EP0257559A3 - Multi-color fluorescence analysis with single wavelength excitation - Google Patents
Multi-color fluorescence analysis with single wavelength excitation Download PDFInfo
- Publication number
- EP0257559A3 EP0257559A3 EP87112065A EP87112065A EP0257559A3 EP 0257559 A3 EP0257559 A3 EP 0257559A3 EP 87112065 A EP87112065 A EP 87112065A EP 87112065 A EP87112065 A EP 87112065A EP 0257559 A3 EP0257559 A3 EP 0257559A3
- Authority
- EP
- European Patent Office
- Prior art keywords
- particles
- fluorescence
- single wavelength
- fluorescence analysis
- color fluorescence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 230000005284 excitation Effects 0.000 title abstract 2
- 238000012921 fluorescence analysis Methods 0.000 title abstract 2
- 239000002245 particle Substances 0.000 abstract 6
- 238000000034 method Methods 0.000 abstract 3
- 238000004458 analytical method Methods 0.000 abstract 2
- 238000000295 emission spectrum Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Electro-optical investigation, e.g. flow cytometers
- G01N15/1456—Electro-optical investigation, e.g. flow cytometers without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
- G01N15/1459—Electro-optical investigation, e.g. flow cytometers without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Electro-optical investigation, e.g. flow cytometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1006—Investigating individual particles for cytology
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Electro-optical investigation, e.g. flow cytometers
- G01N2015/1477—Multiparameters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Electro-optical investigation, e.g. flow cytometers
- G01N2015/1477—Multiparameters
- G01N2015/1479—Using diffuse illumination or excitation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
- G01N2021/6421—Measuring at two or more wavelengths
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
- G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
Abstract
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US898685 | 1986-08-21 | ||
US06/898,685 US4745285A (en) | 1986-08-21 | 1986-08-21 | Multi-color fluorescence analysis with single wavelength excitation |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0257559A2 EP0257559A2 (en) | 1988-03-02 |
EP0257559A3 true EP0257559A3 (en) | 1989-05-03 |
Family
ID=25409885
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP87112065A Ceased EP0257559A3 (en) | 1986-08-21 | 1987-08-20 | Multi-color fluorescence analysis with single wavelength excitation |
Country Status (3)
Country | Link |
---|---|
US (1) | US4745285A (en) |
EP (1) | EP0257559A3 (en) |
JP (1) | JPS63118638A (en) |
Families Citing this family (74)
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US4900934A (en) * | 1987-07-15 | 1990-02-13 | University Of Utah | Apparatus for simultaneous visualization and measurement of fluorescence from fluorescent dye-treated cell preparations and solutions |
US4876190A (en) * | 1987-10-21 | 1989-10-24 | Becton Dickinson & Company | Peridinin-chlorophyll complex as fluorescent label |
US4885633A (en) * | 1988-06-13 | 1989-12-05 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Quantitative surface temperature measurement using two-color thermographic phosphors and video equipment |
GB2228081B (en) * | 1988-12-06 | 1993-07-07 | Loughborough Consult Ltd | A fluorimeter, and a method of carrying out a fluorescent assay of a plurality of analytes |
US5480804A (en) * | 1989-06-28 | 1996-01-02 | Kirin Beverage Corporation | Method of and apparatus for detecting microorganisms |
DE4019025C2 (en) * | 1990-06-14 | 1994-09-22 | Triton Technology Inc | Method for measuring blood flow to organ and / or tissue samples |
US5127730A (en) * | 1990-08-10 | 1992-07-07 | Regents Of The University Of Minnesota | Multi-color laser scanning confocal imaging system |
DE9012816U1 (en) * | 1990-09-07 | 1990-11-08 | Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung Ev, 8000 Muenchen, De | |
US5627040A (en) * | 1991-08-28 | 1997-05-06 | Becton Dickinson And Company | Flow cytometric method for autoclustering cells |
SE9103427D0 (en) * | 1991-11-20 | 1991-11-20 | Pharmacia Biosystems Ab | PROCEDURES FOR QUANTIFYING A SUBSTANCE WITH FLUORESCENCE |
ATE173543T1 (en) * | 1992-04-10 | 1998-12-15 | Thomas Totterman | METHOD FOR DETECTING CMV INFECTION |
US5270548A (en) * | 1992-07-31 | 1993-12-14 | The United States Of America As Represented By The United States Department Of Energy | Phase-sensitive flow cytometer |
ES2051651B1 (en) * | 1992-12-10 | 1995-01-01 | Univ Salamanca | PROCEDURE FOR THE SIMULTANEOUS QUANTIFICATION, IN A SINGLE MEASUREMENT, OF THE MAIN TYPES OF HUMAN LYMPHOCYTES AND THEIR SUB-POPULATIONS. |
US5418855A (en) * | 1993-09-27 | 1995-05-23 | Angstrom Technologies, Inc. | Authentication system and method |
US5459567A (en) * | 1994-02-18 | 1995-10-17 | Brocia; Robert W. | Method for determining the degree of spectral interference in an assay having a test sample |
US5891734A (en) * | 1994-08-01 | 1999-04-06 | Abbott Laboratories | Method for performing automated analysis |
US5656499A (en) * | 1994-08-01 | 1997-08-12 | Abbott Laboratories | Method for performing automated hematology and cytometry analysis |
US5631165A (en) * | 1994-08-01 | 1997-05-20 | Abbott Laboratories | Method for performing automated hematology and cytometry analysis |
DE69417900T2 (en) * | 1994-11-17 | 1999-11-11 | Chemunex Maisons Alfort | Device and method for fast and highly sensitive detection and counting of microorganisms using fluorescence |
US5695990A (en) * | 1995-04-10 | 1997-12-09 | Cubicciotti; Roger S. | Phycobilisomes, derivatives, and uses therefor |
US6342389B1 (en) | 1995-04-10 | 2002-01-29 | Roger S. Cubicciotti | Modified phycobilisomes and uses therefore |
US6008373A (en) | 1995-06-07 | 1999-12-28 | Carnegie Mellon University | Fluorescent labeling complexes with large stokes shift formed by coupling together cyanine and other fluorochromes capable of resonance energy transfer |
US5807536A (en) * | 1996-04-09 | 1998-09-15 | The Regents Of The University Of California | Anatomical imaging with phycocyanins |
US6014904A (en) * | 1996-05-09 | 2000-01-18 | Becton, Dickinson And Company | Method for classifying multi-parameter data |
DE19634873A1 (en) * | 1996-08-29 | 1998-03-12 | Boehringer Mannheim Gmbh | System for the differentiation of fluorescent groups of molecules by time-resolved fluorescence measurement |
US6122396A (en) * | 1996-12-16 | 2000-09-19 | Bio-Tech Imaging, Inc. | Method of and apparatus for automating detection of microorganisms |
EP0974050B1 (en) * | 1997-01-20 | 2002-09-25 | ORPEGEN Pharma GmbH | Basophil degranulation test |
US6139800A (en) * | 1997-06-23 | 2000-10-31 | Luminex Corporation | Interlaced lasers for multiple fluorescence measurement |
DE19742227A1 (en) * | 1997-09-25 | 1999-04-01 | Juergen Prof Dipl Phys Wolfrum | Method of sequencing a single DNA molecule |
AU3897999A (en) | 1998-05-14 | 1999-11-29 | Luminex Corporation | Multi-analyte diagnostic system and computer implemented process for same |
US6628385B1 (en) * | 1999-02-05 | 2003-09-30 | Axon Instruments, Inc. | High efficiency, large field scanning microscope |
DE19915137C2 (en) * | 1999-03-26 | 2001-10-18 | Michael Schaefer | Fluorescence microscopy method for quantifying multiple fluorochromes in a multi-colored sample and uses of the method |
WO2001009592A1 (en) * | 1999-07-30 | 2001-02-08 | California Institute Of Technology | System and method for monitoring cellular activity |
EP1102101A1 (en) * | 1999-11-22 | 2001-05-23 | Leica Microsystems Heidelberg GmbH | Laser scanning microscope |
US6379884B2 (en) | 2000-01-06 | 2002-04-30 | Caliper Technologies Corp. | Methods and systems for monitoring intracellular binding reactions |
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US6858148B2 (en) * | 2003-07-16 | 2005-02-22 | The Regents Of The University Of California | Method and apparatus for detecting chemical binding |
US20040017884A1 (en) * | 2002-07-25 | 2004-01-29 | Havrilla George J. | Flow method and apparatus for screening chemicals using micro x-ray fluorescence |
US6683314B2 (en) | 2001-08-28 | 2004-01-27 | Becton, Dickinson And Company | Fluorescence detection instrument with reflective transfer legs for color decimation |
US6702453B2 (en) | 2001-10-26 | 2004-03-09 | Birchwood Lighting, Inc. | Flexible light fixture |
US6838289B2 (en) * | 2001-11-14 | 2005-01-04 | Beckman Coulter, Inc. | Analyte detection system |
US6750006B2 (en) * | 2002-01-22 | 2004-06-15 | Microbiosystems, Limited Partnership | Method for detecting the presence of microbes and determining their physiological status |
US7186990B2 (en) * | 2002-01-22 | 2007-03-06 | Microbiosystems, Limited Partnership | Method and apparatus for detecting and imaging the presence of biological materials |
US7211377B1 (en) | 2002-01-22 | 2007-05-01 | Microbiosystems, Limited Partnership | Method for detecting the presence of dormant cryptobiotic microorganisms |
US7519145B2 (en) * | 2002-07-25 | 2009-04-14 | Los Alamos National Security, Llc | Flow method and apparatus for screening chemicals using micro x-ray fluorescence |
US6955872B2 (en) * | 2003-03-20 | 2005-10-18 | Coulter International Corp. | Dye compositions which provide enhanced differential fluorescence and light scatter characteristics |
DE20311760U1 (en) * | 2003-07-30 | 2003-12-11 | Trw Automotive Safety Systems Gmbh | vehicle steering wheel |
US7468518B2 (en) * | 2003-10-23 | 2008-12-23 | National University Of Singapore | Fluorescence correlation spectroscopy with single excitation wavelength |
US20070043510A1 (en) * | 2005-08-19 | 2007-02-22 | Beckman Coulter, Inc. | Assay system |
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US7847923B2 (en) * | 2006-09-29 | 2010-12-07 | Millipore Corporation | Differentiation of flow cytometry pulses and applications |
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CN110308127A (en) * | 2019-08-15 | 2019-10-08 | 四川朴澜医疗科技有限公司 | Can more fluorescence signals simultaneously detect optical assay device |
EP4155349A1 (en) | 2021-09-24 | 2023-03-29 | Becton, Dickinson and Company | Water-soluble yellow green absorbing dyes |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4499052A (en) * | 1982-08-30 | 1985-02-12 | Becton, Dickinson And Company | Apparatus for distinguishing multiple subpopulations of cells |
US4520110A (en) * | 1981-10-06 | 1985-05-28 | The Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing a phycobiliprotein labeled ligand or receptor |
US4599307A (en) * | 1983-07-18 | 1986-07-08 | Becton, Dickinson And Company | Method for elimination of selected cell populations in analytic cytology |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3826364A (en) * | 1972-05-22 | 1974-07-30 | Univ Leland Stanford Junior | Particle sorting method and apparatus |
US3918812A (en) * | 1973-05-07 | 1975-11-11 | Us Energy | Diagnoses of disease states by fluorescent measurements utilizing scanning laser beams |
US4542104A (en) * | 1983-04-06 | 1985-09-17 | The Board Of Trustees Of The Leland Stanford Jr. Univ. | Phycobiliprotein fluorescent conjugates |
US4661913A (en) * | 1984-09-11 | 1987-04-28 | Becton, Dickinson And Company | Apparatus and method for the detection and classification of articles using flow cytometry techniques |
-
1986
- 1986-08-21 US US06/898,685 patent/US4745285A/en not_active Expired - Lifetime
-
1987
- 1987-08-20 EP EP87112065A patent/EP0257559A3/en not_active Ceased
- 1987-08-21 JP JP62208036A patent/JPS63118638A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4520110A (en) * | 1981-10-06 | 1985-05-28 | The Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing a phycobiliprotein labeled ligand or receptor |
US4499052A (en) * | 1982-08-30 | 1985-02-12 | Becton, Dickinson And Company | Apparatus for distinguishing multiple subpopulations of cells |
US4599307A (en) * | 1983-07-18 | 1986-07-08 | Becton, Dickinson And Company | Method for elimination of selected cell populations in analytic cytology |
Non-Patent Citations (1)
Title |
---|
CYTOMETRY, vol. 3, no. 5, 1983, pages 359-366, The Society for Analytical Cytology; S. HASKILL et al.: "Simultaneous three color and electronic cell volume analysis with a single UV excitation source" * |
Also Published As
Publication number | Publication date |
---|---|
US4745285A (en) | 1988-05-17 |
JPS63118638A (en) | 1988-05-23 |
US4745285B1 (en) | 1992-08-11 |
EP0257559A2 (en) | 1988-03-02 |
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Inventor name: CHEN, CHIA HUEI Inventor name: RECKTENWALD, DIETHER J. |