EP0881158A1 - Device for dispensing and storing sterile fluids - Google Patents

Device for dispensing and storing sterile fluids Download PDF

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Publication number
EP0881158A1
EP0881158A1 EP19980400777 EP98400777A EP0881158A1 EP 0881158 A1 EP0881158 A1 EP 0881158A1 EP 19980400777 EP19980400777 EP 19980400777 EP 98400777 A EP98400777 A EP 98400777A EP 0881158 A1 EP0881158 A1 EP 0881158A1
Authority
EP
European Patent Office
Prior art keywords
insert
end piece
cover
product
porosity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP19980400777
Other languages
German (de)
French (fr)
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EP0881158B1 (en
Inventor
Jean-Louis Bougamont
Pascal Hennemann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Albea Le Treport SAS
Original Assignee
S O F A B SA
Sofab SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by S O F A B SA, Sofab SA filed Critical S O F A B SA
Publication of EP0881158A1 publication Critical patent/EP0881158A1/en
Application granted granted Critical
Publication of EP0881158B1 publication Critical patent/EP0881158B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/04—Closures with discharging devices other than pumps
    • B65D47/06—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages
    • B65D47/18—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages for discharging drops; Droppers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1443—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters
    • A61J1/145—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters using air filters

Definitions

  • the present invention relates to a device for dispensing and packaging of sterile liquid products and more particularly pharmaceutical products for ophthalmic use.
  • These devices include a product reservoir surmounted by a nozzle which is provided with an internal conduit communicating at its upstream end with the reservoir and opening at its downstream end to the outside via a discharge orifice.
  • the conduit internal is generally sealed, on the one hand, at the level of the discharge orifice, by a valve and, on the other hand, by means an internal sealing lip which is elastically deformable.
  • the object of the present invention is to solve these problems techniques satisfactorily.
  • a device for the distribution and packaging of a sterile liquid product from type comprising a reservoir surmounted by a nozzle provided with a internal conduit communicating at its upstream end with said tank and opening through its downstream end to the outside, via a discharge orifice, characterized in that said end piece comprises of part, an insert of selective porosity at least partially obstructing the internal conduit and allowing, at the same time, a metered flow of the product to the outside and filtration of the air sucked inwards, stopping contaminants and / or biological pollutants, said insert comprising a finger which is inserted into the discharge opening and whose end is projecting from the outside, and on the other hand, a cover covering said end piece and carrying a sealed closure element of said discharge orifice.
  • said element obturation consists of an internal peripheral lip intended to come to bear from the outside around the discharge orifice, when fitting of the cover on the nozzle.
  • said cover comprises a locking member cooperating by snap-fastening with a locking member retaining formed on the nozzle.
  • said cover comprises elements stiffeners bearing on the end piece.
  • said insert has a profile adapted to be housed in the downstream end of said conduit.
  • said tip comprises a valve whose seat is formed by the edges of the discharge orifice, and which is associated with elastic return means carried by said insert.
  • said elastic return means are constituted by an elastically deformable crown retained by its peripheral edge under a shoulder of the nozzle.
  • the device is produced at at least partially with a material containing a chemical agent bactericide and / or antiseptic.
  • the porosity of said insert is between 40% and 60%, and preferably, the diameter of the pores is between 5 and 10 ⁇ m.
  • the porosity of the insert is non-uniform and delimits in its mass channels for the preferential flow of product.
  • the device of the present invention provides both a metering precise and reproducible and bacterial protection of the product in using simple technical means.
  • the porous insert is, moreover, a simple, reliable and economic which has a synergistic action with the other constituents of the device for jointly ensuring the regulation of the product flow, filtration of the intake air and the necessary sealing of the device.
  • the device shown in Figure 1, like those shown in Figures 2 to 4, is more particularly intended for distribution and packaging of a sterile liquid product.
  • This device includes a tank (not shown) surmounted a tip E.
  • the end piece E is provided with a collar C for connection to the tank and an internal conduit 1 communicating at its upstream end 1a with the reservoir and opening, through its downstream end 1b, to outside via an outlet 10.
  • the conduit 1 is, at least partially, obstructed by an insert 2 made with a material of selective porosity.
  • this porosity is such that the insert 2 ensures, on the one hand, a dosage of the product by slowing down its flow rate outwards, when the tank is pressurized, and, on the other hand, filtration of the air drawn inwards when the pressure returns internal tank at atmospheric pressure.
  • the air intake is thus carried out by stopping the contaminants and / or biological pollutants.
  • the insert 2 has a profile adapted to be housed in the downstream end 1b of the conduit 1 with a slight radial tightening or a low compression, occupying the entire free section.
  • the porosity of insert 2 is preferably between 40% and 60% with a pore diameter of between 5 and 10 ⁇ m. What allows to produce, at the same time, a drip dosage in a sense, and a stop or a trapping of the main contaminants in the other direction.
  • the insert is impregnated or produced at least partially with a material having bactericidal activity (for example example an oligodynamic substance based on silver).
  • a material having bactericidal activity for example example an oligodynamic substance based on silver.
  • the insert 2 comprises a finger 20 which is inserted into the discharge orifice 10 with a slight radial tightening.
  • the end 20a of the finger 20 projects outside with a warhead profile favoring the formation of product drops and allowing to calibrate the volume of the drops preferably between 25 ⁇ l and 50 ⁇ l.
  • the device of the invention further comprises a cover 3 intended to cover at least the end of the end piece E.
  • the cover 3 carries a sealed closure element for the orifice Evacuation 10.
  • This element consists, in the embodiment of the Figure 1, a peripheral lip 30 formed on the inner wall of the cover 3 and which is intended to come to bear from the outside around the orifice 10 when the cover 3 is placed on the end piece E.
  • the lip 30 is relatively rigid and borders a cavity 30a, formed on the internal wall of the cover 3, in which is housed, the end 20a in a warhead of the finger 20 of the insert 2.
  • the mutual surfaces in gaze delimits a dead space in which protection is ensured anti-bacterial.
  • the cover 3 also includes a locking member 32 cooperating by snap-fastening with a retaining member 12 formed on end piece E.
  • the position and the geometry of the locking members 32 and retainer 12 are determined so as to provide support sealing of the lip 30 around the orifice 10 and, therefore, an assembly airtight cover 3 on end piece E.
  • the cover 3 further comprises stiffening elements 31 under shape of fins or of a cylinder resting on a shoulder 11 of end piece E.
  • the device In order to strengthen the biological protection of the product, it is planned, if necessary, to make the device (E tip and / or insert 2 and / or cover 3) with a plastic material containing a chemical agent bactericide and / or antiseptic.
  • the closure element carried by the cover 3 consists of an internal lug 33 intended to enter the evacuation orifice 10 during the installation of the cover 3 on end piece E.
  • the internal end of the lug 33 comes into contact with the insert 2 formed of a part housed in the downstream end 16 of the conduit 1 and which, after release of the cover 3, leaves the orifice 10 completely free for product flow.
  • the support of the lug 33 against the insert 2 is limited by one face transverse 34 produced on the internal wall of the cover 3 and which comes in stop on the outside on the end edge of the orifice 10.
  • Figure 3 shows a variant of the device of Figure 2 in which the insert 2 extends inside the duct 1, in direction of the reservoir, by a rod 13 of the same material.
  • the rod 13 has a smaller diameter than the inside diameter of the conduit 1, which provides a coaxial annular cavity 1c around said rod.
  • the rod 13 forms a wick leading the liquid product to the heart of insert 2.
  • the rod 13 can even extend over the entire length of the nozzle E and of the reservoir up to immerse in the product.
  • the porosity is made in a non-uniform manner in the insert, which delimits in its mass, channels for preferential flow and / or circulation of the product.
  • the tip E has a valve 4 whose seat is formed by the edges of the discharge orifice 10.
  • the valve 4 is associated with elastic return means, here under shape of a crown 21, carried by the insert 2 and produced with a elastically deformable material, possibly in one piece with the body of insert 2.
  • the crown 24 is retained by its peripheral edge under the inner wall of the shoulder 11 of the end piece E.
  • the valve 4 is made integral with the insert 2 by means of a necklace 24.

