DE69939732D1 - Apo-2 ligand - Google Patents

Apo-2 ligand

Info

Publication number
DE69939732D1
DE69939732D1 DE69939732T DE69939732T DE69939732D1 DE 69939732 D1 DE69939732 D1 DE 69939732D1 DE 69939732 T DE69939732 T DE 69939732T DE 69939732 T DE69939732 T DE 69939732T DE 69939732 D1 DE69939732 D1 DE 69939732D1
Authority
DE
Germany
Prior art keywords
ligand
apo
antibodies
believed
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69939732T
Other languages
English (en)
Inventor
Avi J Ashkenazi
Robert F Kelley
Mark T O'connel
Robert M Pitti
Ralph H Schwall
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of DE69939732D1 publication Critical patent/DE69939732D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
DE69939732T 1998-01-15 1999-01-15 Apo-2 ligand Expired - Lifetime DE69939732D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US788698A 1998-01-15 1998-01-15
US6053398A 1998-04-15 1998-04-15
PCT/US1999/001039 WO1999036535A1 (en) 1998-01-15 1999-01-15 Apo-2 ligand

Publications (1)

Publication Number Publication Date
DE69939732D1 true DE69939732D1 (de) 2008-11-27

Family

ID=26677483

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69939732T Expired - Lifetime DE69939732D1 (de) 1998-01-15 1999-01-15 Apo-2 ligand

Country Status (13)

Country Link
US (1) US6740739B1 (de)
EP (2) EP2017341A3 (de)
JP (2) JP2002508962A (de)
AT (1) ATE411385T1 (de)
AU (1) AU2325199A (de)
CA (1) CA2318029C (de)
CY (1) CY1108681T1 (de)
DE (1) DE69939732D1 (de)
DK (1) DK1045906T3 (de)
ES (1) ES2316182T3 (de)
HK (1) HK1032603A1 (de)
PT (1) PT1045906E (de)
WO (1) WO1999036535A1 (de)

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US7741285B2 (en) 2001-11-13 2010-06-22 Genentech, Inc. APO-2 ligand/trail formulations
PT1450847E (pt) * 2001-11-13 2011-01-05 Genentech Inc Formulações de ligando de apo2/trail e suas utilizações
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US20060141561A1 (en) * 2002-06-24 2006-06-29 Kelley Robert F Apo-2 ligand/trail variants and uses thereof
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US20140178398A1 (en) 2011-05-03 2014-06-26 Genentech, Inc Vascular disruption agents and uses thereof
EP2752429B1 (de) 2011-09-16 2017-03-01 Beijing Sunbio Biotech Co. Ltd. Fusionsprotein mit kreisförmig permutierter form von trail/apo2l, kodierendes gen und verwendung davon
EP2684896A1 (de) 2012-07-09 2014-01-15 International-Drug-Development-Biotech Antikörper gegen die DR5-Familie, bispezifische oder multivalente Antikörper gegen die DR5-Familie und Verfahren zu deren Verwendung
PT2970473T (pt) 2013-03-14 2017-10-26 Bristol Myers Squibb Co Combinação de agonista de dr5 e antagonista anti-pd-1 e métodos de utilização
US9914761B2 (en) 2014-07-10 2018-03-13 Washington University Oligomers for TNF superfamily inhibition
US20190202926A1 (en) 2015-12-01 2019-07-04 Genmab B.V. Anti-death receptor antibodies and methods of use thereof
JP2020505009A (ja) 2017-01-05 2020-02-20 カール メディカル リミテッド Ｐｄ１−４１ｂｂｌ融合タンパク質およびその使用方法
PT3565828T (pt) 2017-01-05 2022-02-08 Kahr Medical Ltd Proteína de fusão sirp1 alfa-41bbl e seus métodos de utilização
US11566060B2 (en) 2017-01-05 2023-01-31 Kahr Medical Ltd. PD1-CD70 fusion protein and methods of use thereof
US11299530B2 (en) 2017-01-05 2022-04-12 Kahr Medical Ltd. SIRP alpha-CD70 fusion protein and methods of use thereof

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Also Published As

Publication number Publication date
AU2325199A (en) 1999-08-02
CA2318029C (en) 2009-05-19
CA2318029A1 (en) 1999-07-22
EP1045906A1 (de) 2000-10-25
DK1045906T3 (da) 2009-02-16
ES2316182T3 (es) 2009-04-01
ATE411385T1 (de) 2008-10-15
CY1108681T1 (el) 2014-04-09
EP2017341A2 (de) 2009-01-21
JP2002508962A (ja) 2002-03-26
PT1045906E (pt) 2009-01-27
EP2017341A3 (de) 2009-04-08
JP2010246560A (ja) 2010-11-04
HK1032603A1 (en) 2001-07-27
US6740739B1 (en) 2004-05-25
EP1045906B1 (de) 2008-10-15
WO1999036535A9 (en) 2000-03-02
WO1999036535A1 (en) 1999-07-22

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition