EP0861427A1 - Temperature indicating device - Google Patents
Temperature indicating deviceInfo
- Publication number
- EP0861427A1 EP0861427A1 EP96939538A EP96939538A EP0861427A1 EP 0861427 A1 EP0861427 A1 EP 0861427A1 EP 96939538 A EP96939538 A EP 96939538A EP 96939538 A EP96939538 A EP 96939538A EP 0861427 A1 EP0861427 A1 EP 0861427A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- temperature
- indicating
- microporous membrane
- indicating device
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims abstract description 161
- 239000012982 microporous membrane Substances 0.000 claims abstract description 130
- 238000009736 wetting Methods 0.000 claims abstract description 76
- 150000001875 compounds Chemical class 0.000 claims abstract description 70
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 53
- 230000008014 freezing Effects 0.000 claims abstract description 47
- 238000007710 freezing Methods 0.000 claims abstract description 47
- 239000000463 material Substances 0.000 claims description 82
- 239000007788 liquid Substances 0.000 claims description 40
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 34
- -1 poiysulfone Polymers 0.000 claims description 28
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 26
- WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 claims description 22
- 239000003086 colorant Substances 0.000 claims description 22
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 15
- 239000011888 foil Substances 0.000 claims description 13
- 229920000098 polyolefin Polymers 0.000 claims description 11
- 150000001335 aliphatic alkanes Chemical class 0.000 claims description 9
- 150000001336 alkenes Chemical class 0.000 claims description 9
- 238000007711 solidification Methods 0.000 claims description 9
- 230000008023 solidification Effects 0.000 claims description 9
- 230000004044 response Effects 0.000 claims description 8
- 230000005540 biological transmission Effects 0.000 claims description 7
- 150000001298 alcohols Chemical class 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 150000002576 ketones Chemical class 0.000 claims description 6
- 150000002894 organic compounds Chemical class 0.000 claims description 6
- 230000003100 immobilizing effect Effects 0.000 claims description 5
- 229920000728 polyester Polymers 0.000 claims description 5
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 claims description 4
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 4
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims description 4
- LCZVSXRMYJUNFX-UHFFFAOYSA-N 2-[2-(2-hydroxypropoxy)propoxy]propan-1-ol Chemical compound CC(O)COC(C)COC(C)CO LCZVSXRMYJUNFX-UHFFFAOYSA-N 0.000 claims description 4
- 239000002202 Polyethylene glycol Substances 0.000 claims description 4
- 150000002170 ethers Chemical class 0.000 claims description 4
- 150000002334 glycols Chemical class 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- 229920000166 polytrimethylene carbonate Polymers 0.000 claims description 4
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 claims description 4
- 150000001412 amines Chemical class 0.000 claims description 3
- 229920002678 cellulose Polymers 0.000 claims description 3
- 229920002313 fluoropolymer Polymers 0.000 claims description 3
- 239000004811 fluoropolymer Substances 0.000 claims description 3
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 3
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 3
- 230000000979 retarding effect Effects 0.000 claims description 3
- 239000004952 Polyamide Substances 0.000 claims description 2
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 2
- 229920001400 block copolymer Polymers 0.000 claims description 2
- OWBTYPJTUOEWEK-UHFFFAOYSA-N butane-2,3-diol Chemical compound CC(O)C(C)O OWBTYPJTUOEWEK-UHFFFAOYSA-N 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- 239000011140 metalized polyester Substances 0.000 claims description 2
- 229920002647 polyamide Polymers 0.000 claims description 2
- 229960004418 trolamine Drugs 0.000 claims description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 4
- 235000019437 butane-1,3-diol Nutrition 0.000 claims 1
- 239000010410 layer Substances 0.000 description 72
- 239000012528 membrane Substances 0.000 description 55
- 230000004888 barrier function Effects 0.000 description 54
- 239000000853 adhesive Substances 0.000 description 24
- 230000001070 adhesive effect Effects 0.000 description 24
- 239000011148 porous material Substances 0.000 description 23
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 21
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 15
- 238000012360 testing method Methods 0.000 description 14
- 239000000975 dye Substances 0.000 description 13
- 239000007787 solid Substances 0.000 description 13
- 239000004743 Polypropylene Substances 0.000 description 12
- 229920001155 polypropylene Polymers 0.000 description 12
- 239000004698 Polyethylene Substances 0.000 description 9
- 230000008859 change Effects 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- 229920000573 polyethylene Polymers 0.000 description 9
- 235000013772 propylene glycol Nutrition 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 8
- 229920000139 polyethylene terephthalate Polymers 0.000 description 8
- 239000005020 polyethylene terephthalate Substances 0.000 description 8
- 229960004063 propylene glycol Drugs 0.000 description 8
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 7
- 238000005065 mining Methods 0.000 description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 230000004913 activation Effects 0.000 description 6
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 6
- 238000007789 sealing Methods 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 229920001169 thermoplastic Polymers 0.000 description 6
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 5
- 229910052782 aluminium Inorganic materials 0.000 description 5
- 238000010276 construction Methods 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 229920001684 low density polyethylene Polymers 0.000 description 5
- 239000004702 low-density polyethylene Substances 0.000 description 5
- 239000000123 paper Substances 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 239000000523 sample Substances 0.000 description 5
- 239000000377 silicon dioxide Substances 0.000 description 5
- 238000010998 test method Methods 0.000 description 5
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 4
- 229920004439 Aclar® Polymers 0.000 description 4
- 229920004457 Aclar® Rx 160 Polymers 0.000 description 4
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 4
- 239000012790 adhesive layer Substances 0.000 description 4
- 239000002667 nucleating agent Substances 0.000 description 4
- 239000005023 polychlorotrifluoroethylene (PCTFE) polymer Substances 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- 239000004800 polyvinyl chloride Substances 0.000 description 4
- 239000002562 thickening agent Substances 0.000 description 4
- 229920002554 vinyl polymer Polymers 0.000 description 4
- 239000004820 Pressure-sensitive adhesive Substances 0.000 description 3
- 239000003708 ampul Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000007613 environmental effect Effects 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 230000002427 irreversible effect Effects 0.000 description 3
- 230000008018 melting Effects 0.000 description 3
- 238000002844 melting Methods 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 238000004806 packaging method and process Methods 0.000 description 3
- 239000000049 pigment Substances 0.000 description 3
- 229920001296 polysiloxane Polymers 0.000 description 3
- 229920000915 polyvinyl chloride Polymers 0.000 description 3
- 238000009877 rendering Methods 0.000 description 3
- 230000002269 spontaneous effect Effects 0.000 description 3
- 238000004781 supercooling Methods 0.000 description 3
- 239000004416 thermosoftening plastic Substances 0.000 description 3
- 230000000007 visual effect Effects 0.000 description 3
- 229940035437 1,3-propanediol Drugs 0.000 description 2
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- HMEKVHWROSNWPD-UHFFFAOYSA-N Erioglaucine A Chemical compound [NH4+].[NH4+].C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 HMEKVHWROSNWPD-UHFFFAOYSA-N 0.000 description 2
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 description 2
- RZSYLLSAWYUBPE-UHFFFAOYSA-L Fast green FCF Chemical compound [Na+].[Na+].C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC(O)=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 RZSYLLSAWYUBPE-UHFFFAOYSA-L 0.000 description 2
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- 150000001408 amides Chemical class 0.000 description 2
- 239000012298 atmosphere Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 235000010980 cellulose Nutrition 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 229920001971 elastomer Polymers 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 229910021485 fumed silica Inorganic materials 0.000 description 2
- 238000005191 phase separation Methods 0.000 description 2
- 244000144977 poultry Species 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 2
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 2
- 239000005060 rubber Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 238000003856 thermoforming Methods 0.000 description 2
- 229960005486 vaccine Drugs 0.000 description 2
- 239000011800 void material Substances 0.000 description 2
- UOCLXMDMGBRAIB-UHFFFAOYSA-N 1,1,1-trichloroethane Chemical compound CC(Cl)(Cl)Cl UOCLXMDMGBRAIB-UHFFFAOYSA-N 0.000 description 1
- UDJZTGMLYITLIQ-UHFFFAOYSA-N 1-ethenylpyrrolidine Chemical compound C=CN1CCCC1 UDJZTGMLYITLIQ-UHFFFAOYSA-N 0.000 description 1
- KPIQXPLWZCDIHI-ISLYRVAYSA-N 5-hydroxy-1-(4-sulfophenyl)-4-[(e)-(4-sulfophenyl)diazenyl]-1h-pyrazole-3-carboxylic acid Chemical compound OC(=O)C1=NN(C=2C=CC(=CC=2)S(O)(=O)=O)C(O)=C1\N=N\C1=CC=C(S(O)(=O)=O)C=C1 KPIQXPLWZCDIHI-ISLYRVAYSA-N 0.000 description 1
- DXPPIEDUBFUSEZ-UHFFFAOYSA-N 6-methylheptyl prop-2-enoate Chemical compound CC(C)CCCCCOC(=O)C=C DXPPIEDUBFUSEZ-UHFFFAOYSA-N 0.000 description 1
- 229920004441 Aclar® 22A Polymers 0.000 description 1
- 229920004447 Aclar® SupRx 900 Polymers 0.000 description 1
- 229920002126 Acrylic acid copolymer Polymers 0.000 description 1
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 1
- 229910002012 Aerosil® Inorganic materials 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 229920013683 Celanese Polymers 0.000 description 1
- 229920001651 Cyanoacrylate Polymers 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 239000004214 Fast Green FCF Substances 0.000 description 1
- 239000004831 Hot glue Substances 0.000 description 1
- 229920010126 Linear Low Density Polyethylene (LLDPE) Polymers 0.000 description 1
- 229920000459 Nitrile rubber Polymers 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 241000206607 Porphyra umbilicalis Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 229920003027 Thinsulate Polymers 0.000 description 1