Abstract

The container has a top (E) with an inner duct (1) linked to the container at one end and to an outlet (10) at the other. The duct is at least partially closed by an insert (2) with a selective porosity which permits a controlled flow of the product outwards on the one hand and a filtration of indrawn air on the other, holding back contaminants and/or biological pollutants. The top is covered by a protective cap (3) with a seal for the outlet (10), e.g. in the form of an inner seal lip (30) which fits round the outlet, or a projection which fits into the outlet aperture when the cap is put in place over the top.

Description

La présente invention concerne un dispositif pour la distribution et le conditionnement de produits liquides stériles et plus particulièrement de produits pharmaceutiques à usage ophtalmique.The present invention relates to a device for dispensing and packaging of sterile liquid products and more particularly pharmaceutical products for ophthalmic use.

Il existe déjà des dispositifs de ce type tels que celui qui a fait l'objet de la demande de brevet FR 96 00120.There are already devices of this type such as the one that made the subject of patent application FR 96 00120.

Ces dispositifs comprennent notamment un réservoir de produit surmonté d'un embout qui est pourvu d'un conduit interne communiquant à son extrémité amont avec le réservoir et débouchant à son extrémité aval à l'extérieur via un orifice d'évacuation. Le conduit interne est généralement obturé de manière étanche, d'une part, au niveau de l'orifice d'évacuation, par un clapet et, d'autre part, au moyen d'une lèvre interne d'étanchéité qui est élastiquement déformable.These devices include a product reservoir surmounted by a nozzle which is provided with an internal conduit communicating at its upstream end with the reservoir and opening at its downstream end to the outside via a discharge orifice. The conduit internal is generally sealed, on the one hand, at the level of the discharge orifice, by a valve and, on the other hand, by means an internal sealing lip which is elastically deformable.

Cependant, ces moyens d'obturation, qui sont mobiles ou déformables sont complexes et tant leur fabrication que leur montage sur le dispositif, sont des opérations délicates et onéreuses.However, these sealing means, which are mobile or deformable are complex and both their manufacture and their assembly on the device, are delicate and expensive operations.

En outre, ces dispositifs ne permettent pas de garantir un mode de distribution au goutte-à-goutte, ce qui constitue un handicap majeur vis-à-vis de produits dont la posologie peut être prescrite de façon stricte.In addition, these devices do not guarantee a mode of drip distribution, which constitutes a major handicap vis-à-vis products whose dosage can be prescribed in a way strict.

En outre, parmi ces dispositifs certains fonctionnent sans reprise d'air, ce qui entraíne une déformation du réservoir et nécessite une structure souple. Enfin, d'autres ne peuvent assurer la filtration du flux gazeux aspiré vers le réservoir lors de la reprise d'air consécutive à la délivrance d'une dose de produit. Il en résulte un risque important de contamination ou de pollution du produit.In addition, among these devices some operate without recovery air, which causes a deformation of the tank and requires a flexible structure. Finally, others cannot filter the flow gas sucked in towards the reservoir during the return of air following the delivery of a dose of product. This results in a significant risk of contamination or pollution of the product.

La présente invention a pour but de résoudre ces problèmes techniques de manière satisfaisante.The object of the present invention is to solve these problems techniques satisfactorily.

