EP0835667A1 - Tissue adhesive applied with spray - Google Patents
Tissue adhesive applied with spray Download PDFInfo
- Publication number
- EP0835667A1 EP0835667A1 EP97907319A EP97907319A EP0835667A1 EP 0835667 A1 EP0835667 A1 EP 0835667A1 EP 97907319 A EP97907319 A EP 97907319A EP 97907319 A EP97907319 A EP 97907319A EP 0835667 A1 EP0835667 A1 EP 0835667A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- adhesive
- solution
- fibrinogen
- concentration
- thrombin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/106—Fibrin; Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/00491—Surgical glue applicators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/00491—Surgical glue applicators
- A61B2017/00495—Surgical glue applicators for two-component glue
Landscapes
- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Materials For Medical Uses (AREA)
- Surgical Instruments (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Treatment Of Fiber Materials (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
Abstract
Description
Burst pressure (mmHg) | Order of times of determination | Average ± S.D. | |||||||
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | ||
Mixing ratio | |||||||||
1:1 | 16 | 25 | 31 | 32 | 43 | 32 | 20 | 23 | 27.8 ± 8.5 |
5:1 | 40 | 64 | 42 | 40 | 67 | 42 | 42 | 58 | 49.4 ± 11.6 |
Arginine conc. (M) | Coagulating protein conc. (%) | Viscosity of solution (mPa · s) |
0.0 | 7.5 | 18.2 |
0.0 | 7.9 | 24.2 |
0.0 | 8.8 | 36.2 |
0.0 | 9.7 | 61.5 |
0.0 | 11.1 | 152.2 |
0.1 | 11.1 | 82.8 |
0.2 | 11.1 | 84.2 |
0.3 | 11.1 | 77.4 |
0.4 | 11.1 | 77.4 |
0.5 | 11.1 | 78.5 |
Claims (10)
- An adhesive for tissue comprising a fibrinogen solution and a thrombin solution which solutions are separated from each other, said adhesive being to be mixed and sprayed together with a sterile gas for the adhesion or closing of living tissue of a human being or animal, wherein the volume ratio of the fibrinogen solution to the thrombin solution is about 2:1 to 10:1.
- The adhesive of claim 1, wherein the volume ratio of the fibrinogen solution to the thrombin solution is 2:1 to 5:1.
- The adhesive of claim 1, wherein the fibrinogen solution has a concentration of 4 to 15 % (w/v, 40 to 150 mg/ml).
- The adhesive of claim 3, wherein the fibrinogen solution has a concentration of 7 to 12 % (w/v, 70 to 120 mg/ml).
- The adhesive of claim 1, wherein the thrombin solution has a concentration of 100 to 10,000 units/ml (NIH units).
- The adhesive of claim 5, wherein the thrombin solution has a concentration of 250 to 5,000 units/ml (NIH units)
- The adhesive of claim 1, wherein the fibrinogen solution contains at least one viscosity-lowering agent.
- The adhesive of claim 7, wherein the viscosity-lowering agent is arginine.
- The adhesive of claim 8 which contains 0.1 to 1.0 M of arginine.
- The adhesive of claim 9 which contains 0.1 to 0.5 M of arginine.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8756696 | 1996-03-15 | ||
JP87566/96 | 1996-03-15 | ||
JP8756696 | 1996-03-15 | ||
PCT/JP1997/000818 WO1997033633A1 (en) | 1996-03-15 | 1997-03-14 | Tissue adhesive applied with spray |
Publications (3)
Publication Number | Publication Date |
---|---|
EP0835667A1 true EP0835667A1 (en) | 1998-04-15 |
EP0835667A4 EP0835667A4 (en) | 2002-02-20 |
EP0835667B1 EP0835667B1 (en) | 2005-11-09 |
Family
ID=13918548
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP97907319A Revoked EP0835667B1 (en) | 1996-03-15 | 1997-03-14 | Spray device for applying tissue adhesive |
Country Status (9)
Country | Link |
---|---|
US (2) | US5980866A (en) |
EP (1) | EP0835667B1 (en) |
