DE69940138D1 - Miniaturisierte Vorrichtung zur Flüssigkeitsprobenbehandlung und -massenspektrometrie - Google Patents

Miniaturisierte Vorrichtung zur Flüssigkeitsprobenbehandlung und -massenspektrometrie

Info

Publication number
DE69940138D1
DE69940138D1 DE69940138T DE69940138T DE69940138D1 DE 69940138 D1 DE69940138 D1 DE 69940138D1 DE 69940138 T DE69940138 T DE 69940138T DE 69940138 T DE69940138 T DE 69940138T DE 69940138 D1 DE69940138 D1 DE 69940138D1
Authority
DE
Germany
Prior art keywords
mass spectrometry
liquid sample
sample treatment
miniaturized apparatus
miniaturized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69940138T
Other languages
English (en)
Inventor
Hongfeng Yin
John A Chakel
Sally A Swedberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Agilent Technologies Inc
Original Assignee
Agilent Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agilent Technologies Inc filed Critical Agilent Technologies Inc
Application granted granted Critical
Publication of DE69940138D1 publication Critical patent/DE69940138D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/62Detectors specially adapted therefor
    • G01N30/72Mass spectrometers
    • G01N30/7233Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/60Construction of the column
    • G01N30/6095Micromachined or nanomachined, e.g. micro- or nanosize
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/0013Miniaturised spectrometers, e.g. having smaller than usual scale, integrated conventional components
    • H01J49/0018Microminiaturised spectrometers, e.g. chip-integrated devices, MicroElectro-Mechanical Systems [MEMS]
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/04Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0431Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02Adapting objects or devices to another
    • B01L2200/026Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/06Auxiliary integrated devices, integrated components
    • B01L2300/0627Sensor or part of a sensor is integrated
    • B01L2300/0645Electrodes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0816Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0887Laminated structure
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/02Drop detachment mechanisms of single droplets from nozzles or pins
    • B01L2400/027Drop detachment mechanisms of single droplets from nozzles or pins electrostatic forces between substrate and tip
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0475Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Sampling And Sample Adjustment (AREA)
DE69940138T 1998-06-12 1999-06-14 Miniaturisierte Vorrichtung zur Flüssigkeitsprobenbehandlung und -massenspektrometrie Expired - Lifetime DE69940138D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8903398P 1998-06-12 1998-06-12

Publications (1)

Publication Number Publication Date
DE69940138D1 true DE69940138D1 (de) 2009-02-05

Family

ID=22215153

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69940138T Expired - Lifetime DE69940138D1 (de) 1998-06-12 1999-06-14 Miniaturisierte Vorrichtung zur Flüssigkeitsprobenbehandlung und -massenspektrometrie

Country Status (3)

