DE69935230D1 - Vorrichtung für thermische und flüssige zirkulation zur hybridierung von nukleinsäuren - Google Patents
Vorrichtung für thermische und flüssige zirkulation zur hybridierung von nukleinsäurenInfo
- Publication number
- DE69935230D1 DE69935230D1 DE69935230T DE69935230T DE69935230D1 DE 69935230 D1 DE69935230 D1 DE 69935230D1 DE 69935230 T DE69935230 T DE 69935230T DE 69935230 T DE69935230 T DE 69935230T DE 69935230 D1 DE69935230 D1 DE 69935230D1
- Authority
- DE
- Germany
- Prior art keywords
- thermal
- nucleic acids
- liquid circulation
- hybridizing nucleic
- hybridizing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000007788 liquid Substances 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
- G01N1/312—Apparatus therefor for samples mounted on planar substrates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/041—Connecting closures to device or container
- B01L2300/045—Connecting closures to device or container whereby the whole cover is slidable
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0636—Integrated biosensor, microarrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0822—Slides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0877—Flow chambers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
- B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
- B01L2400/049—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics vacuum
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
- G01N2035/00099—Characterised by type of test elements
- G01N2035/00158—Elements containing microarrays, i.e. "biochip"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00346—Heating or cooling arrangements
- G01N2035/00356—Holding samples at elevated temperature (incubation)
- G01N2035/00366—Several different temperatures used
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9610998P | 1998-08-10 | 1998-08-10 | |
US96109P | 1998-08-10 | ||
PCT/US1999/018122 WO2000009650A1 (en) | 1998-08-10 | 1999-08-10 | A thermal/fluidic cycling device for the purpose of nucleic acid hybridization |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69935230D1 true DE69935230D1 (de) | 2007-04-05 |
DE69935230T2 DE69935230T2 (de) | 2007-12-20 |
Family
ID=22255392
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69935230T Expired - Lifetime DE69935230T2 (de) | 1998-08-10 | 1999-08-10 | Vorrichtung für thermische und flüssige zirkulation zur hybridierung von nukleinsäuren |
Country Status (7)
Country | Link |
---|---|
US (2) | US6238910B1 (de) |
EP (1) | EP1105458B1 (de) |
JP (1) | JP2002522065A (de) |
AU (2) | AU772769B2 (de) |
CA (1) | CA2339163C (de) |
DE (1) | DE69935230T2 (de) |
WO (1) | WO2000009650A1 (de) |
Families Citing this family (109)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030017081A1 (en) * | 1994-02-10 | 2003-01-23 | Affymetrix, Inc. | Method and apparatus for imaging a sample on a device |
US6287850B1 (en) * | 1995-06-07 | 2001-09-11 | Affymetrix, Inc. | Bioarray chip reaction apparatus and its manufacture |
DE69527585T2 (de) * | 1994-06-08 | 2003-04-03 | Affymetrix Inc | Verfahren und Vorrichtung zum Verpacken von Chips |
US6429007B1 (en) * | 1997-05-02 | 2002-08-06 | BIOMéRIEUX, INC. | Nucleic acid amplification reaction station for disposable test devices |
US6410275B1 (en) | 1997-05-02 | 2002-06-25 | Biomerieux, Inc. | Disposable test devices for performing nucleic acid amplification reactions |
DE69935230T2 (de) * | 1998-08-10 | 2007-12-20 | Genomic Solutions, Inc., Ann Arbor | Vorrichtung für thermische und flüssige zirkulation zur hybridierung von nukleinsäuren |
US6673620B1 (en) | 1999-04-20 | 2004-01-06 | Cytologix Corporation | Fluid exchange in a chamber on a microscope slide |
US6773676B2 (en) * | 1999-04-27 | 2004-08-10 | Agilent Technologies, Inc. | Devices for performing array hybridization assays and methods of using the same |
WO2001081892A2 (en) * | 2000-04-26 | 2001-11-01 | Arcturus Engineering, Inc. | Laser capture microdissection (lcm) extraction device and device carrier and method for post-lcm fluid processing |
EP1188840A3 (de) * | 2000-07-26 | 2003-04-23 | Agilent Technologies, Inc. (a Delaware corporation) | Chemisches Reaktionsverfahren und Vorrichtung |
KR100916074B1 (ko) * | 2001-03-09 | 2009-09-08 | 바이오마이크로 시스템즈, 인크. | 어레이에 대한 마이크로유체 인터페이스 방법 및인터페이스용 시스템 |
EP1373573B1 (de) * | 2001-03-09 | 2013-10-02 | TrovaGene, Inc. | Konjugatsonden und optischer nachweis von analyten |
US20020192806A1 (en) * | 2001-05-14 | 2002-12-19 | Genomic Solutions, Inc. | Thermal and fluidic cycling device for nucleic acid hybridization |
US9157875B2 (en) * | 2001-05-16 | 2015-10-13 | Benjamin P. Warner | Drug development and manufacturing |
US20080220441A1 (en) * | 2001-05-16 | 2008-09-11 | Birnbaum Eva R | Advanced drug development and manufacturing |
DE50212817D1 (de) * | 2001-05-25 | 2008-11-06 | Tecan Trading Ag | Vorrichtung und Verfahrenseinheit zum Bereitstellen eines Hybridisierraums |
US7294478B1 (en) | 2001-06-06 | 2007-11-13 | Rosetta Inpharmatics Llc | Microarray reaction cartridge |
US6485918B1 (en) | 2001-07-02 | 2002-11-26 | Packard Bioscience Corporation | Method and apparatus for incubation of a liquid reagent and target spots on a microarray substrate |
WO2003093168A2 (en) * | 2001-07-26 | 2003-11-13 | Motorola, Inc. | System and methods for mixing within a microfluidic device |
US6881579B2 (en) * | 2001-07-30 | 2005-04-19 | Agilent Technologies, Inc. | Sample processing apparatus and methods |
US7008788B2 (en) | 2001-07-30 | 2006-03-07 | Agilent Technologies, Inc. | Containers for supports comprising biopolymers |
US7413859B2 (en) * | 2001-11-14 | 2008-08-19 | Siemens Aktiengesellschaft | Method and biosensors for detecting macromolecular biopolymers |
US20030152934A1 (en) * | 2002-02-11 | 2003-08-14 | Industrial Technology Research Institute | High performance nucleic acid hybridization device and process |
US20030162283A1 (en) * | 2002-02-22 | 2003-08-28 | Hitachi, Ltd. | Circulating type biochemical reaction apparatus |
US20030177380A1 (en) * | 2002-03-18 | 2003-09-18 | Woods Stanley P. | Devices for storing array data and methods of using the same |
US20030208936A1 (en) * | 2002-05-09 | 2003-11-13 | Lee Charles Hee | Method for manufacturing embroidery decorated cards and envelopes |
US7452712B2 (en) | 2002-07-30 | 2008-11-18 | Applied Biosystems Inc. | Sample block apparatus and method of maintaining a microcard on a sample block |
US7148057B2 (en) * | 2002-08-13 | 2006-12-12 | Gongin Precision Industries, Co., Ltd | Array biochip workstation |
US20040120861A1 (en) * | 2002-10-11 | 2004-06-24 | Affymetrix, Inc. | System and method for high-throughput processing of biological probe arrays |
US20040157336A1 (en) * | 2002-11-14 | 2004-08-12 | Affymetrix, Inc. | Automated fluid control system and process |
US20040259111A1 (en) * | 2002-12-10 | 2004-12-23 | Rosetta Inpharmatics Llc | Automated system and method for preparing an assay ready biological sample |
US7648678B2 (en) * | 2002-12-20 | 2010-01-19 | Dako Denmark A/S | Method and system for pretreatment of tissue slides |
EP2390352A1 (de) | 2003-03-18 | 2011-11-30 | Quantum Genetics Ireland Limited | Systeme und Methoden zur Erhöhung der Milchproduktion bei Tieren |
WO2004083824A1 (en) * | 2003-03-20 | 2004-09-30 | Dakocytomation Denmark A/S | System for establishing a sample cover on a substrate |
TW579430B (en) * | 2003-05-02 | 2004-03-11 | Dr Chip Biotechnology Inc | Automatic micro-fluid hybridization chip platform |
US7767152B2 (en) | 2003-08-11 | 2010-08-03 | Sakura Finetek U.S.A., Inc. | Reagent container and slide reaction retaining tray, and method of operation |
US7501283B2 (en) * | 2003-08-11 | 2009-03-10 | Sakura Finetek U.S.A., Inc. | Fluid dispensing apparatus |
US9518899B2 (en) * | 2003-08-11 | 2016-12-13 | Sakura Finetek U.S.A., Inc. | Automated reagent dispensing system and method of operation |
US7744817B2 (en) * | 2003-08-11 | 2010-06-29 | Sakura Finetek U.S.A., Inc. | Manifold assembly |
US20050226771A1 (en) * | 2003-09-19 | 2005-10-13 | Lehto Dennis A | High speed microplate transfer |
US7407630B2 (en) * | 2003-09-19 | 2008-08-05 | Applera Corporation | High density plate filler |
US7695688B2 (en) * | 2003-09-19 | 2010-04-13 | Applied Biosystems, Llc | High density plate filler |
US20050226779A1 (en) * | 2003-09-19 | 2005-10-13 | Oldham Mark F | Vacuum assist for a microplate |
US20060233671A1 (en) * | 2003-09-19 | 2006-10-19 | Beard Nigel P | High density plate filler |
US20050226782A1 (en) * | 2003-09-19 | 2005-10-13 | Reed Mark T | High density plate filler |
US20070015289A1 (en) * | 2003-09-19 | 2007-01-18 | Kao H P | Dispenser array spotting |
US7998435B2 (en) | 2003-09-19 | 2011-08-16 | Life Technologies Corporation | High density plate filler |
US20050221358A1 (en) * | 2003-09-19 | 2005-10-06 | Carrillo Albert L | Pressure chamber clamp mechanism |
US20050233472A1 (en) * | 2003-09-19 | 2005-10-20 | Kao H P | Spotting high density plate using a banded format |
US9492820B2 (en) | 2003-09-19 | 2016-11-15 | Applied Biosystems, Llc | High density plate filler |
US20050220675A1 (en) * | 2003-09-19 | 2005-10-06 | Reed Mark T | High density plate filler |
US8277760B2 (en) * | 2003-09-19 | 2012-10-02 | Applied Biosystems, Llc | High density plate filler |
US20060272738A1 (en) * | 2003-09-19 | 2006-12-07 | Gary Lim | High density plate filler |
DK2322278T3 (en) | 2003-10-24 | 2017-04-10 | Aushon Biosystems Inc | Apparatus and method for dispensing liquid, semi-solid and solid samples |
US20050170361A1 (en) * | 2004-02-02 | 2005-08-04 | Chih-Wei Ho | Method of preparing reaction regions for biochips |
AU2005244673B2 (en) | 2004-02-19 | 2009-12-10 | The Governors Of The University Of Alberta | Leptin promoter polymorphisms and uses thereof |
JP5149622B2 (ja) | 2004-05-20 | 2013-02-20 | クエスト ダイアグノスティックス インヴェストメンツ インコーポレイテッド | 単一標識比較ハイブリダイゼーション |
US20050274395A1 (en) * | 2004-06-14 | 2005-12-15 | Applera Corporation | Microarray wash tray |
US7615370B2 (en) * | 2004-07-08 | 2009-11-10 | Tecan Trading Ag | System having device for preventing air bubbles in a hybridization chamber and corresponding method |
CA2839092C (en) * | 2004-08-03 | 2018-04-03 | Becton, Dickinson And Company | Use of magnetic material to direct isolation of compounds and fractionation of multipart samples |
DE102004037848B4 (de) * | 2004-08-04 | 2007-03-29 | Advalytix Ag | Probenträgerwaschbehälter, Probenträgerwaschstation, System zum Waschen von Probenträgern und Verfahren zum Waschen von Probenträgern |
JP2006153785A (ja) * | 2004-12-01 | 2006-06-15 | Hitachi Ltd | 溶液攪拌装置及び分析システム |
KR100612879B1 (ko) | 2004-12-06 | 2006-08-14 | 삼성전자주식회사 | 폐쇄 시스템에서 펌프와 밸브의 제어를 통한 혼성화 장치 |
KR100612880B1 (ko) * | 2004-12-06 | 2006-08-14 | 삼성전자주식회사 | 챔버 샘플투입구의 패킹 장치 |
DE602006018861D1 (de) | 2005-01-27 | 2011-01-27 | Quest Diagnostics Invest Inc | Schnelle komparative genomhybridisierung |
US20060246576A1 (en) * | 2005-04-06 | 2006-11-02 | Affymetrix, Inc. | Fluidic system and method for processing biological microarrays in personal instrumentation |
EP2255880B1 (de) | 2005-06-21 | 2014-05-28 | Tecan Trading AG | Verfahren zum Verhindern von Luftblasen in Hybridisierkammern |
US8076074B2 (en) | 2005-11-29 | 2011-12-13 | Quest Diagnostics Investments Incorporated | Balanced translocation in comparative hybridization |
JP4721425B2 (ja) * | 2005-12-01 | 2011-07-13 | キヤノン株式会社 | 流体移動方法および流体移動装置 |
US7818092B2 (en) * | 2006-01-20 | 2010-10-19 | Fisher Controls International Llc | In situ emission measurement for process control equipment |
JP2007209236A (ja) * | 2006-02-08 | 2007-08-23 | Canon Inc | ハイブリダイゼーション方法および装置 |
US20100200021A1 (en) * | 2006-02-17 | 2010-08-12 | Nils Adey | Slide Conditioning Systems and Methods |
WO2007109354A2 (en) * | 2006-03-21 | 2007-09-27 | Amylin Pharmaceuticals, Inc. | Peptide-peptidase inhibitor conjugates and methods of using same |
US8459509B2 (en) | 2006-05-25 | 2013-06-11 | Sakura Finetek U.S.A., Inc. | Fluid dispensing apparatus |
JP4939910B2 (ja) * | 2006-11-29 | 2012-05-30 | 株式会社東芝 | マイクロ化学分析システム及びマイクロ化学分析装置 |
US7807359B2 (en) | 2006-12-01 | 2010-10-05 | Quest Diagnostics Investments Incorporated | Methods of detecting TPMT mutations |
KR20080060661A (ko) * | 2006-12-27 | 2008-07-02 | 삼성전자주식회사 | 기포 발생을 방지하는 혼성화 챔버용 장치 및 이를포함하는 혼성화 장치 |
ES2665280T3 (es) * | 2007-06-29 | 2018-04-25 | Becton, Dickinson And Company | Métodos para la extracción y purificación de componentes de muestras biológicas |
US7507539B2 (en) | 2007-07-30 | 2009-03-24 | Quest Diagnostics Investments Incorporated | Substractive single label comparative hybridization |
AU2008291469A1 (en) * | 2007-08-29 | 2009-03-05 | Dako Denmark A/S | On-site liquid production |
US7842238B2 (en) * | 2007-10-30 | 2010-11-30 | Industrial Technology Research Institute | Fully automated microarray processing system |
US8093063B2 (en) | 2007-11-29 | 2012-01-10 | Quest Diagnostics Investments Incorporated | Assay for detecting genetic abnormalities in genomic nucleic acids |
US20110190153A1 (en) * | 2008-06-09 | 2011-08-04 | Nils Adey | System and method for hybridization slide processing |
US20100167943A1 (en) * | 2008-06-09 | 2010-07-01 | Nils Adey | System and Method for Hybridization Slide Processing |
JP2012502660A (ja) * | 2008-09-22 | 2012-02-02 | エフ.ホフマン−ラ ロシュ アーゲー | マイクロアレイ基板上の生体物質の選択的プロセシング |
EP2350673B1 (de) * | 2008-10-24 | 2022-05-11 | Leica Biosystems Richmond, Inc. | Modulares system für laborprotokolle und zugehörige verfahren |
CH699853A1 (de) | 2008-11-13 | 2010-05-14 | Tecan Trading Ag | Messgerät und Verfahren zum Bestimmen von durch ein Laborsystem bereitgestellten Fluidparametern. |
US8622072B2 (en) * | 2008-12-05 | 2014-01-07 | Fisher Controls International, Llc | Apparatus to control fluid flow |
US8039794B2 (en) | 2008-12-16 | 2011-10-18 | Quest Diagnostics Investments Incorporated | Mass spectrometry assay for thiopurine-S-methyl transferase activity and products generated thereby |
CA2774116A1 (en) | 2009-09-25 | 2011-03-31 | Signature Genomics Laboratories Llc | Multiplex (+/-) stranded arrays and assays for detecting chromosomal abnormalities associated with cancer and other diseases |
EP2367058A1 (de) | 2010-03-17 | 2011-09-21 | Université Jean-Monnet | Herstellungsverfahren von zylindrischen Gittern |
WO2011117275A1 (de) * | 2010-03-25 | 2011-09-29 | Endress+Hauser Conducta Gesellschaft Für Mess- Und Regeltechnik Mbh+Co. Kg | System zur behandlung von flüssigkeiten |
WO2011139888A2 (en) | 2010-04-29 | 2011-11-10 | Statspin, Inc. | Analytical system for performing laboratory protocols and associated methods |
US20110303197A1 (en) | 2010-06-09 | 2011-12-15 | Honda Motor Co., Ltd. | Microcondenser device |
US8752732B2 (en) | 2011-02-01 | 2014-06-17 | Sakura Finetek U.S.A., Inc. | Fluid dispensing system |
US8580568B2 (en) | 2011-09-21 | 2013-11-12 | Sakura Finetek U.S.A., Inc. | Traceability for automated staining system |
US8932543B2 (en) | 2011-09-21 | 2015-01-13 | Sakura Finetek U.S.A., Inc. | Automated staining system and reaction chamber |
USD753311S1 (en) | 2011-10-12 | 2016-04-05 | Alere Switzerland Gmbh | Isothermal nucleic acid amplification meter |
EP2823281B1 (de) | 2012-03-09 | 2018-11-28 | Leica Biosystems Richmond, Inc. | Vorrichtung und verfahren zur regelung der temperatur in einer strömenden flüssigkeit in einem laborprobenverarbeitungssystem |
US10876936B2 (en) | 2012-12-03 | 2020-12-29 | Leica Biosystems Melbourne Pty Ltd | Thermal module for a sample processing assembly |
BR112016000456B1 (pt) | 2013-08-08 | 2021-06-01 | Illumina, Inc | Sistema e método de reutilização de reagentes |
WO2015051295A1 (en) * | 2013-10-04 | 2015-04-09 | Biogenex Laboratories, Inc. | Assembly for forming microchamber for inverted substrate |
EP3514246B1 (de) | 2014-02-27 | 2021-11-17 | The Broad Institute, Inc. | T-zellen-balance-genexpression und verfahren zur verwendung davon |
US10683552B2 (en) | 2014-11-25 | 2020-06-16 | Presidents And Fellows Of Harvard College | Clonal haematopoiesis |
US11168369B2 (en) | 2014-11-25 | 2021-11-09 | The Brigham And Women's Hospital, Inc. | Method of identifying and treating a person having a predisposition to or afflicted with a cardiometabolic disease |
WO2016138488A2 (en) | 2015-02-26 | 2016-09-01 | The Broad Institute Inc. | T cell balance gene expression, compositions of matters and methods of use thereof |
ES2927121T3 (es) * | 2015-05-29 | 2022-11-02 | Illumina Inc | Portamuestras y sistema de ensayo para realizar reacciones designadas |
US20170216845A1 (en) * | 2016-01-28 | 2017-08-03 | Becton, Dickinson And Company | Enhanced composite liquid cell (clc) devices, and methods for using the same |
EP3615694B1 (de) | 2017-04-25 | 2022-03-30 | The Brigham and Women's Hospital, Inc. | Il-8, il-6, il-1b und tet2 sowie dnmt3a bei atherosklerose |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4753775A (en) * | 1985-04-12 | 1988-06-28 | E. I. Du Pont De Nemours And Company | Rapid assay processor |
EP0270363A3 (de) * | 1986-12-04 | 1988-11-02 | University Of Leicester | Apparat zum Durchführen von Reaktionen mit Flüssigkeiten |
US4847208A (en) * | 1987-07-29 | 1989-07-11 | Bogen Steven A | Apparatus for immunohistochemical staining and method of rinsing a plurality of slides |
US5188963A (en) * | 1989-11-17 | 1993-02-23 | Gene Tec Corporation | Device for processing biological specimens for analysis of nucleic acids |
US5346672A (en) * | 1989-11-17 | 1994-09-13 | Gene Tec Corporation | Devices for containing biological specimens for thermal processing |
US5273905A (en) * | 1991-02-22 | 1993-12-28 | Amoco Corporation | Processing of slide mounted material |
US5849486A (en) * | 1993-11-01 | 1998-12-15 | Nanogen, Inc. | Methods for hybridization analysis utilizing electrically controlled hybridization |
US5364790A (en) * | 1993-02-16 | 1994-11-15 | The Perkin-Elmer Corporation | In situ PCR amplification system |
BR9407947A (pt) * | 1993-11-02 | 1996-11-26 | Affymax Tech Nv | Processo para sintetizar moléculas diversas em uma pluralidade de substratos e uma coleçao molecular etiquetade para realizaçao reaçoes de copulaçao em contas em paralelo para triar uma coleçao molecular etiquetada para detectar a presença de um ou mais diferentes etiquetas e para determinar a sequência de síntese aparelho para reaçoes de copulaçao paralelas em suportes sólidos bloco de alinhamento ótico para uso com um detector ótico sistemas de distribuiçao para distribuir reagentes dispositiv |
US6036923A (en) * | 1995-03-07 | 2000-03-14 | Bioseq, Inc | Pressure cycling reactor and methods of controlling reactions using pressure |
GB9506312D0 (en) * | 1995-03-28 | 1995-05-17 | Medical Res Council | Improvements in or relating to sample processing |
US5589136A (en) * | 1995-06-20 | 1996-12-31 | Regents Of The University Of California | Silicon-based sleeve devices for chemical reactions |
US5804384A (en) * | 1996-12-06 | 1998-09-08 | Vysis, Inc. | Devices and methods for detecting multiple analytes in samples |
DE69935230T2 (de) * | 1998-08-10 | 2007-12-20 | Genomic Solutions, Inc., Ann Arbor | Vorrichtung für thermische und flüssige zirkulation zur hybridierung von nukleinsäuren |
-
1999
- 1999-08-10 DE DE69935230T patent/DE69935230T2/de not_active Expired - Lifetime
- 1999-08-10 JP JP2000565087A patent/JP2002522065A/ja not_active Ceased
- 1999-08-10 CA CA002339163A patent/CA2339163C/en not_active Expired - Fee Related
- 1999-08-10 WO PCT/US1999/018122 patent/WO2000009650A1/en active IP Right Grant
- 1999-08-10 AU AU55532/99A patent/AU772769B2/en not_active Ceased
- 1999-08-10 US US09/371,107 patent/US6238910B1/en not_active Expired - Fee Related
- 1999-08-10 EP EP99942075A patent/EP1105458B1/de not_active Expired - Lifetime
-
2001
- 2001-05-14 US US09/855,008 patent/US6432696B2/en not_active Expired - Fee Related
-
2004
- 2004-03-17 AU AU2004201118A patent/AU2004201118B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
US6238910B1 (en) | 2001-05-29 |
AU2004201118A1 (en) | 2004-04-22 |
WO2000009650A1 (en) | 2000-02-24 |
AU5553299A (en) | 2000-03-06 |
AU772769B2 (en) | 2004-05-06 |
DE69935230T2 (de) | 2007-12-20 |
CA2339163A1 (en) | 2000-02-24 |
US6432696B2 (en) | 2002-08-13 |
US20010046700A1 (en) | 2001-11-29 |
EP1105458B1 (de) | 2007-02-21 |
WO2000009650A9 (en) | 2000-05-18 |
EP1105458A1 (de) | 2001-06-13 |
CA2339163C (en) | 2010-01-12 |
AU2004201118B2 (en) | 2008-01-10 |
EP1105458A4 (de) | 2005-06-29 |
JP2002522065A (ja) | 2002-07-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69935230D1 (de) | Vorrichtung für thermische und flüssige zirkulation zur hybridierung von nukleinsäuren | |
DE69928683D1 (de) | Verfahren zur amplifikation und zur sequenzierung von nukleinsäuren | |
DE59712384D1 (de) | Vorrichtung zur Reinigung von Pipettiernadeln oder Rührern | |
DE69909770T2 (de) | Verfahren und vorrichtung zur temperaturbestimmung und überwachung von verdampfung von flüssigkeitsproben | |
DE69907878D1 (de) | Verfahren und vorrichtung zur elektrokoagulation von flüssigkeiten | |
DE59912604D1 (de) | Verfahren zur isolierung und aufreinigung von nucleinsäuren | |
DE69725076D1 (de) | Modifizierte thermostabile DNA Polymerase und eine DNA Polymerasezusammensetzung zur Amplifikation von Nukleinsäuren | |
DE69837419D1 (de) | Einrichtung zur induktiven Erwärmung von Flüssigkeiten | |
DE69819407D1 (de) | Messverfahren und Messvorrichtung zur Durchführung des Verfahrens | |
DE69928823D1 (de) | Vorrichtung zur befestigung von wirbelsäulenstangen | |
DE59802862D1 (de) | Vorrichtung zur halterung von temperier- und schüttelbaren reaktionsgefässen | |
DE69802991D1 (de) | Verfahren zur Ersetzung von verlegten Rohren und Vorrichtung zur Durchführung des Verfahrens | |
DE69841233D1 (de) | Vorrichtung zum Nachweis der Verschmutzung einer isolierenden Umgebung, und zur lokalen Heizung dergleichen | |
DE59811735D1 (de) | Verfahren und Vorrichtung zur Verbesserung des Wärmeüberganges | |
DE69802689T2 (de) | Vorrichtung zur mischung und belüftung von flüssigkeiten | |
ATA22397A (de) | Verfahren zur erwärmung von dünnschlamm und anordnung zur durchführung des verfahrens | |
DE69910030D1 (de) | Gefässe zum erhitzen von flüssigkeiten | |
DE59912190D1 (de) | Vorrichtung zum thermischen sterilisieren von flüssigkeiten | |
DE69930862D1 (de) | Expressionssysteme zur funktionellen expression von nukleinsäuren | |
DE19983115T1 (de) | Elektrophorese-Gel und Vorrichtung zur Gel-Bildung | |
DE29813001U1 (de) | Einrichtung zur Regelung und Überwachung von Weichenheizungen | |
DE59910171D1 (de) | Einrichtung zur Heizung und Warmwasserbereitung | |
DE29723901U1 (de) | Einrichtung zur Belüftung von Flüssigkeiten | |
DE29720575U1 (de) | Vorrichtung zur Aufbereitung von Kühlflüssigkeit | |
DE29816063U1 (de) | Einrichtung zur Beheizung von Flüssiggasflaschen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |