EP0148116A1 - Coupling piece for an injection syringe - Google Patents

Coupling piece for an injection syringe Download PDF

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Publication number
EP0148116A1
EP0148116A1 EP84810571A EP84810571A EP0148116A1 EP 0148116 A1 EP0148116 A1 EP 0148116A1 EP 84810571 A EP84810571 A EP 84810571A EP 84810571 A EP84810571 A EP 84810571A EP 0148116 A1 EP0148116 A1 EP 0148116A1
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EP
European Patent Office
Prior art keywords
flange
part according
piece
syringes
tip
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP84810571A
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German (de)
French (fr)
Inventor
Piero Orsolini
François Zberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Debiopharm SA
Original Assignee
Debiopharm SA
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Filing date
Publication date
Application filed by Debiopharm SA filed Critical Debiopharm SA
Publication of EP0148116A1 publication Critical patent/EP0148116A1/en
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/45—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
    • B01F25/451—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by means for moving the materials to be mixed or the mixture
    • B01F25/4512—Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by means for moving the materials to be mixed or the mixture with reciprocating pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2044—Separating means having slits

Definitions

  • the present invention relates to the field of accessories for medical instruments, more specifically to a coupling part for injection syringes.
  • microcapsule suspensions For the preparation of microcapsule suspensions, current techniques consist in introducing the intended dose of microcapsules into a first syringe, preferably closed at the end provided with the end piece intended to subsequently receive a needle, to then sterilize it using an appropriate method, then transfer the sterile liquid from the suspension from a second syringe.
  • Commercial syringes are fitted with an elongated closure piece, most often frustoconical, temporarily placed on the tip: such pieces guarantee the sterility of the internal volume of the syringe, but enlarge the space as much closed outside the cylinder of said syringe.
  • the transfer of liquid from one syringe to the other is carried out by means of a flexible tube, of variable length, joining each of the two syringes by their respective nozzle, the homogenization of the suspension being carried out by successive transfers to the heterogeneous mixture, from one syringe to the other.
  • Such transfers must be numerous and, once homogenization has been carried out, there is a significant loss of active product in the flexible tube connecting the two syringes, losses which can sometimes go up to 20% by weight of active product, taking into account the dead volumes of the tips of each of said syringes.
  • a so-called three-way tap is also used in place of the flexible hose, two of the branches of said tap cooperating with the tip of each of the syringes.
  • this type of accessory also requires a high number of successive transfers to achieve the desired homogenization, and losses are observed. of the active product of the same order as above.
  • Such an accessory is also very expensive and increases the cost of an injection of micro-capsules in suspension all the more.
  • the object of the invention is to remedy the shortcomings of current instruments by proposing accessories for injection syringes which minimize the dead volume of the syringes used and also make it possible to prepare suspensions of microcapsules under the best sterility conditions, without loss. excessive time or active product.
  • the invention particularly relates to a coupling part for syringes which, once arranged, also serves as a sealing part. It also relates to a closure piece for injection syringes.
  • the invention is defined in the claims.
  • the part according to the invention is intended for coupling injection syringes comprising an end piece 1 placed inside a threaded sleeve 2. It consists of two hollow end pieces 3,4 arranged coaxially, both integral with an intermediate flange 5.
  • the internal shape of said tips 3, 4 is complementary to that of the tips 1 of the syringes, so as to ensure the closest possible contact. As illustrated, said shape is most generally frustoconical, just like that of the end pieces 1.
  • the length of said end pieces 3,4 is also calculated so that it is practically equal to that of the end pieces 1: this therefore reduces to its value minimum dead volume inherent in any injection syringe, thereby reducing the losses occurring during operations.
  • each of said end pieces 3,4 has at its end opposite to the flange 5 a flange 6,7 intended to cooperate with the thread of the sleeve 2.
  • the coupling piece 11 is secured. to each of the syringes connected to it, simultaneously strengthening the close contact of the tips 1, 3 and 4 and thus guaranteeing the sterility of the product transfer operations from one syringe to another.
  • the coupling piece 11 is characterized in that the flange 5 extends inside the hollow space 8 common to the end pieces 3,4 to delimit an orifice 9 of diameter substantially less than that of space 8.
  • This particular arrangement has the main effect of causing a turbulent regime during the transfer of liquid from one syringe to another and thus promoting rapid homogenization of the suspension. In most cases, 5 to 10 transfers. at most are sufficient.
  • the dimensions of the orifice 9 will of course be such that they will avoid accidental obstruction by solid materials such as microcapsules for example.
  • the part 11 can be made of a rigid material, for example thermoformable, customary in the medical art.
  • a rigid material for example thermoformable, customary in the medical art.
  • polymers such as NYLON, TEFLON, MAKROLON, polystyrene or polyethylene.
  • such a material should preferably withstand sterilization using gamma rays.
  • Part 11 can advantageously be used to couple two syringes, one of which contains a pharmaceutical preparation in the form of sterile microcapsules, the other a sterile solvent intended to suspend said microcapsules .
  • the part 11 is disconnected therefrom, an injection needle then being placed on the end piece 1 thus released. Said syringe is then ready for the injection of a suspension of microcapsules.
  • the losses of active product are less than approximately 5% by weight.
  • the flange 5 is most generally of polygonal shape and acts as a member for handling the part 11.
  • any shape suitable for gripping said flange can be envisaged. It is thus possible to produce small objects that remain easy to handle.
  • one of the end pieces 3,4 may be provided with a plug 10, at least part 12 of which is of shape complementary to that of the interior space of said end pieces, most generally of frustoconical shape.
  • Said part 12 also has a protuberance 13, intended to cooperate with the orifice 9 defined above.
  • Such an assembly connected by its free tip to a syringe, constitutes a obturation piece in which the dead space inherent in the arrangement of the syringes currently known (tip 1 - and threaded sleeve 2) is reduced to its minimum volume.
  • Such an assembly is particularly suitable for closing syringes intended to receive pulverulent materials such as microcapsules for example.
  • the closure of an injection syringe fitted with a tip 1 placed in a threaded sleeve 2 can advantageously be produced using a part 16 consisting of a hollow tip 14, provided a bottom 15, of internal shape complementary to that of the end piece 1 and of length practically equal to that of said end piece.
  • the open end of the end piece 14 has a flange 17 intended to cooperate with the thread of the socket 2, thus ensuring the attachment of the closure part 16 to the end piece 1 syringe.
  • the bottom 15 extends outside of the end piece 14 and acts as a handling member.
  • the shape of said bottom 15 will be designed so as to facilitate gripping: it may advantageously be of polygonal shape.
  • the part 16 and the plug 10, finally, will preferably be made of materials of the same type as that used for the coupling part 11.

