EP0757573A1 - Method of electrical nerve stimulation - Google Patents
Method of electrical nerve stimulationInfo
- Publication number
- EP0757573A1 EP0757573A1 EP95910859A EP95910859A EP0757573A1 EP 0757573 A1 EP0757573 A1 EP 0757573A1 EP 95910859 A EP95910859 A EP 95910859A EP 95910859 A EP95910859 A EP 95910859A EP 0757573 A1 EP0757573 A1 EP 0757573A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- patient
- electrical
- applying
- electrode
- stimulating electrode
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/326—Applying electric currents by contact electrodes alternating or intermittent currents for promoting growth of cells, e.g. bone cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/3603—Control systems
- A61N1/36031—Control systems using physiological parameters for adjustment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/3603—Control systems
- A61N1/36034—Control systems specified by the stimulation parameters
Definitions
- the present invention relates to methods for healing tissues. More particularly, the present invention relates to methods and apparatus for electrical stimulation of the nerve system of a human body synchronous to a cardiac cycle or other events in the human body.
- electrical nerve stimulators are widely used to induce the contraction of skeletal muscle groups and for the relief of pain by blocking nerve conduction.
- electrodes are placed near specific nerves either superficially, percutaneously, or by surgical implantation.
- the stimulation is accomplished by applying an electrical current to the electrodes.
- the current is applied in the form of a series of pulses.
- the duration of an individual pulse, the number of pulses in the series, the time interval of no stimulation after a stimulating pulse series, and the magnitude of the applied electrical current are, in general, variable and are adjusted by the attending physician, therapist, or patient.
- Hotta et al. report about observations that provide some details about the mechanism behind the increase of the flow rate in the extremities in his article "Stimulation of Lumbar Sympathetic Trunk Produces Vasoconstriction of the Vasa Nervorum in the Sciatic Nerve Via o(-Adrenergic Receptors in Rats", Neuroscience Letters, 1991.
- the unilateral electrical stimulation of the lumbar sympathetic trunk at low frequencies produced a substantial increase in the flow of blood in the vasa nervorum of the sciatic nerves in the hind legs of rats. This period of increased flow was followed by a moderate decrease of this flow in the leg on the side of stimulation while only the increase of flow was observed in the leg on the other side.
- the present invention is a method of electrical nerve stimulation for the acceleration of tissue healing of a patient.
- the method of the present invention includes the steps of: (1) applying a receptor electrode to an area of the body of the patient; (2) applying a stimulating electrode to another area of the body of the patient; (3) transmitting a signal from the receptor electrode to an electrocardiograph (ECG) so as to produce a representation of a cardiac cycle (ECG) of the patient; and (4) passing an electrical pulse to the stimulating electrode in timed relationship to the representation of the cardiac cycle.
- ECG electrocardiograph
- ECG cardiac cycle
- the terms "electrode” and “pulse” are inclusive of the plural “electrodes” and “pulses”, respectively.
- the cardiac cycle shows a systolic period and a diastolic period.
- the step of passing includes passing a plurality of electrical pulses during the systolic period of the cardiac cycle in the preferred embodiment. This plurality of electrical pulses occur throughout a selected period of the cardiac cycle, such as the systolic period.
- the step of applying the stimulating electrode includes affixing the stimulating electrode to an area of the body other than the tissue to be healed.
- the stimulating electrode is applied so as to result in the stimulation of the vascular smooth muscles of the splanchnic circulatory system.
- the electrical pulse is passed so as to be of sufficient energy such that the vascular smooth muscles are contracted so as to increase hydraulic resistance of at least a portion of the splanchnic circulatory system.
- the step of applying a- receptor includes applying a plurality of receptor electrodes to the patient.
- the step of transmitting includes connecting the receptor electrodes to an electrocardiograph, amplifying an electrical signal of the heart so as to produce the representation of the cardiac cycle, and creating a graphical illustration of the cardiac cycle.
- a triggering device is connected to the ECG and to the stimulator.
- the triggering device is programmed so as to pass the electrical pulse repeatedly.
- the stimulator serves to transmit stimulating pulses to the patient via the stimulating electrode.
- the programming of the stimulator can include adjusting the magnitude of the voltage or current of the electrical pulse.
- the programming can include adjusting the length of time of the pulse or the amount of time between consecutive pulses.
- the step of programming can further include adjusting the amplitude or frequency modulation of a plurality of electrical pulses within a single pulse train.
- FIGURE 1 is a schematic illustration of the method of the present invention.
- FIGURE 2 is a multiple graphical illustration of the method of the present invention in relation to aortic pressure and the ECG graph.
- FIGURE 1 there is shown at 10, the system of the present invention for the electrical stimulation for the acceleration of tissue healing of the patient 12.
- the system 10 includes the ECG 14, a trigger device 16, and a stimulator 18. Each of these elements are interactive so as to provide the required electrically stimulating effect for the purpose of healing the tissue of patient 12.
- the receptor electrodes 20, 22, and 24 are applied to the patient 12.
- the purpose of the electrodes 20, 22, and 24 is to transmit electrical signals generated by the heart and to communicate such signals to the electrocardiograph via the connecting cables.
- a single receptor electrode could be used.