- 239000004789 Thinsulate Substances 0.000 description 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 150000003926 acrylamides Chemical class 0.000 description 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 235000012745 brilliant blue FCF Nutrition 0.000 description 1
- 239000004161 brilliant blue FCF Substances 0.000 description 1
- NTXGQCSETZTARF-UHFFFAOYSA-N buta-1,3-diene;prop-2-enenitrile Chemical compound C=CC=C.C=CC#N NTXGQCSETZTARF-UHFFFAOYSA-N 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- NLCKLZIHJQEMCU-UHFFFAOYSA-N cyano prop-2-enoate Chemical class C=CC(=O)OC#N NLCKLZIHJQEMCU-UHFFFAOYSA-N 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000011038 discontinuous diafiltration by volume reduction Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 125000003700 epoxy group Chemical group 0.000 description 1
- 229940093476 ethylene glycol Drugs 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 235000019240 fast green FCF Nutrition 0.000 description 1
- 239000002657 fibrous material Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000008398 formation water Substances 0.000 description 1
- 235000013611 frozen food Nutrition 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000005337 ground glass Substances 0.000 description 1
- 238000009998 heat setting Methods 0.000 description 1
- 239000011796 hollow space material Substances 0.000 description 1
- 239000012943 hotmelt Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000002655 kraft paper Substances 0.000 description 1
- 229920000092 linear low density polyethylene Polymers 0.000 description 1
- 239000004707 linear low-density polyethylene Substances 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000002808 molecular sieve Substances 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920000647 polyepoxide Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920000346 polystyrene-polyisoprene block-polystyrene Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
- 238000000807 solvent casting Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 229920000468 styrene butadiene styrene block copolymer Polymers 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 235000012756 tartrazine Nutrition 0.000 description 1
- 239000004149 tartrazine Substances 0.000 description 1
- 229960000943 tartrazine Drugs 0.000 description 1
- UJMBCXLDXJUMFB-GLCFPVLVSA-K tartrazine Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-GLCFPVLVSA-K 0.000 description 1
- 238000002145 thermally induced phase separation Methods 0.000 description 1
- 229920001187 thermosetting polymer Polymers 0.000 description 1
- 125000002348 vinylic group Chemical group 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01K—MEASURING TEMPERATURE; MEASURING QUANTITY OF HEAT; THERMALLY-SENSITIVE ELEMENTS NOT OTHERWISE PROVIDED FOR
- G01K11/00—Measuring temperature based upon physical or chemical changes not covered by groups G01K3/00, G01K5/00, G01K7/00 or G01K9/00
- G01K11/06—Measuring temperature based upon physical or chemical changes not covered by groups G01K3/00, G01K5/00, G01K7/00 or G01K9/00 using melting, freezing, or softening
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S252/00—Compositions
- Y10S252/962—Temperature or thermal history
Definitions
- This invention relates to critical temperature indicating devices More particularly, it relates to a critical temperature indicating device comprising an indicating composition that provides an irreversible visual signal to the user that a product has been exposed to a predetermined temperature
- Blood, emulsions, pharmaceuticals, beverages, and other items are often chilled in order that they may be preserved for later use If exposed to too low a temperature, however, the characteristics of these items may change so that they are undesirable for later use In fact, many of these items may be rendered completely useless if exposed to too low a temperature, such as the freezing point of water It is, therefore, desirable to provide an indicating device that will accurately show whether or not the item is exposed to a temperature below a critical value It is also typically desirable for the device to provide its indication relatively rapidly and that the indication be irreversible so that the user will be alerted to a previously attained c ⁇ tical temperature, even if that condition is not maintained
- Critical temperature indicating devices are known that utilize the expansion characteristic of water to break a frangible ampule That is, once the indicating device is exposed to a temperature below the freezing point of water, the volume increases as the water in the ampule changes to ice, thereby causing the ampule to break After the ice is formed and the surrounding temperature returned to a point about the melting point ofthe ice, the resultant water is absorbed by a pad, thus providing an indication that the device had gone through a freeze stage and back through a thaw stage
- Such indicating devices are not always accurate due to the super-cooling effect of water Under some conditions, water may be cooled to as low as -16°C without freezing This problem has been partially overcome by the addition of nucleating agents to the water to enhance ice formation
- Water-based indicating devices are also known that utilize a microporous layer water, and a second liquid that can wet out the microporous layer upon solidification ofthe water See, U S Patent No 4,846,095 (Emslander) The
- the present invention provides a device for indicating if an object is exposed to a critical temperature; the indicating device comprising: (a) a microporous membrane;
- composition containing less than about 10 wt-% water; the composition comprising:
- a major amount of a primary organic component comprising at least one compound that has a freezing point above the critical temperature and does not spontaneously wet out the microporous membrane at a temperature at least about 0°C above the critical temperature;
- a modifying component comprising at least one compound that has a freezing point below the critical temperature
- a wetting component comprising at least one compound that has a freezing point below the critical temperature and is capable of spontaneously wetting out the microporous membrane at about the critical temperature
- the present invention also provides a device for indicating if an object is exposed to a critical temperature; the indicating device comprising:
- composition containing less than about 1 wt-% water; the composition comprising: (i) at least about 50 wt-%) of a primary organic component comprising at least one compound that has a freezing point above the critical temperature and does not spontaneously wet out the microporous membrane at a temperature at least about
- (c) means for containing the microporous membrane and the indicating composition, wherein the p ⁇ mary organic component, modifying component, and wetting component are miscible liquids above the cntical temperature, and are present in a ratio such that the composition does not spontaneously wet out the microporous membrane at a temperature at least about 30°C above the c ⁇ tical temperature, but does spontaneously wet it out at about the critical temperature upon solidification of a portion ofthe composition
- a further embodiment ofthe present invention is a device for indicating if an object is exposed to a c ⁇ tical temperature, the indicating device comp ⁇ sing
- composition (a) a microporous membrane comp ⁇ sing a polyolefin, (b) an indicating composition containing less than about 1 wt-% water, the composition comprising
- a wetting component compnsing at least one compound selected from the group consisting of alcohols, ketones, ethers, alkanes, alkenes, amines, and combinations thereof, wherein the compound has a freezing point below the critical temperature and is capable of spontaneously wetting out the microporous membrane at about the critical temperature, and (c) means for containing the microporous membrane and the indicating composition and retarding transmission of water vapor into the indicating composition, wherein the primary organic component, modifying component, and wetting component are miscible liquids above the critical temperature, and are present in a ratio such that the composition does not spontaneously wet out the microporous membrane at a temperature at least about 30°C above the c ⁇ tical temperature, but does spontaneously wet it out at about the critical temperature upon solidification of a portion ofthe composition
- a wetting component compnsing at least one compound selected from the group consisting of alcohols, ketones, ethers, alkanes, alkenes, amines, and
- activated refers to the condition of the indicating device wherein the microporous membrane has been "wetted out” thereby providing an irreversible indication (e.g., a message or a colored composition) that the device has been exposed to the critical temperature for which it was designed,
- critical temperature refers to the temperature at, or below which, the object being monitored is damaged such that it is undesirable for later use, at this temperature, a portion of the indicating composition solidifies sufficiently to change the surface tension of the indicating composition and cause wetting out of the pores of the microporous membrane,
- microporous membrane refers to a polymeric material having a void volume (i.e., the total amount of space not occupied by polymer) ranging from about 20%) to about 90%) which is characterized by having open porosity (i.e , external pores or pores open to the surface of the membrane) with interconnected channels, "miscible liquids” refers to a combination of two or more liquids that form a clear solution upon viewing by the unaided eye,
- response time refers to the time required for the indicating device of the present invention to be activated at the critical temperature for which it is designed
- surface energy refers to the critical wetting tension ( ⁇ c ) of a solid, which is equal to the surface tension of a liquid that would yield a zero contact angle when placed in contact with the solid (i e , when the liquid completely wets out the solid)
- surface tension refers to the force acting on the surface of a liquid tending to minimize the area ofthe surface and is equal to the free energy per unit surface area
- spontaneous wet out refers to entry of a portion ofthe liquid indicating composition into the pores ofthe microporous membrane in the absence of a pressure gradient across the membrane; the portion ofthe liquid indicating composition that enters the pores ofthe microporous membrane includes at least the wetting component, but it also may include the modifying component and/or nonsolidified primary component
- Figure 1 is a sectional view of one embodiment ofthe indicating device of this invention
- Figure 2 is a sectional view of a second embodiment ofthe indicating device of this invention.