Abstract

A coupling piece comprising a joining piece (1) placed inside a threaded sleeve (2) is composed of two hollow joining pieces (3, 4) disposed coaxially, both integral with an intermediate flange (5), with an internal shape which complements that of the joining pieces (1) and of a length which is virtually equal to that of the joining pieces (1) of the said syringes. <IMAGE>

Description

La présente invention se rapporte au domaine des accessoires pour instruments médicaux, plus précisément à une pièce d'accouplement pour seringues à injection.The present invention relates to the field of accessories for medical instruments, more specifically to a coupling part for injection syringes.

Actuellement, de nombreuses préparations pharmaceutiques se présentent sous une forme enrobée par micro-encapsu- lation; il s'agit notamment de médicaments à effet retard ou à action prolongée que l'on administre le plus généralement par injection.Currently, many pharmaceutical preparations are in a coated form by microencapsulation; these include delayed-release or long-acting drugs that are most commonly administered by injection.

Divers problèmes se posent, tant au niveau de la manipulation des micro-capsules en vue de leur emploi que de leur mise en suspension. On est toujours à la recherche d'opérations les plus simples et les plus sûres possibles quant au maintien de la stérilité, et permettant également d'éviter des pertes de produit actif avant injection.Various problems arise, both in terms of handling the microcapsules with a view to their use and their suspension. We are always looking for the simplest and safest possible operations for maintaining sterility, and also making it possible to avoid losses of active product before injection.

Pour la préparation de suspensions de micro-capsules, les techniques actuelles consistent à introduire la dose prévue de micro-capsules dans une première seringue, de préférence obturée à l'extrémité munie de l'embout destiné à recevoir par la suite une aiguille, à stériliser ensuite celle-ci à l'aide d'une méthode appropriée, puis à transférer d'une seconde seringue, le liquide stérile de la suspension. Les seringues du commerce sont munies d'une pièce d'obturation de forme allongée, le plus souvent tronconique, provisoirement placée sur l'embout: de telles pièces garantissent la stérilité du volume interne de la seringue, mais agrandissent d'autant l'espace clos hors du cylindre de ladite seringue. Lors de l'introduction de matière solide telles des micro-capsules, une perte plus ou moins importante de produit actif est constatée.For the preparation of microcapsule suspensions, current techniques consist in introducing the intended dose of microcapsules into a first syringe, preferably closed at the end provided with the end piece intended to subsequently receive a needle, to then sterilize it using an appropriate method, then transfer the sterile liquid from the suspension from a second syringe. Commercial syringes are fitted with an elongated closure piece, most often frustoconical, temporarily placed on the tip: such pieces guarantee the sterility of the internal volume of the syringe, but enlarge the space as much closed outside the cylinder of said syringe. During the introduction of solid matter such as microcapsules, a more or less significant loss of active product is noted.

Lors de la préparation de la suspension de micro-capsules proprement dite, le transfert de liquide d'une seringue à l'autre s'effectue par l'entremise d'un tuyau souple, de longueur variable, réunissant chacune des deux seringues par leur embout respectif, l'homogénéisation de la suspension s'effectuant par transferts successifs au mélange hétérogène, d'une seringue dans l'autre. De tels transferts doivent être nombreux et, une fois l'homogénéisation réalisée, on observe une perte importante de produit actif dans le tuyau souple reliant les deux seringues, pertes pouvant aller parfois jusqu'à 20% en poids de produit actif, compte tenu des volumes morts des embouts de chacune desdites seringues. On utilise aussi un robinet dit à trois voies en lieu et place du tuyau souple, deux des branches dudit robinet coopérant avec l'embout de chacune des seringues. Outre le danger accru de pertes de produit due à une manipulation erronée (ouverture sur la troisième voie libre), ce type d'accessoire nécessite également un nombre élevé de transferts successifs pour parvenir à l'homogénéisation souhaitée, et l'on observe des pertes du produit actif du même ordre que ci-dessus. Un tel accessoire est en outre fort cher et renchérit d'autant le coût d'une injection de micro-capsules en suspension.During the preparation of the suspension of microcapsules proper, the transfer of liquid from one syringe to the other is carried out by means of a flexible tube, of variable length, joining each of the two syringes by their respective nozzle, the homogenization of the suspension being carried out by successive transfers to the heterogeneous mixture, from one syringe to the other. Such transfers must be numerous and, once homogenization has been carried out, there is a significant loss of active product in the flexible tube connecting the two syringes, losses which can sometimes go up to 20% by weight of active product, taking into account the dead volumes of the tips of each of said syringes. A so-called three-way tap is also used in place of the flexible hose, two of the branches of said tap cooperating with the tip of each of the syringes. In addition to the increased danger of product loss due to incorrect handling (opening on the third free way), this type of accessory also requires a high number of successive transfers to achieve the desired homogenization, and losses are observed. of the active product of the same order as above. Such an accessory is also very expensive and increases the cost of an injection of micro-capsules in suspension all the more.