- a plurality of such electrodes are used so as to provide a representative reading to the electrocardiograph.
- the electrodes 20, 22, and 24 sense the potential of the electrical currents generated by the heart and communicate them to the electrocardiograph 14.
- the electrocardiograph amplifies these potentials greatly. These potentials will vary in magnitude in a typical fashion during the course of a cardiac cycle.
- FIGURE 2 illustrates such an ECG, together with the simultaneously occurring variation of the aortic pressure during the course of the same cardiac cycle.
- ECG electrocardiogram
- FIGURE 2 illustrates such an ECG, together with the simultaneously occurring variation of the aortic pressure during the course of the same cardiac cycle.
- the electrocardiogram is composed of three very distinct events. These events are the P wave, the so-called QRS complex, and the T wave.
- the P wave occurs at the beginning of each contraction of the atria.
- the QRS complex occurs at the beginning of each contraction of the ventricles.
- the T wave occurs as the ventricles recover electrically and prepare for the next contraction.
- the electrocardiograph 14 provides the ECG as an electrical input to the trigger component 16. It is evident from an inspection of the ECG in FIGURE 2 that considerable and characteristic variations occur that are typical for certain portions and instances within one cardiac cycle. For example, the peak voltages of all three above-mentioned sections (P wave, QRS complex, T wave) are significantly different.
- the slope of the QRS complex differs considerably from that of the P wave or the T wave.
- the slopes, as well as the voltages assume both positive and negative values during the course of a cardiac cycle. Therefore, the peak of a wave, the combination of a voltage and the simultaneously existing rate of its change (slope), or only a voltage, should be characteristic for most instances during these three segments and can therefore be used to identify the instantaneous status of the ventricles within a cardiac cycle.
- the possibility of ambiguity of identification can be reduced by also considering a third variable, besides instantaneous voltage and slope.
- Such a variable could be the time interval between the occurrence of a very distinct and unique point, such as the greatest negative voltage preceded by a sharp negative slope followed by a sharp positive slope (also designated as the Q instant), and the voltage and slope at the instant of recording.
- Various algorithms using such variables as inputs, as well as sophisticated mathematical transforms, filtering, correlation, and signal identification methods, can be utilized to numerically correlate pertinent instances as to their position within the period of one cardiac cycle.
- the trigger device 16 is a processor which will receive the ECG 14 as input and process it in the manner described above so as to activate the stimulator 18 at the desired instance and for the desired period of time.
- the trigger device 16 can also incorporate several channels and outputs so as to activate a multitude of devices at individual instances and for individual intervals.
- SUBSUME and 28 are applied to the body of the patient 12.
- the stimulating electrodes 26 and 28 are positioned on certain areas of the body of the patient 12 other than the tissue to be healed.
- the stimulator electrodes 26 and 28 receive their electrical pulse from the stimulator 18.
- Trigger device 16 can also transmit signals to additional stimulators or other devices.
- the cardiac cycle will have a systolic period and a diastolic period.
- the stimulator 18 will pass electrical pulses during the systole period of the cardiac cycle.
- the electrical stimulation is graphically illustrated in relation to the systolic period, it can also be seen in FIGURE 2 that a plurality of electrical impulses occur throughout an entire systolic period.
- the triggering device 16 is programmed so as to pass the triggering pulse repeatedly at identical instances during sequential cardiac cycles.
- the stimulating electrodes 26 and 28 are placed over or on selected nerves and connected to the stimulator 18.
- a preprogrammed personalized sequence of electrical impulses is delivered from the stimulator 18 to the nerve simultaneously with the onset of cardiac systole. The electrical impulses will continue to be delivered throughout this period.
- the electrical stimulus is structured such that the vascular smooth muscles of the splanchnic circulatory system are innervated, contract, and increase the hydraulic resistance of this part of the systemic circulation.
- the amount of blood flowing into diseased extremities is increased.
- the systolic peak pressure is increased in the diseased extremities because the elevated splanchnic hydraulic input resistance reflects a greater portion of the pulsatile pressure and flow components back into the remaining part of the systemic circulatory system. This increases the pulsatile energy in that part by as much as sixty percent.
- the elevation of the pulse pressure drives more blood through pathologically underperfused blood vessels, generates collateral vessels and, by delivering oxygen and nutrients, accelerates and enables the healing process.
- the endothelial cells release vasodilatory substances, such as prostacyclin, while being mechanically stimulated by blood pressure variations. Therefore, the increase in the flow of blood is further advanced by the restoration and elevation of pressure pulsations and the resulting prostacyclin release in and around tissues and organs with obliterative vascular condition.
- the output of the trigger device allows the medical personnel to enter one, two, or three variables (or a code number), or to place an indicator within a display of the ECG at a point at which they choose to have the trigger device 16 activate the stimulator 18. It also allows the medical personnel to select a second point or time interval at which they choose to terminate the stimulation until the same sequence is automatically resumed during the following cardiac cycles.
- the triggering of the stimulator 18 at the selected instances and in synchrony with the ECG or any other internal or external event constitutes an improvement over prior methods of treatment and also introduces new possibilities of treatment.
- the stimulator 18 upon triggering, provides a structured stimulus to a selected nerve or bundles of nerves via electrodes which are located on the patient's body surface, or are placed percutaneously, or by surgical implantation. Both the location of the electrodes and the structure of the stimulus are specific as to the pathological condition of the patient.
- the stimulator therefore, is equipped for producing various types of stimulation structures in order to treat a variety of pathological conditions. Therefore, the variables that are adjustable by the medical personnel include the shape of the stimulating pulses, the magnitude of their current or voltage, the interval of time of an individual pulse, the interval of time between two consecutive pulses, the number of such pulses within a train
- SUBSTtTUTE SHEET (RUIE 26 of pulses, the amplitude and/or frequency modulation of the pulses within one train, and the time interval between trains of pulses. Since the structure of stimulation is often specific for the pathological condition and/or the patient, the stimulator 18 is equipped with a computer so that, among other functions, the optimal structure, after being determined by the clinic, can be programmed into the stimulator 18. In such a situation, the patient can then use the stimulator safely on his or her own, while performing most of the daily routines.
- the present invention is essentially an electrical nerve stimulation system that incorporates an electrocardiograph in communication with a patient and in communication with an electric signal identifying device.
- This device identifies select points on the electrocardiogram and provides a triggering impulse which activates an electrical nerve stimulator in timed relation with the heart or other intracorporeal or extracorporeal events.
- the stimulator provides a stimulus which is structured to elevate the arterial blood pressure pulse and this effect is maximized by the system's capability to stimulate synchronously with and during the cardiac systole.
- the flow of blood through pathologically underperfused tissues is increased, collateralization is proliferated, and healing of wounds, ulcers, and neuropathic conditions is accelerated and made possible in previously unresponsive cases.
- the present invention is also an electrical nerve stimulation system which can promote healing in relation to an extracorporeal or an internal event relative to the patient.
- the receptor electrode is applied to a source indicative of the extracorporeal or internal event.
- the processor is then used to produce a representation of such event. Electrical pulses are then passed to the stimulating electrodes in timed relationship to the representation of the event.
Abstract
Description
Claims
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US173777 | 1980-07-30 | ||
US08/173,777 US5458626A (en) | 1993-12-27 | 1993-12-27 | Method of electrical nerve stimulation for acceleration of tissue healing |
PCT/US1994/015000 WO1995017921A1 (en) | 1993-12-27 | 1994-12-27 | Method of electrical nerve stimulation |
Publications (3)
Publication Number | Publication Date |
---|---|
EP0757573A1 true EP0757573A1 (en) | 1997-02-12 |
EP0757573A4 EP0757573A4 (en) | 1997-03-26 |
EP0757573B1 EP0757573B1 (en) | 2006-03-15 |
Family
ID=22633443
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP95910859A Expired - Lifetime EP0757573B1 (en) | 1993-12-27 | 1994-12-27 | Apparatus for electrical nerve stimulation |
Country Status (5)
Country | Link |
---|---|
US (1) | US5458626A (en) |
EP (1) | EP0757573B1 (en) |
AU (1) | AU1866795A (en) |
DE (1) | DE69434666T2 (en) |
WO (1) | WO1995017921A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006079484A1 (en) | 2005-01-26 | 2006-08-03 | Cerbomed Gmbh | Device for the transdermal stimulation of a nerve of the human body |
DE102011009528A1 (en) | 2011-01-26 | 2012-07-26 | Cerbomed Gmbh | Device for transcutaneous stimulation of a nerve of the human body |
Families Citing this family (130)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19651600A1 (en) * | 1996-12-11 | 1998-06-18 | Bavaria Patente & Lizenzen | Device for stimulating a muscle or muscle groups |
US7799337B2 (en) | 1997-07-21 | 2010-09-21 | Levin Bruce H | Method for directed intranasal administration of a composition |
US6058331A (en) * | 1998-04-27 | 2000-05-02 | Medtronic, Inc. | Apparatus and method for treating peripheral vascular disease and organ ischemia by electrical stimulation with closed loop feedback control |
CA2331532A1 (en) * | 1998-05-08 | 1999-11-18 | Genetronics, Inc. | Electrically induced vessel vasodilation |
US7599736B2 (en) * | 2001-07-23 | 2009-10-06 | Dilorenzo Biomedical, Llc | Method and apparatus for neuromodulation and physiologic modulation for the treatment of metabolic and neuropsychiatric disease |
