DE69940510D1 - Transplantate für myokardiale narben - Google Patents

Transplantate für myokardiale narben

Info

Publication number
DE69940510D1
DE69940510D1 DE69940510T DE69940510T DE69940510D1 DE 69940510 D1 DE69940510 D1 DE 69940510D1 DE 69940510 T DE69940510 T DE 69940510T DE 69940510 T DE69940510 T DE 69940510T DE 69940510 D1 DE69940510 D1 DE 69940510D1
Authority
DE
Germany
Prior art keywords
transplants
cells
myocardial scars
heart
scars
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69940510T
Other languages
English (en)
Inventor
Donald A Mickle
Ren-Ke Li
Richard D Weisel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genzyme Corp
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Application granted granted Critical
Publication of DE69940510D1 publication Critical patent/DE69940510D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0656—Adult fibroblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0661—Smooth muscle cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/069—Vascular Endothelial cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/069—Vascular Endothelial cells
    • C12N5/0691—Vascular smooth muscle cells; 3D culture thereof, e.g. models of blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/44—Thiols, e.g. mercaptoethanol
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/28—Vascular endothelial cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
DE69940510T 1998-06-19 1999-06-18 Transplantate für myokardiale narben Expired - Lifetime DE69940510D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/099,994 US6099832A (en) 1997-05-28 1998-06-19 Transplants for myocardial scars
PCT/US1999/013850 WO1999066036A1 (en) 1998-06-19 1999-06-18 Transplants for myocardial scars

Publications (1)

Publication Number Publication Date
DE69940510D1 true DE69940510D1 (de) 2009-04-16

Family

ID=22277583

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69940510T Expired - Lifetime DE69940510D1 (de) 1998-06-19 1999-06-18 Transplantate für myokardiale narben

Country Status (9)

Country Link
US (7) US6099832A (de)
EP (1) EP1088062B1 (de)
JP (1) JP2002518006A (de)
AT (1) ATE424454T1 (de)
AU (1) AU4579099A (de)
BR (1) BR9911369A (de)
CA (1) CA2335248A1 (de)
DE (1) DE69940510D1 (de)
WO (1) WO1999066036A1 (de)

Families Citing this family (153)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6110459A (en) * 1997-05-28 2000-08-29 Mickle; Donald A. G. Transplants for myocardial scars and methods and cellular preparations
US6099832A (en) * 1997-05-28 2000-08-08 Genzyme Corporation Transplants for myocardial scars
ATE307195T1 (de) 1997-07-14 2005-11-15 Osiris Therapeutics Inc Herzmuskelregenerierung unter verwendung mesenchymaler stammzellen
US20030103951A1 (en) * 1997-07-14 2003-06-05 Osiris Therapeutics, Inc. Cardiac muscle regeneration using mesenchymal stem cells
US7514074B2 (en) 1997-07-14 2009-04-07 Osiris Therapeutics, Inc. Cardiac muscle regeneration using mesenchymal stem cells
US6775574B1 (en) * 1997-11-07 2004-08-10 Medtronic, Inc. Method and system for myocardial infarction repair
US7031775B2 (en) 1997-11-07 2006-04-18 Medtronic, Inc. Method and system for myocardial infarction repair
WO2003064637A1 (en) * 2001-11-06 2003-08-07 Medtronic, Inc. Method and system for myocardial infarction repair
US6866842B1 (en) 1998-05-01 2005-03-15 University Of Pittsburgh Muscle-derived cells (MDCs) for treating muscle-or bone-related injury or dysfunction
US7115417B1 (en) * 1998-05-01 2006-10-03 Chancellor Michael B Soft tissue and bone augmentation and bulking utilizing muscle-derived progenito compositions, and treatments thereof
WO2000006701A1 (en) * 1998-07-31 2000-02-10 Genzyme Corporation Improvement of cardiac function by mesenchymal stem cell transplantation
US6124131A (en) * 1998-08-25 2000-09-26 The Johns Hopkins University School Of Medicine Mutant hypoxia inducible factor-1 HIF-1
US20030007954A1 (en) * 1999-04-12 2003-01-09 Gail K. Naughton Methods for using a three-dimensional stromal tissue to promote angiogenesis
WO2001007568A2 (en) * 1999-07-23 2001-02-01 Diacrin, Inc. Muscle cells and their use in cardiac repair
US20030113301A1 (en) * 1999-07-23 2003-06-19 Albert Edge Muscle cells and their use in cardiac repair
US7582051B2 (en) * 2005-06-10 2009-09-01 Cardiokinetix, Inc. Peripheral seal for a ventricular partitioning device
US7674222B2 (en) 1999-08-09 2010-03-09 Cardiokinetix, Inc. Cardiac device and methods of use thereof
US8500795B2 (en) 1999-08-09 2013-08-06 Cardiokinetix, Inc. Retrievable devices for improving cardiac function
US10307147B2 (en) 1999-08-09 2019-06-04 Edwards Lifesciences Corporation System for improving cardiac function by sealing a partitioning membrane within a ventricle
US8529430B2 (en) 2002-08-01 2013-09-10 Cardiokinetix, Inc. Therapeutic methods and devices following myocardial infarction
US9694121B2 (en) 1999-08-09 2017-07-04 Cardiokinetix, Inc. Systems and methods for improving cardiac function
US20060229491A1 (en) * 2002-08-01 2006-10-12 Cardiokinetix, Inc. Method for treating myocardial rupture
US8257428B2 (en) * 1999-08-09 2012-09-04 Cardiokinetix, Inc. System for improving cardiac function
US7303526B2 (en) * 1999-08-09 2007-12-04 Cardiokinetix, Inc. Device for improving cardiac function
US8388672B2 (en) 1999-08-09 2013-03-05 Cardiokinetix, Inc. System for improving cardiac function by sealing a partitioning membrane within a ventricle
US20030109770A1 (en) * 1999-08-09 2003-06-12 Sharkey Hugh R. Device with a porous membrane for improving cardiac function
US6810286B2 (en) * 2000-03-06 2004-10-26 Medtronic, Inc Stimulation for delivery of molecular therapy
US7166280B2 (en) 2000-04-06 2007-01-23 Franco Wayne P Combination growth factor therapy and cell therapy for treatment of acute and chronic heart disease
JP5684963B2 (ja) * 2000-04-14 2015-03-18 ユニバーシティ オブ ピッツバーグ オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 筋肉由来前駆細胞、その組成物、および治療法を使用した軟部組織および骨の増大および肥厚
US20040072342A1 (en) * 2000-06-05 2004-04-15 Bothwell Alfred L.M. Production and use of microvessels in fibronectin-containing gel
EP1312669B1 (de) 2000-07-21 2011-09-14 CellSeed Inc. Kultivierte epidermale zellschicht, laminierte kultivierte hautschicht und verfahren zu deren herstellung
JP4679795B2 (ja) * 2000-07-21 2011-04-27 株式会社セルシード 心筋様細胞シート、３次元構造体、心筋様組織及びそれらの製造法
US7862810B2 (en) * 2000-07-31 2011-01-04 New York Medical College Methods and compositions for the repair and/or regeneration of damaged myocardium
US7547674B2 (en) 2001-06-06 2009-06-16 New York Medical College Methods and compositions for the repair and/or regeneration of damaged myocardium
US20020098167A1 (en) * 2000-07-31 2002-07-25 Piero Anversa Methods and compositions for the repair and/or regeneration of damaged myocardium
US20110091428A1 (en) * 2000-07-31 2011-04-21 New York Medical College Compositions of adult organ stem cells and uses thereof
CZ2003444A3 (cs) * 2000-08-08 2003-10-15 M. G. V. S. Ltd. Konstrukty nukleové kyseliny, vaskulární buňky jimi transformované a farmaceutické prostředky a způsoby používající je k indukci angiogenesy
US7399271B2 (en) * 2004-01-09 2008-07-15 Cardiokinetix, Inc. Ventricular partitioning device
US7862500B2 (en) * 2002-08-01 2011-01-04 Cardiokinetix, Inc. Multiple partitioning devices for heart treatment
US7762943B2 (en) * 2004-03-03 2010-07-27 Cardiokinetix, Inc. Inflatable ventricular partitioning device
US9332993B2 (en) 2004-08-05 2016-05-10 Cardiokinetix, Inc. Devices and methods for delivering an endocardial device
US20060030881A1 (en) 2004-08-05 2006-02-09 Cardiokinetix, Inc. Ventricular partitioning device
US9078660B2 (en) 2000-08-09 2015-07-14 Cardiokinetix, Inc. Devices and methods for delivering an endocardial device
US8398537B2 (en) 2005-06-10 2013-03-19 Cardiokinetix, Inc. Peripheral seal for a ventricular partitioning device
US10064696B2 (en) 2000-08-09 2018-09-04 Edwards Lifesciences Corporation Devices and methods for delivering an endocardial device
US9332992B2 (en) 2004-08-05 2016-05-10 Cardiokinetix, Inc. Method for making a laminar ventricular partitioning device
US7998735B2 (en) * 2000-08-21 2011-08-16 Victorian Tissue Engineering Centre Pty. Ltd. Vascularized tissue graft
US7214371B1 (en) * 2000-09-01 2007-05-08 Ben-Gurion University Of The Negev Research & Development Authority Tissue engineered biografts for repair of damaged myocardium
US7294333B1 (en) * 2000-10-20 2007-11-13 Genegrafts Ltd. Nucleic acid constructs and cells, and methods utilizing same for modifying the electrophysiological function of excitable tissues
US7491385B2 (en) * 2001-09-05 2009-02-17 Genegrafts Ltd. Nucleic acid constructs and cells, and methods utilizing same for modifying the electrophysiological function of excitable tissues
FR2819265B1 (fr) * 2001-01-10 2004-01-02 Centre Nat Rech Scient Cellules du tissu adipeux extramedullaire et leurs applications dans la reconstitution des lignees hematopoietiques
WO2002067867A2 (en) * 2001-02-23 2002-09-06 The University Of Pittsburgh Rapid preparation of stem cell matrices for use in tissue and organ treatment and repair
US20020133227A1 (en) * 2001-02-28 2002-09-19 Gregory Murphy Ventricular restoration patch apparatus and method of use
US6681773B2 (en) * 2001-02-28 2004-01-27 Chase Medical, Inc. Kit and method for use during ventricular restoration
US20030181940A1 (en) * 2001-02-28 2003-09-25 Gregory Murphy Ventricular restoration shaping apparatus and method of use
WO2002084281A1 (en) * 2001-04-13 2002-10-24 Anterogen Co., Ltd. Encapsulated cell indicator system
US6702744B2 (en) * 2001-06-20 2004-03-09 Advanced Cardiovascular Systems, Inc. Agents that stimulate therapeutic angiogenesis and techniques and devices that enable their delivery
US7425448B2 (en) * 2001-07-12 2008-09-16 Geron Corporation Cardiomyocyte precursors from human embryonic stem cells
US7732199B2 (en) 2001-07-12 2010-06-08 Geron Corporation Process for making transplantable cardiomyocytes from human embryonic stem cells
US20030113302A1 (en) * 2001-08-31 2003-06-19 Elena Revazova Use of recipient endothelial cells for enhanced vascularization of tissue and tissue-engineered construct transplants
US20060025800A1 (en) * 2001-09-05 2006-02-02 Mitta Suresh Method and device for surgical ventricular repair
US7485088B2 (en) * 2001-09-05 2009-02-03 Chase Medical L.P. Method and device for percutaneous surgical ventricular repair