Ce but est atteint, selon l'invention, au moyen d'un dispositif pour la distribution et le conditionnement d'un produit liquide stérile du type comprenant un réservoir surmonté d'un embout pourvu d'un conduit interne communiquant à son extrémité amont avec ledit réservoir et débouchant par son extrémité aval à l'extérieur, via un orifice d'évacuation, caractérisé en ce que ledit embout comporte d'une part, un insert de porosité sélective obstruant au moins partiellement le conduit interne et permettant, à la fois, un écoulement dosé du produit vers l'extérieur et une filtration de l'air aspiré vers l'intérieur en arrêtant les contaminants et/ou polluants biologiques, ledit insert comportant un doigt qui est inséré dans l'orifice d'évacuation et dont l'extrémité fait saillie à l'extérieur, et d'autre part, un capot coiffant ledit embout et portant un élément d'obturation étanche dudit orifice d'évacuation.This object is achieved, according to the invention, by means of a device for the distribution and packaging of a sterile liquid product from type comprising a reservoir surmounted by a nozzle provided with a internal conduit communicating at its upstream end with said tank and opening through its downstream end to the outside, via a discharge orifice, characterized in that said end piece comprises of part, an insert of selective porosity at least partially obstructing the internal conduit and allowing, at the same time, a metered flow of the product to the outside and filtration of the air sucked inwards, stopping contaminants and / or biological pollutants, said insert comprising a finger which is inserted into the discharge opening and whose end is projecting from the outside, and on the other hand, a cover covering said end piece and carrying a sealed closure element of said discharge orifice.

Selon un mode de réalisation particulier, ledit élément d'obturation est constitué d'une lèvre périphérique interne destinée à venir en appui par l'extérieur autour de l'orifice d'évacuation, lors de la mise en place du capot sur l'embout.According to a particular embodiment, said element obturation consists of an internal peripheral lip intended to come to bear from the outside around the discharge orifice, when fitting of the cover on the nozzle.

Selon une variante de réalisation, ledit capot comporte un organe de verrouillage coopérant par encliquetage avec un organe de retenue ménagé sur l'embout.According to an alternative embodiment, said cover comprises a locking member cooperating by snap-fastening with a locking member retaining formed on the nozzle.

Selon une autre variante, ledit capot comporte des éléments raidisseurs prenant appui sur l'embout.According to another variant, said cover comprises elements stiffeners bearing on the end piece.

Selon une caractéristique avantageuse, ledit insert a un profil adapté pour se loger dans l'extrémité aval dudit conduit.According to an advantageous characteristic, said insert has a profile adapted to be housed in the downstream end of said conduit.

Selon un autre mode de réalisation, ledit embout comporte un clapet dont le siège est formé par les bords de l'orifice d'évacuation, et qui est associé à des moyens de rappel élastique portés par ledit insert.According to another embodiment, said tip comprises a valve whose seat is formed by the edges of the discharge orifice, and which is associated with elastic return means carried by said insert.

Selon une variante, lesdits moyens de rappel élastique sont constitués par une couronne élastiquement déformable retenue par son bord périphérique sous un épaulement de l'embout.According to a variant, said elastic return means are constituted by an elastically deformable crown retained by its peripheral edge under a shoulder of the nozzle.

Selon encore une autre caractéristique, le dispositif est réalisé au moins partiellement avec un matériau contenant un agent chimique bactéricide et/ou antiseptique.According to yet another characteristic, the device is produced at at least partially with a material containing a chemical agent bactericide and / or antiseptic.

Selon d'autres caractéristiques, la porosité dudit insert est comprise entre 40 % et 60 %, et de préférence, le diamètre des pores est compris entre 5 et 10 µm.According to other characteristics, the porosity of said insert is between 40% and 60%, and preferably, the diameter of the pores is between 5 and 10 µm.

Le cas échéant, la porosité de l'insert est non uniforme et délimite dans sa masse des canaux pour l'écoulement préférentiel du produit.If applicable, the porosity of the insert is non-uniform and delimits in its mass channels for the preferential flow of product.

Le dispositif de la présente invention assure à la fois un dosage précis et reproductible et une protection bactérienne du produit en utilisant des moyens techniques simples.The device of the present invention provides both a metering precise and reproducible and bacterial protection of the product in using simple technical means.

L'étanchéité du dispositif est complétée et renforcée par l'action du capot. The tightness of the device is completed and reinforced by the action of the hood.