US20050137644A1 (en) * | 1998-10-26 | 2005-06-23 | Boveja Birinder R. | Method and system for vagal blocking and/or vagal stimulation to provide therapy for obesity and other gastrointestinal disorders |
US6450942B1 (en) | 1999-08-20 | 2002-09-17 | Cardiorest International Ltd. | Method for reducing heart loads in mammals |
US6308102B1 (en) | 1999-09-29 | 2001-10-23 | Stimsoft, Inc. | Patient interactive neurostimulation system and method |
US6654642B2 (en) * | 1999-09-29 | 2003-11-25 | Medtronic, Inc. | Patient interactive neurostimulation system and method |
US6850801B2 (en) | 2001-09-26 | 2005-02-01 | Cvrx, Inc. | Mapping methods for cardiovascular reflex control devices |
US6522926B1 (en) | 2000-09-27 | 2003-02-18 | Cvrx, Inc. | Devices and methods for cardiovascular reflex control |
US7158832B2 (en) | 2000-09-27 | 2007-01-02 | Cvrx, Inc. | Electrode designs and methods of use for cardiovascular reflex control devices |
US7623926B2 (en) | 2000-09-27 | 2009-11-24 | Cvrx, Inc. | Stimulus regimens for cardiovascular reflex control |
US6985774B2 (en) | 2000-09-27 | 2006-01-10 | Cvrx, Inc. | Stimulus regimens for cardiovascular reflex control |
US7840271B2 (en) | 2000-09-27 | 2010-11-23 | Cvrx, Inc. | Stimulus regimens for cardiovascular reflex control |
US7499742B2 (en) | 2001-09-26 | 2009-03-03 | Cvrx, Inc. | Electrode structures and methods for their use in cardiovascular reflex control |
US7616997B2 (en) | 2000-09-27 | 2009-11-10 | Kieval Robert S | Devices and methods for cardiovascular reflex control via coupled electrodes |
US8086314B1 (en) | 2000-09-27 | 2011-12-27 | Cvrx, Inc. | Devices and methods for cardiovascular reflex control |
US7151914B2 (en) * | 2001-08-21 | 2006-12-19 | Medtronic, Inc. | Transmitter system for wireless communication with implanted devices |
JP3535855B2 (en) * | 2001-09-05 | 2004-06-07 | Necエレクトロニクス株式会社 | Scan flip-flop and semiconductor integrated circuit device |
US7010353B2 (en) * | 2002-01-07 | 2006-03-07 | Ebi, L.P. | Non-invasive capacitively coupled electrical stimulation device for treatment of soft tissue wounds |
US7689276B2 (en) * | 2002-09-13 | 2010-03-30 | Leptos Biomedical, Inc. | Dynamic nerve stimulation for treatment of disorders |
US7239912B2 (en) | 2002-03-22 | 2007-07-03 | Leptos Biomedical, Inc. | Electric modulation of sympathetic nervous system |
US7551964B2 (en) * | 2002-03-22 | 2009-06-23 | Leptos Biomedical, Inc. | Splanchnic nerve stimulation for treatment of obesity |
US7689277B2 (en) * | 2002-03-22 | 2010-03-30 | Leptos Biomedical, Inc. | Neural stimulation for treatment of metabolic syndrome and type 2 diabetes |
US7236822B2 (en) * | 2002-03-22 | 2007-06-26 | Leptos Biomedical, Inc. | Wireless electric modulation of sympathetic nervous system |
US7702386B2 (en) * | 2002-03-22 | 2010-04-20 | Leptos Biomedical, Inc. | Nerve stimulation for treatment of obesity, metabolic syndrome, and Type 2 diabetes |
US20090259279A1 (en) * | 2002-03-22 | 2009-10-15 | Dobak Iii John D | Splanchnic nerve stimulation for treatment of obesity |
US7937145B2 (en) * | 2002-03-22 | 2011-05-03 | Advanced Neuromodulation Systems, Inc. | Dynamic nerve stimulation employing frequency modulation |
US8774913B2 (en) | 2002-04-08 | 2014-07-08 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for intravasculary-induced neuromodulation |
US7756583B2 (en) | 2002-04-08 | 2010-07-13 | Ardian, Inc. | Methods and apparatus for intravascularly-induced neuromodulation |
US8150519B2 (en) | 2002-04-08 | 2012-04-03 | Ardian, Inc. | Methods and apparatus for bilateral renal neuromodulation |
US6978174B2 (en) | 2002-04-08 | 2005-12-20 | Ardian, Inc. | Methods and devices for renal nerve blocking |
US8347891B2 (en) | 2002-04-08 | 2013-01-08 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen |
US8145317B2 (en) | 2002-04-08 | 2012-03-27 | Ardian, Inc. | Methods for renal neuromodulation |
US20140018880A1 (en) | 2002-04-08 | 2014-01-16 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for monopolar renal neuromodulation |
US7162303B2 (en) | 2002-04-08 | 2007-01-09 | Ardian, Inc. | Renal nerve stimulation method and apparatus for treatment of patients |
US7620451B2 (en) | 2005-12-29 | 2009-11-17 | Ardian, Inc. | Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach |
US9308044B2 (en) | 2002-04-08 | 2016-04-12 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for therapeutic renal neuromodulation |
US8145316B2 (en) | 2002-04-08 | 2012-03-27 | Ardian, Inc. | Methods and apparatus for renal neuromodulation |
US20070135875A1 (en) | 2002-04-08 | 2007-06-14 | Ardian, Inc. | Methods and apparatus for thermally-induced renal neuromodulation |