L'invention a pour but de remédier aux défauts des instruments actuels en proposant des accessoires pour seringues à injection réduisant au minimum le volume mort des seringues utilisées et permettant également de préparer des suspensions de micro-capsules dans les meilleures conditions de stérilité, sans perte excessive de temps ni de produit actif. L'invention a notamment pour objet une pièce d'accouplement pour seringues qui, une fois agencée, sert également de pièce d'obturation. Elle a aussi pour objet une pièce d'obturation pour seringues à injection. L'invention est définie aux revendications.The object of the invention is to remedy the shortcomings of current instruments by proposing accessories for injection syringes which minimize the dead volume of the syringes used and also make it possible to prepare suspensions of microcapsules under the best sterility conditions, without loss. excessive time or active product. The invention particularly relates to a coupling part for syringes which, once arranged, also serves as a sealing part. It also relates to a closure piece for injection syringes. The invention is defined in the claims.

  • Les figures décrites ci-après illustrent certaines des exécutions de l'invention. Elles ne sont données qu'à titre indicatif. Dans lesdites figures, les seringues ont été représentées opaques, contrairement à la réalité dans la plupart des cas.The figures described below illustrate some of the embodiments of the invention. They are given for information only. In the said figures, the syringes have been shown to be opaque, contrary to reality in most cases.
  • Fig. 1 représente, vue de profil, une exécution de la pièce d'accouplement selon l'invention;Fig. 1 shows a side view of an embodiment of the coupling part according to the invention;
  • Fig. 2 est une vue de face de la pièce représentée par Fig. 1;Fig. 2 is a front view of the part shown in FIG. 1;
  • Fig. 3 est une vue en coupe, légèrement agrandie, de la pièce représentée par Fig. 1;Fig. 3 is a slightly enlarged sectional view of the part shown in FIG. 1;
  • Fig. 4 représente, vue partiellement en coupe, la pièce d'accouplement illustrée par Fig. 1, fixée sur l'embout d'une seringue;Fig. 4 shows, partly in section, the coupling part illustrated in FIG. 1, attached to the tip of a syringe;
  • Fig. 5 représente, vues de profil, deux seringues accouplées à l'aide de la pièce illustrée par Fig. 1.Fig. 5 shows, seen in profile, two syringes coupled using the part illustrated in FIG. 1.
  • Fig. 6 représente, vu de profil, un bouchon destiné à coopérer avec la pièce d'accouplement illustrée par Fig. 1 en vue de former une pièce d'obturation telle que représentée par Fig. 3;Fig. 6 shows, seen in profile, a plug intended to cooperate with the coupling part illustrated in FIG. 1 with a view to forming a closure part as shown in FIG. 3;
  • Fig. 7 représente, vue partiellement en coupe, une autre exécution d'une pièce d'obturation selon l'invention fixée sur l'embout d'une seringue.Fig. 7 shows, partly in section, another embodiment of a closure piece according to the invention fixed on the tip of a syringe.

La pièce selon l'invention est destinée à l'accouplement de seringues à injection comportant un embout 1 placé à l'intérieur d'une douille filetée 2. Elle se compose de deux embouts creux 3,4 disposés coaxialement, tous deux solidaires d'une bride intermédiaire 5. La forme intérieure desdits embouts 3,4 est complémentaire de celle des embouts 1 des seringues, de façon à assurer un contact le plus étroit possible. Comme illustré, ladite forme est le plus généralement tronconique, tout comme celle des embouts 1. La longueur desdits embouts 3,4 est en outre calculée de façon telle qu'elle soit pratiquement égale à celle des embouts 1: on réduit ainsi à sa valeur minimum le volume mort inhérent à toute seringue à injection, ce qui réduit d'autant les pertes intervenant au cours des opérations.The part according to the invention is intended for coupling injection syringes comprising an end piece 1 placed inside a threaded sleeve 2. It consists of two hollow end pieces 3,4 arranged coaxially, both integral with an intermediate flange 5. The internal shape of said tips 3, 4 is complementary to that of the tips 1 of the syringes, so as to ensure the closest possible contact. As illustrated, said shape is most generally frustoconical, just like that of the end pieces 1. The length of said end pieces 3,4 is also calculated so that it is practically equal to that of the end pieces 1: this therefore reduces to its value minimum dead volume inherent in any injection syringe, thereby reducing the losses occurring during operations.

Selon l'invention, chacun desdits embouts 3,4 présente à son extrémité opposée à la bride 5 un rebord 6,7 destiné à coopérer avec le filetage de la douille 2. On assure de cette façon la solidarisation de la pièce d'accouplement 11 à chacune des seringues qui y sont connectées, renforçant simultanément le contact étroit des embouts 1, 3 et 4 et garantissant ainsi la stérilité des opérations de transfert de produit d'une seringue à l'autre.According to the invention, each of said end pieces 3,4 has at its end opposite to the flange 5 a flange 6,7 intended to cooperate with the thread of the sleeve 2. In this way, the coupling piece 11 is secured. to each of the syringes connected to it, simultaneously strengthening the close contact of the tips 1, 3 and 4 and thus guaranteeing the sterility of the product transfer operations from one syringe to another.

Selon l'invention en outre, la pièce d'accouplement 11 se caractérise par le fait que la bride 5 se prolonge à l'intérieur de l'espace creux 8 commun aux embouts 3,4 pour délimiter un orifice 9 de diamètre sensiblement inférieur à celui de l'espace 8. Cet agencement particulier a principalement pour effet de provoquer un régime turbulent lors du .. transfert de liquide d'une seringue à l'autre et de promouvoir ainsi une homogénéisation rapide de la suspension. Dans la plupart des cas, 5 à 10 transferts. au plus sont suffisants. Les dimensions de l'orifice 9 seront bien entendu telles qu'elles en éviteront l'obturation accidentelle par des matières solides telles des micro-capsules par exemple.According to the invention, moreover, the coupling piece 11 is characterized in that the flange 5 extends inside the hollow space 8 common to the end pieces 3,4 to delimit an orifice 9 of diameter substantially less than that of space 8. This particular arrangement has the main effect of causing a turbulent regime during the transfer of liquid from one syringe to another and thus promoting rapid homogenization of the suspension. In most cases, 5 to 10 transfers. at most are sufficient. The dimensions of the orifice 9 will of course be such that they will avoid accidental obstruction by solid materials such as microcapsules for example.

La pièce 11 peut être réalisée en un matériau rigide, par exemple thermoformable, usuel dans l'art médical. On peut citer, à titre d'exemple, les polymères tels que le NYLON, le TEFLON, le MAKROLON, le polystyrène ou le polyéthylène. Un tel matériau doit en outre, de préférence, supporter une stérilisation à l'aide de rayons gamma.The part 11 can be made of a rigid material, for example thermoformable, customary in the medical art. By way of example, mention may be made of polymers such as NYLON, TEFLON, MAKROLON, polystyrene or polyethylene. In addition, such a material should preferably withstand sterilization using gamma rays.

La pièce 11 peut être avantageusement utilisée pour réaliser l'accouplement de deux seringues, l'une d'entre elles contenant une préparation pharmaceutique sous forme de micro-capsules stériles, l'autre un solvant stérile destiné à mettre en suspension lesdites micro-capsules. Après le transfert de la totalité du mélange dans l'une des deux seringues, la pièce 11 est déconnectée de celle-ci, une aiguille à injection étant alors placée sur l'embout 1 ainsi libéré. Ladite seringue est alors prête pour l'injection d'une suspension de micro-capsules. Dans la pratique, on a observé que les pertes en produit actif étaient inférieures à 5% en poids environ.Part 11 can advantageously be used to couple two syringes, one of which contains a pharmaceutical preparation in the form of sterile microcapsules, the other a sterile solvent intended to suspend said microcapsules . After the transfer of the entire mixture into one of the two syringes, the part 11 is disconnected therefrom, an injection needle then being placed on the end piece 1 thus released. Said syringe is then ready for the injection of a suspension of microcapsules. In practice, it has been observed that the losses of active product are less than approximately 5% by weight.

Selon l'invention, la bride 5 est le plus généralement de forme polygonale et fait office d'organe de manipulation de la pièce 11. En fait, toute forme adaptée à la préhension de ladite bride peut être envisagée. On peut ainsi réaliser des objets de petite taille demeurant aisément manipulables.According to the invention, the flange 5 is most generally of polygonal shape and acts as a member for handling the part 11. In fact, any shape suitable for gripping said flange can be envisaged. It is thus possible to produce small objects that remain easy to handle.

Selon l'invention en outre, l'un des embouts 3,4 peut être muni d'un bouchon 10 dont une partie 12 au moins est de forme complémentaire à celle de l'espace intérieur desdits embouts, le plus généralement de forme tronconique. Ladite partie 12 présente en outre une protubérance 13, destinée à coopérer avec l'orifice 9 défini plus haut. Un tel ensemble, connecté par son embout libre à une seringue, constitue une pièce d'obturation dans laquelle l'espace mort inhérent à l'agencement des seringues actuellement connues (embout 1-et douille filetée 2) est réduit à son volume minimum. Un tel ensemble convient particulièrement bien à l'obturation de seringues destinées à recevoir des matières pulvérulentes telles des micro-capsules par exemple.According to the invention, moreover, one of the end pieces 3,4 may be provided with a plug 10, at least part 12 of which is of shape complementary to that of the interior space of said end pieces, most generally of frustoconical shape. Said part 12 also has a protuberance 13, intended to cooperate with the orifice 9 defined above. Such an assembly, connected by its free tip to a syringe, constitutes a obturation piece in which the dead space inherent in the arrangement of the syringes currently known (tip 1 - and threaded sleeve 2) is reduced to its minimum volume. Such an assembly is particularly suitable for closing syringes intended to receive pulverulent materials such as microcapsules for example.

Selon une autre exécution de l'invention, l'obturation de seringue à injection munie d'un embout 1 placé dans une douille filetée 2 peut être avantageusement réalisée à l'aide d'une pièce 16 constituée d'un embout creux 14, muni d'un fond 15, de forme intérieure complémentaire de celle de l'embout 1 et de longueur pratiquement égale à celle dudit embout. Tout comme dans le cas de la pièce 11, l'extrémité ouverte de l'embout 14 présente un rebord 17 destiné à coopérer avec le filetage de la douille 2, assurant ainsi la solidarisation de la pièce d'obturation 16 à l'embout 1 de la seringue. De façon analogue, le fond 15 se prolonge à l'extérieur de l'embout 14 et fait office d'organe de manipulation. De même que dans le cas de la bride 5 de la pièce 11, la forme dudit fond 15 sera conçue de façon à en faciliter la préhension: elle pourra être avantageusement de forme polygonale.According to another embodiment of the invention, the closure of an injection syringe fitted with a tip 1 placed in a threaded sleeve 2 can advantageously be produced using a part 16 consisting of a hollow tip 14, provided a bottom 15, of internal shape complementary to that of the end piece 1 and of length practically equal to that of said end piece. As in the case of the part 11, the open end of the end piece 14 has a flange 17 intended to cooperate with the thread of the socket 2, thus ensuring the attachment of the closure part 16 to the end piece 1 syringe. Similarly, the bottom 15 extends outside of the end piece 14 and acts as a handling member. As in the case of the flange 5 of the part 11, the shape of said bottom 15 will be designed so as to facilitate gripping: it may advantageously be of polygonal shape.

La pièce 16 et le bouchon 10, finalement, seront de préférence réalisés dans des matériaux du même type que celui utilisé pour la pièce d'accouplement 11.The part 16 and the plug 10, finally, will preferably be made of materials of the same type as that used for the coupling part 11.

Claims (10)

1. Pièce d'accouplement pour seringues à injection comportant un embout (1) placé à l'intérieur d'une douille filetée (2), caractérisée en ce qu'elle se compose de deux embouts creux (3,4) disposés coaxialement, tous deux solidaires d'une bride intermédiaire (5), de forme intérieure complémentaire de celle des embouts (1) et de longueur pratiquement égale à celle des embouts (1) desdites seringues.1. Coupling piece for injection syringes comprising a tip (1) placed inside a threaded sleeve (2), characterized in that it consists of two hollow tips (3,4) arranged coaxially, both secured to an intermediate flange (5), of internal shape complementary to that of the tips (1) and of length practically equal to that of the tips (1) of said syringes. 2. Pièce selon la revendication 1, caractérisée en ce que chacun desdits embouts (3,4) présente à son extrémité opposée à la bride (5) un rebord (6,7) destiné à coopérer avec le filetage de la douille (2).2. Part according to claim 1, characterized in that each of said end pieces (3,4) has at its end opposite the flange (5) a flange (6,7) intended to cooperate with the thread of the sleeve (2) . 3. Pièce selon l'une des revendications 1 et 2, caractérisée en ce que la bride (5) se prolonge à l'intérieur de l'espace creux (8) commun aux embouts (3,4) pour délimiter un orifice (9) de diamètre sensiblement inférieur à celui de l'espace creux (8).3. Part according to one of claims 1 and 2, characterized in that the flange (5) extends inside the hollow space (8) common to the end pieces (3,4) to delimit an orifice (9 ) of diameter substantially smaller than that of the hollow space (8). 4. Pièce selon l'une des revendications 1 à 3, caractérisée en ce que la bride est de forme générale polygonale et qu'elle fait office d'organe de manipulation.4. Part according to one of claims 1 to 3, characterized in that the flange is of generally polygonal shape and that it acts as a handling member. 5. Utilisation de la pièce selon l'une des revendications 1 à 4 pour l'accouplement de deux seringues, l'une d'entre elles contenant une préparation pharmaceutique sous forme de micro-capsules stériles, l'autre un solvant stérile destiné à mettre en suspension lesdites micro-capsules.5. Use of the part according to one of claims 1 to 4 for coupling two syringes, one of them containing a pharmaceutical preparation in the form of sterile microcapsules, the other a sterile solvent intended for suspend said microcapsules. 6. Pièce d'obturation pour seringue à injection munie d'un embout (1) placé à l'intérieur d'une douille filetée (2), caractériséeen ce qu'ellese compose d'une pièce d'accouplement (11) telle que définie à la revendication 1 et d'un bouchon (10) dont une partie (12) au moins est de forme complémentaire à celle de l'espace intérieur de l'un des embouts (3,4) et de longueur au moins égale à celle dudit embout (3,4).6. Sealing piece for injection syringe provided with a tip (1) placed inside a threaded sleeve (2), characterized in that it consists of a coupling piece (11) such that defined in claim 1 and of a plug (10) of which at least one part (12) is of shape complementary to that of the interior space of one of the end pieces (3,4) and of length at least equal to that of said tip (3,4). 7. Pièce selon la revendication 6, caractérisée en ce que ladite partie (12) présente une protubérance (13) destinée à obturer l'orifice (9) de la pièce (11).7. Part according to claim 6, characterized in that said part (12) has a protuberance (13) intended to close the orifice (9) of the part (11). 8. Pièce d'obturation pour seringue à injection munie d'un embout (1) placé dans une douille filetée (2), caractérisée en ce qu'elle consiste en un embout creux (14) muni d'un fond (15), de forme intérieure complémentaire de celle de l'embout (1) et de longueur pratiquement égale à celle dudit embout (1) de la seringue.8. Sealing piece for injection syringe fitted with a nozzle (1) placed in a threaded sleeve (2), characteristic sée in that it consists of a hollow end piece (14) provided with a bottom (15), of internal shape complementary to that of the end piece (1) and of length practically equal to that of said end piece (1) of the syringe. 9. Pièce selon la revendication 8, caractérisée en ce que l'extrémité ouverte de l'embout (14) présente un rebord (17) destiné à coopérer avec le filetage de la douille (2).9. Part according to claim 8, characterized in that the open end of the nozzle (14) has a flange (17) intended to cooperate with the thread of the sleeve (2). 10. Pièce selon l'une des revendications 8 et 9, caractérisée en ce que le fond (15) se prolonge à l'extérieur de l'embout (14) et fait office d'organe de manipulation.10. Part according to one of claims 8 and 9, characterized in that the bottom (15) extends outside the tip (14) and acts as a handling member.
EP84810571A 1983-12-02 1984-11-23 Coupling piece for an injection syringe Withdrawn EP0148116A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH6469/83 1983-12-02
CH6469/83A CH665127A5 (en) 1983-12-02 1983-12-02 COUPLING PART FOR INJECTION SYRINGES.

