EP0737467B1 - Device for putting together a first liquid component and a second rigid or liquid component by means of vacuum under sterile conditions - Google Patents

Device for putting together a first liquid component and a second rigid or liquid component by means of vacuum under sterile conditions Download PDF

Info

Publication number
EP0737467B1
EP0737467B1 EP19960103858 EP96103858A EP0737467B1 EP 0737467 B1 EP0737467 B1 EP 0737467B1 EP 19960103858 EP19960103858 EP 19960103858 EP 96103858 A EP96103858 A EP 96103858A EP 0737467 B1 EP0737467 B1 EP 0737467B1
Authority
EP
European Patent Office
Prior art keywords
hollow body
cannula
container
cannula holder
holder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP19960103858
Other languages
German (de)
French (fr)
Other versions
EP0737467A1 (en
Inventor
Thomas Dr. Pfeifer
Dietmar Weitzel
Wolfgang Kneip
Bernhard Dr. Vohwinkel
Axel Von Brand
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CLS BEHRING GmbH
Axel Von Brand GmbH
Original Assignee
Centeon Pharma GmbH
Axel Von Brand GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centeon Pharma GmbH, Axel Von Brand GmbH filed Critical Centeon Pharma GmbH
Publication of EP0737467A1 publication Critical patent/EP0737467A1/en
Application granted granted Critical
Publication of EP0737467B1 publication Critical patent/EP0737467B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2065—Connecting means having aligning and guiding means

Definitions

  • the invention relates to a device for merging a first liquid and a second solid or liquid component by means of negative pressure sterile conditions, with a first receiving the first component Container and a receiving the second component, under vacuum standing second container, and a cylindrical hollow body for receiving of the first container in the area of its closure in a first Hollow body opening and a second, arranged diametrically to this Hollow body opening, for receiving the second container in the area thereof Closure, and at least one stored in the hollow body and in it Longitudinally displaceable cannula for piercing the containers each sealing plug, the cannula in one Cannula holder is stored.
  • Such a device that is part of a pre-assembled system for Transfer of liquids forms is known from DE 38 17 101 A1.
  • the System allows the second container with the attached device in the Bring to trade so that liquid can be transferred to this second container only the first container to the through the second container and the Device formed unit must be plugged.
  • the sliding Storage of the cannula in the hollow body and in the path of the cannula holder protruding overrun resistance ensure that the inserted in the hollow body second container is connected to this, but not in contact with the Cannula arrives. Only after piercing the liquid absorbing first container is the further insertion of the container neck of the first Overrun container overrun resistance and the plug of the pierced the second container, leaving the inside of the two containers is connected by means of the cannula.
  • the known device is both on the cannula holder and on one Part of the hollow body-forming bearing sleeve is a circumferential projection intended.
  • the resistance resulting from the contact of the two projections to drive over the bearing sleeve-side projection is larger than that Penetration resistance of the cannula when penetrating into the plug of the first container.
  • the disadvantage here is that the formation of the parts with the Projections an exact dimensioning of the projection outer diameter of the Needle carrier and projection inner diameter of the bearing sleeve required to the To achieve successive piercing of the sealing plugs of the containers.
  • the projections also require increased manufacturing costs Device related to the manufacture of the cannula holder and the hollow body, otherwise the assembly of the device in the area of the cannula holder is right complex.
  • the problem is solved with a device of the type mentioned in that the cannula holder as a plate-shaped, perpendicular to the longitudinal direction of the hollow body oriented body is formed, the holding webs with the Inner wall of the hollow body is connected, the holding webs through Applying a manual force that is greater than that Penetration force of the cannula when piercing the plug of the first Container.
  • the cannula carrier is thus inserted into the cannula the stopper of the second container by means of the plate-shaped Retaining bars are fixed to the inner wall of the hollow body.
  • a shift in Cannula is therefore only possible if the holding bars have been applied beforehand the manual force were torn. It is therefore a safe sequential Sequence of movement guaranteed.
  • the design of the device enables their simple design by, as appropriate, except for the cannula Plastic injection molded part is designed.
  • the Cannula holder with directed towards the inner wall of the hollow body Leadership approaches. These allow after separating the Retaining webs a relatively tilt-free guidance of the cannula holder relative to the inner wall of the hollow body, thus a largely exact guidance of the Cannula in the puncture area to the second container, the cannula also in the sealing plug of the first container.
  • the hollow body advantageously has an opening with a circular cross section.
  • the cannula holder has, for example, the shape of an equilateral triangle, with three Guiding approaches that are in the middle of the triangle sides of the Cannula holder are connected to this.
  • a circular cannula holder are preferably four, each offset by 90 degrees to each other Guide approaches connected to the circumference of the cannula holder.
  • the Guiding lugs can be concentric on the outside radially and in the longitudinal direction of the hollow body have extending guide tabs.
  • a preferred development of the invention provides that with the inner wall of the hollow body are connected in the longitudinal direction extending lugs, between which the guide lugs or the corners of the cannula holder are arranged.
  • the respective management approach should be via a middle bar be connected to the cannula holder and two guide approaches each Reach behind the leadership approach in the area of the center bar.
  • the design of the Hollow body with guide lugs requires a defined positioning of the Cannula holder relative to the hollow body during its displacement in the longitudinal direction and also prevents relative rotation or tilting of the Cannula holder to the hollow body.
  • the extension causes the container not only in the area of the plug having the container neck is held, but the extended portion of the Hollow body also the generally enlarged, voluminous area of the Contains at least partially with more or less large distance, so that a tilting of the container in the hollow body is excluded. From This is particularly important for the container that contains the substance Vacuum or vacuum conditions, so when transferring the Liquid in this container does not have to be actively carried, but only this the other, the liquid-absorbing container is required.
  • the elongated section of the hollow body expediently has one Inner diameter that is slightly larger than the outer diameter of the Container. This will not only prevent the accidental tilting of the Prevented container, but led the container defined.
  • the device with the two containers forms a pre-assembled, sterile packaged system in which the two containers are kept out of contact with the cannula in the cylindrical hollow body and a Packaging that encloses the containers and the hollow body sterile.
  • Figure 1 shows a cylindrical hollow body 3, the two hollow body openings 6 and 7 have the same inner diameter.
  • the upper hollow body opening 6, based on the orientation of FIG. 1, serves to hold a bottle 1 which holds a liquid
  • the lower opening 7 serves to hold a bottle 2 which holds a substance under negative pressure or vacuum conditions.
  • the opening of the respective bottle 1 or 2 closes Rubber stopper, not shown, which is held by means of a crimp cap 4 or 5.
  • the bottle 1 or 2 is inserted into the hollow body 3 and held by the latter.
  • a plate-shaped cannula holder 9 is arranged inside the hollow body 3, which is positioned perpendicular to the central longitudinal axis 31 of the hollow body 3.
  • the cannula support 9 is fixedly connected to the inner wall 30 of the hollow body 3 via a plurality of radially extending holding webs 13.
  • the cannula holder 9 has a through hole for receiving a cannula 8, the through axis of which coincides with the central longitudinal axis 31.
  • the bottle 2 After insertion into the hollow body 3, the bottle 2 contacts stops 10 connected to the inner wall 30 of the hollow body 3, so that it cannot be pushed further into the hollow body 3 in the direction of the cannula 8, but rather is clamped between the assigned inner wall section of the hollow body 3 .
  • the liquid-absorbing bottle 1, on the other hand, is held in a preassembled position in a section of the hollow body 3 facing the actual hollow body opening area, an inner annular bead 33 oriented parallel to the cannula holder 9 projecting into the displacement path of the crimp cap 4 and thus defining the installation position. In the preassembled position shown in FIG.
  • the transfer system is already sealed and sterilized by the pharmaceutical manufacturer in a peelable outer packaging 14, as is illustrated in FIG. 2.
  • This outer packaging 14 consists of a thermoformed soft blister film, preferably PA / PE and a sterilizable, sealable medical paper or a polyethylene spunbond. After the labeled and assembled units have been sealed in, they are sterilized, for example with ethylene oxide. In an appropriately designed secondary packaging, the user then prepares the components in the sterile outer packaging, while maintaining sterility despite tapping the respective containers.
  • Figures 3a to 3c illustrate the processes around the components merge.
  • Figure 3a illustrates the pre-assembled system as shown in Figure 1 is shown. Proceeding from this, the liquid absorbing Bottle 1 further inserted into the hollow body 3, the cannula 8 the Plug of bottle 1, which is made of rubber, penetrates. This is possible because the penetration or penetration force of the cannula 8 in or by the rubber stopper of the bottle 1 is less than the force required is connected to the hollow body 3 via the holding webs 13 Separate cannula holder 9 from this.
  • Figures 4a and 4b illustrate those in Figures 1 to 3c Transfer system described device for merging the components in detail.
  • the hollow body 3 is in the Area of the hollow body opening 6 as a ring 34 with only thin points interconnected holding webs 16 are formed.
  • the Cannula holder 9 essentially has the shape of a circle and is four Guide approaches 35 provided on the circumference of the cannula holder 9 each 90 ° offset from each other.
  • the leadership approaches 35 have a radially outer concentric to the cannula 8 and in the longitudinal direction of the Hollow body 3 extending guide surface 36. This is a short distance away arranged to the inner wall 30 of the hollow body 3, so that the cannula holder 9th after tearing the retaining webs 13 free of play and thus tilt-proof in the hollow body 3 is movable.
  • the hollow body 3 is inside with four, in the longitudinal direction of the hollow body 3 extending, each offset by 90 ° to each other arranged ribs 37 which provide the receiving diameter of the Specify the hollow body 3 for the bottle 1 and thus an exact positioning of the Ensure bottle 1, the insertion of this bottle 1 because of it System with its crimp cap 4 on the ribs 37 with little effort can be done.
  • the ribs 37 pass through recesses 38 between the Leadership approaches 35.
  • the cannula holder 9 has a essentially the shape of an equilateral triangle and there are three Guide approaches 35 provided in the center of the triangular sides of the Cannula holder 9 are connected to this.
  • Guide approaches 35 With the inner wall 30 of Hollow body 3 are wing-like guide lugs extending in its longitudinal direction 12, between which the guide lugs 35 of the cannula holder 9 are arranged.
  • the respective guide approach 35 is connected via a central web 39 connected to the cannula holder 9 and engage behind two adjacent ones Guiding approaches 12 the guiding approach 35 in the area of the central web 39.
  • everyone Guide projection 35 is connected to the hollow body 3 via a retaining web 13.
  • the triangular dimension of the cannula holder 9 is chosen so that its tips are positioned with minimal play to the inner wall 30 of the hollow body 3 what otherwise also for the position of the guide surface 36 of the respective Guide approach 35 and inner wall 30 of the hollow body 3 applies.
  • Neighbors Guide lugs 12 are arranged diverging from the inner wall 30 so that they take a corner 40 of the cannula holder 9 between them.
  • the hollow body opening has 7 (compared to the embodiment according to FIG. 6a) a greater longitudinal extent on. This is achieved by extending the opening Ring section 45 of the hollow body 3.
  • the inner diameter of the ring section is dimensioned slightly larger than the outer diameter of the bottle 2 in Bottle section 46.
  • Figure 7 illustrates that the outer diameter of the crimp cap 5 is smaller than the outer diameter of the container 2 and the ring section 45 extends to the side of the flange section 46. This causes a tilting of the Bottle 2 effectively prevented in the hollow body opening 7.
  • the upper Hollow body opening 6 is designed accordingly, that is, it also takes place there a guidance of the bottle 1 in the area of its bottle section 46, thus hers maximum expanded area.
  • the transfer device according to FIGS. 4a and 4b is suitable for injection bottles 1 and 2 with a nominal size of 20 mm.
  • the transfer device 5a and 5b is used to transfer a substance from a Bottle 1 with a nominal size of 13 mm into a bottle 2 with a nominal size of 20 mm.
  • the device serves to hold bottles 1 and 2 with a nominal size of 13 mm.
  • the embodiment according to FIGS. 7a and 7b serves to hold bottles 1 and 2 with a nominal size of 13 mm.