US7653438B2 (en) | 2002-04-08 | 2010-01-26 | Ardian, Inc. | Methods and apparatus for renal neuromodulation |
US9636174B2 (en) | 2002-04-08 | 2017-05-02 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for therapeutic renal neuromodulation |
US20070129761A1 (en) | 2002-04-08 | 2007-06-07 | Ardian, Inc. | Methods for treating heart arrhythmia |
US8131371B2 (en) | 2002-04-08 | 2012-03-06 | Ardian, Inc. | Methods and apparatus for monopolar renal neuromodulation |
US7617005B2 (en) | 2002-04-08 | 2009-11-10 | Ardian, Inc. | Methods and apparatus for thermally-induced renal neuromodulation |
US8175711B2 (en) | 2002-04-08 | 2012-05-08 | Ardian, Inc. | Methods for treating a condition or disease associated with cardio-renal function |
US8774922B2 (en) | 2002-04-08 | 2014-07-08 | Medtronic Ardian Luxembourg S.A.R.L. | Catheter apparatuses having expandable balloons for renal neuromodulation and associated systems and methods |
US20080213331A1 (en) | 2002-04-08 | 2008-09-04 | Ardian, Inc. | Methods and devices for renal nerve blocking |
US7853333B2 (en) | 2002-04-08 | 2010-12-14 | Ardian, Inc. | Methods and apparatus for multi-vessel renal neuromodulation |
US9308043B2 (en) | 2002-04-08 | 2016-04-12 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for monopolar renal neuromodulation |
US20040082859A1 (en) | 2002-07-01 | 2004-04-29 | Alan Schaer | Method and apparatus employing ultrasound energy to treat body sphincters |
US20070083240A1 (en) * | 2003-05-08 | 2007-04-12 | Peterson David K L | Methods and systems for applying stimulation and sensing one or more indicators of cardiac activity with an implantable stimulator |
US7162304B1 (en) * | 2003-05-08 | 2007-01-09 | Advanced Bionics Corporation | System for measuring cardiac rhythm parameters for assessment of spinal cord stimulation |
AU2003904303A0 (en) * | 2003-08-12 | 2003-08-28 | National Ageing Research Institute Incorporated | Nerve function and tissue healing |
US7480532B2 (en) | 2003-10-22 | 2009-01-20 | Cvrx, Inc. | Baroreflex activation for pain control, sedation and sleep |
US7775087B2 (en) * | 2004-03-16 | 2010-08-17 | Northwestern University | Microchannel forming method and nanotipped dispensing device having a microchannel |
US8082038B2 (en) * | 2004-07-09 | 2011-12-20 | Ebi, Llc | Method for treating degenerative disc disease using noninvasive capacitively coupled electrical stimulation device |
US7623924B2 (en) * | 2004-08-31 | 2009-11-24 | Leptos Biomedical, Inc. | Devices and methods for gynecologic hormone modulation in mammals |
US20120277839A1 (en) * | 2004-09-08 | 2012-11-01 | Kramer Jeffery M | Selective stimulation to modulate the sympathetic nervous system |
JP5132310B2 (en) | 2004-09-08 | 2013-01-30 | スパイナル・モデュレーション・インコーポレイテッド | Neural stimulation method and system |
US9205261B2 (en) | 2004-09-08 | 2015-12-08 | The Board Of Trustees Of The Leland Stanford Junior University | Neurostimulation methods and systems |
ATE439162T1 (en) * | 2004-09-10 | 2009-08-15 | Power Of Grace Pty Ltd | DEVICE FOR TREATING DIABETES IN A MAMMAL |
WO2006031899A2 (en) * | 2004-09-10 | 2006-03-23 | The Cleveland Clinic Foundation | Intraluminal electrode assembly |
US8676326B1 (en) * | 2004-10-21 | 2014-03-18 | Pacesetter, Inc | Implantable device with responsive vascular and cardiac controllers |
US7937143B2 (en) | 2004-11-02 | 2011-05-03 | Ardian, Inc. | Methods and apparatus for inducing controlled renal neuromodulation |
US7519431B2 (en) * | 2005-04-11 | 2009-04-14 | Medtronic, Inc. | Shifting between electrode combinations in electrical stimulation device |
WO2006110206A1 (en) * | 2005-04-11 | 2006-10-19 | Medtronic, Inc. | Shifting between electrode combinations in electrical stimulation device |
US9592136B2 (en) | 2005-07-25 | 2017-03-14 | Vascular Dynamics, Inc. | Devices and methods for control of blood pressure |
US9125732B2 (en) | 2005-07-25 | 2015-09-08 | Vascular Dynamics, Inc. | Devices and methods for control of blood pressure |
US8862243B2 (en) * | 2005-07-25 | 2014-10-14 | Rainbow Medical Ltd. | Electrical stimulation of blood vessels |
US8923972B2 (en) | 2005-07-25 | 2014-12-30 | Vascular Dynamics, Inc. | Elliptical element for blood pressure reduction |
US9642726B2 (en) | 2005-07-25 | 2017-05-09 | Vascular Dynamics, Inc. | Devices and methods for control of blood pressure |
US8109879B2 (en) | 2006-01-10 | 2012-02-07 | Cardiac Pacemakers, Inc. | Assessing autonomic activity using baroreflex analysis |
US8295926B2 (en) | 2006-06-02 | 2012-10-23 | Advanced Neuromodulation Systems, Inc. | Dynamic nerve stimulation in combination with other eating disorder treatment modalities |
EP2106275A2 (en) * | 2006-06-09 | 2009-10-07 | Leptos Biomedical, Inc. | Dynamic nerve stimulation employing frequency modulation |