Publications (1)

Publication Number Publication Date
EP0148116A1 true EP0148116A1 (en) 1985-07-10

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Application Number Title Priority Date Filing Date
EP84810571A Withdrawn EP0148116A1 (en) 1983-12-02 1984-11-23 Coupling piece for an injection syringe

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EP (1) EP0148116A1 (en)
CH (1) CH665127A5 (en)

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EP0266058A2 (en) * 1986-09-29 1988-05-04 Collagen Corporation Collagen/mineral mixing device and method
EP0292472A1 (en) * 1987-05-21 1988-11-23 IMMUNO Aktiengesellschaft Set for putting in readiness and applying a tissue adhesive
DE4002858A1 (en) * 1989-03-22 1990-09-27 Disetronic Ag Insulin mixt. adaptor - made of specified plastic for precise dosages
EP0426634A2 (en) * 1989-11-03 1991-05-08 Bent Heimreid An arrangement in connection with a rack for orderly storage and/or for keeping syringes with a luer tip ready for use
WO1992011928A1 (en) * 1990-12-28 1992-07-23 Byk Gulden Lomberg Chemische Fabrik Gmbh Dosage form for micro-bubble echo contrast agents
US5425580A (en) * 1990-12-28 1995-06-20 Byk Gulden Lomberg Chemische Fabrik Gmbh Dosage form for micro-bubble echo contrast agents
WO1996008227A1 (en) * 1994-09-16 1996-03-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Mixing device for agents to be administered with a syringe
EP1322422A1 (en) * 2000-07-18 2003-07-02 The Regents Of The University Of California Method and apparatus for preparing lipidic mesophase material
US6875204B1 (en) 2000-06-30 2005-04-05 Abbott Laboratories Universal connector
DE10151104B4 (en) * 2001-10-16 2006-01-19 E. Braun Gmbh Device for mixing two components
WO2008089550A1 (en) * 2007-01-22 2008-07-31 Duoject Medical System Inc. Airless mixing with a by-pass syringe
DE102008019222A1 (en) 2008-04-17 2009-10-22 Koll, Rolf, Dipl.-Ing. Pre-filled sealing cap for use as solitary packaging for bottles, has different interlocking systems, where cap is made up of plastic or metal and is so designed that it is mounted on crown cork bottles
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US8348867B2 (en) 2005-09-07 2013-01-08 Cabochon Aesthetics, Inc. Method for treating subcutaneous tissues
US8894678B2 (en) 2009-08-07 2014-11-25 Ulthera, Inc. Cellulite treatment methods
WO2014205063A1 (en) * 2013-06-20 2014-12-24 Nordson Corporation Device and method for improving hydration of a biomaterial
US9011473B2 (en) 2005-09-07 2015-04-21 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9039722B2 (en) 2007-10-09 2015-05-26 Ulthera, Inc. Dissection handpiece with aspiration means for reducing the appearance of cellulite
US9248317B2 (en) 2005-12-02 2016-02-02 Ulthera, Inc. Devices and methods for selectively lysing cells
US9272124B2 (en) 2005-12-02 2016-03-01 Ulthera, Inc. Systems and devices for selective cell lysis and methods of using same
US9358064B2 (en) 2009-08-07 2016-06-07 Ulthera, Inc. Handpiece and methods for performing subcutaneous surgery
US9358033B2 (en) 2005-09-07 2016-06-07 Ulthera, Inc. Fluid-jet dissection system and method for reducing the appearance of cellulite
US9486274B2 (en) 2005-09-07 2016-11-08 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
DE102005027333B4 (en) * 2005-06-13 2017-04-13 Terra Nano Ltd. Nanoskalische Reaktivdesorption - a process for the preparation of colloidal drug or Vitalstoffspezies, in particular corresponding drug or nutrient concentrates and devices for carrying out the same