L'insert poreux est, en outre, un constituant simple, fiable et économique qui a une action synergique avec les autres constituants du dispositif pour assurer conjointement, la régulation du débit de produit, la filtration de l'air aspiré et la nécessaire étanchéité du dispositif.The porous insert is, moreover, a simple, reliable and economic which has a synergistic action with the other constituents of the device for jointly ensuring the regulation of the product flow, filtration of the intake air and the necessary sealing of the device.

La présente invention sera mieux comprise à la lecture de la description qui va suivre accompagnée des dessins sur lesquels :

  • la figure 1 représente une vue en coupe d'un premier mode de réalisation du dispositif de l'invention ;
  • la figure 2 représente une vue en coupe d'un second mode de réalisation du dispositif de l'invention ;
  • la figure 3 représente une vue en coupe d'une variante de réalisation du dispositif de la figure 2 ;
  • la figure 4 représente une vue en coupe d'un troisième mode de réalisation du dispositif de l'invention.
The present invention will be better understood on reading the description which follows, accompanied by the drawings in which:
  • Figure 1 shows a sectional view of a first embodiment of the device of the invention;
  • Figure 2 shows a sectional view of a second embodiment of the device of the invention;
  • Figure 3 shows a sectional view of an alternative embodiment of the device of Figure 2;
  • Figure 4 shows a sectional view of a third embodiment of the device of the invention.

Le dispositif représenté sur la figure 1, tout comme ceux représentés sur les figures 2 à 4, est plus particulièrement destiné à la distribution et au conditionnement d'un produit liquide stérile.The device shown in Figure 1, like those shown in Figures 2 to 4, is more particularly intended for distribution and packaging of a sterile liquid product.

Ce dispositif comprend un réservoir (non représenté) surmonté d'un embout E.This device includes a tank (not shown) surmounted a tip E.

L'embout E est pourvu d'une collerette C de raccordement au réservoir et d'un conduit interne 1 communiquant à son extrémité amont 1a avec le réservoir et débouchant, par son extrémité aval 1b, à l'extérieur via un orifice d'évacuation 10.The end piece E is provided with a collar C for connection to the tank and an internal conduit 1 communicating at its upstream end 1a with the reservoir and opening, through its downstream end 1b, to outside via an outlet 10.

Le conduit 1 est, au moins partiellement, obstrué par un insert 2 réalisé avec un matériau de porosité sélective.The conduit 1 is, at least partially, obstructed by an insert 2 made with a material of selective porosity.

Plus précisément, cette porosité est telle que, l'insert 2 assure, d'une part, un dosage du produit en ralentissant son débit d'écoulement vers l'extérieur, lors de la mise en pression du réservoir, et , d'autre part, une filtration de l'air aspiré vers l'intérieur lors du retour de la pression interne du réservoir à la pression atmosphérique.More precisely, this porosity is such that the insert 2 ensures, on the one hand, a dosage of the product by slowing down its flow rate outwards, when the tank is pressurized, and, on the other hand, filtration of the air drawn inwards when the pressure returns internal tank at atmospheric pressure.

La reprise d'air s'effectue ainsi en arrêtant les contaminants et/ou polluants biologiques.The air intake is thus carried out by stopping the contaminants and / or biological pollutants.

Sur la figure 1, l'insert 2 a un profil adapté pour se loger dans l'extrémité aval 1b du conduit 1 avec un léger serrage radial ou une faible compression, en occupant toute la section libre. In FIG. 1, the insert 2 has a profile adapted to be housed in the downstream end 1b of the conduit 1 with a slight radial tightening or a low compression, occupying the entire free section.

Par suite, le flux total de produit liquide est amené à traverser l'insert 2, ce qui assure une régulation du débit. Le transfert s'effectue sous pression, d'abord par imprégnation de l'insert, au travers des pores, puis par libération du produit.As a result, the total flow of liquid product is caused to pass through insert 2, which regulates the flow. The transfer takes place under pressure, first by impregnating the insert, through the pores, then by release of the product.