WO2008070808A2 (en) * | 2006-12-06 | 2008-06-12 | Spinal Modulation, Inc. | Expandable stimulation leads and methods of use |
US9314618B2 (en) | 2006-12-06 | 2016-04-19 | Spinal Modulation, Inc. | Implantable flexible circuit leads and methods of use |
EP2099374A4 (en) | 2006-12-06 | 2012-10-03 | Spinal Modulation Inc | Hard tissue anchors and delivery devices |
WO2008070807A2 (en) | 2006-12-06 | 2008-06-12 | Spinal Modulation, Inc. | Delivery devices, systems and methods for stimulating nerve tissue on multiple spinal levels |
JP5562648B2 (en) * | 2007-01-29 | 2014-07-30 | スパイナル・モデュレーション・インコーポレイテッド | Non-stitched top retaining mechanism |
US8249705B1 (en) | 2007-03-20 | 2012-08-21 | Cvrx, Inc. | Devices, systems, and methods for improving left ventricular structure and function using baroreflex activation therapy |
US8594794B2 (en) | 2007-07-24 | 2013-11-26 | Cvrx, Inc. | Baroreflex activation therapy with incrementally changing intensity |
US20090118777A1 (en) * | 2007-08-09 | 2009-05-07 | Kobi Iki | Efferent and afferent splanchnic nerve stimulation |
US8731665B1 (en) | 2007-10-24 | 2014-05-20 | Pacesetter, Inc. | Posture detection using pressure and other physiologic sensors |
US9005106B2 (en) * | 2008-01-31 | 2015-04-14 | Enopace Biomedical Ltd | Intra-aortic electrical counterpulsation |
US8626299B2 (en) | 2008-01-31 | 2014-01-07 | Enopace Biomedical Ltd. | Thoracic aorta and vagus nerve stimulation |
US8538535B2 (en) | 2010-08-05 | 2013-09-17 | Rainbow Medical Ltd. | Enhancing perfusion by contraction |
US8626290B2 (en) | 2008-01-31 | 2014-01-07 | Enopace Biomedical Ltd. | Acute myocardial infarction treatment by electrical stimulation of the thoracic aorta |
US8473062B2 (en) | 2008-05-01 | 2013-06-25 | Autonomic Technologies, Inc. | Method and device for the treatment of headache |
ES2725524T3 (en) | 2008-09-26 | 2019-09-24 | Vascular Dynamics Inc | Devices and methods to control blood pressure |
EP2373378B1 (en) | 2008-10-27 | 2017-04-26 | Spinal Modulation Inc. | Selective stimulation systems and signal parameters for medical conditions |
AU2008246284A1 (en) * | 2008-11-19 | 2010-06-10 | Zao, Ritm Okb | Method for electrical influance on a living organism and device thereof |
US8412336B2 (en) | 2008-12-29 | 2013-04-02 | Autonomic Technologies, Inc. | Integrated delivery and visualization tool for a neuromodulation system |
US8652129B2 (en) | 2008-12-31 | 2014-02-18 | Medtronic Ardian Luxembourg S.A.R.L. | Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation |
US8974445B2 (en) | 2009-01-09 | 2015-03-10 | Recor Medical, Inc. | Methods and apparatus for treatment of cardiac valve insufficiency |
US9320908B2 (en) | 2009-01-15 | 2016-04-26 | Autonomic Technologies, Inc. | Approval per use implanted neurostimulator |
US8494641B2 (en) | 2009-04-22 | 2013-07-23 | Autonomic Technologies, Inc. | Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism |
EP2411091A4 (en) | 2009-03-24 | 2012-09-12 | Spinal Modulation Inc | Pain management with stimulation subthreshold to paresthesia |
US8321030B2 (en) | 2009-04-20 | 2012-11-27 | Advanced Neuromodulation Systems, Inc. | Esophageal activity modulated obesity therapy |
US8340772B2 (en) | 2009-05-08 | 2012-12-25 | Advanced Neuromodulation Systems, Inc. | Brown adipose tissue utilization through neuromodulation |
US9259569B2 (en) * | 2009-05-15 | 2016-02-16 | Daniel M. Brounstein | Methods, systems and devices for neuromodulating spinal anatomy |
JP6231384B2 (en) | 2010-05-10 | 2017-11-15 | スパイナル・モデュレーション・インコーポレイテッドSpinal Modulation Inc. | Method, system and device for suppressing misalignment |
CN107007348B (en) | 2010-10-25 | 2019-05-31 | 美敦力Af卢森堡有限责任公司 | For the estimation of nerve modulation treatment and device, the system and method for feedback |
US8649863B2 (en) | 2010-12-20 | 2014-02-11 | Rainbow Medical Ltd. | Pacemaker with no production |
AU2012212150B2 (en) | 2011-02-02 | 2016-09-29 | Spinal Modulation, Inc | Devices, systems and methods for the targeted treatment of movement disorders |
US8855783B2 (en) | 2011-09-09 | 2014-10-07 | Enopace Biomedical Ltd. | Detector-based arterial stimulation |
WO2013035092A2 (en) | 2011-09-09 | 2013-03-14 | Enopace Biomedical Ltd. | Wireless endovascular stent-based electrodes |
US9386991B2 (en) | 2012-02-02 | 2016-07-12 | Rainbow Medical Ltd. | Pressure-enhanced blood flow treatment |
AU2013230781B2 (en) | 2012-03-08 | 2015-12-03 | Medtronic Af Luxembourg S.A.R.L. | Ovarian neuromodulation and associated systems and methods |
RU2644933C2 (en) | 2012-03-08 | 2018-02-14 | Медтроник Аф Люксембург Сарл | Biomarker samples selection as part of devices for neuromodulation and relevant systems and methods |
US20140110296A1 (en) | 2012-10-19 | 2014-04-24 | Medtronic Ardian Luxembourg S.A.R.L. | Packaging for Catheter Treatment Devices and Associated Devices, Systems, and Methods |