US10166347B1 (en) 2014-07-18 2019-01-01 Patrick Vitello Closure assembly for a medical device
US10166343B1 (en) 2015-03-13 2019-01-01 Timothy Brandon Hunt Noise evident tamper cap
US10183129B1 (en) 2010-12-03 2019-01-22 Medical Device Engineering, Llc Tamper indicating closure assembly
US10207099B1 (en) 2014-02-21 2019-02-19 Patrick Vitello Closure assembly for medical fitting
US10300263B1 (en) 2015-02-27 2019-05-28 Timothy Brandon Hunt Closure assembly for a medical connector
US10307548B1 (en) 2016-12-14 2019-06-04 Timothy Brandon Hunt Tracking system and method for medical devices
US10315024B1 (en) 2015-03-19 2019-06-11 Patick Vitello Torque limiting closure assembly
US10548659B2 (en) 2006-01-17 2020-02-04 Ulthera, Inc. High pressure pre-burst for improved fluid delivery
US10758684B1 (en) 2017-03-03 2020-09-01 Jonathan J. Vitello Tamper evident assembly
USD903865S1 (en) 2018-11-19 2020-12-01 International Medical Industries, Inc. Self-righting tip cap
US10888672B1 (en) 2017-04-06 2021-01-12 International Medical Industries, Inc. Tamper evident closure assembly for a medical device
US10898659B1 (en) 2017-05-19 2021-01-26 International Medical Industries Inc. System for handling and dispensing a plurality of products
US10912898B1 (en) 2014-02-03 2021-02-09 Medical Device Engineering Llc Tamper evident cap for medical fitting
US10933202B1 (en) 2017-05-19 2021-03-02 International Medical Industries Inc. Indicator member of low strength resistance for a tamper evident closure
US10953162B1 (en) 2016-12-28 2021-03-23 Timothy Brandon Hunt Tamper evident closure assembly
US11040149B1 (en) 2017-03-30 2021-06-22 International Medical Industries Tamper evident closure assembly for a medical device
US11096708B2 (en) 2009-08-07 2021-08-24 Ulthera, Inc. Devices and methods for performing subcutaneous surgery
US11097071B1 (en) 2016-12-14 2021-08-24 International Medical Industries Inc. Tamper evident assembly
CN113546539A (en) * 2020-04-24 2021-10-26 透策生技股份有限公司 Treatment method for accelerating dispersion of injection filler by using pressurization means
USD948713S1 (en) 2019-09-03 2022-04-12 International Medical Industries, Inc. Asymmetrical self righting tip cap
US11357588B1 (en) 2019-11-25 2022-06-14 Patrick Vitello Needle packaging and disposal assembly
US11413406B1 (en) 2018-03-05 2022-08-16 Jonathan J. Vitello Tamper evident assembly
US11426328B1 (en) 2018-08-31 2022-08-30 Alexander Ollmann Closure for a medical container
US11471610B1 (en) 2018-10-18 2022-10-18 Robert Banik Asymmetrical closure for a medical device
US11523970B1 (en) 2020-08-28 2022-12-13 Jonathan Vitello Tamper evident shield
US11541180B1 (en) 2017-12-21 2023-01-03 Patrick Vitello Closure assembly having a snap-fit construction
US11690994B1 (en) 2018-07-13 2023-07-04 Robert Banik Modular medical connector
US11697527B1 (en) 2019-09-11 2023-07-11 Logan Hendren Tamper evident closure assembly
US11779520B1 (en) 2018-07-02 2023-10-10 Patrick Vitello Closure for a medical dispenser including a one-piece tip cap
US11793987B1 (en) 2018-07-02 2023-10-24 Patrick Vitello Flex tec closure assembly for a medical dispenser
US11857751B1 (en) 2018-07-02 2024-01-02 International Medical Industries Inc. Assembly for a medical connector
US11872187B1 (en) 2020-12-28 2024-01-16 Jonathan Vitello Tamper evident seal for a vial cover
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Cited By (89)