Abstract

At least one cannula (8) is mounted in the hollow body (3) so as to move in its longitudinal direction, and pierces the closure stopper closing the receptacles. The cannula is mounted in a plate-shaped holder (9) pointing at right angles to the longitudinal direction (31) of the hollow body. The holder is joined to the inner wall (30) of the hollow body by holder arms (13) which can be severed on the application of manual force greater than the penetration force of the cannula when piercing the closure stopper of the first receptacle (1).

Description

Die Erfindung betrifft eine Vorrichtung zum Zusammenführen einer ersten flüssigen und einer zweiten festen oder flüssigen Komponente mittels Unterdruck unter sterilen Bedingungen, mit einem die erste Komponente aufnehmenden ersten Behältnis und einem die zweite Komponente aufnehmenden, unter Unterdruck stehenden zweiten Behältnis, sowie einem zylindrischen Hohlkörper zur Aufnahme des ersten Behältnisses im Bereich dessen Verschlusses in einer ersten Hohlkörperöffnung und einer zweiten, diametral zu dieser angeordneten Hohlkörperöffnung, zur Aufnahme des zweiten Behältnisses im Bereich dessen Verschlusses, sowie mindestens einer im Hohlkörper gelagerten und in dessen Längsrichtung verschiebbaren Kanüle zum Durchstechen der die Behältnisse jeweils verschließenden Verschlußstopfen, wobei die Kanüle in einem Kanülenträger gelagert ist.The invention relates to a device for merging a first liquid and a second solid or liquid component by means of negative pressure sterile conditions, with a first receiving the first component Container and a receiving the second component, under vacuum standing second container, and a cylindrical hollow body for receiving of the first container in the area of its closure in a first Hollow body opening and a second, arranged diametrically to this Hollow body opening, for receiving the second container in the area thereof Closure, and at least one stored in the hollow body and in it Longitudinally displaceable cannula for piercing the containers each sealing plug, the cannula in one Cannula holder is stored.

Eine derartige Vorrichtung, die Bestandteil eines vormontierten Systems zur Überleitung von Flüssigkeiten bildet, ist aus der DE 38 17 101 A1 bekannt. Das System erlaubt es, das zweite Behältnis mit der aufgesteckten Vorrichtung in den Handel zu bringen, so daß zum Überleiten von Flüssigkeit in dieses zweite Behältnis nur noch das erste Behältnis auf die durch das zweite Behältnis und die Vorrichtung gebildete Einheit aufgesteckt werden muß. Die verschiebbare Lagerung der Kanüle im Hohlkörper und ein in den Weg des Kanülenträgers ragender Überfahrwiderstand stellen sicher, daß das in den Hohlkörper eingesetzte zweite Behältnis zwar mit diesem verbunden ist, aber nicht in Kontakt mit der Kanüle gelangt. Erst nach dem Anstechen des die Flüssigkeit aufnehmenden ersten Behältnisses wird beim weiteren Einführen des Behälterstutzens des ersten Behältnisses der Überfahrwiderstand überfahren und der Verschlußstopfen des zweiten Behältnisses durchstochen, womit das Innere der beiden Behältnisse mittels der Kanüle verbunden ist.Such a device that is part of a pre-assembled system for Transfer of liquids forms is known from DE 38 17 101 A1. The System allows the second container with the attached device in the Bring to trade so that liquid can be transferred to this second container only the first container to the through the second container and the Device formed unit must be plugged. The sliding Storage of the cannula in the hollow body and in the path of the cannula holder protruding overrun resistance ensure that the inserted in the hollow body second container is connected to this, but not in contact with the Cannula arrives. Only after piercing the liquid absorbing first container is the further insertion of the container neck of the first Overrun container overrun resistance and the plug of the pierced the second container, leaving the inside of the two containers is connected by means of the cannula.

Bei der bekannten Vorrichtung ist sowohl am Kanülenträger als auch an einer Bestandteil des Hohlkörpers bildenden Lagerhülse ein umlaufender Vorsprung vorgesehen. Der beim Kontakt der beiden Vorsprünge sich ergebende Widerstand zum Überfahren des lagerhülsenseitigen Vorsprunges ist größer als der Durchdringwiderstand der Kanüle beim Eindringen in den Verschlußstopfen des ersten Behältnisses. Nachteilig ist hierbei, daß die Ausbildung der Teile mit den Vorsprüngen eine exakte Bemessung von Vorsprungaußendurchmesser des Kanülenträgers und Vorsprunginnendurchmesser der Lagerhülse erfordert, um die zeitlich abfolgende Durchstechung der Verschlußstopfen der Behälter zu erzielen. Die Vorsprünge bedingen im übrigen einen erhöhten Fertigungsaufwand der Vorrichtung, bezogen auf die Herstellung des Kanülenträgers und des Hohlkörpers, im übrigen ist die Montage der Vorrichtung im Bereich des Kanülenträgers recht aufwendig.In the known device is both on the cannula holder and on one Part of the hollow body-forming bearing sleeve is a circumferential projection intended. The resistance resulting from the contact of the two projections to drive over the bearing sleeve-side projection is larger than that Penetration resistance of the cannula when penetrating into the plug of the first container. The disadvantage here is that the formation of the parts with the Projections an exact dimensioning of the projection outer diameter of the Needle carrier and projection inner diameter of the bearing sleeve required to the To achieve successive piercing of the sealing plugs of the containers. The projections also require increased manufacturing costs Device related to the manufacture of the cannula holder and the hollow body, otherwise the assembly of the device in the area of the cannula holder is right complex.

Es ist Aufgabe der vorliegenden Erfindung, eine Vorrichtung der eingangs genannten Art so weiter zu bilden, daß diese bei baulich einfacher Gestaltung eine unkomplizierte verwechselungssichere und nicht umkehrbare Handhabung ermöglicht.It is an object of the present invention, a device of the beginning mentioned type so that they are a structurally simple design enables uncomplicated, confusion-free and irreversible handling.

Gelöst wird die Aufgabe bei einer Vorrichtung der eingangs genannten Art dadurch, daß der Kanülenträger als plattenförmiger, senkrecht zur Längsrichtung des Hohlkörpers orientierter Körper ausgebildet ist, der über Haltestege mit der Innenwandung des Hohlkörpers verbunden ist, wobei die Haltestege durch Aufbringen einer manuellen Kraft zerreißbar sind, die größer ist als die Durchdringkraft der Kanüle beim Durchstechen des Verschlußstopfens des ersten Behältnisses.The problem is solved with a device of the type mentioned in that the cannula holder as a plate-shaped, perpendicular to the longitudinal direction of the hollow body oriented body is formed, the holding webs with the Inner wall of the hollow body is connected, the holding webs through Applying a manual force that is greater than that Penetration force of the cannula when piercing the plug of the first Container.

Erfindungsgemäß wird damit der Kanülenträger vor dem Einstechen der Kanüle in den Verschlußstopfen des zweiten Behältnisses mittels der plattenförmigen Haltestege an der Innenwandung des Hohlkörpers fixiert. Eine Verschiebung der Kanüle ist deshalb nur dann möglich, wenn die Haltestege zuvor durch Aufbringen der manuellen Kraft zerrissen wurden. Es ist damit eine sichere sequentielle Abfolge der Bewegung gewährleistet. Die Ausbildung der Vorrichtung ermöglicht deren einfache Gestaltung, indem sie, gegebenenfalls bis auf die Kanüle, als Kunststoffspritzgußteil ausgestaltet ist.According to the invention, the cannula carrier is thus inserted into the cannula the stopper of the second container by means of the plate-shaped Retaining bars are fixed to the inner wall of the hollow body. A shift in Cannula is therefore only possible if the holding bars have been applied beforehand the manual force were torn. It is therefore a safe sequential Sequence of movement guaranteed. The design of the device enables their simple design by, as appropriate, except for the cannula Plastic injection molded part is designed.

Gemäß einer besonderen Ausführungsform der Erfindung ist vorgesehen, daß der Kanülenträger mit auf die Innenwandung des Hohlkörpers zu gerichteten Führungsansätzen verbunden ist. Diese ermöglichen nach dem Trennen der Haltestege eine weitgehend verkantungsfreie Führung des Kanülenträgers relativ zur Innenwandung des Hohlkörpers, somit eine weitgehend exakte Führung der Kanüle im Einstechbereich zum zweiten Behältnis, wobei die Kanüle zudem im Verschlußstopfen des ersten Behältnisses gehalten ist.According to a particular embodiment of the invention it is provided that the Cannula holder with directed towards the inner wall of the hollow body Leadership approaches. These allow after separating the Retaining webs a relatively tilt-free guidance of the cannula holder relative to the inner wall of the hollow body, thus a largely exact guidance of the Cannula in the puncture area to the second container, the cannula also in the sealing plug of the first container.

Vorteilhaft weist der Hohlkörper eine Öffnung mit Kreisquerschnitt auf. Insbesondere bei einer solchen Gestaltung der Hohlkörperöffnung bietet sich eine dreieck- oder kreisförmige Ausbildung des Kanülenträgers an. Der Kanülenträger weist beispielsweise die Form eines gleichseitigen Dreiecks auf, mit drei Führungsansätzen, die im Bereich der Mitten der Dreiecksseiten des Kanülenträgers mit diesem verbunden sind. Bei einem kreisförmigen Kanülenträger sind bevorzugt vier jeweils um 90 Grad zueinander versetzt angeordnete Führungsansätze am Umfang des Kanülenträgers mit diesem verbunden. Die Führungsansätze können radial außen konzentrisch zur Kanüle und sich in Längsrichtung des Hohlkörpers erstreckende Führungsfahnen aufweisen.The hollow body advantageously has an opening with a circular cross section. In particular, with such a design of the hollow body opening, one offers triangular or circular design of the cannula holder. The cannula holder has, for example, the shape of an equilateral triangle, with three Guiding approaches that are in the middle of the triangle sides of the Cannula holder are connected to this. With a circular cannula holder are preferably four, each offset by 90 degrees to each other Guide approaches connected to the circumference of the cannula holder. The Guiding lugs can be concentric on the outside radially and in the longitudinal direction of the hollow body have extending guide tabs.

Eine bevorzugte Weiterbildung der Erfindung sieht vor, daß mit der Innenwandung des Hohlkörpers in dessen Längsrichtung verlaufende Leitansätze verbunden sind, zwischen denen die Führungsansätze oder die Ecken des Kanülenträgers angeordnet sind. Der jeweilige Führungsansatz sollte dabei über einen Mittelsteg mit dem Kanülenträger verbunden sein und jeweils zwei Leitansätze den Führungsansatz im Bereich des Mittelsteges hintergreifen. Die Gestaltung des Hohlkörpers mit Leitansätzen bedingt eine definierte Positionierung des Kanülenträgers relativ zum Hohlkörper während dessen Verschiebung in Längsrichtung und verhindert dabei auch eine relative Drehung bzw. ein Kippen des Kanülenträgers zum Hohlkörper.A preferred development of the invention provides that with the inner wall of the hollow body are connected in the longitudinal direction extending lugs, between which the guide lugs or the corners of the cannula holder are arranged. The respective management approach should be via a middle bar be connected to the cannula holder and two guide approaches each Reach behind the leadership approach in the area of the center bar. The design of the Hollow body with guide lugs requires a defined positioning of the Cannula holder relative to the hollow body during its displacement in the longitudinal direction and also prevents relative rotation or tilting of the Cannula holder to the hollow body.

Zum Verbessern der Führung des Behältnisses im Hohlkörper, ist dieser vorteilhaft im Bereich mindestens eines Endes parallel zum von der zugeordneten Hohlkörperöffnung aufzunehmenden Behältnis verlängert. Die Verlängerung bewirkt, daß das Behältnis nicht nur im Bereich des den Verschlußstopfen aufweisenden Behälterhalses gehalten ist, sondern der verlängerte Abschnitt des Hohlkörpers auch den in aller Regel erweiterten, voluminösen Bereich des Behältnisses zumindest teilweise mit mehr oder wenig großem Abstand umgibt, so daß ein Kippen des Behältnisses im Hohlkörper ausgeschlossen ist. Von Bedeutung ist dies insbesondere für das Behältnis, das die Substanz unter Unterdruck bzw. Vakuumbedingungen aufnimmt, demnach beim Überleiten der Flüssigkeit in dieses Behältnis nicht aktiv geführt werden muß, sondern dies nur bei dem anderen, die Flüssigkeit aufnehmenden Behältnis erforderlich ist. Zweckmäßig weist der verlängerte Abschnitt des Hohlkörpers einen Innendurchmesser auf, der geringfügig größer ist als der Außendurchmesser des Behältnisses. Es wird hierdurch nicht nur das versehentliche Kippen des Behältnisses verhindert, sondern das Behältnis definiert geführt.This is advantageous for improving the guidance of the container in the hollow body in the area of at least one end parallel to that of the associated one Hollow body opening to be extended container. The extension causes the container not only in the area of the plug having the container neck is held, but the extended portion of the Hollow body also the generally enlarged, voluminous area of the Contains at least partially with more or less large distance, so that a tilting of the container in the hollow body is excluded. From This is particularly important for the container that contains the substance Vacuum or vacuum conditions, so when transferring the Liquid in this container does not have to be actively carried, but only this the other, the liquid-absorbing container is required. The elongated section of the hollow body expediently has one Inner diameter that is slightly larger than the outer diameter of the Container. This will not only prevent the accidental tilting of the Prevented container, but led the container defined.

Es ist insbesondere vorgesehen, daß die Vorrichtung mit den beiden Behältnissen ein vormontiertes, steril verpacktes System bildet, bei dem die beiden Behältnisse außer Kontakt mit der Kanüle im zylindrischen Hohlkörper gehalten sind und ein Packmittel die Behältnisse und den Hohlkörper steril einschließt.It is particularly provided that the device with the two containers forms a pre-assembled, sterile packaged system in which the two containers are kept out of contact with the cannula in the cylindrical hollow body and a Packaging that encloses the containers and the hollow body sterile.

Nachdem die Überleitung der Flüssigkeit unter sterilen Verhältnissen in einer Umverpackung möglich ist, stehen damit ein Überleitsystem und eine Verpackung zur Verfügung, die die Zubereitung der in den Behältnissen befindlichen Komponenten deutlich vereinfachen, beschleunigen und eine von der unmittelbaren Anwendung zeitlich völlig getrennte Vorbereitung gestatten, sowie eine Lagerung der rekonstituierten Komponenten über mehrere Tage ermöglichen. Die Gestaltung und Anordnung des Überleitsystems ermöglicht eine schnelle, sichere, verwechselungsfreie und nicht umkehrbare Überleitung der im ersten Behältnis befindlichen Komponente in das die andere Komponente enthaltende zweite Behältnis unter geringstmöglichem Aufwand für den Anwender und unter Aufrechterhaltung der Sterilität auch nach dem Zusammenführen der Komponenten.After transferring the liquid under sterile conditions in a Outer packaging is possible, so there is a transfer system and packaging available for the preparation of the contained in the containers Components significantly simplify, accelerate and one of the immediate Allow application completely separate preparation in time, as well as a Allow the reconstituted components to be stored for several days. The Design and arrangement of the transfer system enables fast, safe, confusion-free and irreversible transfer of the first container located component in the second containing the other component Container with the least possible effort for the user and under Maintaining sterility even after the merge Components.

Weitere Merkmale der Erfindung sind in den Unteransprüchen, der Beschreibung der Figuren und den Figuren selbst dargestellt, wobei bemerkt wird, daß alle Einzelmerkmale und alle Kombinationen von Einzelmerkmalen erfindungswesentlich sind. Further features of the invention are in the dependent claims, the description of the figures and the figures themselves, it being noted that all Individual characteristics and all combinations of individual characteristics are essential to the invention.

In den Figuren ist die Erfindung anhand mehrerer Ausführungsformen beispielsweise dargestellt, ohne auf diese beschränkt zu sein. Es zeigt in schematischer Darstellung:

Figur 1
den grundsätzlichen Aufbau eines vormontierten Überleitsystems unter Verwendung der Überleitvorrichtung, in einem Längsschnitt durch die Vorrichtung dargestellt,
Figur 2
das vormontierte Überleitsystem gemäß Figur 1, das von einer sterilen Umverpackung aufgenommen ist,
Figur 3a
eine verkleinerte Darstellung des vormontierten Überleitsystems, d.h. vor dem Anstechen des ersten Behältnisses,
Figur 3b
das Überleitsystem nach Figur 3a nach dem Anstechen des ersten Behältnisses,
Figur 3c
das Überleitsystem gemäß der Figuren 3a und 3b, nach dem Anstechen des zweiten Behältnisses,
Figur 4a
eine vergrößerte Darstellung der in Figur 1 gezeigten Überleitvorrichtung, in einem Längsmittelschnitt veranschaulicht,
Figur 4b
einen Schnitt durch die Ausführungsform nach Figur 4a, senkrecht zur Längsachse der Kanüle im Bereich des Kanülenträgers geschnitten,
Figur 5a
eine gegenüber der Ausführungsform nach den Figuren 4a und 4b modifizierte Gestaltung der Vorrichtung, in einem Längsmittelschnitt,
Figur 5b
einen Schnitt durch die Ausführungsform nach Figur 5a, senkrecht zur Längsachse der Kanüle im Bereich des Kanülenträgers geschnitten,
Figur 6a
eine weitere, gegenüber der Ausführungsform nach den Figuren 4a und 4b modifizierte Gestaltung der Vorrichtung, in einem Längsmittelschnitt gesehen,
Figur 6b
einen Schnitt durch die Ausführungsform nach Figur 6a, senkrecht zur Längsachse der Kanüle im Bereich des Kanülenträgers geschnitten,
Figur 7a
eine weitere, gegenüber der Ausführungsform nach Figur 6a modifizierte Gestaltung der Vorrichtung, in einem Längsmittelschnitt gesehen, mit beidendig eingeführten, teilweise dargestellten Behältnissen und
Figur 7b
einen Schnitt gemäß der Linie A-A in Figur 7a.
In the figures, the invention is illustrated, for example, using several embodiments, without being limited to these. It shows in a schematic representation:
Figure 1
the basic structure of a pre-assembled transfer system using the transfer device, shown in a longitudinal section through the device,
Figure 2
the pre-assembled transfer system according to Figure 1, which is received by a sterile outer packaging,
Figure 3a
a reduced representation of the preassembled transfer system, ie before the first container is pierced,
Figure 3b
the transfer system according to FIG. 3a after piercing the first container,
Figure 3c
the transfer system according to FIGS. 3a and 3b, after the second container has been pierced,
Figure 4a
2 shows an enlarged illustration of the transfer device shown in FIG. 1, illustrated in a longitudinal central section,
Figure 4b
4 a section through the embodiment according to FIG. 4 a, cut perpendicular to the longitudinal axis of the cannula in the region of the cannula holder,
Figure 5a
a design of the device modified in comparison to the embodiment according to FIGS. 4a and 4b, in a longitudinal central section,
Figure 5b
5 a section through the embodiment according to FIG. 5 a, cut perpendicular to the longitudinal axis of the cannula in the region of the cannula holder,
Figure 6a
4 shows a further design of the device, modified from the embodiment according to FIGS. 4a and 4b, seen in a longitudinal central section,
Figure 6b
6 a section through the embodiment according to FIG. 6 a, cut perpendicular to the longitudinal axis of the cannula in the region of the cannula holder,
Figure 7a
a further, compared to the embodiment of Figure 6a modified design of the device, seen in a longitudinal central section, with both ends inserted, partially shown containers and
Figure 7b
a section along the line AA in Figure 7a.

