996-01-16 | 1999-06-01 | University Of Chicago | Use of continuous/contiguous stacking hybridization as a diagnostic tool |
US6090549A (en) | 1996-01-16 | 2000-07-18 | University Of Chicago | Use of continuous/contiguous stacking hybridization as a diagnostic tool |
DE69738687D1 (de) * | 1996-04-12 | 2008-06-26 | Phri Properties Inc | Sonden, kits und assays |
US5881269A (en) | 1996-09-30 | 1999-03-09 | International Business Machines Corporation | Simulation of multiple local area network clients on a single workstation |
-
1998
- 1998-02-25 US US09/030,156 patent/US6207373B1/en not_active Expired - Lifetime
-
1999
- 1999-02-12 EP EP99908154A patent/EP1056887B1/de not_active Expired - Lifetime
- 1999-02-12 AU AU27653/99A patent/AU2765399A/en not_active Abandoned
- 1999-02-12 WO PCT/US1999/003175 patent/WO1999043853A1/en active IP Right Grant
- 1999-02-12 CN CNB998052078A patent/CN1252282C/zh not_active Expired - Fee Related
- 1999-02-12 AT AT99908154T patent/ATE328114T1/de not_active IP Right Cessation
- 1999-02-12 DE DE69931608T patent/DE69931608T2/de not_active Expired - Lifetime
- 1999-02-12 CA CA002322206A patent/CA2322206A1/en not_active Abandoned
- 1999-02-12 JP JP2000533592A patent/JP2002519998A/ja active Pending
-
2000
- 2000-08-24 US US09/645,757 patent/US6395493B1/en not_active Expired - Lifetime
-
2002
- 2002-03-25 US US10/108,280 patent/US6753148B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ATE328114T1 (de) | 2006-06-15 |
WO1999043853A9 (en) | 1999-11-11 |
CA2322206A1 (en) | 1999-09-02 |
EP1056887A4 (de) | 2002-08-28 |
WO1999043853A1 (en) | 1999-09-02 |
US6395493B1 (en) | 2002-05-28 |
EP1056887B1 (de) | 2006-05-31 |
DE69931608T2 (de) | 2007-05-16 |
US6753148B2 (en) | 2004-06-22 |
US6207373B1 (en) | 2001-03-27 |
EP1056887A1 (de) | 2000-12-06 |
AU2765399A (en) | 1999-09-15 |
JP2002519998A (ja) | 2002-07-09 |
US20020115098A1 (en) | 2002-08-22 |
CN1252282C (zh) | 2006-04-19 |
CN1297489A (zh) | 2001-05-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |