DE69933549D1 - Pharmakophore rekombination zur identifizierung von "lead"-verbindungen von kleinmolekül-medikamenten - Google Patents

Pharmakophore rekombination zur identifizierung von "lead"-verbindungen von kleinmolekül-medikamenten

Info

Publication number
DE69933549D1
DE69933549D1 DE69933549T DE69933549T DE69933549D1 DE 69933549 D1 DE69933549 D1 DE 69933549D1 DE 69933549 T DE69933549 T DE 69933549T DE 69933549 T DE69933549 T DE 69933549T DE 69933549 D1 DE69933549 D1 DE 69933549D1
Authority
DE
Germany
Prior art keywords
identification
compounds
lead
small molecule
medicaments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69933549T
Other languages
English (en)
Other versions
DE69933549T2 (de
Inventor
A Ellman
Ingrid Choong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California filed Critical University of California
Publication of DE69933549D1 publication Critical patent/DE69933549D1/de
Application granted granted Critical
Publication of DE69933549T2 publication Critical patent/DE69933549T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/807—Hapten conjugated with peptide or protein
DE69933549T 1998-03-27 1999-03-26 Pharmakophore rekombination zur identifizierung von "lead"-verbindungen von kleinmolekül-medikamenten Expired - Lifetime DE69933549T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/049,754 US6344330B1 (en) 1998-03-27 1998-03-27 Pharmacophore recombination for the identification of small molecule drug lead compounds
US49754 1998-03-27
PCT/US1999/006734 WO1999049314A1 (en) 1998-03-27 1999-03-26 Pharmacophore recombination for the identification of small molecule drug lead compounds

Publications (2)

Publication Number Publication Date
DE69933549D1 true DE69933549D1 (de) 2006-11-23
DE69933549T2 DE69933549T2 (de) 2007-06-21

Family

ID=21961533

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69933549T Expired - Lifetime DE69933549T2 (de) 1998-03-27 1999-03-26 Pharmakophore rekombination zur identifizierung von "lead"-verbindungen von kleinmolekül-medikamenten

Country Status (9)

Country Link
US (5) US6344330B1 (de)
EP (1) EP1066522B1 (de)
JP (1) JP2002507748A (de)
AT (1) ATE342507T1 (de)
AU (1) AU759327B2 (de)
CA (1) CA2326341C (de)
DE (1) DE69933549T2 (de)
IL (1) IL138717A0 (de)
WO (1) WO1999049314A1 (de)

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US20020172967A1 (en) * 2001-02-13 2002-11-21 Gadek Thomas R. Identification of non-covalent complexes by mass spectrometry
US9157875B2 (en) * 2001-05-16 2015-10-13 Benjamin P. Warner Drug development and manufacturing
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RU2295518C2 (ru) * 2001-11-21 2007-03-20 Сьюнесис Фармасьютикалс, Инк. Способ нахождения лигандов
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US7519145B2 (en) * 2002-07-25 2009-04-14 Los Alamos National Security, Llc Flow method and apparatus for screening chemicals using micro x-ray fluorescence
AU2003287250B9 (en) * 2002-10-30 2010-01-28 Ptc Therapeutics, Inc. Identifying therapeutic compounds based on their physical-chemical properties
DE60311879T2 (de) 2002-12-23 2007-12-20 Astex Therapeutics Ltd., Cambridge Synthese und screening von liganden mit hilfe von röntgenkristallographie
US7736909B2 (en) * 2003-01-09 2010-06-15 Board Of Regents, The University Of Texas System Methods and compositions comprising capture agents
US20040265909A1 (en) * 2003-04-11 2004-12-30 Jeff Blaney Compound libraries and methods for drug discovery
WO2006124644A2 (en) * 2005-05-12 2006-11-23 Board Of Regents, The University Of Texas System Protein and antibody profiling using small molecule microarrays
JP5174672B2 (ja) * 2005-10-04 2013-04-03 アルケミア リミティッド 薬物設計の方法
CN101384757A (zh) * 2006-01-03 2009-03-11 哈佛大学校长及研究员协会 小分子印渍
JP5143841B2 (ja) 2006-10-10 2013-02-13 ロス アラモス ナショナル セキュリティー，エルエルシー 高度な薬物開発及び製造
DE102007023102A1 (de) * 2006-12-19 2008-06-26 Bayer Cropscience Ag Bisoxime als Fungizide
JP5743135B2 (ja) 2007-09-28 2015-07-01 エックスアールプロ・サイエンシーズ・インコーポレーテッド タンパク質翻訳後修飾を測定するための方法及び装置
CA2719579C (en) 2008-03-25 2020-07-21 Sunesis Pharmaceuticals, Inc. Methods of chemotype evolution
US20100303835A1 (en) * 2009-05-29 2010-12-02 The Board Of Regents Of The University Of Texas System Peptoid ligands for isolation and treatment of autoimmune t-cells
JP5828837B2 (ja) * 2009-06-02 2015-12-09 ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム 神経変性疾患を有する被験者において抗体により認識される小分子の同定
US8759259B2 (en) * 2009-10-16 2014-06-24 The Board Of Regents Of The University Of Texas System Compositions and methods for producing cyclic peptoid libraries
US20130102631A1 (en) 2010-07-02 2013-04-25 Syngenta Crop Protection Llc Novel microbiocidal dioxime ether derivatives
CN103038217A (zh) 2010-07-29 2013-04-10 先正达参股股份有限公司 新颖的杀微生物的二肟醚衍生物
AU2012230880B2 (en) 2011-03-24 2017-04-13 Opko Pharmaceuticals, Llc Biomarker discovery in complex biological fluid using bead or particle based libraries and diagnostic kits and therapeutics
WO2013024040A2 (en) 2011-08-12 2013-02-21 B.S.R.C. Alexander Fleming Tnf superfamily trimerization inhibitors
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CN102731450A (zh) * 2012-07-04 2012-10-17 中山大学 一种苯并呋喃或吲哚的制备方法
WO2015023724A1 (en) 2013-08-13 2015-02-19 The Scripps Research Institute Cysteine-reactive ligand discovery in proteomes
CN104897826B (zh) * 2015-06-16 2016-06-22 广西师范大学 一种用于细胞原位检测小分子化合物与靶蛋白相互作用的方法
US10493127B2 (en) 2015-08-11 2019-12-03 Arch Biopartners, Inc. DPEP-1 binding compositions and methods of use
JP6953400B2 (ja) 2015-10-22 2021-10-27 ザ スクリプス リサーチ インスティテュート システイン反応性プローブとその使用
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Also Published As

Publication number Publication date
ATE342507T1 (de) 2006-11-15
EP1066522A1 (de) 2001-01-10
EP1066522B1 (de) 2006-10-11
CA2326341A1 (en) 1999-09-30
US20040063157A1 (en) 2004-04-01
EP1066522A4 (de) 2005-02-02
US20040132100A1 (en) 2004-07-08
IL138717A0 (en) 2001-10-31
US20020115107A1 (en) 2002-08-22
US6344330B1 (en) 2002-02-05
WO1999049314A9 (en) 1999-11-18
JP2002507748A (ja) 2002-03-12
AU759327B2 (en) 2003-04-10
AU3211399A (en) 1999-10-18
DE69933549T2 (de) 2007-06-21
US6344334B1 (en) 2002-02-05
US7001727B2 (en) 2006-02-21
WO1999049314A1 (en) 1999-09-30
CA2326341C (en) 2009-02-17

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