Figur 1 zeigt einen zylindrischen Hohlkörper 3, dessen beide Hohlkörperöffnungen 6 und 7 gleichen Innendurchmesser aufweisen. Die auf die Orientierung der Figur 1 bezogen obere Hohlkörperöffnung 6 dient der Aufnahme einer eine Flüssigkeit aufnehmenden Flasche 1, die untere Öffnung 7 der Aufnahme einer eine Substanz unter Unterdruck bzw. Vakuumbedingungen aufnehmenden Flasche 2. Die Öffnung der jeweiligen Flasche 1 bzw. 2 verschließt ein nicht gezeigter Gummistopfen, der mittels einer Bördelkappe 4 bzw. 5 gehalten ist. Im Bereich der jeweiligen Bördelkappe 4 bzw. 5 ist die Flasche 1 bzw. 2 in den Hohlkörper 3 eingesteckt und von dieser gehalten. Etwa im Bereich der halben Länge des Hohlkörpers 3 ist ein plattenförmiger Kanülenträger 9 innerhalb des Hohlkörpers 3 angeordnet, der senkrecht zur Mittellängsachse 31 des Hohlkörpers 3 positioniert ist. Der Kanülenträger 9 ist über mehrere radial verlaufende Haltestege 13 mit der Innenwandung 30 des Hohlkörpers 3 fest verbunden. Der Kanülenträger 9 weist ein Durchgangsloch zur Aufnahme einer Kanüle 8 auf, deren Durchgangsachse mit der Mittellängsachse 31 zusammenfällt.
Die Flasche 2 kontaktiert nach dem Einstecken in den Hohlkörper 3 mit der Innenwandung 30 des Hohlkörpers 3 verbundene Anschläge 10, so daß sie nicht weiter in Richtung der Kanüle 8 in den Hohlkörper 3 einschiebbar ist, sondern vielmehr zwischen dem zugeordneten Innenwandungsabschnitt des Hohlkörpers 3 geklemmt ist. Die die Flüssigkeit aufnehmende Flasche 1 hingegen ist in einer vormontierten Stellung in einem dem eigentlichen Hohlkörperöffnungsbereich zugewandten Abschnitt des Hohlkörpers 3 gehalten, wobei ein parallel zum Kanülenträger 9 orientierter innerer Ringwulst 33 in den Verschiebeweg der Bördelkappe 4 ragt und damit die Montageposition definiert. In der in Figur 1 gezeigten, vormontierten Stellung des aus den beiden Flaschen 1 und 2 und dem Hohlkörper 3 mit Kanülenträger 9 und Kanüle 8 gebildeten Überleitsystems befinden sich die Bördelkappen 4 und 5 und somit die Gummistopfen zum Verschließen der Flaschen 1 und 2 in geringfügigem Abstand zu den beiden Enden der Kanüle 8. In diesem Zustand wird das Überleitsystem bereits beim pharmazeutischen Hersteller in eine peelbare Umverpackung 14 eingesiegelt und sterilisiert, wie es in Figur 2 veranschaulicht ist. Diese Umverpackung 14 besteht aus einer tiefziehbaren Weichblisterfolie, vorzugsweise PA/PE und einem sterilisierfähigen, siegelbaren medizinischen Papier oder einem Polyethylen-Spinnvlies. Nach dem Einsiegeln der etikettierten und montierten Einheiten erfolgt eine Sterilisation beispielsweise mit Ethylenoxid. In einer entsprechend gestalteten Sekundärverpackung führt der Anwender dann die Zubereitung der Komponenten in der sterilen Umverpackung durch, unter Aufrechterhaltung der Sterilität trotz Anstechens der jeweiligen Behältnisse.Figure 1 shows a cylindrical hollow body 3, the two hollow body openings 6 and 7 have the same inner diameter. The upper hollow body opening 6, based on the orientation of FIG. 1, serves to hold a bottle 1 which holds a liquid, the lower opening 7 serves to hold a bottle 2 which holds a substance under negative pressure or vacuum conditions. The opening of the respective bottle 1 or 2 closes Rubber stopper, not shown, which is held by means of a crimp cap 4 or 5. In the area of the respective crimp cap 4 or 5, the bottle 1 or 2 is inserted into the hollow body 3 and held by the latter. Approximately in the region of half the length of the hollow body 3, a plate-shaped cannula holder 9 is arranged inside the hollow body 3, which is positioned perpendicular to the central longitudinal axis 31 of the hollow body 3. The cannula support 9 is fixedly connected to the inner wall 30 of the hollow body 3 via a plurality of radially extending holding webs 13. The cannula holder 9 has a through hole for receiving a cannula 8, the through axis of which coincides with the central longitudinal axis 31.
After insertion into the hollow body 3, the bottle 2 contacts stops 10 connected to the inner wall 30 of the hollow body 3, so that it cannot be pushed further into the hollow body 3 in the direction of the cannula 8, but rather is clamped between the assigned inner wall section of the hollow body 3 . The liquid-absorbing bottle 1, on the other hand, is held in a preassembled position in a section of the hollow body 3 facing the actual hollow body opening area, an inner annular bead 33 oriented parallel to the cannula holder 9 projecting into the displacement path of the crimp cap 4 and thus defining the installation position. In the preassembled position shown in FIG. 1 of the transfer system formed from the two bottles 1 and 2 and the hollow body 3 with cannula holder 9 and cannula 8, the crimp caps 4 and 5 and thus the rubber stoppers for closing the bottles 1 and 2 are at a slight distance to the two ends of the cannula 8. In this state, the transfer system is already sealed and sterilized by the pharmaceutical manufacturer in a peelable outer packaging 14, as is illustrated in FIG. 2. This outer packaging 14 consists of a thermoformed soft blister film, preferably PA / PE and a sterilizable, sealable medical paper or a polyethylene spunbond. After the labeled and assembled units have been sealed in, they are sterilized, for example with ethylene oxide. In an appropriately designed secondary packaging, the user then prepares the components in the sterile outer packaging, while maintaining sterility despite tapping the respective containers.

Die Figuren 3a bis 3c verdeutlichen die Vorgänge, um die Komponenten zusammenzuführen. Figur 3a veranschaulicht das vormontierte System, wie es in Figur 1 dargestellt ist. Ausgehend hiervon wird die die Flüssigkeit aufnehmende Flasche 1 weiter in den Hohlkörper 3 eingeschoben, wobei die Kanüle 8 den Verschlußstopfen der Flasche 1, der aus Gummi besteht, durchdringt. Dies ist deshalb möglich, weil die Eindring- bzw. Durchdringkraft der Kanüle 8 in bzw. durch den Gummistopfen der Flasche 1 geringer ist als die Kraft, die erforderlich ist, um den über die Haltestege 13 an den Hohlkörper 3 angebundenen Kanülenträger 9 von diesem zu trennen. In der in Figur 3b gezeigten vorgeschobenen Position der Flasche 1, bei der die Kanüle 8 den Gummistopfen durchstochen hat, gelangt die Bördelkappe 4 dieser Flasche 1 in Anlage mit dem Kanülenträger 9, womit die manuell auf die Flasche 1 ausgeübte Einschiebekraft zum Einschieben der Flasche 1 in den Hohlkörper 3 unmittelbar auf den Kanülenträger 9 übertragen wird. Beim Aufbringen einer entsprechend hohen manuellen Kraft reißen die Haltestege 13, so daß die Flasche 1 zusammen mit dem Kanülenträger 9 und damit der Kanüle 8 weiter in Richtung der Flasche 2 innerhalb des Hohlkörpers 3 verschoben wird, sodaß die Kanüle 8 den Gummistopfen dieser Flasche 2 durchsticht. Der in der Flasche 2 befindliche Unterdruck saugt die Flüssigkeit aus der Flasche 1 in die Flasche 2 und führt zur Auflösung bzw. Durchmischung der in dieser befindlichen festen bzw. flüssigen Komponente. Das System mit in Überleitstellung befindlicher Kanüle 8 ist in Figur 3c gezeigt.Figures 3a to 3c illustrate the processes around the components merge. Figure 3a illustrates the pre-assembled system as shown in Figure 1 is shown. Proceeding from this, the liquid absorbing Bottle 1 further inserted into the hollow body 3, the cannula 8 the Plug of bottle 1, which is made of rubber, penetrates. This is possible because the penetration or penetration force of the cannula 8 in or by the rubber stopper of the bottle 1 is less than the force required is connected to the hollow body 3 via the holding webs 13 Separate cannula holder 9 from this. In the advanced shown in Figure 3b Position of the bottle 1 at which the cannula 8 pierced the rubber stopper has, the crimp cap 4 of this bottle 1 comes into contact with the cannula holder 9, with which the pushing-in force manually exerted on the bottle 1 for pushing-in the bottle 1 in the hollow body 3 transferred directly to the cannula holder 9 becomes. When a correspondingly high manual force is applied, they tear Retaining webs 13 so that the bottle 1 together with the cannula holder 9 and so that the cannula 8 continues in the direction of the bottle 2 within the hollow body 3 is moved so that the cannula 8 the rubber stopper of this bottle 2nd punctures. The negative pressure in the bottle 2 sucks out the liquid the bottle 1 into the bottle 2 and leads to the dissolution or mixing of the in this solid or liquid component. The system with in transition located cannula 8 is shown in Figure 3c.

Die Figuren 4a und 4b veranschaulichen die in den Figuren 1 bis 3c zum Überleitsystem beschriebene Vorrichtung zum Zusammenführen der Komponenten im Detail. Bei dieser Ausführungsform der Vorrichtung ist der Hohlkörper 3 im Bereich der Hohlkörperöffnung 6 als Kranz 34 mit nur durch Dünnstellen miteinander verbundenen Haltestegen 16 ausgebildet. Hierdurch ist es möglich, Flaschen 1 unterschiedlichen Volumens zu verwenden, beispielsweise alle Injektionsflaschen von 6 bis 100 ml, da beim Aktivieren der Flasche 1 mit einem Nennvolumen größer/gleich 10 ml ein Einschieben in den Hohlkörper 3 nur möglich ist, wenn der zunächst zur Fixierung benutzte Ring gesprengt wird und dem größeren Körperdurchmesser der Flasche 1 Platz bietet. Figures 4a and 4b illustrate those in Figures 1 to 3c Transfer system described device for merging the components in detail. In this embodiment of the device, the hollow body 3 is in the Area of the hollow body opening 6 as a ring 34 with only thin points interconnected holding webs 16 are formed. This makes it possible To use bottles of 1 different volume, for example all Injection bottles from 6 to 100 ml, because when activating bottle 1 with a Nominal volume greater than or equal to 10 ml can only be inserted into the hollow body 3 is when the ring initially used for fixing is blown up and the larger body diameter of the bottle offers 1 space.

Wie insbesondere der Darstellung der Figur 4b zu entnehmen ist, weist der Kanülenträger 9 im wesentlichen die Form eines Kreises auf und ist mit vier Führungsansätzen 35 versehen, die am Umfang des Kanülenträgers 9 um jeweils 90° zueinander versetzt mit diesem verbunden sind. Die Führungsansätze 35 weisen radial außen eine konzentrisch zur Kanüle 8 und sich in Längsrichtung des Hohlkörpers 3 erstreckende Führungsfläche 36 auf. Diese ist in geringem Abstand zur Innenwandung 30 des Hohlkörpers 3 angeordnet, so daß der Kanülenträger 9 nach dem Zerreißen der Haltestege 13 spielfrei und damit kippsicher im Hohlkörper 3 verschieblich ist. Im übrigen ist der Hohlkörper 3 innen mit vier, in Längsrichtung des Hohlkörpers 3 verlaufenden, jeweils um 90° zueinander versetzt angeordneten Rippen 37 versehen, die den Aufnahmedurchmesser des Hohlkörpers 3 für die Flasche 1 vorgeben und damit eine exakte Positionierung der Flasche 1 gewährleisten, wobei das Einschieben dieser Flasche 1 wegen deren Anlage mit ihrer Bördelkappe 4 an den Rippen 37 bei geringem Kraftaufwand erfolgen kann. Die Rippen 37 durchsetzen Ausnehmungen 38 zwischen den Führungsansätzen 35.As can be seen in particular from the illustration in FIG. 4b, the Cannula holder 9 essentially has the shape of a circle and is four Guide approaches 35 provided on the circumference of the cannula holder 9 each 90 ° offset from each other. The leadership approaches 35 have a radially outer concentric to the cannula 8 and in the longitudinal direction of the Hollow body 3 extending guide surface 36. This is a short distance away arranged to the inner wall 30 of the hollow body 3, so that the cannula holder 9th after tearing the retaining webs 13 free of play and thus tilt-proof in the hollow body 3 is movable. Otherwise, the hollow body 3 is inside with four, in the longitudinal direction of the hollow body 3 extending, each offset by 90 ° to each other arranged ribs 37 which provide the receiving diameter of the Specify the hollow body 3 for the bottle 1 and thus an exact positioning of the Ensure bottle 1, the insertion of this bottle 1 because of it System with its crimp cap 4 on the ribs 37 with little effort can be done. The ribs 37 pass through recesses 38 between the Leadership approaches 35.

Mit der Bezugsziffer 15 ist ein in der Ebene der Anschläge 10 angeordneter und mit dem Inneren des Hohlkörpers 3 verbundener Haltesteg bezeichnet, der nach der Rekonstitution der Komponenten beim Herausziehen der Flasche 2 aus dem Hohlkörper 3 verhindert, daß der Kanülenträger 9 aus dem Hohlkörper 3 herausfällt bzw. die im Kanülenträger 9 gehaltene Kanüle 8 im Gummistopfen der Flasche 2 stecken bleibt.With the reference number 15 is arranged in the plane of the stops 10 and with the interior of the hollow body 3 connected holding web referred to the Reconstitution of the components when pulling bottle 2 out of the Hollow body 3 prevents the cannula holder 9 from falling out of the hollow body 3 or the cannula 8 held in the cannula holder 9 in the rubber stopper of the bottle 2 gets stuck.

Bei der Ausführungsform nach den Figuren 5a und 5b weist der Kanülenträger 9 im wesentlichen die Form eines gleichseitigen Dreieckes auf und es sind drei Führungsansätze 35 vorgesehen, die im Bereich der Mitten der Dreiecksseiten des Kanülenträgers 9 mit diesem verbunden sind. Mit der Innenwandung 30 des Hohlkörpers 3 sind in dessen Längsrichtung verlaufende, flügelartige Leitansätze 12 verbunden, zwischen denen die Führungsansätze 35 des Kanülenträgers 9 angeordnet sind. Der jeweilige Führungsansatz 35 ist über einen Mittelsteg 39 mit dem Kanülenträger 9 verbunden und es hintergreifen jeweils zwei benachbarte Leitansätze 12 den Führungsansatz 35 im Bereich des Mittelsteges 39. Jeder Führungsansatz 35 ist über einen Haltesteg 13 mit dem Hohlkörper 3 verbunden. Die Dreiecksabmessung des Kanülenträgers 9 ist so gewählt, daß dessen Spitzen mit minimalem Spiel zur Innenwandung 30 des Hohlkörpers 3 positioniert sind, was im übrigen auch für die Position von Führungsfläche 36 des jeweiligen Führungsansatzes 35 und Innenwandung 30 des Hohlkörpers 3 gilt. Benachbarte Leitansätze 12 sind so zur Innenwandung 30 divergierend angeordnet, daß sie zwischen sich eine Ecke 40 des Kanülenträgers 9 aufnehmen.In the embodiment according to FIGS. 5a and 5b, the cannula holder 9 has a essentially the shape of an equilateral triangle and there are three Guide approaches 35 provided in the center of the triangular sides of the Cannula holder 9 are connected to this. With the inner wall 30 of Hollow body 3 are wing-like guide lugs extending in its longitudinal direction 12, between which the guide lugs 35 of the cannula holder 9 are arranged. The respective guide approach 35 is connected via a central web 39 connected to the cannula holder 9 and engage behind two adjacent ones Guiding approaches 12 the guiding approach 35 in the area of the central web 39. Everyone Guide projection 35 is connected to the hollow body 3 via a retaining web 13. The triangular dimension of the cannula holder 9 is chosen so that its tips are positioned with minimal play to the inner wall 30 of the hollow body 3 what otherwise also for the position of the guide surface 36 of the respective Guide approach 35 and inner wall 30 of the hollow body 3 applies. Neighbors Guide lugs 12 are arranged diverging from the inner wall 30 so that they take a corner 40 of the cannula holder 9 between them.

Bei der Ausführungsform nach den Figuren 5a und 5b erfolgt die Vormontage der Bördelkappe 4 der Flasche 1 auf den Leitansätzen 12 bis gegen die rückspringenden Ansätze 11 der Leitansätze 12. Beim weiteren Einschieben dieser Flasche 1 zum Durchstechen der Kanüle 8 werden die Leitansätze 12 nach radial außen gebogen, die Bördelkappe 4 gelangt in Anlage mit dem Kanülenträger 9 und es werden beim Aufbringen einer erhöhten manuellen Kraft die Haltestege 13 gesprengt.In the embodiment according to FIGS. 5a and 5b, the pre-assembly of the Crimp cap 4 of the bottle 1 on the guide lugs 12 to against recessed approaches 11 of the guiding approaches 12. When inserting these further Bottle 1 for piercing the cannula 8, the guide lugs 12 are radial bent outside, the crimp cap 4 comes into contact with the cannula holder 9 and there are the holding webs 13 when applying an increased manual force blown up.

Bei der Ausführungsform nach den Figuren 7a und 7b weist die Hohlkörperöffnung 7 (gegenüber der Ausführungsform nach Figur 6a) eine größere Längserstreckung auf. Erreicht wird dies durch eine Verlängerung des die Öffnung bildenden Ringabschnittes 45 des Hohlkörpers 3. Der Innendurchmesser des Ringabschnittes ist geringfügig größer bemessen als der Außendurchmesser der Flasche 2 im Flaschenabschnitt 46. Bei vollständig in die untere Öffnung 7 eingesetzter Flasche 2 kontaktiert diese mit ihrer den Gummistopfen umschließenden Bördelkappe 5 die Anschläge 10 des Hohlkörpers 3, wobei die Bördelkappe 5 mittels Rippen 47 geführt ist, die diametral mit der Innenwandung 30 des Hohlkörpers 3 verbunden sind. Figur 7 verdeutlicht, daß der Außendurchmesser der Bördelkappe 5 geringer ist als der Außendurchmesser des Behältnisses 2 und sich der Ringabschnitt 45 bis seitlich des Flanschabschnittes 46 erstreckt. Hierdurch ist ein Kippen der Flasche 2 in der Hohlkörperöffnung 7 wirksam verhindert. Die obere Hohlkörperöffnung 6 ist entsprechend ausgebildet, das heißt es erfolgt auch dort eine Führung der Flasche 1 im Bereich ihres Flaschenabschnittes 46, somit ihres maximal erweiterten Bereiches.In the embodiment according to FIGS. 7a and 7b, the hollow body opening has 7 (compared to the embodiment according to FIG. 6a) a greater longitudinal extent on. This is achieved by extending the opening Ring section 45 of the hollow body 3. The inner diameter of the ring section is dimensioned slightly larger than the outer diameter of the bottle 2 in Bottle section 46. With the bottle fully inserted into the lower opening 7 2 contacts them with their crimp cap 5 surrounding the rubber stopper Stops 10 of the hollow body 3, the crimp cap 5 by means of ribs 47 is guided, which is diametrically connected to the inner wall 30 of the hollow body 3 are. Figure 7 illustrates that the outer diameter of the crimp cap 5 is smaller than the outer diameter of the container 2 and the ring section 45 extends to the side of the flange section 46. This causes a tilting of the Bottle 2 effectively prevented in the hollow body opening 7. The upper Hollow body opening 6 is designed accordingly, that is, it also takes place there a guidance of the bottle 1 in the area of its bottle section 46, thus hers maximum expanded area.

Die Überleitvorrichtung gemäß der Figuren 4a und 4b ist geeignet für Injektionsflaschen 1 und 2 mit einer Nenngröße von 20 mm. Die Überleitvorrichtung nach den Figuren 5a und 5b dient dem Überleiten einer Substanz aus einer Flasche 1 mit einer Nenngröße von 13 mm in eine Flasche 2 mit einer Nenngröße von 20 mm. Bei der Ausführungsform nach den Figuren 6a und 6b, die bis auf die Gestaltung der Hohlkörperöffnung 7 identisch ist mit der Ausführungsform nach den Figuren 5a und 5b, dient die Vorrichtung der Aufnahme von Flaschen 1 und 2 mit einer Nenngröße von 13 mm. Auch die Ausführungsform nach den Figuren 7a und 7b dient der Aufnahme von Flaschen 1 und 2 mit einer Nenngröße von 13 mm.The transfer device according to FIGS. 4a and 4b is suitable for injection bottles 1 and 2 with a nominal size of 20 mm. The transfer device 5a and 5b is used to transfer a substance from a Bottle 1 with a nominal size of 13 mm into a bottle 2 with a nominal size of 20 mm. In the embodiment according to Figures 6a and 6b, except for the Design of the hollow body opening 7 is identical to the embodiment according to 5a and 5b, the device serves to hold bottles 1 and 2 with a nominal size of 13 mm. The embodiment according to FIGS. 7a and 7b serves to hold bottles 1 and 2 with a nominal size of 13 mm.

Claims (17)

  1. An apparatus for combining a first liquid component and a second solid or liquid component by means of reduced pressure under sterile conditions, having a first container (1) receiving the first component and a second container (2) under reduced pressure receiving the second component, and a cylindrical hollow body (3) for receiving the first container in the region of its closure in a first hollow body orifice (6) and a second hollow body orifice (7) arranged diametrically to this for receiving the second container in the region of its closure, and at least one cannula (8) which is mounted in the hollow body and is displaceable in its longitudinal direction for penetrating the closure stoppers sealing each of the containers, the cannula being mounted in a cannula holder (9), wherein the cannula holder (9) is designed as a lamellar body orientated perpendicularly to the longitudinal direction (31) of the hollow body (3) and connected via retainer bridges (13) to the inner wall (30) of the hollow body (3), the retainer bridges (13) being able to be ruptured by applying a manual force which is greater than the penetration force of the cannula (8) on penetrating the closure stopper of the first container (1).
  2. The apparatus as claimed in claim 1, wherein the cannula holder (9) is joined to guide lugs (35) directed toward the inner wall (30) of the hollow body (3).
  3. The apparatus as claimed in claim 2, wherein each guide lug (35) on its side facing the inner wall (30) of the hollow body (3) has a contour matching the radial contour of the inner wall (30) of the hollow body (3).
  4. The apparatus as claimed in one of claims 1 to 3, wherein a cannula (8) is firmly held in the cannula holder (9).
  5. The apparatus as claimed in one of claims 1 to 4, wherein the hollow body (3) has orifices (6, 7) with a circular cross section.
  6. The apparatus as claimed in one of claims 1 to 5, wherein the cannula holder (9) has a triangular shape.
  7. The apparatus as claimed in claim 6, wherein the cannula holder (9) has the shape of an equilateral triangle and three guide lugs (35) are provided which are joined to the cannula holder (9) in the region of the centers of the sides of the triangle of the cannula holder (9).
  8. The apparatus as claimed in one of claims 1 to 5, wherein the cannula holder (9) has the shape of a circle and four guide lugs (35) are provided which are joined to the cannula holder (9) at the periphery thereof, each offset from one another by 90°.
  9. The apparatus as claimed in one of claims 6 to 8, wherein the retainer bridges (13) join the inner wall (30) of the hollow body (3) to the guide lugs (35) or the corners (40) of the cannula holder (9).
  10. The apparatus as claimed in one of claims 2 to 9, wherein the guide lugs (35), radially outward, have a guide surface (36) extending concentrically to the cannula (8) and extending in the longitudinal direction of the hollow body (3).
  11. The apparatus as claimed in one of claims 2 to 10, wherein directing strips (12) running in the longitudinal direction of the hollow body (3) are joined to the inner wall (30) of the hollow body (3), between which directing strips (12) are arranged the guide lugs (35) or the corners (40) of the cannula holder (9).
  12. The apparatus as claimed in claim 11, wherein each guide lug (35) is joined via a central bridge (39) to the cannula holder (9) and two directing strips (12) engage behind each guide lug (35) in the region of the central bridge (39).
  13. The apparatus as claimed in one of claims 1 to 12, wherein the hollow body (3) in the region of its first hollow body orifice (6) has a hollow body section (34) which is constructed as a collar, the collar components (16) of which are joined to one another by thin points.
  14. The apparatus as claimed in one of claims 1 to 13, wherein the hollow body (3) has stops (10, 15) on the inside for restricting the insertion movement of the second container (2) and/or the displacement movement of the cannula holder (9).
  15. The apparatus as claimed in one of claims 1 to 14, wherein, to guide the container (2) in the hollow body (3), the latter is lengthened in the region of at least one end (45) in parallel to the container (2) to be received by the assigned hollow body orifice (7).
  16. The apparatus as claimed in claim 15, wherein the lengthened section (45) of the hollow body (3) has an internal diameter which is slightly larger than the external diameter of the container (2).
  17. The apparatus as claimed in one of claims 1 to 16, wherein this forms, with the two containers (1, 2), a ready-to-use preassembled, sterilely packaged system, in which the two containers (1, 2) are held in the hollow body (3) out of contact with the cannula (8) and an outer packaging (14) sterilely encloses the containers (1, 2) and the hollow body (3).
EP19960103858 1995-04-11 1996-03-12 Device for putting together a first liquid component and a second rigid or liquid component by means of vacuum under sterile conditions Expired - Lifetime EP0737467B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1995113666 DE19513666C1 (en) 1995-04-11 1995-04-11 Device for bringing together a first liquid and a second solid or liquid component by means of negative pressure under sterile conditions
DE19513666 1995-04-11

Publications (2)

Publication Number Publication Date
EP0737467A1 EP0737467A1 (en) 1996-10-16
EP0737467B1 true EP0737467B1 (en) 1999-06-02

Family

ID=7759443

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19960103858 Expired - Lifetime EP0737467B1 (en) 1995-04-11 1996-03-12 Device for putting together a first liquid component and a second rigid or liquid component by means of vacuum under sterile conditions

Country Status (12)

Country Link
US (1) US5743312A (en)
EP (1) EP0737467B1 (en)
JP (2) JP3228496B2 (en)
KR (1) KR100388864B1 (en)
AT (1) ATE180663T1 (en)
AU (1) AU697521B2 (en)
CA (1) CA2173823C (en)
DE (2) DE19513666C1 (en)
DK (1) DK0737467T3 (en)
ES (1) ES2134527T3 (en)
GR (1) GR3030958T3 (en)
ZA (1) ZA962802B (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10142450C1 (en) * 2001-08-31 2003-06-18 Aventis Behring Gmbh Device for bringing components together under sterile conditions
US7923431B2 (en) 2001-12-21 2011-04-12 Ferrosan Medical Devices A/S Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis
US7923031B2 (en) 2004-01-30 2011-04-12 Ferrosan Medical Devices A/S Haemostatic sprays and compositions
US7955288B2 (en) 2002-12-11 2011-06-07 Ferrosan Medical Devices A/S Gelatine-based materials as swabs
US8021684B2 (en) 2004-07-09 2011-09-20 Ferrosan Medical Devices A/S Haemostatic composition comprising hyaluronic acid
US8642831B2 (en) 2008-02-29 2014-02-04 Ferrosan Medical Devices A/S Device for promotion of hemostasis and/or wound healing
US9265858B2 (en) 2012-06-12 2016-02-23 Ferrosan Medical Devices A/S Dry haemostatic composition

Families Citing this family (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL114960A0 (en) * 1995-03-20 1995-12-08 Medimop Medical Projects Ltd Flow control device
HU223484B1 (en) * 1997-08-27 2004-07-28 Pentapharm Ag. Dual vial connecting system for lyophilized products
US7425209B2 (en) 1998-09-15 2008-09-16 Baxter International Inc. Sliding reconstitution device for a diluent container
US6113583A (en) * 1998-09-15 2000-09-05 Baxter International Inc. Vial connecting device for a sliding reconstitution device for a diluent container
DE10022835B4 (en) * 2000-05-10 2004-10-28 Kellermann, Johann Mechanism for mixing liquids and granules
US6558365B2 (en) * 2001-01-03 2003-05-06 Medimop Medical Projects, Ltd. Fluid transfer device
US7413910B2 (en) 2001-03-08 2008-08-19 Exelixis, Inc. Multi-well apparatus
US20050226786A1 (en) * 2001-03-08 2005-10-13 Hager David C Multi-well apparatus
KR100431704B1 (en) * 2001-08-13 2004-05-17 주식회사 대웅 Container plus syringe system
FR2828802A1 (en) * 2001-08-22 2003-02-28 Map France Safety package for flask for medical use, e.g. for perfusion fluid, comprising cylindrical tubular body with partition and holder for transfer element
DE50214614D1 (en) * 2001-08-29 2010-10-07 Michael W Dahm METHOD AND DEVICE FOR PREPARING A BIOLOGICAL TEST FOR DETERMINING AT LEAST ONE COMPONENT INCLUDED THEREIN
CN1290586C (en) * 2001-12-21 2006-12-20 弗劳森公司 A haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis
EP1454650B1 (en) * 2003-03-06 2007-10-10 CSL Behring GmbH Transfer device, in particular for medical fluids
US7641851B2 (en) 2003-12-23 2010-01-05 Baxter International Inc. Method and apparatus for validation of sterilization process
IL161660A0 (en) 2004-04-29 2004-09-27 Medimop Medical Projects Ltd Liquid drug delivery device
US7615041B2 (en) * 2004-07-29 2009-11-10 Boston Scientific Scimed, Inc. Vial adaptor
DK1919432T3 (en) 2005-08-11 2012-01-30 Medimop Medical Projects Ltd Liquid Medication Transfer Devices for Safe Safe Resting Connection on Medical Vials
EP2540276B1 (en) 2006-05-25 2016-03-16 Bayer Healthcare LLC Method of assembling a reconstitution device
AT503915B1 (en) * 2006-06-21 2008-02-15 Friedrich Ing Pipelka Transfer device for transferring a fluid from one container to another container comprises locking protrusions arranged in an adapter for locking a container in holders of the adapter
DE102006035545B4 (en) 2006-07-27 2008-04-30 Csl Behring Gmbh Device for bringing components together by means of negative pressure under sterile conditions
RU2009127718A (en) * 2006-12-19 2011-01-27 Ферросан А/С (Dk) WOUND OR TISSUE BANDING MATERIAL CONTAINING LACTIC ACID BACTERIA
IL182605A0 (en) 2007-04-17 2007-07-24 Medimop Medical Projects Ltd Fluid control device with manually depressed actuator
US8287513B2 (en) * 2007-09-11 2012-10-16 Carmel Pharma Ab Piercing member protection device
EP2190518B1 (en) 2007-09-18 2016-01-27 Medimop Medical Projects Ltd. Medicament mixing and injection apparatus
IL186290A0 (en) 2007-09-25 2008-01-20 Medimop Medical Projects Ltd Liquid drug delivery devices for use with syringe having widened distal tip
EP2271387B1 (en) * 2008-04-01 2016-06-15 Yukon Medical, LLC Dual container fluid transfer device
WO2010052707A1 (en) * 2008-11-04 2010-05-14 Situ Gen Ltd. Dually activated connector
USD641080S1 (en) 2009-03-31 2011-07-05 Medimop Medical Projects Ltd. Medical device having syringe port with locking mechanism
US9345640B2 (en) 2009-04-14 2016-05-24 Yukon Medical, Llc Fluid transfer device
USD616984S1 (en) 2009-07-02 2010-06-01 Medimop Medical Projects Ltd. Vial adapter having side windows
WO2011030787A1 (en) * 2009-09-08 2011-03-17 テルモ株式会社 Mixing apparatus and piercing method for a double-ended needle
CA2774108C (en) 2009-09-14 2017-06-06 Nestec S.A. Package with foil seals and penetrating means
USD630732S1 (en) 2009-09-29 2011-01-11 Medimop Medical Projects Ltd. Vial adapter with female connector
IL201323A0 (en) 2009-10-01 2010-05-31 Medimop Medical Projects Ltd Fluid transfer device for assembling a vial with pre-attached female connector
IL202070A0 (en) 2009-11-12 2010-06-16 Medimop Medical Projects Ltd Inline liquid drug medical device
IL202069A0 (en) 2009-11-12 2010-06-16 Medimop Medical Projects Ltd Fluid transfer device with sealing arrangement
EP2512399B1 (en) * 2010-02-24 2015-04-08 Medimop Medical Projects Ltd. Fluid transfer assembly with venting arrangement
JP5709905B2 (en) 2010-02-24 2015-04-30 メディモップ・メディカル・プロジェクツ・リミテッド Liquid transfer device including vial adapter with vent
EP2371342A1 (en) * 2010-04-01 2011-10-05 Siemens Healthcare Diagnostics Products GmbH Device for storing and metering a solution
USD655017S1 (en) 2010-06-17 2012-02-28 Yukon Medical, Llc Shroud
USD669980S1 (en) 2010-10-15 2012-10-30 Medimop Medical Projects Ltd. Vented vial adapter
IL209290A0 (en) 2010-11-14 2011-01-31 Medimop Medical Projects Ltd Inline liquid drug medical device having rotary flow control member
WO2012132829A1 (en) 2011-03-25 2012-10-04 テルモ株式会社 Double-ended needle and mixing instrument
IL212420A0 (en) 2011-04-17 2011-06-30 Medimop Medical Projects Ltd Liquid drug transfer assembly
USD681230S1 (en) 2011-09-08 2013-04-30 Yukon Medical, Llc Shroud
IL215699A0 (en) 2011-10-11 2011-12-29 Medimop Medical Projects Ltd Liquid drug reconstitution assemblage for use with iv bag and drug vial
USD720451S1 (en) 2012-02-13 2014-12-30 Medimop Medical Projects Ltd. Liquid drug transfer assembly
USD674088S1 (en) 2012-02-13 2013-01-08 Medimop Medical Projects Ltd. Vial adapter
USD737436S1 (en) 2012-02-13 2015-08-25 Medimop Medical Projects Ltd. Liquid drug reconstitution assembly
EP2822474B1 (en) 2012-03-06 2018-05-02 Ferrosan Medical Devices A/S Pressurized container containing haemostatic paste
IL219065A0 (en) 2012-04-05 2012-07-31 Medimop Medical Projects Ltd Fluid transfer device with manual operated cartridge release arrangement
USD769444S1 (en) 2012-06-28 2016-10-18 Yukon Medical, Llc Adapter device
IL221634A0 (en) 2012-08-26 2012-12-31 Medimop Medical Projects Ltd Universal drug vial adapter
IL221635A0 (en) 2012-08-26 2012-12-31 Medimop Medical Projects Ltd Drug vial mixing and transfer device for use with iv bag and drug vial
JP5868555B2 (en) 2012-09-13 2016-02-24 メディモップ・メディカル・プロジェクツ・リミテッド Nested female vial adapter
US8931665B2 (en) 2012-11-06 2015-01-13 Amit Gold Multi-compartment apparatus for in-situ mixing of a plurality of components before use
USD734868S1 (en) 2012-11-27 2015-07-21 Medimop Medical Projects Ltd. Drug vial adapter with downwardly depending stopper
IL225734A0 (en) 2013-04-14 2013-09-30 Medimop Medical Projects Ltd Ready-to-use drug vial assemblages including drug vial and drug vial closure having fluid transfer member, and drug vial closure therefor
DK2983745T3 (en) 2013-05-10 2018-10-22 West Pharma Services Il Ltd Medical devices comprising ampoule adapter with interconnected module for dry drug
AU2014283170B2 (en) 2013-06-21 2017-11-02 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
USD767124S1 (en) 2013-08-07 2016-09-20 Medimop Medical Projects Ltd. Liquid transfer device with integral vial adapter
JP3205560U (en) 2013-08-07 2016-08-04 メディモップ・メディカル・プロジェクツ・リミテッド Liquid transfer device for use with a drip liquid container
USD765837S1 (en) 2013-08-07 2016-09-06 Medimop Medical Projects Ltd. Liquid transfer device with integral vial adapter
JP6489485B2 (en) 2013-12-11 2019-03-27 フェロサン メディカル デバイシーズ エイ／エス Dry composition containing an extrusion enhancing factor
USD794183S1 (en) 2014-03-19 2017-08-08 Medimop Medical Projects Ltd. Dual ended liquid transfer spike
KR101646998B1 (en) * 2014-08-14 2016-08-10 대한약품공업 주식회사 Socket for mixing and making medicine for injection and Medical product including the socket
USD757933S1 (en) 2014-09-11 2016-05-31 Medimop Medical Projects Ltd. Dual vial adapter assemblage
BR112017007466B1 (en) 2014-10-13 2021-03-02 Ferrosan Medical Devices A/S method for preparing a dry composition, method for reconstituting the dry composition, paste, dry composition, container, homeostatic kit, and, using a dry composition
CN104340540B (en) * 2014-10-31 2017-05-17 佛山市塑冠包装有限公司 Instant liquid mixing beverage bottle and filling method thereof
KR101657150B1 (en) * 2014-11-20 2016-09-19 대한약품공업 주식회사 Socket for mixing and making medicine for injection and Medical product including the socket
US10653837B2 (en) 2014-12-24 2020-05-19 Ferrosan Medical Devices A/S Syringe for retaining and mixing first and second substances
CN108601706B (en) 2015-01-05 2019-06-25 麦迪麦珀医疗工程有限公司 With for guaranteeing the vial adapter component of proper use of quick release vial adapter
US10918796B2 (en) 2015-07-03 2021-02-16 Ferrosan Medical Devices A/S Syringe for mixing two components and for retaining a vacuum in a storage condition
EP3319576B1 (en) 2015-07-16 2019-10-02 West Pharma. Services IL, Ltd Liquid drug transfer devices for secure telescopic snap fit on injection vials
US20170127863A1 (en) * 2015-11-06 2017-05-11 Lonny R. Kirby Multiple Container Holder
USD801522S1 (en) 2015-11-09 2017-10-31 Medimop Medical Projects Ltd. Fluid transfer assembly
EP3380058B1 (en) 2015-11-25 2020-01-08 West Pharma Services IL, Ltd. Dual vial adapter assemblage including drug vial adapter with self-sealing access valve
IL245800A0 (en) 2016-05-24 2016-08-31 West Pharma Services Il Ltd Dual vial adapter assemblages including identical twin vial adapters
IL245803A0 (en) 2016-05-24 2016-08-31 West Pharma Services Il Ltd Dual vial adapter assemblages including vented drug vial adapter and vented liquid vial adapter
IL246073A0 (en) 2016-06-06 2016-08-31 West Pharma Services Il Ltd Fluid transfer devices for use with drug pump cartridge having slidable driving plunger
BE1023806B1 (en) * 2016-06-28 2017-07-27 R&O Lab Sprl MIXING CONTAINER ADAPTABLE TO ANY RECEPTOR CONTAINER
IL247376A0 (en) 2016-08-21 2016-12-29 Medimop Medical Projects Ltd Syringe assembly
US10926025B2 (en) * 2016-09-15 2021-02-23 Tandem Diabetes Care, Inc. Vial supporter for medicament pump
USD832430S1 (en) 2016-11-15 2018-10-30 West Pharma. Services IL, Ltd. Dual vial adapter assemblage
IL249408A0 (en) 2016-12-06 2017-03-30 Medimop Medical Projects Ltd Liquid transfer device for use with infusion liquid container and pincers-like hand tool for use therewith for releasing intact drug vial therefrom
US11701301B2 (en) 2017-03-06 2023-07-18 All India Institute Of Medical Sciences (Aiims) Device, method and kit for the reconstitution of a solid or semi solid pharmaceutical composition
IL251458A0 (en) 2017-03-29 2017-06-29 Medimop Medical Projects Ltd User actuated liquid drug transfer devices for use in ready-to-use (rtu) liquid drug transfer assemblages
IL254802A0 (en) 2017-09-29 2017-12-31 Medimop Medical Projects Ltd Dual vial adapter assemblages with twin vented female vial adapters
AU2019266529A1 (en) 2018-05-09 2020-12-03 Ethicon Inc. Method for preparing a haemostatic composition
US11090227B2 (en) * 2018-06-01 2021-08-17 Bio-Rad Laboratories, Inc. Connector for transferring the contents of a container
USD903864S1 (en) 2018-06-20 2020-12-01 West Pharma. Services IL, Ltd. Medication mixing apparatus
JP7031990B2 (en) * 2018-06-29 2022-03-08 株式会社吉野工業所 Two-component mixing container and two-component mixing ejection container
CZ2018317A3 (en) * 2018-06-29 2020-03-25 Regshare, s.r.o. Container, in particular for liquids, and mixing valve, in particular for safely mixing and spilling liquids
JP6995706B2 (en) * 2018-06-29 2022-01-17 株式会社吉野工業所 Two-component mixing container and two-component mixing ejection container
JP1630477S (en) 2018-07-06 2019-05-07
USD923812S1 (en) 2019-01-16 2021-06-29 West Pharma. Services IL, Ltd. Medication mixing apparatus
JP1648075S (en) 2019-01-17 2019-12-16
US11918542B2 (en) 2019-01-31 2024-03-05 West Pharma. Services IL, Ltd. Liquid transfer device
WO2020222220A1 (en) 2019-04-30 2020-11-05 West Pharma. Services IL, Ltd. Liquid transfer device with dual lumen iv spike
USD956958S1 (en) 2020-07-13 2022-07-05 West Pharma. Services IL, Ltd. Liquid transfer device
EP4112035A1 (en) * 2021-06-29 2023-01-04 Kairish Innotech Private Ltd. Tray for positioning a medical vial together with a vial adapter in a fixed positional relationship relative to each other and packaging unit comprising the same

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3872867A (en) * 1971-06-02 1975-03-25 Upjohn Co Wet-dry additive assembly
US4274543A (en) * 1978-01-23 1981-06-23 The Upjohn Company Vial and closure structure
US4759756A (en) * 1984-09-14 1988-07-26 Baxter Travenol Laboratories, Inc. Reconstitution device
US4722733A (en) * 1986-02-26 1988-02-02 Intelligent Medicine, Inc. Drug handling apparatus and method
JPH021277A (en) * 1988-03-31 1990-01-05 Fujisawa Pharmaceut Co Ltd Infusion container
DE3817101C2 (en) * 1988-05-19 1998-05-20 Axel Von Brand Device for transferring liquid from one container to another container
JP2605345Y2 (en) * 1992-05-01 2000-07-10 株式会社大塚製薬工場 Drug container
JPH05317383A (en) * 1992-05-19 1993-12-03 Nissho Corp Solution container equipped with means for communicating with chemical container
JPH0686738U (en) * 1992-06-16 1994-12-20 森下ルセル株式会社 Medical container
DE4314090C2 (en) * 1993-04-29 1997-09-04 Wolfgang Dr Vilmar Medical cutlery for the manufacture of a drug solution
JP3493198B2 (en) * 1993-06-28 2004-02-03 味の素ファルマ株式会社 Medical container