Country Link
US (1) US6459080B1 (de)
EP (1) EP0964428B1 (de)
DE (1) DE69940138D1 (de)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6774359B1 (en) * 1998-08-06 2004-08-10 Hitachi, Ltd. Sample-introduction tool, and an ion source and a mass spectrometer using the sample-introduction tool
CN100435900C (zh) 1998-09-17 2008-11-26 阿德文生物科学公司 液相色谱系统,化学分离装置及质谱分析装置和方法
EP1230544B1 (de) * 1999-06-18 2004-07-28 Gamera Bioscience Corporation Vorrichtungen und verfahren zur durchführung miniaturisierter homogener tests
DE19947495C2 (de) * 1999-10-01 2003-05-28 Agilent Technologies Inc Mikrofluidischer Mikrochip
US6596988B2 (en) 2000-01-18 2003-07-22 Advion Biosciences, Inc. Separation media, multiple electrospray nozzle system and method
DE10154601B4 (de) * 2000-11-13 2007-02-22 Agilent Technologies, Inc. (n.d.Ges.d.Staates Delaware), Palo Alto Ein Mikrobauelement mit einem integrierten hervorstehenden Elektrospray-Emitter und ein Verfahren zum Herstellen des Mikrobauelements
US6653625B2 (en) * 2001-03-19 2003-11-25 Gyros Ab Microfluidic system (MS)
US20040099310A1 (en) * 2001-01-05 2004-05-27 Per Andersson Microfluidic device
WO2002075312A1 (en) 2001-03-19 2002-09-26 Gyros Ab Characterization of reaction variables
US6717136B2 (en) * 2001-03-19 2004-04-06 Gyros Ab Microfludic system (EDI)
US6610978B2 (en) * 2001-03-27 2003-08-26 Agilent Technologies, Inc. Integrated sample preparation, separation and introduction microdevice for inductively coupled plasma mass spectrometry
US6803568B2 (en) * 2001-09-19 2004-10-12 Predicant Biosciences, Inc. Multi-channel microfluidic chip for electrospray ionization
US6627076B2 (en) * 2001-10-19 2003-09-30 Sandia National Laboratories Compact microchannel system
US7105810B2 (en) * 2001-12-21 2006-09-12 Cornell Research Foundation, Inc. Electrospray emitter for microfluidic channel
US7303727B1 (en) 2002-03-06 2007-12-04 Caliper Life Sciences, Inc Microfluidic sample delivery devices, systems, and methods
US6621076B1 (en) * 2002-04-30 2003-09-16 Agilent Technologies, Inc. Flexible assembly for transporting sample fluids into a mass spectrometer
US6706091B1 (en) * 2002-12-17 2004-03-16 Sandia Corporation Sub-to super-ambient temperature programmable microfabricated gas chromatography column
US7007710B2 (en) 2003-04-21 2006-03-07 Predicant Biosciences, Inc. Microfluidic devices and methods
US7081623B2 (en) * 2003-09-05 2006-07-25 Lucent Technologies Inc. Wafer-based ion traps
US7537807B2 (en) 2003-09-26 2009-05-26 Cornell University Scanned source oriented nanofiber formation
US7282705B2 (en) * 2003-12-19 2007-10-16 Agilent Technologies, Inc. Microdevice having an annular lining for producing an electrospray emitter
US7522786B2 (en) 2005-12-22 2009-04-21 Palo Alto Research Center Incorporated Transmitting light with photon energy information
US7291824B2 (en) * 2005-12-22 2007-11-06 Palo Alto Research Center Incorporated Photosensing throughout energy range and in subranges
US20060060769A1 (en) 2004-09-21 2006-03-23 Predicant Biosciences, Inc. Electrospray apparatus with an integrated electrode
US7591883B2 (en) 2004-09-27 2009-09-22 Cornell Research Foundation, Inc. Microfiber supported nanofiber membrane
JP5008568B2 (ja) * 2004-10-07 2012-08-22 ウオーターズ・テクノロジーズ・コーポレイシヨン Hplcキャピラリーカラム装置
WO2006081135A2 (en) * 2005-01-25 2006-08-03 Oscillogy Llc Temperature controller for small fluid samples having different heat capacities
TWI282775B (en) * 2005-04-27 2007-06-21 Ind Tech Res Inst Fabricated technique of micro spray nozzles
EP1882950A4 (de) * 2005-05-19 2012-08-15 Konica Minolta Med & Graphic Testchip zur analyse einer in einem analyten enthaltenen zielsubstanz und umfangreiches mikroskopisches analysesystem
US7259846B2 (en) * 2005-08-30 2007-08-21 Agilent Technologies, Inc. Lab in a cuvette
US7315667B2 (en) * 2005-12-22 2008-01-01 Palo Alto Research Center Incorporated Propagating light to be sensed
US7420677B2 (en) * 2005-12-22 2008-09-02 Palo Alto Research Center Incorporated Sensing photon energies of optical signals
US7433552B2 (en) * 2005-12-22 2008-10-07 Palo Alto Research Center Incorporated Obtaining analyte information
US8437582B2 (en) 2005-12-22 2013-05-07 Palo Alto Research Center Incorporated Transmitting light with lateral variation
US7358476B2 (en) * 2005-12-22 2008-04-15 Palo Alto Research Center Incorporated Sensing photons from objects in channels
US7386199B2 (en) * 2005-12-22 2008-06-10 Palo Alto Research Center Incorporated Providing light to channels or portions
US7547904B2 (en) * 2005-12-22 2009-06-16 Palo Alto Research Center Incorporated Sensing photon energies emanating from channels or moving objects
TWI274040B (en) * 2005-12-23 2007-02-21 Ind Tech Res Inst Microfluidic device and method of manufacturing the same
US9164037B2 (en) 2007-01-26 2015-10-20 Palo Alto Research Center Incorporated Method and system for evaluation of signals received from spatially modulated excitation and emission to accurately determine particle positions and distances
US8821799B2 (en) 2007-01-26 2014-09-02 Palo Alto Research Center Incorporated Method and system implementing spatially modulated excitation or emission for particle characterization with enhanced sensitivity
US7936463B2 (en) 2007-02-05 2011-05-03 Palo Alto Research Center Incorporated Containing analyte in optical cavity structures
US7817276B2 (en) 2007-02-05 2010-10-19 Palo Alto Research Center Incorporated Distinguishing objects
US7633629B2 (en) * 2007-02-05 2009-12-15 Palo Alto Research Center Incorporated Tuning optical cavities
US8320983B2 (en) 2007-12-17 2012-11-27 Palo Alto Research Center Incorporated Controlling transfer of objects affecting optical characteristics
US8373860B2 (en) 2008-02-01 2013-02-12 Palo Alto Research Center Incorporated Transmitting/reflecting emanating light with time variation
US8629981B2 (en) 2008-02-01 2014-01-14 Palo Alto Research Center Incorporated Analyzers with time variation based on color-coded spatial modulation
WO2010102194A1 (en) 2009-03-06 2010-09-10 Waters Technologies Corporation Electrospray interface to a microfluidic substrate
GB0914762D0 (en) 2009-08-24 2009-09-30 Univ Glasgow Fluidics apparatus and fluidics substrate
GB201103211D0 (en) 2011-02-24 2011-04-13 Univ Glasgow Fluidics apparatus, use of fluidics apparatus and process for the manufacture of fluidics apparatus
GB201108462D0 (en) * 2011-05-19 2011-07-06 Univ Glasgow Sample nebulization
US9029800B2 (en) 2011-08-09 2015-05-12 Palo Alto Research Center Incorporated Compact analyzer with spatial modulation and multiple intensity modulated excitation sources
US8723140B2 (en) 2011-08-09 2014-05-13 Palo Alto Research Center Incorporated Particle analyzer with spatial modulation and long lifetime bioprobes
GB201420061D0 (en) 2014-11-11 2014-12-24 Univ Glasgow Nebulisation of liquids