US20040243170A1 (en) * 2001-09-05 2004-12-02 Mitta Suresh Method and device for percutaneous surgical ventricular repair
US8608661B1 (en) 2001-11-30 2013-12-17 Advanced Cardiovascular Systems, Inc. Method for intravascular delivery of a treatment agent beyond a blood vessel wall
AU2003220562A1 (en) * 2002-04-01 2003-10-20 Peter K. Law Cellular transplantation for heart regeneration
AU2003228808A1 (en) * 2002-05-02 2003-11-17 Regents Of The University Of Minnesota Fibrin-based biomatrix
US20040242469A1 (en) * 2002-05-13 2004-12-02 Lee Richard T. Angiogenesis and cardiac tissue engineering with peptide hydrogels and related compositions and methods of use thereof
US7361368B2 (en) 2002-06-28 2008-04-22 Advanced Cardiovascular Systems, Inc. Device and method for combining a treatment agent and a gel
WO2004012791A2 (en) * 2002-08-06 2004-02-12 Genvec, Inc. Improved injection system
WO2004014302A2 (en) * 2002-08-09 2004-02-19 Law Peter K Mechanisms of myoblast transfer in treating heart failure
US20040193284A1 (en) * 2003-03-25 2004-09-30 Taheri Syde A. Myometrium as a source for cardiomyoplasty
US8383158B2 (en) 2003-04-15 2013-02-26 Abbott Cardiovascular Systems Inc. Methods and compositions to treat myocardial conditions
US8038991B1 (en) 2003-04-15 2011-10-18 Abbott Cardiovascular Systems Inc. High-viscosity hyaluronic acid compositions to treat myocardial conditions
US8821473B2 (en) 2003-04-15 2014-09-02 Abbott Cardiovascular Systems Inc. Methods and compositions to treat myocardial conditions
US20040213770A1 (en) * 2003-04-22 2004-10-28 Endobionics, Inc. Methods and systems for treating ischemic cardiac and other tissues
CN103230415B (zh) * 2003-04-25 2016-05-04 匹兹堡大学联邦制高等教育 用于促进和增强神经修复和再生的肌肉来源的细胞（mdc）
ITRM20030376A1 (it) 2003-07-31 2005-02-01 Univ Roma Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia.
US7840263B2 (en) 2004-02-27 2010-11-23 Cardiac Pacemakers, Inc. Method and apparatus for device controlled gene expression
US7452718B2 (en) * 2004-03-26 2008-11-18 Geron Corporation Direct differentiation method for making cardiomyocytes from human embryonic stem cells
US20050214938A1 (en) * 2004-03-26 2005-09-29 Gold Joseph D Cardiac bodies: clusters of spontaneously contracting cells for regenerating cardiac function
US20080176209A1 (en) * 2004-04-08 2008-07-24 Biomatrica, Inc. Integration of sample storage and sample management for life science
SG151298A1 (en) * 2004-04-08 2009-04-30 Biomatrica Inc Integration of sample storage and sample management for life science
US20060099567A1 (en) * 2004-04-08 2006-05-11 Biomatrica, Inc. Integration of sample storage and sample management for life science
US7764995B2 (en) 2004-06-07 2010-07-27 Cardiac Pacemakers, Inc. Method and apparatus to modulate cellular regeneration post myocardial infarct
US7828711B2 (en) * 2004-08-16 2010-11-09 Cardiac Pacemakers, Inc. Method and apparatus for modulating cellular growth and regeneration using ventricular assist device
AU2005279934A1 (en) * 2004-08-30 2006-03-09 Theregen, Inc. Compositions and methods of promoting hair growth
WO2006050459A2 (en) * 2004-10-28 2006-05-11 Cook Incorporated Methods and systems for modifying vascular valves
US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
AU2005306270A1 (en) * 2004-11-22 2006-05-26 Theregen, Inc. Use of cutured three-dimensional tissue for treating congestive heart failure
US7410497B2 (en) * 2004-12-14 2008-08-12 Boston Scientific Scimed, Inc. Stimulation of cell growth at implant surfaces
US7981065B2 (en) 2004-12-20 2011-07-19 Cardiac Pacemakers, Inc. Lead electrode incorporating extracellular matrix
US8060219B2 (en) 2004-12-20 2011-11-15 Cardiac Pacemakers, Inc. Epicardial patch including isolated extracellular matrix with pacing electrodes
WO2006099334A2 (en) 2005-03-11 2006-09-21 Wake Forest University Health Sciences Production of tissue engineered heart valves
WO2006103770A1 (ja) * 2005-03-30 2006-10-05 Osaka Prefectural Hospital Organization 血管新生制御方法