KR (1) | KR100450142B1 (en) |
AT (1) | ATE309006T1 (en) |
AU (1) | AU715822B2 (en) |
CA (1) | CA2220927C (en) |
DE (1) | DE69734557T2 (en) |
DK (1) | DK0835667T3 (en) |
WO (1) | WO1997033633A1 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6471670B1 (en) | 1998-10-05 | 2002-10-29 | Karl Enrenfels | Fibrin sealant applicator system |
US6783514B2 (en) | 1997-01-31 | 2004-08-31 | United States Surgical Corporation | Fibrin sealant applicator |
US7018357B2 (en) | 2001-02-27 | 2006-03-28 | Tyco Healthcare Group Lp | External mixer assembly |
US9775930B2 (en) | 2006-11-17 | 2017-10-03 | Abbott Cardiovascular Systems Inc. | Composition for modifying myocardial infarction expansion |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7654998B1 (en) | 1999-08-23 | 2010-02-02 | Aeris Therapeutics, Inc. | Tissue volume reduction |
US6610043B1 (en) | 1999-08-23 | 2003-08-26 | Bistech, Inc. | Tissue volume reduction |
US6509514B1 (en) * | 2000-03-17 | 2003-01-21 | Kmt Hepatech, Inc. | Chimeric animal model susceptible to human hepatitis C virus infection |
JP4733283B2 (en) * | 2000-03-28 | 2011-07-27 | 一般財団法人化学及血清療法研究所 | Liquid fibrinogen preparation |
US6921532B1 (en) | 2000-06-22 | 2005-07-26 | Spinal Restoration, Inc. | Biological Bioadhesive composition and methods of preparation and use |
WO2002005898A1 (en) * | 2000-07-17 | 2002-01-24 | Haemacure Corporation | Spray head for applying a multi-component mixture |
WO2002022072A2 (en) * | 2000-09-11 | 2002-03-21 | Closure Medical Corporation | Bronchial occlusion method and apparatus |
US20020165483A1 (en) * | 2000-11-10 | 2002-11-07 | Curtis Miller | Gas assisted spray applicator |
US6732887B2 (en) * | 2002-03-26 | 2004-05-11 | Ultradent Products, Inc. | Two-part composition syringe delivery system |
US7077339B2 (en) * | 2003-02-03 | 2006-07-18 | Biomet, Inc. | Spray applicator |
US8206448B2 (en) | 2004-10-29 | 2012-06-26 | Spinal Restoration, Inc. | Injection of fibrin sealant using reconstituted components in spinal applications |
US7597687B2 (en) | 2004-10-29 | 2009-10-06 | Spinal Restoration, Inc. | Injection of fibrin sealant including an anesthetic in spinal applications |
US8419722B2 (en) * | 2004-10-29 | 2013-04-16 | Spinal Restoration, Inc. | Apparatus and method for injection of fibrin sealant in spinal applications |
US8124075B2 (en) * | 2004-07-16 | 2012-02-28 | Spinal Restoration, Inc. | Enhanced biological autologous tissue adhesive composition and methods of preparation and use |
US8403923B2 (en) * | 2004-10-29 | 2013-03-26 | Spinal Restoration, Inc. | Injection of fibrin sealant in the absence of corticosteroids in spinal applications |
US7273963B2 (en) * | 2004-08-20 | 2007-09-25 | Kmt Hepatech, Inc. | Malarial animal model having a chimeric human liver |
US7766900B2 (en) | 2005-02-21 | 2010-08-03 | Biomet Manufacturing Corp. | Method and apparatus for application of a fluid |
US8828433B2 (en) | 2005-04-19 | 2014-09-09 | Advanced Cardiovascular Systems, Inc. | Hydrogel bioscaffoldings and biomedical device coatings |
US9242005B1 (en) | 2006-08-21 | 2016-01-26 | Abbott Cardiovascular Systems Inc. | Pro-healing agent formulation compositions, methods and treatments |
US8741326B2 (en) | 2006-11-17 | 2014-06-03 | Abbott Cardiovascular Systems Inc. | Modified two-component gelation systems, methods of use and methods of manufacture |
US8192760B2 (en) | 2006-12-04 | 2012-06-05 | Abbott Cardiovascular Systems Inc. | Methods and compositions for treating tissue using silk proteins |
WO2008106646A2 (en) * | 2007-03-01 | 2008-09-04 | Introgen Therapeutics, Inc | Methods and formulations for topical gene therapy |
US8182769B2 (en) | 2008-04-04 | 2012-05-22 | Biomet Biologics, Llc | Clean transportation system |
US8518272B2 (en) | 2008-04-04 | 2013-08-27 | Biomet Biologics, Llc | Sterile blood separating system |
US20110111526A1 (en) * | 2008-04-09 | 2011-05-12 | B.R.A.H.M.S Gmbh | Pro-endothelin-1 for the prediction of impaired peak oxygen consumption |
US9211554B2 (en) | 2010-06-30 | 2015-12-15 | Actamax Surgical Materials, Llc | Self-contained hand-held direct drive device for dispensing a two-part adhesive aerosol |
US8678238B2 (en) | 2010-06-30 | 2014-03-25 | Actamax Surgical Materials, Llc | Self-contained hand-held yoke-connected device for dispensing a two-part adhesive aerosol |
AU2012360048B2 (en) | 2011-12-29 | 2017-05-25 | Omrix Biopharmaceuticals Ltd. | Method and device for fast dissolution of solid protein composition |
US20130202656A1 (en) | 2012-02-03 | 2013-08-08 | Dynasil Biomedical Corporation | Systems and kits for the fabrication of tissue patches |
MX357254B (en) | 2012-05-14 | 2018-07-03 | Teijin Pharma Ltd | Sheet molding and hemostatic material. |
US20150265821A1 (en) | 2012-11-05 | 2015-09-24 | Smith & Nephew, Inc. | Assemblies and methods for fluid delivery |
USD772804S1 (en) * | 2013-09-05 | 2016-11-29 | Sony Corporation | Rechargeable battery |
EP3125774B1 (en) | 2014-04-04 | 2020-05-27 | HyperBranch Medical Technology, Inc. | Extended tip spray applicator for two-component surgical selant, and methods of use thereof |
US9833538B2 (en) | 2015-08-07 | 2017-12-05 | Xcede Technologies, Inc. | Adhesive compositions and related methods |
AU2016307447A1 (en) | 2015-08-07 | 2018-02-22 | Xcede Technologies, Inc. | Adhesive compositions and related methods |
US9540548B1 (en) | 2015-08-07 | 2017-01-10 | Xcede Technologies, Inc. | Adhesive compositions and related methods |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4650678A (en) * | 1982-02-04 | 1987-03-17 | Behringwerke Aktiengesellschaft | Readily dissolvable lyophilized fibrinogen formulation |
US4735616A (en) * | 1985-06-20 | 1988-04-05 | Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte | Arrangement for applying a tissue adhesive |
WO1992022312A1 (en) * | 1991-06-17 | 1992-12-23 | Wadstroem Jonas | Tissue treatment composition comprising fibrin or fibrinogen and biodegradable and biocompatible polymer |
WO1993005067A1 (en) * | 1991-09-05 | 1993-03-18 | Baxter International, Inc. | Topical fibrinogen complex |
WO1993019805A1 (en) * | 1992-03-02 | 1993-10-14 | Cryolife, Inc. | Fibrin sealant delivery method |
WO1996007444A1 (en) * | 1994-09-09 | 1996-03-14 | Bioseal, Limited Liability Corporation | Method of making fibrin coated substrates |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT359652B (en) * | 1979-02-15 | 1980-11-25 | Immuno Ag | METHOD FOR PRODUCING A TISSUE ADHESIVE |
ATE13810T1 (en) * | 1981-06-25 | 1985-07-15 | Serapharm Gmbh & Co Kg | ENRICHED PLASMA DERIVES TO ASSIST WOUND CLOSURE AND COVERAGE. |
ATE20824T1 (en) * | 1981-06-25 | 1986-08-15 | Serapharm Gmbh & Co Kg | ENRICHED PLASMA DERIVES TO SUPPORT WOUND CLOSURE AND HEALING. |
JPS63174924A (en) * | 1987-01-14 | 1988-07-19 | Toko Yakuhin Kogyo Kk | Ointment base and ointment |
FR2618784B1 (en) * | 1987-07-30 | 1990-04-06 | Lille Transfusion Sanguine | CONCENTRATE OF THROMBIN-COAGULABLE PROTEINS, PROCESS FOR OBTAINING SAME AND ITS USE AS A BIOLOGICAL GLUE |
US5461081A (en) * | 1989-09-28 | 1995-10-24 | Alcon Laboratories, Inc. | Topical ophthalmic pharmaceutical vehicles |
US5030215A (en) * | 1990-01-03 | 1991-07-09 | Cryolife, Inc. | Preparation of fibrinogen/factor XIII precipitate |
DE69324004T3 (en) * | 1992-09-26 | 2005-09-01 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | APPLICATOR FOR TISSUE ADHESIVE |
-
1997
- 1997-03-14 AU AU19411/97A patent/AU715822B2/en not_active Ceased
- 1997-03-14 US US08/945,882 patent/US5980866A/en not_active Expired - Lifetime
- 1997-03-14 CA CA002220927A patent/CA2220927C/en not_active Expired - Fee Related
- 1997-03-14 AT AT97907319T patent/ATE309006T1/en not_active IP Right Cessation
- 1997-03-14 DE DE69734557T patent/DE69734557T2/en not_active Expired - Fee Related
- 1997-03-14 EP EP97907319A patent/EP0835667B1/en not_active Revoked
- 1997-03-14 KR KR1019970708159A patent/KR100450142B1/en active IP Right Grant
- 1997-03-14 WO PCT/JP1997/000818 patent/WO1997033633A1/en active IP Right Grant
- 1997-03-14 DK DK97907319T patent/DK0835667T3/en active
-
1999
- 1999-04-28 US US09/299,916 patent/US6251370B1/en not_active Expired - Fee Related
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4650678A (en) * | 1982-02-04 | 1987-03-17 | Behringwerke Aktiengesellschaft | Readily dissolvable lyophilized fibrinogen formulation |
US4735616A (en) * | 1985-06-20 | 1988-04-05 | Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte | Arrangement for applying a tissue adhesive |
US5318524A (en) * | 1990-01-03 | 1994-06-07 | Cryolife, Inc. | Fibrin sealant delivery kit |
WO1992022312A1 (en) * | 1991-06-17 | 1992-12-23 | Wadstroem Jonas | Tissue treatment composition comprising fibrin or fibrinogen and biodegradable and biocompatible polymer |
WO1993005067A1 (en) * | 1991-09-05 | 1993-03-18 | Baxter International, Inc. | Topical fibrinogen complex |
WO1993019805A1 (en) * | 1992-03-02 | 1993-10-14 | Cryolife, Inc. | Fibrin sealant delivery method |
WO1996007444A1 (en) * | 1994-09-09 | 1996-03-14 | Bioseal, Limited Liability Corporation | Method of making fibrin coated substrates |
Non-Patent Citations (4)
Title |
---|
KRAM H B ET AL: "SPRAYING AEROSOLIZED FIBRIN GLUE IN THE TREATMENT OF NONSUTURABLE HEMORRHAGE" AMERICAN SURGEON, vol. 57, no. 6, 1991, pages 381-384, XP001037761 ISSN: 0003-1348 * |
SANDERS ROBERT P ET AL: "Effect of fibrinogen and thrombin concentrations on mastectomy seroma prevention." JOURNAL OF SURGICAL RESEARCH, vol. 61, no. 1, 1996, pages 65-70, XP001034090 ISSN: 0022-4804 * |
See also references of WO9733633A1 * |
SPOTNITZ W D ET AL: "REDUCTION OF PERIOPERATIVE HEMORRHAGE BY ANTERIOR MEDIASTINAL SPRAY APPLICATION OF FIBRIN GLUE DURING CARDIAC OPERATIONS" ANNALS OF THORACIC SURGERY, vol. 44, no. 5, 1987, pages 529-531, XP001034057 ISSN: 0003-4975 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6783514B2 (en) | 1997-01-31 | 2004-08-31 | United States Surgical Corporation | Fibrin sealant applicator |
US6471670B1 (en) | 1998-10-05 | 2002-10-29 | Karl Enrenfels | Fibrin sealant applicator system |
US7018357B2 (en) | 2001-02-27 | 2006-03-28 | Tyco Healthcare Group Lp | External mixer assembly |
US9775930B2 (en) | 2006-11-17 | 2017-10-03 | Abbott Cardiovascular Systems Inc. | Composition for modifying myocardial infarction expansion |
Also Published As
Publication number | Publication date |
---|---|
AU715822B2 (en) | 2000-02-10 |
US6251370B1 (en) | 2001-06-26 |
WO1997033633A1 (en) | 1997-09-18 |
ATE309006T1 (en) | 2005-11-15 |
KR19990014815A (en) | 1999-02-25 |
CA2220927C (en) | 2008-04-22 |
EP0835667A4 (en) | 2002-02-20 |
CA2220927A1 (en) | 1997-09-18 |
EP0835667B1 (en) | 2005-11-09 |
DE69734557D1 (en) | 2005-12-15 |
DK0835667T3 (en) | 2005-12-05 |
US5980866A (en) | 1999-11-09 |
KR100450142B1 (en) | 2004-11-16 |
DE69734557T2 (en) | 2006-07-27 |
AU1941197A (en) | 1997-10-01 |
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