- Figure 3 is a sectional view of a third embodiment ofthe indicating device of this invention
- Figure 4 is a sectional view of the embodiment of Figure 3 adhered to an object being monitored
- the present invention provides a device for indicating whether an object has been exposed to a critical temperature (i e., a predetermined temperature below which the object should not be exposed)
- the indicating device includes a microporous membrane, an indicating composition containing less than about 10 percent by weight (wt-%)) water, based on the total weight ofthe indicating composition, and means for containing the microporous membrane and the indicating composition, and preferably, retarding the transmission of water vapor into the indicating composition
- the indicating composition contains less than about 1 wt-%> water
- indicating devices containing less than about 10 wt-% water are not sub j ect to the problems associated with super-cooling They tend to be relatively rapidly responsive
- preferred indicating devices of the present invention have a response time of no greater than about 60 minutes (more preferably, no greater than about 45 minutes, and most preferably no greater than about 30 minutes) They also tend to be more precise and reproducible within a relatively narrow temperature range
- indicating devices of the present invention
- the indicating composition can be a solution a dispersion, a gel (l e , a high viscosity solution or dispersion) or the like It includes at least three components a first organic component (I e , the p ⁇ mary organic component) that includes at least one compound that has a freezing point above the critical temperature and does not spontaneously wet out the microporous membrane at a temperature at least about 30°C above the desired c ⁇ tical temperature of the object (e g , pharmaceutical substance, plant mate ⁇ al, microorganism etc ) being monitored, a second component (I e , the modifying component) that includes at least one compound that has a freezing point below the critical temperature (I e , it is a liquid at the c ⁇ tical temperature and is used to modify the temperature at which the indicating device is activated), and a third component (I e , the wetting component) that includes at least one compound that has a freezing point below the c ⁇ tical temperature and is capable of spontaneously wetting
- the temperature at which the primary organic component solidifies can be modified through the use ofthe modifying component
- the pure form ofthe p ⁇ mary organic component (or pure torms of the individual compounds ofthe p ⁇ mary organic component if more than one compound is used) has a freezing point above (preferably, at least about 5°C above) the critical temperature for which the indicating device is designed
- the pure form ofthe modifying component (or pure forms ofthe individual compounds ofthe modifying component if more than one compound is used) has a freezing point below (preferably, at least about 5°C below) the c ⁇ tical temperature for which the indicating device is designed
- the modifying component may cocrystallize with the p ⁇ mary organic component or may simply depress its freezing point
- the temperature at which the p ⁇ mary organic component solidifies (1 e , its freezing temperature) when pure is higher than the temperature at which solidification occurs in the indicating composition
- a portion ofthe indicating composition solidifies, the concentration ofthe wetting component in the
- the device is a visual indicator in that the membrane is initially opaque and becomes transparent, or at least translucent when it is wetted out Under normal conditions of use (1 e , temperatures of about 0- 60°C without a pressure gradient across the membrane), the membrane will stay generally transparent or translucent If colorant, such as a dye or pigment, is present, however, the membrane will not necessarily become transparent or even translucent Rather, the colorant can be carried into the pores ofthe membrane and thereby change the color ofthe membrane This change in opacity and/or color indicates that the temperature has dropped to, or below, the c ⁇ tical temperature to be indicated
- the indicating device ofthe present invention can be in a vanety of configurations That is, means for containing the indicating composition and microporous membrane can be in the form of a pouch, a blister pack, etc The container is
- the temperature indicating device 10 includes two layers 12 and 13 of bar ⁇ er mate ⁇ al, each of which is bonded to a microporous membrane 14 and 15, thereby forming reservoir 16 between microporous membranes 14 and 15
- the microporous membranes may be bonded to the barrier layers about their penphery, or across the entire membrane That is, microporous membrane 14, for example, can be bonded to barrier layer 12 about the periphery ofthe membrane Alternatively, the entire surface ofthe membrane can be bonded to the barrier layer Barrier layers 12 and 13 are preferably bonded to microporous membranes 14 and 15 by heat sealing, although an adhesive or alternative means of bonding could be used
- Reservoir 16 contains the indicating composition It is believed that once the indicating device is exposed to the critical temperature for which it is designed, at least the primary organic component solidifies (which may cocrystallize with either the modifying component or the wetting component or both) and the concentration ofthe wetting component increases in the liquid phase to a point where this nonsolidified portion ofthe
- the reservoir can also be formed by a washer (i e , a flat ring) made of a nonporous material, such as a thermoplastic, thermoset, or metallic material This washer is adhered to a layer of a barrier material on one side, and a second layer of a barrier material with a microporous membrane adhered thereto is adhered to the other side ofthe washer The reservoir is thereby formed for placement ofthe indicating composition
- a layer of adhesive on a release liner could also be a temporary barrier, thereby eliminating the need for a barrier layer at least on one side ofthe indicating device Once the release liner is removed, the adhesive could be placed against a glass container, or some other object, that could act as a barrier. Alternatively, if the adhesive is sufficiently hydrophobic (e.g., a rubber-based adhesive), it may serve as a barrier even when place on a porous substrate.
- the barrier material not only provides the container for the indicating composition and microporous membrane, but it can provide a barrier to retard the evaporation ofthe components ofthe indicating composition and it acts to seal out water and water vapor, which may adversely affect the reproducibility and precision of the indicating device.
- the barrier material is typically at least partially transmissive to visible light so that the visible indicator may be seen therethrough once the indicating device has been activated. If the barrier material is attached to a surface ofthe object being monitored and is therefore on the "backside" of the indicating device, however, it does not need to be transmissive to visible light.
- an indicating device can include more than one type of barrier material, as long as at least a portion ofthe barrier material is at least partially transmissive to visible light.
- the temperature indicating device 20 includes a thermoformed barrier material 22 and a microporous membrane 24 bonded thereto, and backing 28 bonded to the periphery ofthe thermoformed barrier material 22, thereby forming reservoir 26 for the indicating composition.
- Thermoformed barrier material 22 is preferably bonded to microporous membrane 24 using a layer of adhesive (not shown) about the periphery ofthe membrane, although other means of bonding can be used (e.g., thermal and ultrasonic welding).
- a layer of adhesive not shown
- backing 28 is not transmissive to visible light, although it could be if desired.
- backing 28 could be made ofthe same material as thermoformed barrier material 22, although it is generally preferred that the backing 28 be made of a metallic foil, plastic, or a laminate that has a sufficiently low water vapor transmission rate and that prevents the transmission of visible light.
- the backing 28 can be coated with a heat sealable material such that it can be thermally bonded to the thermoformed barrier material 22, although an adhesive could be used.
- the backing 28 can bear an image (e g , "REJECT” or “FROZEN 7 ') thereon that cannot be seen through microporous membrane 24 prior to the indicating device being activated Once activated, however, the image could be seen through the thermoformed barrier material 22 and the microporous membrane 24 Alternatively, the indicating composition could include a colorant that would be seen upon wetting out ofthe microporous membrane, or the indicating composition could be colorless and backing 28 could be colored
- the temperature indicating device 30 includes a layer 32 of barrier material, thermoformed barrier material 33, and microporous membrane 34
- the microporous membrane 34 is bonded to the barrier material 32, preferably by heat sealing, although an adhesive layer or other means of sealing could be used
- the ba ⁇ ier material 32 is bonded to thermoformed barrier material 33, thereby forming reservoir 36 for the indicating composition
- the microporous membrane 34 can be fused between the barrier material 32 and the thermoformed barrier material 33 depending on the materials used
- Thermoformed barrier material 33 is backed with an adhesive layer 38 forming hollow space 39
- Adhesive layer 38 is used to attach the indicating device to the surface of the object to be monitored
- bar ⁇ er mate ⁇ al 32 is at least partially transmissive to visible light because that is the portion of the indicating device through which a person would look
- the indicating composition in this embodiment would include a colorant, such that it would become visible as a result ofthe microporous membrane losing its opacity and/or as a result
- the temperature indicating device 40 includes a layer 42 of barrier material, thermoformed barrier material 43, and microporous membrane 44
- the microporous membrane 44 is bonded to the barrier material 42, preferably by heat sealing, although an adhesive layer or other means of sealing could be used
- the barrier material 42 is bonded to thermoformed barrier material 43, thereby forming reservoir 46 for the indicating composition
- the microporous membrane 44 can be fused between the barrier material 42 and the thermoformed barrier material 43 depending on the materials used.