AU2006244639A1 (en) * 2005-03-31 2006-11-16 Mytogen, Inc. Treatment for heart disease
US8303972B2 (en) * 2005-04-19 2012-11-06 Advanced Cardiovascular Systems, Inc. Hydrogel bioscaffoldings and biomedical device coatings
US9539410B2 (en) 2005-04-19 2017-01-10 Abbott Cardiovascular Systems Inc. Methods and compositions for treating post-cardial infarction damage
US8187621B2 (en) 2005-04-19 2012-05-29 Advanced Cardiovascular Systems, Inc. Methods and compositions for treating post-myocardial infarction damage
US20080125745A1 (en) 2005-04-19 2008-05-29 Shubhayu Basu Methods and compositions for treating post-cardial infarction damage
US8828433B2 (en) 2005-04-19 2014-09-09 Advanced Cardiovascular Systems, Inc. Hydrogel bioscaffoldings and biomedical device coatings
US8889122B2 (en) * 2005-05-09 2014-11-18 Mytogen, Inc. Cellular cardiomyoplasty as supportive therapy in patients with heart disease
JP5121449B2 (ja) * 2005-05-26 2013-01-16 株式会社サインポスト 疾患の発症予測提示方法
JP2008546686A (ja) * 2005-06-17 2008-12-25 セレゲン，インコーポレーテッド 虚血組織の治療方法
JP5560393B2 (ja) 2005-06-22 2014-07-23 アステリアス バイオセラピューティクス インコーポレイテッド 心筋細胞系列細胞への霊長類多能性幹細胞の分化
US20070048289A1 (en) * 2005-08-31 2007-03-01 Grandjean Pierre A Cellular intervention to treat damaged myocardium
EP1948247A4 (de) * 2005-11-15 2010-07-07 Univ Leland Stanford Junior Zusammensetzungen zur koordinierten vegf- und pdgf-expression sowie verwendungsverfahren dafür
US8038595B2 (en) * 2006-01-25 2011-10-18 Beth Israel Deaconess Medical Center Devices and methods for tissue transplant and regeneration
US8974542B2 (en) 2006-06-27 2015-03-10 University of Pittsburgh—of the Commonwealth System of Higher Education Biodegradable elastomeric patch for treating cardiac or cardiovascular conditions
US7732190B2 (en) * 2006-07-31 2010-06-08 Advanced Cardiovascular Systems, Inc. Modified two-component gelation systems, methods of use and methods of manufacture
US9242005B1 (en) 2006-08-21 2016-01-26 Abbott Cardiovascular Systems Inc. Pro-healing agent formulation compositions, methods and treatments
US20080112927A1 (en) * 2006-10-23 2008-05-15 Genegrafts Ltd. Cells and methods utilizing same for modifying the electrophysiological function of excitable tissues
WO2008058273A2 (en) * 2006-11-09 2008-05-15 The Johns Hopkins University Dedifferentiation of adult mammalian cardiomyocytes into cardiac stem cells
US9005672B2 (en) 2006-11-17 2015-04-14 Abbott Cardiovascular Systems Inc. Methods of modifying myocardial infarction expansion
US8741326B2 (en) * 2006-11-17 2014-06-03 Abbott Cardiovascular Systems Inc. Modified two-component gelation systems, methods of use and methods of manufacture
AU2007325698B2 (en) * 2006-11-28 2014-03-20 University Of Pittsburgh Muscle derived cells for the treatment of cardiac pathologies and methods of making and using the same
US8192760B2 (en) * 2006-12-04 2012-06-05 Abbott Cardiovascular Systems Inc. Methods and compositions for treating tissue using silk proteins
JP5570814B2 (ja) * 2006-12-18 2014-08-13 ユニバーシティー オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション 胃食道病理学を処置するための筋由来細胞ならびにその作成法および使用法
US20100158875A1 (en) 2006-12-18 2010-06-24 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Muscle derived cells for the treatment of gastro-esophageal pathologies and methods of making and using the same
AU2008205278B2 (en) * 2007-01-11 2014-06-12 University Of Pittsburgh Muscle derived cells for the treatment of urinary tract pathologies and methods of making and using the same
US20090004155A1 (en) * 2007-02-26 2009-01-01 Casey Patrick J Method for treating a mammal having damaged myocardium tissue
WO2008153813A2 (en) * 2007-05-29 2008-12-18 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Bone augmentation utilizing muscle-derived progenitor compositions, and treatments thereof
CA2743184A1 (en) 2007-11-09 2009-05-14 New York Medical College Methods and compositions for the repair and/or regeneration of damaged myocardium using cytokines and variants thereof
WO2009092005A2 (en) * 2008-01-18 2009-07-23 The J. David Gladstone Institutes Methods of generating cardiomyocytes and cardiac progenitors and compositions
KR20110005682A (ko) 2008-01-30 2011-01-18 제론 코포레이션 줄기 세포 유래 심근세포 배양용 합성 표면
AU2009282619B2 (en) * 2008-08-18 2015-08-20 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Bone augmentation utilizing muscle-derived progenitor compositions in biocompatible matrix, and treatments thereof
US20100233138A1 (en) * 2008-11-07 2010-09-16 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Vocal Cord Augmentation Utilizing Muscle-Derived Progenitor Compositions, and Treatments Thereof
CA2758208A1 (en) 2009-04-09 2010-10-14 Jordan Lancaster Cellular seeding and co-culture of a three dimensional fibroblast construct
CA2777552C (en) 2009-10-19 2019-05-21 Cellular Dynamics International, Inc. Cardiomyocyte production
JP5875986B2 (ja) 2009-10-26 2016-03-02 カーディオキネティックス・インコーポレイテッドＣａｒｄｉｏｋｉｎｅｔｉｘ， Ｉｎｃ． 心室容積縮小
GB2489081B (en) * 2010-03-16 2013-03-27 Organovo Inc Multilayered vascular tubes
US9845457B2 (en) 2010-04-30 2017-12-19 Cedars-Sinai Medical Center Maintenance of genomic stability in cultured stem cells
US9249392B2 (en) 2010-04-30 2016-02-02 Cedars-Sinai Medical Center Methods and compositions for maintaining genomic stability in cultured stem cells
JP5933544B2 (ja) 2010-07-26 2016-06-08 バイオマトリカ， インコーポレーテッド 外界温度で出荷および貯蔵中の血中ｄｎａ、ｒｎａおよびタンパク質ならびに他の生体試料を安定化させるための組成物
US9845489B2 (en) 2010-07-26 2017-12-19 Biomatrica, Inc. Compositions for stabilizing DNA, RNA and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
CN103476439A (zh) 2011-02-28 2013-12-25 学校法人东京女子医科大学 细胞因子产生细胞片及其利用方法
EP2691512B1 (de) 2011-03-29 2019-05-01 Asterias Biotherapeutics, Inc. Angereicherte populationen von herzmuskelzellen aus pluripotenten stammzellen
WO2012138453A1 (en) 2011-04-03 2012-10-11 The General Hospital Corporation Efficient protein expression in vivo using modified rna (mod-rna)
US9395354B2 (en) 2011-07-21 2016-07-19 The Board Of Trustees Of The Leland Stanford Junior University Cardiomyocytes from induced pluripotent stem cells from patients and methods of use thereof
JP2015521054A (ja) 2012-06-05 2015-07-27 カプリコール，インコーポレイテッド 心臓組織から心臓幹細胞を作製するための最適化方法および心臓治療におけるそれらの使用
CA2881394A1 (en) 2012-08-13 2014-02-20 Cedars-Sinai Medical Center Exosomes and micro-ribonucleic acids for tissue regeneration
WO2014100755A2 (en) 2012-12-20 2014-06-26 Biomatrica, Inc. Formulations and methods for stabilizing pcr reagents
US10092679B2 (en) 2013-10-18 2018-10-09 Wake Forest University Health Sciences Laminous vascular constructs combining cell sheet engineering and electrospinning technologies
ES2786373T3 (es) 2014-06-10 2020-10-09 Biomatrica Inc Estabilización de trombocitos a temperaturas ambiente
KR20170066470A (ko) 2014-09-28 2017-06-14 카디오키네틱스 인크. 심장 기능장애를 치료하기 위한 장치
CA2962444C (en) 2014-10-03 2023-09-05 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy
EP3387411B1 (de) 2015-12-08 2023-05-10 Biomatrica, INC. Verringerung der erythrozytensedimentationsrate
EP3402543B1 (de) 2016-01-11 2021-09-08 Cedars-Sinai Medical Center Aus kardiosphäre stammende zellen und durch solche zellen sekretierte exosomen in der behandlung von herzversagen mit konservierter auswurffraktion
WO2017210652A1 (en) 2016-06-03 2017-12-07 Cedars-Sinai Medical Center Cdc-derived exosomes for treatment of ventricular tachyarrythmias
EP3515459A4 (de) 2016-09-20 2020-08-05 Cedars-Sinai Medical Center Kardiosphärenzellen und deren extrazelluläre vesikel zur verzögerung oder umkehr des alterungsprozesses und altersbedingten erkrankungen
US10898330B2 (en) 2017-03-28 2021-01-26 Edwards Lifesciences Corporation Positioning, deploying, and retrieving implantable devices
EP3612191A4 (de) 2017-04-19 2020-12-30 Cedars-Sinai Medical Center Verfahren und zusammensetzungen zur behandlung von skelettmuskeldystrophie
US11660355B2 (en) 2017-12-20 2023-05-30 Cedars-Sinai Medical Center Engineered extracellular vesicles for enhanced tissue delivery
AU2022343749A1 (en) 2021-09-13 2024-03-28 FUJIFILM Cellular Dynamics, Inc. Methods for the production of committed cardiac progenitor cells