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10142450C1 (en) * 2001-08-31 2003-06-18 Aventis Behring Gmbh Device for bringing components together under sterile conditions
US8172824B2 (en) 2001-08-31 2012-05-08 Csl Behring Gmbh Apparatus for combining components under sterile conditions
US7923431B2 (en) 2001-12-21 2011-04-12 Ferrosan Medical Devices A/S Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis
US8283320B2 (en) 2001-12-21 2012-10-09 Ferrosan Medical Devices A/S Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostasis
US7955288B2 (en) 2002-12-11 2011-06-07 Ferrosan Medical Devices A/S Gelatine-based materials as swabs
US7923031B2 (en) 2004-01-30 2011-04-12 Ferrosan Medical Devices A/S Haemostatic sprays and compositions
US8021684B2 (en) 2004-07-09 2011-09-20 Ferrosan Medical Devices A/S Haemostatic composition comprising hyaluronic acid
US8642831B2 (en) 2008-02-29 2014-02-04 Ferrosan Medical Devices A/S Device for promotion of hemostasis and/or wound healing
US9533069B2 (en) 2008-02-29 2017-01-03 Ferrosan Medical Devices A/S Device for promotion of hemostasis and/or wound healing
US9265858B2 (en) 2012-06-12 2016-02-23 Ferrosan Medical Devices A/S Dry haemostatic composition

Also Published As

Publication number Publication date
JPH08280778A (en) 1996-10-29
GR3030958T3 (en) 1999-11-30
KR100388864B1 (en) 2004-03-19
US5743312A (en) 1998-04-28
KR960037033A (en) 1996-11-19
JP3704295B2 (en) 2005-10-12
CA2173823C (en) 2006-06-20
CA2173823A1 (en) 1996-10-12
ES2134527T3 (en) 1999-10-01
DE19513666C1 (en) 1996-11-28
JP3228496B2 (en) 2001-11-12
DK0737467T3 (en) 1999-11-29
ZA962802B (en) 1996-10-11
DE59602051D1 (en) 1999-07-08
AU697521B2 (en) 1998-10-08
JP2001333961A (en) 2001-12-04
EP0737467A1 (en) 1996-10-16
AU5053996A (en) 1996-10-24
ATE180663T1 (en) 1999-06-15

Similar Documents

Publication Publication Date Title
EP0737467B1 (en) Device for putting together a first liquid component and a second rigid or liquid component by means of vacuum under sterile conditions
DE60210735T2 (en) Transfer device and system with a cap assembly, a container and the transfer device
DE60019446T2 (en) LIQUID TRANSFER SET FOR PHYOLS AND OTHER MEDICAL CONTAINERS
EP0235139B1 (en) Injection syringe
DE69922147T2 (en) SLIDING RECOVERY DEVICE FOR A DILUENT CONTAINER
EP2667838B1 (en) Connecting device for connecting a first reservoir to a second reservoir
DE69831747T2 (en) CONTAINER CAP WITH INTEGRATED PENETRATOR
DE60130016T2 (en) AXIAL ACTIVATED ACCESS ADAPTER FOR ONE PHIOLE
DE4122476A1 (en) Sterile liq. transfer in e.g. medical infusion mixts. - using double, self sealing, spined cannula coupling
EP2903583A1 (en) Transfer device for tapping or delivering a fluid
WO1997015267A2 (en) Adapter for extracting a liquid from a container closed with a stopper
DE2028662B2 (en) Blood collection needle
DE10247963A1 (en) Pre-filled syringe with membrane seal, has cylinder, connector and sealing membrane constructed in one piece as plastic injection-molded part
DE2650951A1 (en) HYPODERMATIC SYRINGE
DE102014008610A1 (en) dispenser
EP0830874B1 (en) Connector device for medical use
EP3565766A1 (en) Container
DE102013012809A1 (en) Head piece for a container that can be filled with a medium
EP3174812B1 (en) Container having a head piece, which container can be or is filled with a medium
DE60224940T2 (en) SAFETY PACKAGING FOR A BOTTLE FOR MEDICAL APPLICATIONS
WO2018060333A1 (en) Sealing cap for a container for holding a medical liquid
DE2149550A1 (en) DEVICE FOR POURING LIQUIDS INTO BODY CELLS OR VESSELS, OR SUCTIONING LIQUIDS FROM SUCH
EP0766956A1 (en) Container for medical liquid
EP3976139A1 (en) Medical hollow article, medical hollow article having a closure cap, method for producing a medical hollow article, and kit
WO2008012018A1 (en) Device for combining components by means of negative pressure under sterile conditions

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE

17P Request for examination filed

Effective date: 19970416

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: AXEL VON BRAND

Owner name: CENTEON PHARMA GMBH

GRAG Despatch of communication of intention to grant

Free format text: ORIGINAL CODE: EPIDOS AGRA

17Q First examination report despatched

Effective date: 19980714

GRAG Despatch of communication of intention to grant

Free format text: ORIGINAL CODE: EPIDOS AGRA

GRAH Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOS IGRA

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: AXEL VON BRAND GMBH

Owner name: CENTEON PHARMA GMBH

GRAH Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOS IGRA

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE

REF Corresponds to:

Ref document number: 180663

Country of ref document: AT

Date of ref document: 19990615

Kind code of ref document: T

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REF Corresponds to:

Ref document number: 59602051

Country of ref document: DE

Date of ref document: 19990708

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

Free format text: GERMAN

ET Fr: translation filed
GBT Gb: translation of ep patent filed (gb section 77(6)(a)/1977)

Effective date: 19990729

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2134527

Country of ref document: ES

Kind code of ref document: T3

REG Reference to a national code

Ref country code: DK

Ref legal event code: T3

REG Reference to a national code

Ref country code: PT

Ref legal event code: SC4A

Free format text: AVAILABILITY OF NATIONAL TRANSLATION

Effective date: 19990809

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed
REG Reference to a national code

Ref country code: CH

Ref legal event code: PFA

Free format text: CENTEON PHARMA GMBH;AXEL VON BRAND GMBH TRANSFER- AXEL VON BRAND GMBH;AVENTIS BEHRING GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG

REG Reference to a national code

Ref country code: PT

Ref legal event code: PD4A

Free format text: AVENTIS BEHRING GMBH DE

Effective date: 20000316

NLT1 Nl: modifications of names registered in virtue of documents presented to the patent office pursuant to art. 16 a, paragraph 1

Owner name: AVENTIS BEHRING GMBH;AXEL VON BRAND GMBH

REG Reference to a national code

Ref country code: FR

Ref legal event code: CD

REG Reference to a national code

Ref country code: GB

Ref legal event code: IF02

REG Reference to a national code

Ref country code: CH

Ref legal event code: PFA

Owner name: AXEL VON BRAND GMBH

Free format text: AXEL VON BRAND GMBH#MORGENSTRASSE 1A#55257 BUDENHEIM (DE) $ AVENTIS BEHRING GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG#POSTFACH 1230#35002 MARBURG (DE) -TRANSFER TO- AXEL VON BRAND GMBH#MORGENSTRASSE 1A#55257 BUDENHEIM (DE) $ ZLB BEHRING GMBH#P.O. BOX 1230#35002 MARBURG (DE)

NLT1 Nl: modifications of names registered in virtue of documents presented to the patent office pursuant to art. 16 a, paragraph 1

Owner name: ZLB BEHRING GMBH

Owner name: AXEL VON BRAND GMBH

REG Reference to a national code

Ref country code: PT

Ref legal event code: PD4A

Free format text: ZLB BEHRING GMBH DE

Effective date: 20041018

REG Reference to a national code

Ref country code: FR

Ref legal event code: CD

Ref country code: FR

Ref legal event code: CA

REG Reference to a national code

Ref country code: CH

Ref legal event code: PK

Ref country code: CH

Ref legal event code: PFA

Owner name: AXEL VON BRAND GMBH

Free format text: AXEL VON BRAND GMBH#MORGENSTRASSE 1A#55257 BUDENHEIM (DE) $ ZLB BEHRING GMBH#P.O. BOX 1230#35002 MARBURG (DE) -TRANSFER TO- AXEL VON BRAND GMBH#MORGENSTRASSE 1A#55257 BUDENHEIM (DE) $ CLS BEHRING GMBH#EMIL VON BEHRING STRASSE 76#35041 MARBURG (DE)

REG Reference to a national code

Ref country code: ES

Ref legal event code: PC2A

REG Reference to a national code

Ref country code: FR

Ref legal event code: CD

REG Reference to a national code

Ref country code: PT

Ref legal event code: PD4A

Owner name: CSL BEHRING GMBH, DE

Effective date: 20070807

NLT1 Nl: modifications of names registered in virtue of documents presented to the patent office pursuant to art. 16 a, paragraph 1

Owner name: CLS BEHRING GMBH

Owner name: AXEL VON BRAND GMBH

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DK

Payment date: 20110208

Year of fee payment: 16

Ref country code: IE

Payment date: 20110310

Year of fee payment: 16

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: PT

Payment date: 20110301

Year of fee payment: 16

Ref country code: SE

Payment date: 20110210

Year of fee payment: 16

Ref country code: CH

Payment date: 20110307

Year of fee payment: 16

Ref country code: AT

Payment date: 20110209

Year of fee payment: 16

Ref country code: FR

Payment date: 20110217

Year of fee payment: 16

Ref country code: NL

Payment date: 20110216

Year of fee payment: 16

Ref country code: LU

Payment date: 20110415

Year of fee payment: 16

Ref country code: IT

Payment date: 20110321

Year of fee payment: 16

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GR

Payment date: 20110217

Year of fee payment: 16

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: ES

Payment date: 20110414

Year of fee payment: 16

Ref country code: GB

Payment date: 20110215

Year of fee payment: 16

Ref country code: DE

Payment date: 20110331

Year of fee payment: 16

Ref country code: BE

Payment date: 20110311

Year of fee payment: 16

REG Reference to a national code

Ref country code: PT

Ref legal event code: MM4A

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20120912

BERE Be: lapsed

Owner name: AXEL *VON BRAND G.M.B.H.

Effective date: 20120331

Owner name: *CSL BEHRING G.M.B.H.

Effective date: 20120331

REG Reference to a national code

Ref country code: NL

Ref legal event code: V1

Effective date: 20121001

REG Reference to a national code

Ref country code: SE

Ref legal event code: EUG

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120313

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

REG Reference to a national code

Ref country code: DK

Ref legal event code: EBP

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20120312

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120912

REG Reference to a national code

Ref country code: GR

Ref legal event code: ML

Ref document number: 990402039

Country of ref document: GR

Effective date: 20121008

REG Reference to a national code

Ref country code: AT

Ref legal event code: MM01

Ref document number: 180663

Country of ref document: AT

Kind code of ref document: T

Effective date: 20120312

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST

Effective date: 20121130

REG Reference to a national code

Ref country code: IE

Ref legal event code: MM4A

REG Reference to a national code

Ref country code: DE

Ref legal event code: R119

Ref document number: 59602051

Country of ref document: DE

Effective date: 20121002

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120402

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120331

Ref country code: AT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120312

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120331

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120312

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120331

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120312

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20121008

Ref country code: IT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120312

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20121001

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120331

REG Reference to a national code

Ref country code: ES

Ref legal event code: FD2A

Effective date: 20130710

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120313

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20120312

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20121002