WO2015068167A2 (en) | 2013-11-06 | 2015-05-14 | Enopace Biomedical Ltd. | Wireless endovascular stent-based electrodes |
US10194980B1 (en) | 2014-03-28 | 2019-02-05 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for catheter-based renal neuromodulation |
US9980766B1 (en) | 2014-03-28 | 2018-05-29 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and systems for renal neuromodulation |
US10194979B1 (en) | 2014-03-28 | 2019-02-05 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for catheter-based renal neuromodulation |
US10376308B2 (en) | 2015-02-05 | 2019-08-13 | Axon Therapies, Inc. | Devices and methods for treatment of heart failure by splanchnic nerve ablation |
US9956393B2 (en) | 2015-02-24 | 2018-05-01 | Elira, Inc. | Systems for increasing a delay in the gastric emptying time for a patient using a transcutaneous electro-dermal patch |
US10376145B2 (en) | 2015-02-24 | 2019-08-13 | Elira, Inc. | Systems and methods for enabling a patient to achieve a weight loss objective using an electrical dermal patch |
US10335302B2 (en) | 2015-02-24 | 2019-07-02 | Elira, Inc. | Systems and methods for using transcutaneous electrical stimulation to enable dietary interventions |
US10765863B2 (en) | 2015-02-24 | 2020-09-08 | Elira, Inc. | Systems and methods for using a transcutaneous electrical stimulation device to deliver titrated therapy |
US10864367B2 (en) | 2015-02-24 | 2020-12-15 | Elira, Inc. | Methods for using an electrical dermal patch in a manner that reduces adverse patient reactions |
WO2016138176A1 (en) | 2015-02-24 | 2016-09-01 | Elira Therapeutics Llc | Systems and methods for enabling appetite modulation and/or improving dietary compliance using an electro-dermal patch |
US10207110B1 (en) | 2015-10-13 | 2019-02-19 | Axon Therapies, Inc. | Devices and methods for treatment of heart failure via electrical modulation of a splanchnic nerve |
CA3031766A1 (en) | 2016-07-29 | 2018-02-01 | Howard Levin | Devices, systems, and methods for treatment of heart failure by splanchnic nerve ablation |
US10561461B2 (en) | 2017-12-17 | 2020-02-18 | Axon Therapies, Inc. | Methods and devices for endovascular ablation of a splanchnic nerve |
CA3089217A1 (en) | 2018-01-26 | 2019-08-01 | Dorin Panescu | Methods and devices for endovascular ablation of a splanchnic nerve |
EP3917426B1 (en) | 2019-06-20 | 2023-09-06 | Axon Therapies, Inc. | Devices for endovascular ablation of a splanchnic nerve |
JP2023510597A (en) | 2020-01-17 | 2023-03-14 | アクソン セラピーズ,インク. | Method and device for endovascular ablation of visceral nerves |
US11400299B1 (en) | 2021-09-14 | 2022-08-02 | Rainbow Medical Ltd. | Flexible antenna for stimulator |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE346468B (en) * | 1969-02-24 | 1972-07-10 | Lkb Medical Ab | |
US4453547A (en) * | 1981-04-06 | 1984-06-12 | Physio Technology, Inc. | T-Wave inhibiting system |
GB8406509D0 (en) * | 1984-03-13 | 1984-04-18 | Bio Medical Res Ltd | Electrical stimulation of muscle |
US4974599A (en) * | 1988-10-25 | 1990-12-04 | Sharp Kabushiki Kaisha | Portable electrocardiograph |
US5056519A (en) * | 1990-05-14 | 1991-10-15 | Vince Dennis J | Unilateral diaphragmatic pacer |
US5058584A (en) * | 1990-08-30 | 1991-10-22 | Medtronic, Inc. | Method and apparatus for epidural burst stimulation for angina pectoris |
US5146918A (en) * | 1991-03-19 | 1992-09-15 | Medtronic, Inc. | Demand apnea control of central and obstructive sleep apnea |
-
1993
- 1993-12-27 US US08/173,777 patent/US5458626A/en not_active Expired - Lifetime
-
1994
- 1994-12-27 WO PCT/US1994/015000 patent/WO1995017921A1/en active IP Right Grant
- 1994-12-27 AU AU18667/95A patent/AU1866795A/en not_active Abandoned
- 1994-12-27 EP EP95910859A patent/EP0757573B1/en not_active Expired - Lifetime
- 1994-12-27 DE DE69434666T patent/DE69434666T2/en not_active Expired - Lifetime
Non-Patent Citations (2)
Title |
---|
No further relevant documents disclosed * |
See also references of WO9517921A1 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006079484A1 (en) | 2005-01-26 | 2006-08-03 | Cerbomed Gmbh | Device for the transdermal stimulation of a nerve of the human body |
DE102011009528A1 (en) | 2011-01-26 | 2012-07-26 | Cerbomed Gmbh | Device for transcutaneous stimulation of a nerve of the human body |
WO2012100913A1 (en) | 2011-01-26 | 2012-08-02 | Cerbomed Gmbh | Device for arranging on or in an ear for transcutaneous stimulation of a nerve |
Also Published As
Publication number | Publication date |
---|---|
DE69434666T2 (en) | 2007-02-01 |
WO1995017921A1 (en) | 1995-07-06 |
EP0757573A4 (en) | 1997-03-26 |
DE69434666D1 (en) | 2006-05-11 |
AU1866795A (en) | 1995-07-17 |
US5458626A (en) | 1995-10-17 |
EP0757573B1 (en) | 2006-03-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US5458626A (en) | Method of electrical nerve stimulation for acceleration of tissue healing | |
Campbell et al. | Peripheral nerve stimulation in the treatment of intractable pain | |
US5358513A (en) | Parameter selection and electrode placement of neuromuscular electrical stimulation apparatus | |
RU2291723C2 (en) | Method and device for treating living organism to reduce heart load | |
US8868204B2 (en) | Esthetic device useful for increasing skin beautification and methods thereof | |
JP4401057B2 (en) | Electrical stimulation system for wound treatment | |
Mercola et al. | The basis for microcurrent electrical therapy in conventional medical practice | |
BORST et al. | Optimal frequency of carotid sinus nerve stimulation in treatment of angina pectoris | |
KR20040071166A (en) | Device and method to modulate blood pressure by electrical waveforms | |
Gorodnichev et al. | Transcutaneous electrical stimulation of the spinal cord: A noninvasive tool for the activation of stepping pattern generators in humans | |
JP2007535978A (en) | Electromagnetic induction processing apparatus and method | |
AU2008326528A1 (en) | System and method for generating complex bioelectric stimulation signals while conserving power | |
RU2002107014A (en) | METHOD FOR TREATING A LIVING ORGANISM FOR REDUCING THE LOAD OF THE HEART AND A DEVICE FOR IMPLEMENTING THIS METHOD | |
US20020120309A1 (en) | System and method for providing recovery from muscle denervation | |
US20020183659A1 (en) | Method and apparatus for promoting the healing of human tissue | |
Peters et al. | Search for optimal frequencies and amplitudes of therapeutic electrical carotid sinus nerve stimulation by application of the evolution strategy | |
Lau et al. | Fatigue reduction by sequential stimulation of multiple motor points in a muscle. | |
US20030220672A1 (en) | Muscle stimulation in a cast-immobilized limb | |
RU2412728C2 (en) | Method of treating and rehabilitation of patients with severe injuries of radial nerve | |
CN110840736A (en) | Paralytic limb movement function reconstruction system adopting electric needle and electric moxibustion medical technology | |
Shealy et al. | Modern medical electricity in the management of pain | |
EP1694404A1 (en) | Electrotherapy apparatus and method of treating a person or a mammal using such electrotherapy apparatus | |
RU2122394C1 (en) | Method for curing paralysis and paresis decease | |
RU2045286C1 (en) | Method of electrotherapy and device for carrying out same | |
SU1146061A1 (en) | Method of restoring the function of injured peripheric nerve |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19960817 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): DE FR GB IT NL |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19970210 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): DE FR GB IT NL |
|
17Q | First examination report despatched |
Effective date: 20010629 |
|
GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
RTI1 | Title (correction) |
Free format text: APPARATUS FOR ELECTRICAL NERVE STIMULATION |
|
GRAS | Grant fee paid |
Free format text: ORIGINAL CODE: EPIDOSNIGR3 |
|
GRAA | (expected) grant |
Free format text: ORIGINAL CODE: 0009210 |
|
AK | Designated contracting states |
Kind code of ref document: B1 Designated state(s): DE FR GB IT NL |
|
REG | Reference to a national code |
Ref country code: GB Ref legal event code: FG4D |
|
REF | Corresponds to: |
Ref document number: 69434666 Country of ref document: DE Date of ref document: 20060511 Kind code of ref document: P |
|
ET | Fr: translation filed | ||
PLBE | No opposition filed within time limit |
Free format text: ORIGINAL CODE: 0009261 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT |
|
26N | No opposition filed |
Effective date: 20061218 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: GB Payment date: 20131219 Year of fee payment: 20 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: IT Payment date: 20131223 Year of fee payment: 20 Ref country code: NL Payment date: 20131219 Year of fee payment: 20 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: DE Payment date: 20140117 Year of fee payment: 20 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: FR Payment date: 20131220 Year of fee payment: 20 |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R071 Ref document number: 69434666 Country of ref document: DE |
|
REG | Reference to a national code |
Ref country code: NL Ref legal event code: V4 Effective date: 20141227 |
|
REG | Reference to a national code |
Ref country code: GB Ref legal event code: PE20 Expiry date: 20141226 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: GB Free format text: LAPSE BECAUSE OF EXPIRATION OF PROTECTION Effective date: 20141226 |