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4963489A (en) * 1987-04-14 1990-10-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US5202120A (en) * 1987-09-11 1993-04-13 Case Western Reserve University Methods of reducing glial scar formation and promoting axon and blood vessel growth and/or regeneration through the use of activated immature astrocytes
US5197985A (en) * 1990-11-16 1993-03-30 Caplan Arnold I Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells
US5199942A (en) * 1991-06-07 1993-04-06 Immunex Corporation Method for improving autologous transplantation
US5543318A (en) * 1991-06-12 1996-08-06 Smith; David A. Method of isolation, culture and proliferation of human atrial myocytes
WO1992022636A1 (en) * 1991-06-12 1992-12-23 Smith David A Method for inducing human myocardial cell proliferation
WO1995012979A1 (en) * 1993-11-08 1995-05-18 The University Of Southern California Compositions and methods for transduction of cells
US5602301A (en) * 1993-11-16 1997-02-11 Indiana University Foundation Non-human mammal having a graft and methods of delivering protein to myocardial tissue
US5785966A (en) * 1994-06-15 1998-07-28 Coles; John G. Inhibition of human xenogenic or allogenic antibodies to reduce xenograft or allograft rejection in human recipients
US5919449A (en) * 1995-05-30 1999-07-06 Diacrin, Inc. Porcine cardiomyocytes and their use in treatment of insufficient cardiac function
US6110459A (en) * 1997-05-28 2000-08-29 Mickle; Donald A. G. Transplants for myocardial scars and methods and cellular preparations
US6099832A (en) * 1997-05-28 2000-08-08 Genzyme Corporation Transplants for myocardial scars
WO2001007568A2 (en) * 1999-07-23 2001-02-01 Diacrin, Inc. Muscle cells and their use in cardiac repair