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2191110B (en) 1986-06-06 1989-12-06 Plessey Co Plc Chromatographic separation device
US4908112A (en) 1988-06-16 1990-03-13 E. I. Du Pont De Nemours & Co. Silicon semiconductor wafer for analyzing micronic biological samples
US5132012A (en) 1988-06-24 1992-07-21 Hitachi, Ltd. Liquid chromatograph
GB2244135B (en) 1990-05-04 1994-07-13 Gen Electric Co Plc Sensor devices
US5571410A (en) 1994-10-19 1996-11-05 Hewlett Packard Company Fully integrated miniaturized planar liquid sample handling and analysis device
US5658413A (en) 1994-10-19 1997-08-19 Hewlett-Packard Company Miniaturized planar columns in novel support media for liquid phase analysis
US5571398A (en) 1994-12-23 1996-11-05 Northeastern University Precise capillary electrophoretic interface for sample collection or analysis
US5872010A (en) 1995-07-21 1999-02-16 Northeastern University Microscale fluid handling system
US5716825A (en) * 1995-11-01 1998-02-10 Hewlett Packard Company Integrated nucleic acid analysis system for MALDI-TOF MS
US6068749A (en) 1996-01-19 2000-05-30 Northeastern University Subatmospheric, variable pressure sample delivery chamber for electrospray ionization/mass spectrometry and other applications
US5779868A (en) * 1996-06-28 1998-07-14 Caliper Technologies Corporation Electropipettor and compensation means for electrophoretic bias
US6008980A (en) * 1997-11-13 1999-12-28 Maxwell Energy Products, Inc. Hermetically sealed EMI feedthrough filter capacitor for human implant and other applications

Also Published As

Publication number Publication date
US6459080B1 (en) 2002-10-01
EP0964428A3 (de) 2002-08-21
EP0964428B1 (de) 2008-12-24
EP0964428A2 (de) 1999-12-15

Similar Documents

Publication Publication Date Title
DE69940138D1 (de) Miniaturisierte Vorrichtung zur Flüssigkeitsprobenbehandlung und -massenspektrometrie
DE69934219D1 (de) Vorrichtung zur blutanalyse
DE69931257D1 (de) Verfahren und vorrichtung zur spektralanalyse und kodierer
GB2334688B (en) Method and apparatus for the evaporation of liquid samples
DE69839689D1 (de) Probenpositionierungsverfahren und Vorrichtung zur dessen Durchführung
DE69941565D1 (de) Vorrichtung und verfahren zur spektralen abbildung
EP1406081A4 (de) Verfahren und vorrichtung zur optischen messung biologischer proben
DE60040530D1 (de) Verfahren und vorrichtung zur elektrosprüh-massenspektrometrie
DE69935464D1 (de) Verfahren und Vorrichtung zur Betrachtung von Rundfunkprogrammen
DE69709835D1 (de) Vorrichtung zur bildvorhersage und decodierung
ATE289684T1 (de) Vorrichtung und apparat zur gleichzeitigen detektion von mehreren analyten
DE59702254D1 (de) Vorrichtung zur durchführung von untersuchungen an zellproben und dergleichen
DE29620372U1 (de) Vorrichtung zur Blutzuckermessung
AU2921001A (en) Apparatus and method for removing small molecules and ions from low volume biological samples
DE69835000D1 (de) Vorrichtung zur Gasbehandlung
DE69833488D1 (de) Vorrichtung zur mikrobiellen probenahme und anreicherung
DE69833430D1 (de) Vorrichtung zur abwasserbehandlung
DE69522019D1 (de) Einteilige Vorrichtung zur Aufbereitung von biologischen Proben
DE69514509D1 (de) Vorrichtung zur flussigkeitsanalyse
DE69818413D1 (de) Bildherstellungverfahren und Vorrichtung zur Bildherstellung
DE59509212D1 (de) Vorrichtung zur entnahme von speichelproben
DE50214617D1 (de) Vorrichtung zur behandlung von histologischen proben
DE59814164D1 (de) Vorrichtung zur behandlung und infiltration von histologischen proben
DE69934684D1 (de) Vorrichtung zur gasbehandlung
DE59904802D1 (de) Vorrichtung zur Behandlung von Biomolekülen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition