EP0445974A3 - Spirocyclic antipsychotic agents - Google Patents

Spirocyclic antipsychotic agents Download PDF

Info

Publication number
EP0445974A3
EP0445974A3 EP19910301683 EP91301683A EP0445974A3 EP 0445974 A3 EP0445974 A3 EP 0445974A3 EP 19910301683 EP19910301683 EP 19910301683 EP 91301683 A EP91301683 A EP 91301683A EP 0445974 A3 EP0445974 A3 EP 0445974A3
Authority
EP
European Patent Office
Prior art keywords
spirocyclic
antipsychotic agents
antipsychotic
agents
spirocyclic antipsychotic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP19910301683
Other versions
EP0445974A2 (en
Inventor
David C. Billington
Mark S. Chambers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
Original Assignee
Merck Sharp and Dohme Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909004900A external-priority patent/GB9004900D0/en
Priority claimed from GB909025385A external-priority patent/GB9025385D0/en
Application filed by Merck Sharp and Dohme Ltd filed Critical Merck Sharp and Dohme Ltd
Publication of EP0445974A2 publication Critical patent/EP0445974A2/en
Publication of EP0445974A3 publication Critical patent/EP0445974A3/en
Ceased legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20Spiro-condensed ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
EP19910301683 1990-03-05 1991-02-28 Spirocyclic antipsychotic agents Ceased EP0445974A3 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB909004900A GB9004900D0 (en) 1990-03-05 1990-03-05 Therapeutic agents
GB9004900 1990-03-05
GB9025385 1990-11-22
GB909025385A GB9025385D0 (en) 1990-11-22 1990-11-22 Therapeutic agents

Publications (2)

Publication Number Publication Date
EP0445974A2 EP0445974A2 (en) 1991-09-11
EP0445974A3 true EP0445974A3 (en) 1992-04-29

Family

ID=26296748

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19910301683 Ceased EP0445974A3 (en) 1990-03-05 1991-02-28 Spirocyclic antipsychotic agents

Country Status (4)

Country Link
US (2) US5219860A (en)
EP (1) EP0445974A3 (en)
JP (1) JPH04211662A (en)
CA (1) CA2037467A1 (en)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ243065A (en) * 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
US5693643A (en) * 1991-09-16 1997-12-02 Merck & Co., Inc. Hydantoin and succinimide-substituted derivatives of spiroindanylcamphorsulfonyl oxytocin antagonists
EP0533243B1 (en) * 1991-09-16 1997-12-17 Merck & Co. Inc. Hydantoin and succinimide-substituted spiroindanylcamphorsulfonyl derivatives
US5204349A (en) * 1991-09-16 1993-04-20 Merck & Co., Inc. Amide-substituted derivatives of spiroindanylcamphorsulfonyl oxytocin antagonists
WO1994014438A1 (en) * 1992-12-23 1994-07-07 Merck & Co., Inc. Hydantoin and succinimide-substituted derivatives of spiroindanylcamphorsulfonyl oxytocin antagonists
DK78692D0 (en) * 1992-06-12 1992-06-12 Lundbeck & Co As H DIMER PIPERIDINE AND PIPERAZINE DERIVATIVES
AU5292393A (en) * 1992-10-07 1994-04-26 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
US5869496A (en) * 1993-01-28 1999-02-09 Merck & Co., Inc. Spiro-substituted azacycles as tachykinin receptor antagonists
US6060473A (en) * 1993-04-01 2000-05-09 Ucb S.A. - Dtb 7-azabicyclo[2.2.1]-heptane and -heptene derivatives as cholinergic receptor ligands
US5817679A (en) * 1993-04-01 1998-10-06 University Of Virginia 7-Azabicyclo 2.2.1!-heptane and -heptene derivatives as cholinergic receptor ligands
CA2171440A1 (en) 1993-09-10 1995-03-16 Changgeng Qian Epibatidine and derivatives thereof as cholinergic receptor agonists and antagonists
US5670509A (en) * 1993-09-27 1997-09-23 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
US5457207A (en) * 1993-10-05 1995-10-10 Regents Of The University Of Minnesota Spirovesamicols
US5439914A (en) * 1994-02-18 1995-08-08 Merck & Co., Inc. Spirocycles
US6117889A (en) * 1994-04-01 2000-09-12 University Of Virginia 7-Azabicyclo-[2.2.1]-heptane and -heptene derivatives as analgesics and anti-inflammatory agents
US5725838A (en) * 1996-05-31 1998-03-10 Resolution Pharmaceuticals, Inc. Radiolabeled D4 receptor ligands
US5976497A (en) * 1997-08-04 1999-11-02 Resolution Pharmaceuticals, Inc. Dopamine D4 receptor ligands
US6374762B1 (en) * 1997-10-27 2002-04-23 Correct Craft, Inc. Water sport towing apparatus
SI1385514T1 (en) * 2001-04-18 2009-04-30 Euro Celtique Sa Spiroindene and spiroindane compounds
US7045527B2 (en) 2002-09-24 2006-05-16 Amgen Inc. Piperidine derivatives
US7786141B2 (en) * 2004-08-19 2010-08-31 Vertex Pharmaceuticals Incorporated Dihydrospiroindene modulators of muscarinic receptors
NZ553202A (en) * 2004-08-19 2010-12-24 Vertex Pharma Modulators of muscarinic receptors
BRPI0514692A (en) 2004-08-27 2008-06-17 Esteve Labor Dr sigma receptor inhibitors
KR20070046194A (en) 2004-08-27 2007-05-02 라보라토리오스 델 드라. 에스테브.에스.에이. Sigma receptor inhibitors
EP1634873A1 (en) 2004-08-27 2006-03-15 Laboratorios Del Dr. Esteve, S.A. Sigma receptor inhibitors
ES2396421T3 (en) 2004-08-27 2013-02-21 Laboratorios Del Dr. Esteve, S.A. Sigma receptor inhibitors
US7863449B2 (en) * 2004-11-29 2011-01-04 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
EP1943250A1 (en) 2005-09-09 2008-07-16 Euro-Celtique S.A. Fused and spirocycle compounds and the use thereof
US7858635B2 (en) 2005-12-22 2010-12-28 Vertex Pharmaceuticals Incorporated Spiro compounds as modulators of muscarinic receptors
JP2009527569A (en) * 2006-02-22 2009-07-30 バーテックス ファーマシューティカルズ インコーポレイテッド Modulator of muscarinic receptor
US8003660B2 (en) 2006-02-22 2011-08-23 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
EP1829875A1 (en) 2006-03-01 2007-09-05 Laboratorios Del Dr. Esteve, S.A. Pyrazole derivatives as sigma receptor inhibitors
WO2007098953A1 (en) * 2006-03-01 2007-09-07 Laboratorios Del Dr. Esteve, S.A. Pyrazole derivatives as sigma receptor inhibitors
EP1829866A1 (en) 2006-03-02 2007-09-05 Laboratorios Del Dr. Esteve, S.A. Sigma receptor inhibitors
EP1829867A1 (en) 2006-03-03 2007-09-05 Laboratorios Del Dr. Esteve, S.A. Imidazole compounds having pharmaceutical activity towards the sigma receptor
CA2656183A1 (en) 2006-06-29 2008-01-10 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
CA2660903A1 (en) 2006-08-15 2008-02-21 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
EP2051715A2 (en) * 2006-08-18 2009-04-29 Vertex Pharmceuticals Incorporated Modulators of muscarinic receptors
JP2010540640A (en) * 2007-10-03 2010-12-24 バーテックス ファーマシューティカルズ インコーポレイテッド Muscarinic receptor modulators
EP2116539A1 (en) 2008-04-25 2009-11-11 Laboratorios Del. Dr. Esteve, S.A. 1-aryl-3-aminoalkoxy-pyrazoles as sigma ligands enhancing analgesic effects of opioids and attenuating the dependency thereof
EP2353591A1 (en) 2010-02-04 2011-08-10 Laboratorios Del. Dr. Esteve, S.A. Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof
EP2353598A1 (en) 2010-02-04 2011-08-10 Laboratorios Del. Dr. Esteve, S.A. Sigma ligands for use in the prevention and/or treatment of postoperative pain
EP2388005A1 (en) 2010-05-21 2011-11-23 Laboratorios Del. Dr. Esteve, S.A. Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy
EP2395003A1 (en) 2010-05-27 2011-12-14 Laboratorios Del. Dr. Esteve, S.A. Pyrazole compounds as sigma receptor inhibitors
EP2415471A1 (en) 2010-08-03 2012-02-08 Laboratorios Del. Dr. Esteve, S.A. Use of sigma ligands in opioid-induced hyperalgesia
EP2524694A1 (en) 2011-05-19 2012-11-21 Laboratorios Del. Dr. Esteve, S.A. Use of sigma ligands in diabetes type-2 associated pain
CA2933511A1 (en) 2013-12-17 2015-06-25 Laboratorios Del Dr. Esteve, S.A. Serotonin-norepinephrine reuptake inhibitors (snris) and sigma receptor ligands combinations

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3125580A (en) * 1964-03-17 x d diphenyl -
US3301857A (en) * 1963-08-26 1967-01-31 Hoffmann La Roche Spiro
US3654287A (en) * 1970-08-26 1972-04-04 Mead Johnson & Co Spiroindanylpiperidines
US3959475A (en) * 1973-12-12 1976-05-25 American Hoechst Corporation Substituted 1,3-dihydrospiro(isobenzofuran)s
EP0414289B1 (en) * 1989-07-26 1994-02-23 Merck Sharp & Dohme Ltd. Spirocyclic antipsychotic agents

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179732A (en) * 1977-06-10 1979-12-18 Dataproducts Corporation Microprogrammable processor control printer system
JPS55143980A (en) * 1979-04-27 1980-11-10 Dai Ichi Seiyaku Co Ltd Anti-allergic preparation
GB8808433D0 (en) * 1988-04-11 1988-05-11 Merck Sharp & Dohme Therapeutic agents
GB8816299D0 (en) * 1988-07-08 1988-08-10 Merck Sharp & Dohme Therapeutic agents
IL96507A0 (en) * 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
US5091387A (en) * 1990-03-02 1992-02-25 Merck & Co., Inc. Spirocyclic oxytocin antagonists

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3125580A (en) * 1964-03-17 x d diphenyl -
US3301857A (en) * 1963-08-26 1967-01-31 Hoffmann La Roche Spiro
US3654287A (en) * 1970-08-26 1972-04-04 Mead Johnson & Co Spiroindanylpiperidines
US3959475A (en) * 1973-12-12 1976-05-25 American Hoechst Corporation Substituted 1,3-dihydrospiro(isobenzofuran)s
EP0414289B1 (en) * 1989-07-26 1994-02-23 Merck Sharp & Dohme Ltd. Spirocyclic antipsychotic agents

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ARCH. PHARM., vol. 323, no. 1, January 1990, pages 35-39; E. REIMANN et al.: "Synthese und pharmakologische Prüfung homologer und hydroxylierter 3,4-Dihydro-1'-methylspiro[naphthalin-1(2H),4'-piperidine]" *
PATENT ABSTRACTS OF JAPAN, vol. 5, no. 16, 30th January 1981, page 688-C-41; & JP-A-55 143 980 (DAIICHI SEIYAKU K.K.) 10-11-1980 *

Also Published As

Publication number Publication date
US5324733A (en) 1994-06-28
US5219860A (en) 1993-06-15
EP0445974A2 (en) 1991-09-11
JPH04211662A (en) 1992-08-03
CA2037467A1 (en) 1991-09-06

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