EP0231623A3 - Couette membrane filtration apparatus for separating suspended components in a fluid medium using high shear - Google Patents

Couette membrane filtration apparatus for separating suspended components in a fluid medium using high shear Download PDF

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Publication number
EP0231623A3
EP0231623A3 EP86309692A EP86309692A EP0231623A3 EP 0231623 A3 EP0231623 A3 EP 0231623A3 EP 86309692 A EP86309692 A EP 86309692A EP 86309692 A EP86309692 A EP 86309692A EP 0231623 A3 EP0231623 A3 EP 0231623A3
Authority
EP
European Patent Office
Prior art keywords
particles
rmf
donor
fluid
design
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP86309692A
Other languages
German (de)
French (fr)
Other versions
EP0231623A2 (en
Inventor
Richard J. Fischel
Robert C. Brumfield
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HEMOLOGICS Inc
Original Assignee
HEMOLOGICS Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by HEMOLOGICS Inc filed Critical HEMOLOGICS Inc
Publication of EP0231623A2 publication Critical patent/EP0231623A2/en
Publication of EP0231623A3 publication Critical patent/EP0231623A3/en
Withdrawn legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/16—Rotary, reciprocated or vibrated modules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D65/00—Accessories or auxiliary operations, in general, for separation processes or apparatus using semi-permeable membranes
    • B01D65/08—Prevention of membrane fouling or of concentration polarisation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
    • B01D2321/10—Use of feed
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction

Abstract

The present invention provides significant improve­ ments in the design and performance of a specific type of Rotary Membrane Filter (RMF) apparatus which has the cap­ ability of separating particles from a fluid having the same and nearly the same density as the particles by utilizing shear to achieve separation, not centrifugal forces. A particular app­ lication for the apparatus is in the processing of fluid suspen­ sions in which the suspensions contain fragile particles which are subject to damage due to excessive shear stresses. The prior art describes processing at constant shear rate, whereas the present invention provides the design and optimization of operation of such an apparatus at constant shear stress, which is maintained at a value below that at which significant damage to the fragile particles is encountered. The use of the invention is plasmapheresis (blood separations) is described in detail, it being understood that the teachings of the inven­ tion are also directly applicable to other fluids containing fragile particles.
The application of the RMF in a continuous flow pro­ cessing system designed to extract blood plasma from a donor is described, including return of corpuscular com­ ponents to the donor.
EP86309692A 1985-12-23 1986-12-12 Couette membrane filtration apparatus for separating suspended components in a fluid medium using high shear Withdrawn EP0231623A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/812,936 US4755300A (en) 1985-12-23 1985-12-23 Couette membrane filtration apparatus for separating suspended components in a fluid medium using high shear
US812936 1985-12-23

Publications (2)

Publication Number Publication Date
EP0231623A2 EP0231623A2 (en) 1987-08-12
EP0231623A3 true EP0231623A3 (en) 1987-11-04

Family

ID=25211025

Family Applications (1)

Application Number Title Priority Date Filing Date
EP86309692A Withdrawn EP0231623A3 (en) 1985-12-23 1986-12-12 Couette membrane filtration apparatus for separating suspended components in a fluid medium using high shear

Country Status (2)

Country Link
US (1) US4755300A (en)
EP (1) EP0231623A3 (en)

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Also Published As

Publication number Publication date
US4755300A (en) 1988-07-05
EP0231623A2 (en) 1987-08-12

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