Also Published As

Publication number Publication date
AU4579099A (en) 2000-01-05
US20020127210A1 (en) 2002-09-12
EP1088062A4 (de) 2002-06-05
US7067121B2 (en) 2006-06-27
EP1088062A1 (de) 2001-04-04
EP1088062B1 (de) 2009-03-04
US6579523B1 (en) 2003-06-17
US20060093587A1 (en) 2006-05-04
WO1999066036A1 (en) 1999-12-23
WO1999066036A9 (en) 2000-05-04
US20050025749A1 (en) 2005-02-03
US6682730B2 (en) 2004-01-27
JP2002518006A (ja) 2002-06-25
ATE424454T1 (de) 2009-03-15
US6099832A (en) 2000-08-08
CA2335248A1 (en) 1999-12-23
US20070031389A1 (en) 2007-02-08
BR9911369A (pt) 2001-03-13
US20040071669A1 (en) 2004-04-15

Similar Documents

Publication Publication Date Title
ATE424454T1 (de) Transplantate für myokardiale narben
ATE488244T1 (de) Transplantate für myokardiale narben, methoden and zelluläre präparationen dafür
EP1100870A4 (de) Verbesserung der herzfunktion durch transplantation mesenchymaler stammzellen
DE60039871D1 (de) Körper zum erzeugen von knochenwachstum und/oder bindegewebe und verfahren zur herstellung solches körpers
ATE305967T1 (de) Biotechnisch konstruiertes gewebe und verfahren zu dessen produktion und benutzung
WO1999049015A3 (en) Cardiac-derived stem cells
ATE265191T1 (de) Herstellungsverfahren von gewebe zur implantation
DK0987998T3 (da) Decellulering af væv
EP1083828A4 (de) Biotechnisch erzeugte gefässprothese für die implantation
EP1425390A4 (de) Material und verfahren zur förderung der reparatur von nervengewebe
ATE295875T1 (de) Verfahren zur in vitro herstellung von knochen
WO2002007646A3 (en) Artificial vascular grafts, and methods of producing and using same
HK1042052A1 (zh) 內皮血管生長因子-2
NO20052949D0 (no) Implantat inneholdende dyrkede bruksceller og fremgangsmate for fremstilling
DE69738753D1 (de) AUF TGF-beta 1 ANSPRECHENDE KNOCHENMARKZELLEN
AU1154701A (en) Hair transplantation
NO992569D0 (no) FremgangsmÕter for Õ hindre podingsforkastelse i transplantasjon og for fremstilling av en universell genterapi vertcelle ved Õ anvende lymfocytt aktivering (LAG-3)
WO1999061589A3 (en) Expansion of hematopoietic stem cells transduced with mdr-1 and methods of use thereof
AU3000601A (en) Method for production of a skin graft and the graft produced thereby
WO1998003669A3 (en) Vectors for inhibiting hiv and tumor growth
AU3612099A (en) Complex formed by a peptide and a major histocompatibility complex at the surface of phages
WO2002009718A3 (de) Corticosteroid-enthaltendes mittel zur verringerung der abstossungsreaktionen bei transplantaten
MX9705612A (es) Induccion dirigida por linaje de la diferenciacion de celulas mesenquimatosas humanas de origen.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition