EP0817619A4 - Novel "burst-free" sustained release poly-(lactide/glycolide) mi crospheres - Google Patents
Novel "burst-free" sustained release poly-(lactide/glycolide) mi crospheresInfo
- Publication number
- EP0817619A4 EP0817619A4 EP96944247A EP96944247A EP0817619A4 EP 0817619 A4 EP0817619 A4 EP 0817619A4 EP 96944247 A EP96944247 A EP 96944247A EP 96944247 A EP96944247 A EP 96944247A EP 0817619 A4 EP0817619 A4 EP 0817619A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- crospheres
- glycolide
- lactide
- burst
- novel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US59097396A | 1996-01-24 | 1996-01-24 | |
US590973 | 1996-01-24 | ||
PCT/US1996/019440 WO1997026869A1 (en) | 1996-01-24 | 1996-11-18 | Novel 'burst-free' sustained release poly-(lactide/glycolide) microspheres |
CNB961947683A CN100391445C (en) | 1996-01-24 | 1996-11-18 | Novel 'burst-free' sustained release poly-(lactide/glycolide) mi crospheres |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0817619A1 EP0817619A1 (en) | 1998-01-14 |
EP0817619A4 true EP0817619A4 (en) | 1999-02-03 |
Family
ID=25744089
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP96944247A Ceased EP0817619A4 (en) | 1996-01-24 | 1996-11-18 | Novel "burst-free" sustained release poly-(lactide/glycolide) mi crospheres |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0817619A4 (en) |
JP (1) | JPH11509862A (en) |
CN (1) | CN100391445C (en) |
AP (1) | AP665A (en) |
AU (1) | AU722884B2 (en) |
BR (1) | BR9607752B1 (en) |
NZ (1) | NZ325561A (en) |
WO (1) | WO1997026869A1 (en) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7033608B1 (en) * | 1995-05-22 | 2006-04-25 | The United States Of America As Represented By The Secretary Of The Army | “Burst-free” sustained release poly-(lactide/glycolide) microspheres |
TW577759B (en) | 1997-04-18 | 2004-03-01 | Ipsen Pharma Biotech | Sustained release compositions in the form of microcapsules or implants and the process for their preparation |
CN1075945C (en) * | 1998-02-26 | 2001-12-12 | 中国科学院化学研究所 | High-polymer encapsulated insulin microsome and its preparation method and use |
CN1073412C (en) * | 1998-03-19 | 2001-10-24 | 中国科学院化学研究所 | Method for prepn. of macromolecule microcapsule |
US7217770B2 (en) * | 2000-05-17 | 2007-05-15 | Samyang Corporation | Stable polymeric micelle-type drug composition and method for the preparation thereof |
US6726918B1 (en) | 2000-07-05 | 2004-04-27 | Oculex Pharmaceuticals, Inc. | Methods for treating inflammation-mediated conditions of the eye |
DE60114229T2 (en) | 2000-11-29 | 2006-07-06 | Allergan, Inc., Irvine | PREVENTING TRANSPLANT DISCHARGE IN THE EYE |
US20040137059A1 (en) * | 2003-01-09 | 2004-07-15 | Thierry Nivaggioli | Biodegradable ocular implant |
US20050048099A1 (en) | 2003-01-09 | 2005-03-03 | Allergan, Inc. | Ocular implant made by a double extrusion process |
US7993634B2 (en) | 2004-04-30 | 2011-08-09 | Allergan, Inc. | Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods |
US7799336B2 (en) | 2004-04-30 | 2010-09-21 | Allergan, Inc. | Hypotensive lipid-containing biodegradable intraocular implants and related methods |
US9498457B2 (en) | 2004-04-30 | 2016-11-22 | Allergan, Inc. | Hypotensive prostamide-containing biodegradable intraocular implants and related implants |
US20050244469A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Extended therapeutic effect ocular implant treatments |
US8722097B2 (en) | 2004-04-30 | 2014-05-13 | Allergan, Inc. | Oil-in-water method for making polymeric implants containing a hypotensive lipid |
GB0517674D0 (en) * | 2005-08-31 | 2005-10-05 | Astrazeneca Ab | Formulation |
GB0517673D0 (en) * | 2005-08-31 | 2005-10-05 | Astrazeneca Ab | Formulation |
CN101007169B (en) * | 2006-01-23 | 2011-05-25 | 珠海市嘉族生物科技有限公司 | A microcapsule of egg yolk immunoglobulin, preparing process and use thereof |
KR100816065B1 (en) | 2006-11-27 | 2008-03-24 | 동국제약 주식회사 | Preparation method of sustained-release microcapsules having good initial burst inhibiting property and the microcapsules thereby |
US8956641B2 (en) * | 2008-04-18 | 2015-02-17 | Warsaw Orthopedic, Inc. | Alpha adrenergic receptor agonists for treatment of inflammatory diseases |
US8889173B2 (en) * | 2008-04-18 | 2014-11-18 | Warsaw Orthopedic, Inc. | Alpha adrenergic receptor agonists for treatment of pain and/or inflammation |
CN101612111B (en) * | 2008-06-24 | 2011-11-23 | 上海医药工业研究院 | Sustained-release microsphere of nomegestrol acetate of analogs thereof and preparation method and application thereof |
KR20100037389A (en) * | 2008-10-01 | 2010-04-09 | 연세대학교 산학협력단 | Solid microstructure with multi-controlled release and process for preparing the same |
USRE49251E1 (en) | 2010-01-04 | 2022-10-18 | Mapi Pharma Ltd. | Depot systems comprising glatiramer or pharmacologically acceptable salt thereof |
CN102357080B (en) * | 2011-11-04 | 2014-07-16 | 无锡中科光远生物材料有限公司 | Intelligent multifunctional hollow microsphere capable of quickly releasing medicine in acid environment and preparation method for intelligent multifunctional hollow microsphere |
US10675376B2 (en) * | 2012-05-24 | 2020-06-09 | Ethicon Llc | Mechanically strong absorbable polymeric blend compositions of precisely controllable absorption rates, processing methods, and products therefrom |
HUE036141T2 (en) * | 2013-06-20 | 2018-06-28 | Pharmathen Sa | Preparation of polylactide-polyglycolide microparticles having a sigmoidal release profile |
US20170022256A1 (en) * | 2015-07-23 | 2017-01-26 | General Biologicals Corporation | Anti-fungal and anti-bacterial peptide and therapeutic method using same |
CN110382052A (en) | 2017-03-26 | 2019-10-25 | Mapi医药公司 | The copaxone store system of multiple sclerosis for therapeutic advance type form |
CN113384536B (en) * | 2020-03-14 | 2024-04-02 | 鲁南制药集团股份有限公司 | Sustained release galanthamine pamoate particles for injection and preparation method thereof |
CN115025290A (en) * | 2022-06-15 | 2022-09-09 | 浙江天妍生物科技有限公司 | Degradable microsphere and production process thereof |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0052510A2 (en) * | 1980-11-18 | 1982-05-26 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble polypeptides |
DE4005415A1 (en) * | 1990-02-21 | 1991-08-22 | Boehringer Ingelheim Kg | Polyester based on hydroxy-carboxylic acids, esp. alpha-hydroxy acids - obtd. by reaction of acids or oligomers in condensn. catalyst, esp. phosgene, carbonyl:di:imidazole, di:cyclo:hexyl:carbo:di:imide |
EP0463194A1 (en) * | 1990-06-23 | 1992-01-02 | Boehringer Ingelheim Kg | Process for the preparation of poly(D,L-lactide) and its use as a drug carrier |
DE4235312A1 (en) * | 1991-10-23 | 1993-04-29 | Boehringer Ingelheim Kg | Semi-solid mixts. of D- or L-lactic acid oligomer or polymer - used e.g. as resorbable implants, or bone waxes |
US5410016A (en) * | 1990-10-15 | 1995-04-25 | Board Of Regents, The University Of Texas System | Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers |
DE19513659A1 (en) * | 1995-03-10 | 1996-09-12 | Boehringer Mannheim Gmbh | Microparticle formulations of aggregation-sensitive polypeptides |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4622244A (en) * | 1979-09-04 | 1986-11-11 | The Washington University | Process for preparation of microcapsules |
US4623588A (en) * | 1984-02-06 | 1986-11-18 | Biotek, Inc. | Controlled release composite core coated microparticles |
DK0724431T3 (en) * | 1993-10-22 | 2003-01-06 | Genentech Inc | Methods and compositions for microencapsulating adjuvants |
GB9412273D0 (en) * | 1994-06-18 | 1994-08-10 | Univ Nottingham | Administration means |
-
1996
- 1996-11-18 EP EP96944247A patent/EP0817619A4/en not_active Ceased
- 1996-11-18 NZ NZ325561A patent/NZ325561A/en not_active IP Right Cessation
- 1996-11-18 AU AU14104/97A patent/AU722884B2/en not_active Ceased
- 1996-11-18 JP JP9526833A patent/JPH11509862A/en active Pending
- 1996-11-18 AP APAP/P/1997/001088A patent/AP665A/en active
- 1996-11-18 CN CNB961947683A patent/CN100391445C/en not_active Expired - Fee Related
- 1996-11-18 WO PCT/US1996/019440 patent/WO1997026869A1/en not_active Application Discontinuation
- 1996-11-18 BR BRPI9607752-2A patent/BR9607752B1/en not_active IP Right Cessation
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0052510A2 (en) * | 1980-11-18 | 1982-05-26 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble polypeptides |
DE4005415A1 (en) * | 1990-02-21 | 1991-08-22 | Boehringer Ingelheim Kg | Polyester based on hydroxy-carboxylic acids, esp. alpha-hydroxy acids - obtd. by reaction of acids or oligomers in condensn. catalyst, esp. phosgene, carbonyl:di:imidazole, di:cyclo:hexyl:carbo:di:imide |
EP0463194A1 (en) * | 1990-06-23 | 1992-01-02 | Boehringer Ingelheim Kg | Process for the preparation of poly(D,L-lactide) and its use as a drug carrier |
US5410016A (en) * | 1990-10-15 | 1995-04-25 | Board Of Regents, The University Of Texas System | Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers |
DE4235312A1 (en) * | 1991-10-23 | 1993-04-29 | Boehringer Ingelheim Kg | Semi-solid mixts. of D- or L-lactic acid oligomer or polymer - used e.g. as resorbable implants, or bone waxes |
DE19513659A1 (en) * | 1995-03-10 | 1996-09-12 | Boehringer Mannheim Gmbh | Microparticle formulations of aggregation-sensitive polypeptides |
Non-Patent Citations (2)
Title |
---|
R. JEYANTHI ET AL.: "NOVEL BURST FREE PROGRAMMABLE BIODEGRADABLE MICROSPHERES FOR CONTROLLED RELEASE OF POLYPEPTIDES", PROC. INT. SYMP. CONTROL. RELEASE BIOACT. MATER. (1996), July 1996 (1996-07-01), KYOTO, pages 351 - 352, XP002086331 * |
See also references of WO9726869A1 * |
Also Published As
Publication number | Publication date |
---|---|
BR9607752B1 (en) | 2009-05-05 |
CN1188408A (en) | 1998-07-22 |
AP665A (en) | 1998-08-19 |
AP9701088A0 (en) | 1997-10-31 |
CN100391445C (en) | 2008-06-04 |
BR9607752A (en) | 1999-11-30 |
WO1997026869A1 (en) | 1997-07-31 |
JPH11509862A (en) | 1999-08-31 |
AU1410497A (en) | 1997-08-20 |
EP0817619A1 (en) | 1998-01-14 |
AU722884B2 (en) | 2000-08-10 |
NZ325561A (en) | 1999-06-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
17P | Request for examination filed |
Effective date: 19980130 |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19981216 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED |
|
18R | Application refused |
Effective date: 19991209 |