- Indicating device 40 is positioned against container 47 and held in place by extensions 48 and 49 of thermoformed bamer mate ⁇ al 43 Alternatively, or additionally, indicating device 40 can be held in place by adhesive positioned between the surfaces ofthe indicating device and the container that are in contact Polyme ⁇ c microporous membranes (depicted as, for example, 14 and 15 in
- Figure 1 may be made from polyolefins such as polypropylene and polyethylene, polysulfones, polytetrafluoroethylene (PTFE), polyamide, polyester, cellulose acetate and other cellulose derivatives, and the like, as well as from combinations of these polymers
- Preferred microporous membranes include polyolefins such as polyethylene or polypropylene
- Microporous membranes may be produced by solvent casting of polymers, or by a phase separation processes, for example The surface energy ofthe membranes can be modified by corona treating, flame treating, or by adding a surface active agent, for example
- Suitable microporous membranes have a void volume of about 20-90%, more preferably about 40-85%
- the structure is characte ⁇ zed by having open porosity with interconnected channels
- An example of a material that is suitable for use as the microporous membrane is described in U S Patent No 4,726,989 (Mrozinski)
- This microporous membrane includes a multiplicity of spaced, randomly dispersed, nonuniformly shaped, equiaxed (I e , approximately equal dimensions in all directions) particles of a crystallizable thermoplastic polymer (e g , a polyolefin such as polypropylene) coated with a compound with which the thermoplastic polymer is miscible
- a crystallizable thermoplastic polymer e g , a polyolefin such as polypropylene
- these particles are separated from one another to provide a network of interconnected micropores, yet they are connected to one another by fibrils ofthe thermoplastic polymer
- these particles include
- microporous membranes include a particle-filled polyethylene commercially available under the trade designation "EXXAIRE FILM” from Exxon Chemical Co of Florida, TX, and polypropylene membranes commercially avaiiable under the trade designation “AKZO” from Akzona of Germany or “CELGARD” from Hoechst Celanese of Sommerville, NJ Also available are particle- filled microporous membranes available under the trade designation "EXEPORE” from Mitsubishi Chemical of Yokohama, Japan
- the micropores ofthe microporous membrane cause scattering of incident light, causing the microporous membrane to appear opaque
- the voids are substantially filled with a liquid having substantially the same index of refraction as the matenal ofthe microporous membrane, the substantially filled voids result in a dramatic decrease in scattering, thus rende ⁇ ng the microporous layer transmissive to visible light
- the indicating composition of the present invention includes a colorant, the wetting compound does not have to have substantially the same index of
- the bamer mate ⁇ al is at least partially transmissive to visible light, although it can be completely opaque
- Suitable barrier materials include polymeric films, metallized polyme ⁇ c films, metallic foils, and laminates compnsing films and foils
- at least one ofthe layers of bamer matenal is at least partially transmissive to visible light, so that the change in the opacity of the membrane is visible when the c ⁇ tical temperature is reached
- the prefened bamer mate ⁇ als are such polymeric films as fluoropolymers, polyolefins such as polyethylene, polyesters halogenated polyolefins such as polyvinyl chlo ⁇ de, metallized polyesters, and metallic foils such as aluminum
- Suitable commercially available bar ⁇ er materials include laminated mate ⁇ als
- One such laminate is a polymeric laminate commercially available under the product designation "MLL-B-22191 , Type 1, Class 2" from Georgia Packaging, Inc of Columbus, GA
- thermoformable matenal is used in making blister packages
- shaped mate ⁇ als are particularly useful for protecting gelatin capsules for the pharmaceutical industry
- thermoformable materials include polyvinyl chlo ⁇ des, polystyrenes, polycarbonates, cellulosics, and the like
- Prefened thermoformable bamer matenals are laminated "ACLAR" materials, which are commercially available from Tek Plex, Inc of Somerville, NJ
- barrier materials having WVTR values of less than about 1 g/m 2 /24 hours are prefened, this is not a requirement
- Materials that are permeable to water vapor and/or environmental gases can be used to form the containment means, however, such materials are not suitable for highly hygroscopic indicating compositions
- a wide variety of materials can be used to form the bar ⁇ er mate ⁇ al Examples include a polyester copolymer available under the trade designation "SCOTCHPAK 146" from Minnesota Mining and Manufacturing Company of St Paul, MN as well as other "SCOTCHPAK” st ⁇ ppable lid films
- the bamer material may have an image applied thereto, which will be masked when the pores ofthe microporous membrane are not wetted out (l e , when the microporous membrane appears opaque), but will be visible when the pores ofthe microporous membrane are wetted out (thus appearing transparent or translucent)
- the image can be a printed message on at least one major surface
- the indicating composition contains less than about 10 wt-%> water Preferably, it contains less than about 1 wt-%) water Compositions with less than about 10 wt-% water, and particularly with less than about 1 wt-%, provide indicating devices with good precision and reproducibility For example, they will preferably be reproducibly activated within about ⁇ 2°C, and more preferably within about ⁇ I °C, of the desired c ⁇ tical temperature, using the test method descnbed in the examples section, which generally involves a cooling rate of 1°C/ 30 minutes Compositions with less than about 10 wt-%> water provide indicating devices with relatively short response times For example, the indicating devices ofthe present invention preferably respond m no greater than about 60 minutes, more preferably, in no greater than about 45 minutes, and most preferably, in no greater than about 30 minutes Furthermore, they make it possible to indicate at temperatures other than 0°C
- the pnmary organic component includes compounds that do not wet out the microporous membrane under normal use and/or transportation conditions Typically, suitable compounds for use in the p ⁇ mary orgamc component do not spontaneously wet out the microporous membrane at a temperature at least about 30°C above the critical temperature Preferred such compounds do not spontaneously wet it out at a temperature at least about 45°C (and more preferably, at least about 60°C) above the critical temperature
- the wetting component includes compounds that do spontaneously wet out the microporous membrane at about the critical temperature In its initial state (i e , prior to being activated), the indicating composition does not spontaneously wet out the microporous membrane at a temperature at least about 30°C above the critical temperature for which the indicating device is designed It is believed that at or below about the desired critical temperature (i e., the temperature to be avoided), a sufficient amount ofthe primary organic component solidifies, causing the concentration of the wetting component to increase, allowing the remaining liquid portion (i e
- the membrane becomes at least partially transmissive to visible light If a colorant (i e , a pigment or dye) is present, the color will be apparent when the membrane becomes transparent If a soluble colorant is in the indicating composition, the colorant can be carried into the pores ofthe microporous membrane The microporous membrane then changes from opaque (white) to the color ofthe colorant (e g , dye)
- the colorant When a colorant is used, it is preferably soluble in the indicating composition within the temperature range over which the indicating device is to be used
- the colorant typically in the form of a pigment or dye, can penetrate the pores ofthe microporous membrane once the temperature has dropped to about the critical temperature It can also remain in the pores even if the indicating device is exposed to elevated temperatures within normal use and transportation conditions
- the color imparted to the device by the colorant should be easily seen by the unaided eye
- the colorant is generally safe for human contact, such as a food-grade dye
- Preferred dyes are commercially available under the product designations "ERIOGLAUCINE” (blue CI 42090), “ERITHROSIN B” (red CI 45430), “TARTRAZINE” (yellow CI 19140), and "FAST GREEN FCF”(green CI 42053) from Aldrich Chemical Co of Milwaukee, WI
- the colorant is added in an amount sufficient to color the indicating composition and make the color change apparent
- the primary organic component includes at least one organic compound that does not enter the pores ofthe microporous membrane when in the pure state at least in the absence of a pressure gradient across the membrane at a temperature at least about 30°C above the critical temperature for which the indicating device is designed Prefened such compounds do not spontaneously wet it out at a temperature at least about 45°C (and more preferably, at least about 60°C) above the critical temperature
- Such compounds have a generally high dipole moment resulting in a generally high surface tension
- the surface tension is greater than about 30 dynes/cm, more preferably, greater than about 35 dynes/cm, and most preferably, greater than about 40 dynes/cm, as measured using ASTM Test Method Dl 331-89, Method A, at 23 °C for materials that are liquid at this temperature
- the surface tension is measured at 5°C above the freezing point
- the surface tension of the primary organic component is greater than the surface energy of the microporous membrane chosen For example, for example, for example, for
- the freezing point of such compounds are no more than about 60°C above the desired critical temperature
- Suitable compounds include polyfunctional alcohols such as 1,3 -propanediol, ethylene glycol, di(ethylene glycol), glycerol, tripropylene glycol, as well as polyethoxylated derivatives of these glycols, and polyethylene glycol
- suitable compounds include very polar esters and amides, for example
- the primary organic component comprises at least one polyfunctional alcohol
- the modifying component includes at least one compound that has a freezing point below (preferably, at least about 5°C below, more preferably, at least about 10°C below, and most preferably, at least about 15°C below) the desired critical temperature.
- the freezing point of such compounds are no more than about 60°C below the desired critical temperature
- such compounds do not spontaneously enter the pores ofthe microporous membrane when in a pure state in the absence of a pressure gradient across the membrane at a temperature at least about 30°C above the critical temperature (although when mixed with the wetting component, the modifying component may contribute to the wet out ofthe membrane)
- compounds suitable for use in the modifying component do not spontaneously wet out the microporous membrane at a temperature at least about 45°C (and most preferably, at least about 60°C) above the critical temperature
- Preferred compounds suitable for use in the modifying component have a generally high dipole moment resulting in a generally high surface tension.
- the surface tension is greater than about 30 dynes/cm, more preferably, greater than about 35 dynes/cm, and most preferably, greater than about 40 dynes/cm, as measured using ASTM Test Method D1331-89, Method A, at 23°C for materials that are liquid at this temperature For materials that are solids at this temperature, the surface tension is measured at 5°C above the freezing point
- the surface tension ofthe prefe ⁇ ed modifying component is greater than the surface energy ofthe microporous membrane chosen.
- the surface energy is about 30 dynes/cm.
- suitable compounds for the modifying component have a surface tension greater than about 30 dynes/cm when the microporous membrane is polypropylene.
- compounds used in the modifying component have a viscosity greater than about 10 centipoise, more preferably, greater than about 30 centipoise, and most preferably, greater than about 50 centipoise, measured at 23°C for materials that are liquid at this temperature. For materials that are solids at this temperature, the viscosity is measured at 5°C above the freezing point
- Suitable compounds include polyfunctional alcohols such as 1,3-butanediol, 1,4-butanediol, 2, 3 -butanediol, 1,3- propanediol, triethanol amine, ethylene glycol, di(ethylene glycol), triethylene glycol, propylene glycol, glycerol.
- the modifying component comprises at least one polyfunctional alcohol
- the wetting component includes at least one organic compound that is capable of wetting out the pores ofthe microporous membrane when in the pure state at about the critical temperature in the absence of a pressure gradient across the membrane
- Such compounds have characteristics such as a generally low viscosity and a generally low surface tension
- the viscosity is less than about 50 centipoise, more preferably, iess than about 25 centipoise, and most preferably, less than about 10 centipoise, at 23°C for materials that are liquid at this temperature
- the viscosity is measured at 5°C above the freezing point
- the surface tension ofthe wetting component is iess than the surface energy ofthe microporous membrane chosen
- the surface tension of compounds used in the wetting component is less than about 30 dynes/cm, more preferably, less than about 27 dynes/cm at 23°C for materials that are liquid at this temperature.
- Suitable wetting compounds include alcohols, ketones, ethers, halogenated or nonhalogenated alkanes, halogenated or nonhalogenated alkenes, amines, and combinations thereof
- the wetting compounds include propylene glycols having a weight average molecular weight of less than about 2000, (d-C 8 )alcohols (e g , methanol, ethanol, propanol, and butanol), (C -C 8 )ketones (e g , acetone, 2-butanone), (C 2 -C 8 )ethers, (C5-C.
- the freezing point ofthe p ⁇ mary organic component (whether one p ⁇ mary organic compound or a mixture of such compounds is used) should be at a higher temperature than the critical indicating temperature
- an amount ofthe wetting component (whether one wetting compound or a mixture of such compounds is used) is used to ensure wetting ofthe microporous membrane at about the critical indicating temperature, but not at useful temperatures greater than the cnticai indicating temperature
- At least about 50 wt-% ofthe primary organic component is used in an indicating composition
- at least about 70 wt-% (more preferably, at least about 80 wt-%>) and no greater than about 98 wt-%> ofthe indicating composition is the pnmary organic component
- at least about 1 wt-% ofthe wetting component is used in an indicating composition
- at least about 3 wt-% and no greater than about 20 wt-%> (more preferably, no greater than about 15 wt-%>, and most preferably, no greater than about 10 wt-%>) ofthe indicating composition is the wetting component
- at least about 1 wt-% ofthe modifying component is used in an indicating composition
- at least about 10 wt-% and no greater than about 40 wt-% (more preferably, no greater than about 30 wt-%) ofthe indicating composition is the modifying component If water is used in the modifying component
- ком ⁇ онент can be added to control the freezing point and/or alter the viscosity of the solution
- immobilizing agents can be added to control the rate of diffusion and/or build viscosity
- Immobilizing agents such as thickeners and viscosifiers can be added to increase the viscosity ofthe indicating composition, and even form a gel
- thickeners and viscosifiers include modified celluloses, starches, proteins, polymers prepared from ethylenically unsaturated monomers such as acrylates, acrylamides, vinyl pyrrolidine, vinyl acetate, acrylonitrile, styrene, and the like, polyurethanes, fumed silicas (such as that available under the trade designations "AEROSIL” from Degussa AG of Frankfort, Germany or "Cab
- Nucleating agents can also be added (although it is envisioned that they are not necessary) to prevent super-cooling and improve reproducibility
- examples of such nucleating agents include Agl, silica, fumed silica, ground glass, or other materials having a high surface area with a rough topology
- the indicating devices ofthe present invention are relatively easy to make Generally, the only precaution that needs to be taken is to ensure that the indicating composition does not include any significant amount of water absorbed from the atmosphere Standard handling techniques for this are known to one of skill in the art.
- the indicating composition is prepared, it is placed in the desired container, typically via pipette or microsyringe Preferably it is filled in a way which eliminates air bubbles, although this is not a requirement
- the container is sealed together completely, and the device is ready for use.
- the container can be in a variety of shapes and sizes, as shown in Figures 1-4
- the indicating device can include separate compartments to avoid activation during shipping from the point of manufacture to the point of use
- the indicating composition can be encased in a rupturable container, which is impermeable to the indicating composition
- a preferred rupturable container is formed of polymeric material, and can be sealed by means of heat or adhesive Prior to using the indicating device, the rupturable container should be broken, typically by hand pressure, so the indicating composition and microporous membrane come in contact.
- the adhesives are preferably pressure-sensitive adhesives, such as, for example, silicone-based adhesives, e g., polysiloxanes, acrylic- based adhesives, e g., isooctyl acrylate/acrylic acid copolymers, rubber-based adhesives, e.g., styrene-isoprene-styrene block copolymers, styrene-butadiene-styrene block copolymers, and nitrile rubbers, e.g , acrylonitrile-butadiene, and mixtures of these Pressure-sensitive adhesives are well-known to one of ordinary skill in the art Also useful are foam adhesives and double sided tapes (such as "9579" tape or "409" carpet tape, which are commercially available from Minnesota Mining and Manufacturing Company of St Paul, MN) Also useful are curable adhesives such as e
- the indicating device is useful when used as an indicator for flash frozen foods (such as poultry), paints, water-based adhesives, dairy products, plants, pharmaceuticals or water-based chemicals It can be used to indicate when the product is exposed to undesirably low temperatures. It is useful as an indicator on food products, for instances where it is important that the temperature remain cold but not so cold that the product freezes, such as fresh poultry or frozen meat It is also useful on pharmaceuticals and medicines, where the temperature should remain about +5°C For example, at 5°C, vaccines are stable for up to one year, if exposed to temperatures of about 0°C, the reliability of the vaccines is questionable
- devices of the present invention were prepared and then tested at desired temperatures in a water bath The devices were conditioned by holding for one hour in a desiccator pnor to the test
- a water bath (commercially available as NESLAB RTE- 1 1 1 from Neslab Instruments of Newington, NH) controllable to temperatures + 0 1°C, was used The temperature was set at a desired testing temperature and equilibrated for 30 minutes pnor to testing a sample The samples were placed on clips and completely immersed into the bath They were held for 30 minutes in the bath, and then examined to see if any changes in the transparency of the microporous membrane had occurred If the device had not been activated, the temperature was reduced 1 °C and held for 30 minutes This procedure was repeated until activation occu ⁇ ed A minimum of three samples were tested and averaged Typically, five samples were used The membrane in the indicating device changes from opaque to transparent at the c ⁇ tical temperature, or if a dye is present, the membrane may change color to that of the dye
- Test 1 A section of microporous membrane was cut into 2 5 cm squares The membrane was placed on a bench top A 0 33 ml sample ofthe component was deposited via microsyringe onto the membrane If the microporous membrane became transparent in 5-10 minutes, the component was considered to be a wetting component If the membrane did not become transparent in this time interval, the component was considered a primary organic component or a modifying component For components that are solids at room temperature (22-25°C), exactly the same procedure was carried out, except that the component was warmed up until it was liquid and then tested with the liquid and membrane maintained at a temperature just above the freezing point (i e , melting point)
- Test 2 If the component was observed to wet out the membrane, the component was placed into an indicating device prepared as described in Example 1, below The effect ofthe component was readiiy observed by seeing the changes in the membrane, which was covered by a transparent bar ⁇ er layer If the microporous membrane became transparent in 5- 10 minutes, the component was considered to be a wetting component If the membrane did not become transparent in this time interval, the component was considered a primary organic component or a modifying component For components which were solids at room temperature (22° - 25°C), exactly the same procedure was carried out, except that the component was warmed up until it was liquid and then deposited into the reservoir in the indicating device, which was also held at this elevated temperature Test 3 If the component passed both Tests 1 and 2 (I e , it wetted out the membrane), it was used as a wetting component in an indicating composition Several suitable indicating solutions are shown in Table 2.