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Publication number Priority date Publication date Assignee Title
EP0266058A2 (en) * 1986-09-29 1988-05-04 Collagen Corporation Collagen/mineral mixing device and method
EP0266058A3 (en) * 1986-09-29 1989-10-25 Collagen Corporation Collagen/mineral mixing device and method
EP0292472A1 (en) * 1987-05-21 1988-11-23 IMMUNO Aktiengesellschaft Set for putting in readiness and applying a tissue adhesive
DE4002858A1 (en) * 1989-03-22 1990-09-27 Disetronic Ag Insulin mixt. adaptor - made of specified plastic for precise dosages
EP0426634A2 (en) * 1989-11-03 1991-05-08 Bent Heimreid An arrangement in connection with a rack for orderly storage and/or for keeping syringes with a luer tip ready for use
EP0426634A3 (en) * 1989-11-03 1992-03-04 Bent Heimreid An arrangement in connection with a rack for orderly storage and/or for keeping syringes with a luer tip ready for use
US5425580A (en) * 1990-12-28 1995-06-20 Byk Gulden Lomberg Chemische Fabrik Gmbh Dosage form for micro-bubble echo contrast agents
JPH06503976A (en) * 1990-12-28 1994-05-12 ビイク　グルデン　ロンベルク　ヒエーミツシエ　フアブリーク　ゲゼルシヤフト　ミツト　ベシユレンクテル　ハフツング Dosage form for microbubble echo contrast agent
WO1992011928A1 (en) * 1990-12-28 1992-07-23 Byk Gulden Lomberg Chemische Fabrik Gmbh Dosage form for micro-bubble echo contrast agents
WO1996008227A1 (en) * 1994-09-16 1996-03-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Mixing device for agents to be administered with a syringe
DE4432993C1 (en) * 1994-09-16 1996-06-20 Byk Gulden Lomberg Chem Fab Mixing device for agents to be administered by means of a syringe
US6875204B1 (en) 2000-06-30 2005-04-05 Abbott Laboratories Universal connector
US7482166B2 (en) 2000-07-18 2009-01-27 The Regents Of The University Of California Method and apparatus for preparing lipidic mesophase material
EP1322422A1 (en) * 2000-07-18 2003-07-02 The Regents Of The University Of California Method and apparatus for preparing lipidic mesophase material
EP1322422A4 (en) * 2000-07-18 2004-11-17 Univ California Method and apparatus for preparing lipidic mesophase material
US6821487B2 (en) 2000-07-18 2004-11-23 Regents Of The University Of California Method and apparatus for preparing lipidic mesophase material
US7410803B2 (en) 2000-07-18 2008-08-12 The Regents Of The University Of California Method and apparatus for preparing lipidic mesophase material
DE10151104B4 (en) * 2001-10-16 2006-01-19 E. Braun Gmbh Device for mixing two components
DE102005027333B4 (en) * 2005-06-13 2017-04-13 Terra Nano Ltd. Nanoskalische Reaktivdesorption - a process for the preparation of colloidal drug or Vitalstoffspezies, in particular corresponding drug or nutrient concentrates and devices for carrying out the same
US9364246B2 (en) 2005-09-07 2016-06-14 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US9011473B2 (en) 2005-09-07 2015-04-21 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
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US9179928B2 (en) 2005-09-07 2015-11-10 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
US8348867B2 (en) 2005-09-07 2013-01-08 Cabochon Aesthetics, Inc. Method for treating subcutaneous tissues
US9358033B2 (en) 2005-09-07 2016-06-07 Ulthera, Inc. Fluid-jet dissection system and method for reducing the appearance of cellulite
US9486274B2 (en) 2005-09-07 2016-11-08 Ulthera, Inc. Dissection handpiece and method for reducing the appearance of cellulite
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US9248317B2 (en) 2005-12-02 2016-02-02 Ulthera, Inc. Devices and methods for selectively lysing cells
US10548659B2 (en) 2006-01-17 2020-02-04 Ulthera, Inc. High pressure pre-burst for improved fluid delivery
WO2008089550A1 (en) * 2007-01-22 2008-07-31 Duoject Medical System Inc. Airless mixing with a by-pass syringe
US9039722B2 (en) 2007-10-09 2015-05-26 Ulthera, Inc. Dissection handpiece with aspiration means for reducing the appearance of cellulite
US10220122B2 (en) 2007-10-09 2019-03-05 Ulthera, Inc. System for tissue dissection and aspiration
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US8167280B2 (en) 2009-03-23 2012-05-01 Cabochon Aesthetics, Inc. Bubble generator having disposable bubble cartridges
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US8900262B2 (en) 2009-08-07 2014-12-02 Ulthera, Inc. Device for dissection of subcutaneous tissue
US10531888B2 (en) 2009-08-07 2020-01-14 Ulthera, Inc. Methods for efficiently reducing the appearance of cellulite
US8900261B2 (en) 2009-08-07 2014-12-02 Ulthera, Inc. Tissue treatment system for reducing the appearance of cellulite
US11337725B2 (en) 2009-08-07 2022-05-24 Ulthera, Inc. Handpieces for tissue treatment
US9510849B2 (en) 2009-08-07 2016-12-06 Ulthera, Inc. Devices and methods for performing subcutaneous surgery
US9358064B2 (en) 2009-08-07 2016-06-07 Ulthera, Inc. Handpiece and methods for performing subcutaneous surgery
US8906054B2 (en) 2009-08-07 2014-12-09 Ulthera, Inc. Apparatus for reducing the appearance of cellulite
US8894678B2 (en) 2009-08-07 2014-11-25 Ulthera, Inc. Cellulite treatment methods
US8920452B2 (en) 2009-08-07 2014-12-30 Ulthera, Inc. Methods of tissue release to reduce the appearance of cellulite
US8979881B2 (en) 2009-08-07 2015-03-17 Ulthera, Inc. Methods and handpiece for use in tissue dissection
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US11779520B1 (en) 2018-07-02 2023-10-10 Patrick Vitello Closure for a medical dispenser including a one-piece tip cap
US11690994B1 (en) 2018-07-13 2023-07-04 Robert Banik Modular medical connector
US11426328B1 (en) 2018-08-31 2022-08-30 Alexander Ollmann Closure for a medical container
US11471610B1 (en) 2018-10-18 2022-10-18 Robert Banik Asymmetrical closure for a medical device
USD903865S1 (en) 2018-11-19 2020-12-01 International Medical Industries, Inc. Self-righting tip cap
US11911339B1 (en) 2019-08-15 2024-02-27 Peter Lehel Universal additive port cap
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US11697527B1 (en) 2019-09-11 2023-07-11 Logan Hendren Tamper evident closure assembly
US11357588B1 (en) 2019-11-25 2022-06-14 Patrick Vitello Needle packaging and disposal assembly
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US11523970B1 (en) 2020-08-28 2022-12-13 Jonathan Vitello Tamper evident shield
US11872187B1 (en) 2020-12-28 2024-01-16 Jonathan Vitello Tamper evident seal for a vial cover

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