EP0384731A3 - Osteogenic growth polypeptides identified from regenerating bone marrow - Google Patents

Osteogenic growth polypeptides identified from regenerating bone marrow Download PDF

Info

Publication number
EP0384731A3
EP0384731A3 EP19900301862 EP90301862A EP0384731A3 EP 0384731 A3 EP0384731 A3 EP 0384731A3 EP 19900301862 EP19900301862 EP 19900301862 EP 90301862 A EP90301862 A EP 90301862A EP 0384731 A3 EP0384731 A3 EP 0384731A3
Authority
EP
European Patent Office
Prior art keywords
gly
bone marrow
osteogenic growth
regenerating bone
polypeptides identified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP19900301862
Other languages
German (de)
French (fr)
Other versions
EP0384731B1 (en
EP0384731A2 (en
Inventor
Gideon A. Rodan
Mohinder K. Sardana
John W. Jacobs
Dan Gazit
Itai A. Bab
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yissum Research Development Co of Hebrew University of Jerusalem
Original Assignee
Yissum Research Development Co of Hebrew University of Jerusalem
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Research Development Co of Hebrew University of Jerusalem, Merck and Co Inc filed Critical Yissum Research Development Co of Hebrew University of Jerusalem
Publication of EP0384731A2 publication Critical patent/EP0384731A2/en
Publication of EP0384731A3 publication Critical patent/EP0384731A3/en
Application granted granted Critical
Publication of EP0384731B1 publication Critical patent/EP0384731B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

The present invention comprises a biochemically pure polypeptide(s), termed osteogenic growth polypeptide (OGP), which exhibits stimulatory effects on osteoblastlc cells and in vivo bone formation. OGP, identified from regenerating bone marrow, has an amino acid sequence of
Ala-Leu-Lys-Arg-Gln-Gly-Arg-Thr-Leu-­ Tyr-Gly-Phe-Gly-Gly
EP90301862A 1989-02-23 1990-02-21 Osteogenic growth polypeptides identified from regenerating bone marrow Expired - Lifetime EP0384731B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US314602 1981-10-26
US31460289A 1989-02-23 1989-02-23

Publications (3)

Publication Number Publication Date
EP0384731A2 EP0384731A2 (en) 1990-08-29
EP0384731A3 true EP0384731A3 (en) 1991-06-26
EP0384731B1 EP0384731B1 (en) 1996-12-18

Family

ID=23220610

Family Applications (1)

Application Number Title Priority Date Filing Date
EP90301862A Expired - Lifetime EP0384731B1 (en) 1989-02-23 1990-02-21 Osteogenic growth polypeptides identified from regenerating bone marrow

Country Status (4)

Country Link
EP (1) EP0384731B1 (en)
JP (1) JPH07103156B2 (en)
CA (1) CA2010660A1 (en)
DE (1) DE69029415T2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5461034A (en) * 1989-02-23 1995-10-24 Yissum Research Development Company Of The Hebrew University Of Jerusalem Osteogenic growth polypeptides identified from regenerating bone marrow
US5206023A (en) * 1991-01-31 1993-04-27 Robert F. Shaw Method and compositions for the treatment and repair of defects or lesions in cartilage
US5693615A (en) * 1991-06-05 1997-12-02 The Procter & Gamble Company Therapeutic compositions for osteoinduction
DK0573668T3 (en) * 1991-12-26 1998-04-27 Snow Brand Milk Products Co Ltd Bone-boosting factor and foods and beverages containing the same factor
IL101747A0 (en) * 1992-04-30 1992-12-30 Yissum Res Dev Co C-terminal modified osteogenic growth polypeptides
IL104954A (en) * 1993-03-04 2006-08-01 Yissum Res Dev Co Use of osteogenic oligopeptides in the preparation of pharmaceutical compositions for the treatment of bone diseases and some such novel oligopeptides, pharmaceutical compositions containing them and their preparation
IL117426A (en) 1996-03-10 2005-09-25 Yissum Res Dev Co Synthetic pseudopeptides having osteogenic activity and pharmaceutical compositions containing the same
DE19906096A1 (en) 1999-02-13 2000-08-17 Walter Sebald Protein with a heparin-binding epitope

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4434094A (en) * 1983-04-12 1984-02-28 Collagen Corporation Partially purified osteogenic factor and process for preparing same from demineralized bone
US4455256A (en) * 1981-05-05 1984-06-19 The Regents Of The University Of California Bone morphogenetic protein
EP0241578A2 (en) * 1986-04-18 1987-10-21 MARROW-TECH INCORPORATED (a Delaware corporation) Process for replicating bone marrow in vitro
EP0349048A2 (en) * 1988-06-27 1990-01-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem Osteogenic growth factors derived from regenerating bone marrow

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4455256A (en) * 1981-05-05 1984-06-19 The Regents Of The University Of California Bone morphogenetic protein
US4434094A (en) * 1983-04-12 1984-02-28 Collagen Corporation Partially purified osteogenic factor and process for preparing same from demineralized bone
EP0241578A2 (en) * 1986-04-18 1987-10-21 MARROW-TECH INCORPORATED (a Delaware corporation) Process for replicating bone marrow in vitro
EP0349048A2 (en) * 1988-06-27 1990-01-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem Osteogenic growth factors derived from regenerating bone marrow

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 74, no. 1, 4 January 1971 Columbus, Ohio, USA Sautiere P. et al: "Carboxyl terminal sequence of histone rich in glycine and arginine isolated from a rat chloroleukemic tumor." & C.R.ACAD.SCI.SER.D,1970,271(13),1131-3 *
CHEMICAL ABSTRACTS, vol. 76, no. 7, 14 February 1972 Columbus, Ohio, USA Sautiere P. et al: "Primary structure of the glycine- and arginine- rich histone isolated from rat chloroleukemic tumor." & BIOCHIMIE 1971, 53[4], 479-83 *

Also Published As

Publication number Publication date
EP0384731B1 (en) 1996-12-18
CA2010660A1 (en) 1990-08-23
DE69029415T2 (en) 1997-04-03
JPH07103156B2 (en) 1995-11-08
JPH02282396A (en) 1990-11-19
EP0384731A2 (en) 1990-08-29
CA2010660C (en) 1990-08-23
DE69029415D1 (en) 1997-01-30

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