- Indicating compositions were made up and deposited via microsyringe into the device prepared as described in Example 1 To test the critical temperature ofthe device, it was placed in a freezer at a temperature of -15°C It was checked at 30 minute intervals to see if the indicating de ⁇
- composition had wet out the microporous membrane (thus rendering it transparent), and if it was solid rather than liquid.
- Example 1 This example illustrates the preparation of a device of this invention wherein a receptacle is formed between two layers of microporous film This construction is similar to that depicted in Figure 1
- a piece of barrier layer material available under the trade designation "MIL SPEC B22191, Type 1, Class 2" from Georgia Packaging Inc of Columbus, GA, which consisted of a layer of 0 015 mm “ACLAR R 160", a layer of 0 018 mm low density polyethylene, a layer of 0 012 mm polyethylene terephthalate, and a layer of 0 064 mm low density polyethylene, was cut to about 2 8 cm by about 33 cm
- the microporous membrane was placed on the lower jaw of a laboratory heat sealer (commercially available under the trade designation Sentinel Heat Sealer from Sentinel Corp of Hyannis, MA)
- the bamer film was positioned on top ofthe microporous membrane such that the membrane was about 0 63 cm from the edge of the barrier film
- the sealer was activated, the settings were 121 1°C ⁇ 2 8°C, 0 28 MP
- the pouch was filled with the desired indicating composition by using about 0 3 cm 1 of desired indicating mixture, care being taken to remove all air bubbles from the pouch
- the top ofthe pouch was heat sealed, as in step 2)
- the device was then ready for testing (as described above) or for placement on a container by use of a pressure sensitive adhesive (commercially available under product number 467 from Minnesota Mining and Manufacturing Company of St Paul, MN)
- compositions were prepared by combining the compounds in Table 1 in the weight percentages indicated Each ofthe components, some of which are very hygroscopic, was stored in a sealed container with molecular sieve under an atmosphere of nitrogen All compositions were prepared in air and then purged with nitrogen Each of composition included 0 1 gram Euroglaucine dye from Aldrich Chemical Co of Milwaukee, WI 1 ,4-Butanediol (99% pure, 0 35% water),
- 1,2-propanediol (99%> pure), triethylene glycol (99% pure), and diethylene glycol (99% pure) were obtained from Aldrich Chemical Co of Milwaukee, WI, isopropanol (reagent grade, 99 7% pure) was obtained from EM Science of Gibbstown, NJ, glycerol (99 5%> pure, 0 5%> water) was obtained from Mallinckrodt Baker, Inc of St Louis, MO, ethylene glycol (99 991 ) pure, 0 009%) water) and methyl ethyl ketone (99 7% pure, 0 02% water) was obtained from JT Baker Inc of Phillipsburg, NJ The critical temperature for each is an average of 10 trials The error for each is less than about 1°C Table 1
- 1,2-propaned ⁇ ol 20 6 14 8 (modifying component) isopropanol 5 5 5 5 5 5 5 5 (wetting component) methanol 5
- a barrier material (depicted as 28 in Figure 2) is a laminate of a layer of polyethylene terephthalate (PE), a layer of low density polyethylene (LDPE), a layer of aluminum foil, another layer of low density polyethylene (LDPE), and a layer of 0.064 mm linear low density polyethylene (LLDPE), which is commercially available under the trade designation "BN 48" from Georgia Packaging Inc. of Columbus, GA In this construction, the LLDPE side ofthe laminate faces the inside ofthe device and the PET side is on the outside
- a second barrier material (depicted as 22 in Figure 2) is a thermoformed laminate of a layer of 0 19 mm polyvinyl chloride (PVC), a layer of 0 051 mm LDPE, a layer of 0 015 mm "ACLAR Rxl ⁇ O" fluoropolymer, and a layer 0 051 mm LDPE, which is commercially under the trade designation "VPA 760" from Tekni Plex Inc of Somerville, NJ.
- the LDPE side of the laminate faces the inside of the device and the PVC side is on the outside
- the microporous polypropylene membrane (depicted as 24 in Figure 2) descnbed in Example 1 was cut into a 1 cm diameter disc and heat sealed under the conditions descnbed in Example 1 around the periphery to the bottom ofthe reservoir formed by the second barner material
- the desired indicating composition was then placed in the reservoir and the first barrier material was heat sealed to the second bamer matenal across the top
- This example demonstrates the effect of a thickener on the indicating composition and the device
- Three indicating compositions were prepared, each having a different thickener concentration, and the time to wet out the membrane was recorded
- the indicating composition included 81% 1 4-butaned ⁇ ol, 14% 1,2- propanediol, and 5% isopropyl alcohol
- This indicating composition has a cntical indicating temperature of -0 4°C
- To 100 grams of this dye-containing composition was added 3 75 grams, 2 5 grams, or 1 25 grams, respectively, of fumed silica, which is commercially available under the trade designation "Cab-O-Sil Ml 5" from Cabot Corp Of Tuscosa, IL
- These mixtures were placed in individual jars purged with nitrogen, sealed, and placed on a shaker overnight to agitate the compositions
- An indicating device was prepared as described in Example 1 To each of 5 such devices for
- This example illustrates the lower level of wetting component and modifying component needed for activation Indicating devices as described in Example 1 were used
- Five samples of each composition were tested at -3 °C for 30 minutes
- Each of the following compositions included 0 1 gram Euroglaucine dye
- For a composition containing 98%> 1,4-butanediol, 1%> 1,2-propaned ⁇ ol, and 1%> isopropanol none ofthe samples were activated
- a composition containing 97% 1 ,4-butanediol, 2% 1,2- propanediol, and 1% isopropanol two ofthe five samples were activated
- a composition containing 97% 1,4-butanediol, 1% 1,2-propanediol, and 2% isopropanol five ofthe five samples were activated
- Example 2 This example illustrates that a three component system can provide indicating devices that activate at a wide variety of temperatures over a relatively broad temperature range Indicating devices as described in Example 1 were used Ten samples of each composition were tested Each ofthe following compositions included 0 1 gram Euroglaucine dye Samples were placed in a low temperature bath at a temperature above the c ⁇ tical temperature and the temperature was lowered by 1°C increments every 30 minutes The temperature at which each ofthe samples activated was recorded For any one composition, the critical temperature recorded in Table 2, below, was an average of ten samples
Abstract
Description
Claims
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/558,892 US5964181A (en) | 1995-11-16 | 1995-11-16 | Temperature indicating device |
US558892 | 1995-11-16 | ||
PCT/US1996/017652 WO1997018449A1 (en) | 1995-11-16 | 1996-10-31 | Temperature indicating device |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0861427A1 true EP0861427A1 (en) | 1998-09-02 |
EP0861427B1 EP0861427B1 (en) | 2002-03-27 |
Family
ID=24231414
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP96939538A Expired - Lifetime EP0861427B1 (en) | 1995-11-16 | 1996-10-31 | Temperature indicating device |
Country Status (7)
Country | Link |
---|---|
US (1) | US5964181A (en) |
EP (1) | EP0861427B1 (en) |
JP (1) | JP2000500575A (en) |
AU (1) | AU7668396A (en) |
BR (1) | BR9611283A (en) |
DE (1) | DE69620217T2 (en) |
WO (1) | WO1997018449A1 (en) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6558628B1 (en) * | 1999-03-05 | 2003-05-06 | Specialty Silicone Products, Inc. | Compartment cover, kit and method for forming the same |
DE20000317U1 (en) * | 2000-01-08 | 2001-06-07 | Trender Lutz | Device for permanent, permanent detection and display of an overshoot / undershoot of a predetermined temperature |
US6863437B2 (en) * | 2000-08-23 | 2005-03-08 | National Institute Of Advanced Industrial Science And Technology | Temperature-responsive polymer/polymer complex |
US6698378B1 (en) * | 2000-09-12 | 2004-03-02 | Sud-Chemie Inc. | Irreversible humidity indicator cards |
US6532720B2 (en) * | 2000-12-15 | 2003-03-18 | International Paper Company | Packaging method using elastic memory foam as safety indicator for heat damage |
US7770534B2 (en) * | 2001-08-10 | 2010-08-10 | Isadore Cooperman | Changed condition indicator |
US6694913B2 (en) * | 2001-08-10 | 2004-02-24 | Isadore Cooperman | Changed condition indicator |
WO2003052367A1 (en) * | 2001-12-19 | 2003-06-26 | Uriel Bachrach | A device for monitoring a predetermined temperature |
US7424455B2 (en) * | 2002-09-17 | 2008-09-09 | First Data Corporation | Method and systems for providing merchant services with right-time creation and updating of merchant accounts |
US6957623B2 (en) * | 2004-03-09 | 2005-10-25 | Guisinger Robert E | Critical temperature indicator |
US7097353B2 (en) * | 2004-10-12 | 2006-08-29 | Wieder Horst K | Method and device for indicating temperature |
US20060130735A1 (en) * | 2004-12-16 | 2006-06-22 | Beech Tree Sensors Llc | Temperature sensor |
US7940605B2 (en) * | 2005-04-29 | 2011-05-10 | Prasidiux, Llc | Stimulus indicating device employing polymer gels |
US20120032117A1 (en) | 2005-04-29 | 2012-02-09 | Ambrozy Rel S | Stimulus indicating device employing polymer gels |
WO2006119141A2 (en) * | 2005-04-29 | 2006-11-09 | Ambrozy Rel S | Stimulus indication employing polymer gels |
US8166906B2 (en) | 2005-04-29 | 2012-05-01 | Ambrozy Rel S | Stimulus indicating device employing polymer gels |
US8077554B2 (en) | 2005-04-29 | 2011-12-13 | Ambrozy Rel S | Stimulus indicating device employing polymer gels |
US9182292B2 (en) | 2005-04-29 | 2015-11-10 | Prasidiux, Llc | Stimulus indicating device employing polymer gels |
US20070116402A1 (en) * | 2005-06-30 | 2007-05-24 | Infoscitex Corporation | Humidity sensor and method for monitoring moisture in concrete |
US20070058898A1 (en) * | 2005-06-30 | 2007-03-15 | Infoscitex | Humidity sensor and method for monitoring moisture in concrete |
US7343872B2 (en) * | 2005-11-07 | 2008-03-18 | Temptime Corporation | Freeze indicators suitable for mass production |
GB2464867B (en) * | 2005-11-07 | 2010-07-14 | Temptime Corp | Freeze indicators suitable for mass production |
EP1952110B1 (en) | 2005-11-08 | 2015-05-20 | Temptime Corporation | Combination freeze indicators |
US7571695B2 (en) | 2006-11-06 | 2009-08-11 | Temptime Corporation | Freeze indicators, flexible freeze indicators and manufacturing methods |
US20080184927A1 (en) * | 2007-02-02 | 2008-08-07 | Paul Phong Anh Pham | Container cap for assuring quality |
JP5415712B2 (en) * | 2008-04-24 | 2014-02-12 | 日本サーモスタット株式会社 | Temperature sensitive indicator device |
WO2011026020A2 (en) * | 2009-08-31 | 2011-03-03 | Temptime Corporation | Freeze indicators with a controlled temperature response |
KR20130117775A (en) * | 2010-09-23 | 2013-10-28 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | Porous chemical indicator for gaseous media |
US8671871B2 (en) | 2010-09-29 | 2014-03-18 | Temptime Corporation | Temperature-activated time-temperature indicator |
US8430053B2 (en) * | 2010-09-30 | 2013-04-30 | Temptime Corporation | Color-changing emulsions for freeze indicators |
GB2485420A (en) * | 2010-11-15 | 2012-05-16 | Pirtsemit Ltd | Lower threshold temperature indicator device |
WO2014028849A1 (en) | 2012-08-16 | 2014-02-20 | Temptime Corporation | Freeze indicator employing light scattering and method of making same |
KR20140126552A (en) * | 2013-04-23 | 2014-10-31 | 인텔렉추얼디스커버리 주식회사 | Freeze indicator |
DE102016005070A1 (en) | 2016-04-27 | 2017-11-02 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Apparatus and method for monitoring the temperature of a cryopreserved biological sample |
DE102016005133A1 (en) | 2016-04-27 | 2017-11-02 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Method and device for monitoring the temperature of a cryopreserved biological sample |
DE102016005075A1 (en) * | 2016-04-27 | 2017-11-02 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Method and device for monitoring the temperature of a cryopreserved biological sample |
DE102017003171A1 (en) * | 2017-03-31 | 2018-10-04 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | TIEFTEMPERATUR-INDIKATORMISCHUNG, DEVICE AND METHOD FOR MONITORING A TEMPERATURE TRANSITION AT DEEP TEMPERATURES |
US11035740B1 (en) * | 2017-07-31 | 2021-06-15 | Prasidiux, Llc | Stimulus indicating device employing thermoreversible amphiphilic gels |
US11029240B2 (en) * | 2018-10-12 | 2021-06-08 | Aerosol Dynamics Inc. | Wick moisture sensor for airborne particle condensational growth systems |
US11241902B1 (en) | 2020-09-17 | 2022-02-08 | Temptime Corporation | Environmental history monitor with positional displacement and security features |
US11951761B2 (en) | 2020-09-17 | 2024-04-09 | Temptime Corporation | Environmental history monitor with security features |
Family Cites Families (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2460215A (en) * | 1946-07-08 | 1949-01-25 | Kenneth J Chase | Telltale for frozen food packages |
US2903188A (en) * | 1956-04-02 | 1959-09-08 | Leonard H Hutchinson | Control of tropical cyclone formation |
US2971852A (en) * | 1956-07-23 | 1961-02-14 | Schulein Joseph | Temperature telltale |
US3055759A (en) * | 1959-04-13 | 1962-09-25 | John C Busby | Temperature indicators |
US3177843A (en) * | 1964-02-13 | 1965-04-13 | Robert S Geocaris | Frozen food indicator |
US3414415A (en) * | 1965-10-22 | 1968-12-03 | Robert L. Broad Jr. | Thaw indicator |
US3545400A (en) * | 1969-03-25 | 1970-12-08 | Von L Smith | Freeze and thaw indicator |
US3702077A (en) * | 1970-08-19 | 1972-11-07 | Bela G Szabo | Defrost evincing devices |
US3826141A (en) * | 1971-03-04 | 1974-07-30 | Bio Medical Sciences Inc | Temperature indicator |
US3946612A (en) * | 1971-03-04 | 1976-03-30 | Bio-Medical Sciences, Inc. | Temperature indicating compositions |
BE791100A (en) * | 1971-11-11 | 1973-03-01 | Bio Medical Sciences Inc | TEMPERATURE INDICATOR COMPOSITION |
US3922917A (en) * | 1973-08-31 | 1975-12-02 | Becton Dickinson Co | Disposable thermometer |
US3958528A (en) * | 1973-10-23 | 1976-05-25 | Robert Hill | Product thaw indicator |
US3967579A (en) * | 1975-10-29 | 1976-07-06 | Stanton H. Kaye | Telltale device |
US4028944A (en) * | 1975-10-31 | 1977-06-14 | The Franklin Institute | Device for recording temperature minimums |
US4022149A (en) * | 1976-02-06 | 1977-05-10 | Lee Berger | Thaw indicator |
SE410229B (en) * | 1976-05-11 | 1979-10-01 | Kockums Chem | AQUATIC COMPOSITION WITH REGULATED PH SHIFT WHEN FREEZING, AND SET FOR ITS PREPARATION |
US4120818A (en) * | 1976-08-10 | 1978-10-17 | The United States Of America As Represented By The Secretary Of The Army | Irreversible warmup indicator |
FR2361635A1 (en) * | 1976-08-13 | 1978-03-10 | Thomson Csf | DEVICE CAPABLE OF DETECTING IN A SUSTAINABLE WAY A PASSENGER HEATING OF A FROZEN PRODUCT |
US4145918A (en) * | 1976-09-07 | 1979-03-27 | Akzona Incorporated | Freeze-thaw indicator |
US4163427A (en) * | 1977-12-05 | 1979-08-07 | Isadore Cooperman | Freeze-thaw indicator apparatus |
GB1549584A (en) * | 1978-03-02 | 1979-08-08 | Standard Telephones Cables Ltd | Temperature responsive device |
CH642177A5 (en) * | 1979-07-13 | 1984-03-30 | Thomas Allmendinger | METHOD FOR MONITORING THE TEMPERATURE HISTORY OF A GOOD, INDICATOR FOR IMPLEMENTING THE METHOD AND APPLYING THE METHOD. |
US4428321A (en) * | 1981-11-16 | 1984-01-31 | Minnesota Mining And Manufacturing Co. | Thermally-activated time-temperature indicator |
US4469452A (en) * | 1982-04-14 | 1984-09-04 | Whitman Medical Corporation | Indicator system and means for irreversibly recording a temperature limit |
GB2119511A (en) * | 1982-04-28 | 1983-11-16 | Luigi Bolla | Sensor for signalling that a preselected temperature has been exceeded |
JPS5917121A (en) * | 1982-07-21 | 1984-01-28 | Kao Corp | Composition for temperature recording |
US4539256A (en) * | 1982-09-09 | 1985-09-03 | Minnesota Mining And Manufacturing Co. | Microporous sheet material, method of making and articles made therewith |
ES267379Y (en) * | 1982-09-21 | 1983-10-16 | "IRREVERSIBLE INDICATOR OF TEMPERATURE DEFROSTING THAT IS REQUIRED". | |
US4457252A (en) * | 1982-11-09 | 1984-07-03 | Minnesota Mining And Manufacturing Company | Critical temperature indicator |
US4457253A (en) * | 1982-11-09 | 1984-07-03 | Minnesota Mining And Manufacturing Company | Critical temperature indicator |
JPS59175172A (en) * | 1983-03-23 | 1984-10-03 | Nichicon Capacitor Ltd | Photocoupler device |
US4629330A (en) * | 1985-03-14 | 1986-12-16 | Moleculon Research Company | Color-change indicator |
US4726989A (en) * | 1986-12-11 | 1988-02-23 | Minnesota Mining And Manufacturing | Microporous materials incorporating a nucleating agent and methods for making same |
US4846095A (en) * | 1987-10-02 | 1989-07-11 | Minnesota Mining And Manufacturing Company | Critical temperature indicating device |
FR2625556A1 (en) * | 1988-01-05 | 1989-07-07 | Guitteny Serge | Device for indicating whether a frozen or deep frozen product has been kept under good conditions |
US5119021A (en) * | 1989-07-13 | 1992-06-02 | Thermal Management, Inc. | Method and apparatus for maintaining electrically operating device temperatures |
US5120137A (en) * | 1991-03-29 | 1992-06-09 | Minnesota Mining And Manufacturing Company | Time and temperature indicating device |
US5111768A (en) * | 1991-06-07 | 1992-05-12 | Pymah Corporation | Freeze indicator |
AU6191094A (en) * | 1993-05-18 | 1994-11-24 | Sealed Air New Zealand Limited | A temperature sensitive fluid indicator |
US5667303A (en) * | 1995-03-10 | 1997-09-16 | Minnesota Mining And Manufacturing Company | Time-temperature integrating indicator device |
-
1995
- 1995-11-16 US US08/558,892 patent/US5964181A/en not_active Expired - Lifetime
-
1996
- 1996-10-31 BR BR9611283A patent/BR9611283A/en not_active Application Discontinuation
- 1996-10-31 AU AU76683/96A patent/AU7668396A/en not_active Abandoned
- 1996-10-31 EP EP96939538A patent/EP0861427B1/en not_active Expired - Lifetime
- 1996-10-31 DE DE69620217T patent/DE69620217T2/en not_active Expired - Lifetime
- 1996-10-31 JP JP9518902A patent/JP2000500575A/en active Pending
- 1996-10-31 WO PCT/US1996/017652 patent/WO1997018449A1/en active IP Right Grant
Non-Patent Citations (1)
Title |
---|
See references of WO9718449A1 * |
Also Published As
Publication number | Publication date |
---|---|
US5964181A (en) | 1999-10-12 |
DE69620217D1 (en) | 2002-05-02 |
DE69620217T2 (en) | 2002-10-31 |
BR9611283A (en) | 1999-01-26 |
JP2000500575A (en) | 2000-01-18 |
EP0861427B1 (en) | 2002-03-27 |
AU7668396A (en) | 1997-06-05 |
WO1997018449A1 (en) | 1997-05-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0861427B1 (en) | Temperature indicating device | |
US4846095A (en) | Critical temperature indicating device | |
EP1425560B1 (en) | Changed condition indicator | |
US10514340B2 (en) | Dual-function heat indicator and method of manufacture | |
KR0139054B1 (en) | Refrigerant | |
US3243303A (en) | Temperature monitor employing a flowable aqueous composition containing dispersed polyvinyl acetate as a flow retardant | |
US4057029A (en) | Time-temperature indicator | |
US4212153A (en) | Time color indicator | |
AU2002329716A1 (en) | Changed condition indicator | |
AU2011330895B2 (en) | Lower threshold temperature indicator device | |
US20060032427A1 (en) | Temperature indicating display device | |
WO2008144348A1 (en) | Freeze indicators, flexible freeze indicators and manufacturing methods | |
PT1285861E (en) | Case-ready package having absorbent pad and method of manufacturing thereof | |
JP2009515200A (en) | Freezing indicator suitable for mass production | |
JP2003072857A (en) | Ink composition for detecting carbon dioxide, carbon dioxide indicator using it, packaging body with carbon dioxide indicator disposed thereon, and pin hole detecting method using it | |
CA2236032A1 (en) | Temperature indicating device | |
JPS62259059A (en) | Oxygen indicator | |
JP2533994B2 (en) | Solid thin chemiluminescent device | |
JP4284481B2 (en) | Oxygen detector with oxygen detection function | |
KR102415311B1 (en) | Device for indicating temperature change history | |
JP2003195763A (en) | Tack label having hygroscopicity | |
JP2004168387A (en) | Lid member with indicator, and temporary seal for lid member | |
JP2005308239A (en) | Temperature managing medium |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19980508 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): BE CH DE FR GB IT LI |
|
GRAG | Despatch of communication of intention to grant |
Free format text: ORIGINAL CODE: EPIDOS AGRA |
|
17Q | First examination report despatched |
Effective date: 20010521 |
|
GRAG | Despatch of communication of intention to grant |
Free format text: ORIGINAL CODE: EPIDOS AGRA |
|
GRAG | Despatch of communication of intention to grant |
Free format text: ORIGINAL CODE: EPIDOS AGRA |
|
GRAH | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOS IGRA |
|
REG | Reference to a national code |
Ref country code: GB Ref legal event code: IF02 |
|
GRAH | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOS IGRA |
|
GRAA | (expected) grant |
Free format text: ORIGINAL CODE: 0009210 |
|
AK | Designated contracting states |
Kind code of ref document: B1 Designated state(s): BE CH DE FR GB IT LI |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: IT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT;WARNING: LAPSES OF ITALIAN PATENTS WITH EFFECTIVE DATE BEFORE 2007 MAY HAVE OCCURRED AT ANY TIME BEFORE 2007. THE CORRECT EFFECTIVE DATE MAY BE DIFFERENT FROM THE ONE RECORDED. Effective date: 20020327 Ref country code: FR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20020327 Ref country code: BE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20020327 |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: EP |
|
REF | Corresponds to: |
Ref document number: 69620217 Country of ref document: DE Date of ref document: 20020502 |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: NV Representative=s name: E. BLUM & CO. PATENTANWAELTE |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: GB Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20021031 |
|
EN | Fr: translation not filed | ||
PLBE | No opposition filed within time limit |
Free format text: ORIGINAL CODE: 0009261 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT |
|
26N | No opposition filed |
Effective date: 20021230 |
|
GBPC | Gb: european patent ceased through non-payment of renewal fee | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: WD Ref document number: 1015875 Country of ref document: HK |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: PFA Owner name: MINNESOTA MINING AND MANUFACTURING COMPANY Free format text: MINNESOTA MINING AND MANUFACTURING COMPANY#3M CENTER, P.O. BOX 33427#ST. PAUL, MINNESOTA 55133-3427 (US) -TRANSFER TO- MINNESOTA MINING AND MANUFACTURING COMPANY#3M CENTER, P.O. BOX 33427#ST. PAUL, MINNESOTA 55133-3427 (US) |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: DE Payment date: 20101027 Year of fee payment: 15 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: CH Payment date: 20111012 Year of fee payment: 16 |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: PL |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LI Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20121031 Ref country code: CH Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20121031 Ref country code: DE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20130501 |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R119 Ref document number: 69620217 Country of ref document: DE Effective date: 20130501 |