La porosité de l'insert 2 est, de préférence, comprise entre 40% et 60 % avec un diamètre de pores compris entre 5 et 10 µm. Ce qui permet de produire, à la fois, un dosage au goutte-à-goutte dans un sens, et un arrêt ou un piégeage des principaux agents contaminants dans l'autre sens.The porosity of insert 2 is preferably between 40% and 60% with a pore diameter of between 5 and 10 µm. What allows to produce, at the same time, a drip dosage in a sense, and a stop or a trapping of the main contaminants in the other direction.

Le cas échéant, l'insert est imprégné ou réalisé au moins partiellement avec une matière ayant une activité bactéricide (par exemple une substance oligodynamique à base d'argent).If necessary, the insert is impregnated or produced at least partially with a material having bactericidal activity (for example example an oligodynamic substance based on silver).

Dans le mode de réalisation de la figure 1, l'insert 2 comporte un doigt 20 qui est inséré dans l'orifice d'évacuation 10 avec un léger serrage radial. L'extrémité 20a du doigt 20 fait saillie à l'extérieur avec un profil en ogive favorisant la formation des gouttes de produit et permettant de calibrer le volume des gouttes de préférence entre 25µl et 50µl.In the embodiment of FIG. 1, the insert 2 comprises a finger 20 which is inserted into the discharge orifice 10 with a slight radial tightening. The end 20a of the finger 20 projects outside with a warhead profile favoring the formation of product drops and allowing to calibrate the volume of the drops preferably between 25µl and 50µl.

Le dispositif de l'invention comporte, en outre, un capot 3 destiné à coiffer au moins l'extrémité de l'embout E.The device of the invention further comprises a cover 3 intended to cover at least the end of the end piece E.

Le capot 3 porte un élément d'obturation étanche de l'orifice d'évacuation 10.The cover 3 carries a sealed closure element for the orifice Evacuation 10.

Cet élément est constitué, dans le mode de réalisation de la figure 1, d'une lèvre périphérique 30 réalisée sur la paroi interne du capot 3 et qui est destinée à venir en appui par l'extérieur autour de l'orifice 10 lors de la mise en place du capot 3 sur l'embout E.This element consists, in the embodiment of the Figure 1, a peripheral lip 30 formed on the inner wall of the cover 3 and which is intended to come to bear from the outside around the orifice 10 when the cover 3 is placed on the end piece E.

La lèvre 30 est relativement rigide et borde une cavité 30a, ménagée sur la paroi interne du capot 3, dans laquelle vient se loger, l'extrémité 20a en ogive du doigt 20 de l'insert 2.The lip 30 is relatively rigid and borders a cavity 30a, formed on the internal wall of the cover 3, in which is housed, the end 20a in a warhead of the finger 20 of the insert 2.

Dans le cas où l'extrémité 20a du doigt 20 est ajustée avec un léger jeu aux dimensions de la cavité 30a, les surfaces mutuelles en regard délimitent un espace mort dans lequel est assurée une protection anti-bactérienne.In the case where the end 20a of the finger 20 is adjusted with a slight clearance to the dimensions of the cavity 30a, the mutual surfaces in gaze delimits a dead space in which protection is ensured anti-bacterial.

Le capot 3 comporte aussi un organe de verrouillage 32 coopérant par encliquetage avec un organe de retenue 12 ménagé sur l'embout E. The cover 3 also includes a locking member 32 cooperating by snap-fastening with a retaining member 12 formed on end piece E.

La position et la géométrie des organes de verrouillage 32 et de retenue 12 sont déterminées de façon à assurer une mise en appui étanche de la lèvre 30 autour de l'orifice 10 et, donc, un assemblage hermétique du capot 3 sur l'embout E.The position and the geometry of the locking members 32 and retainer 12 are determined so as to provide support sealing of the lip 30 around the orifice 10 and, therefore, an assembly airtight cover 3 on end piece E.

Le capot 3 comporte, en outre, des éléments raidisseurs 31 sous forme d'ailettes ou d'un cylindre prenant appui sur un épaulement 11 de l'embout E.The cover 3 further comprises stiffening elements 31 under shape of fins or of a cylinder resting on a shoulder 11 of end piece E.

En vue de renforcer la protection biologique du produit, il est prévu, le cas échéant, de réaliser le dispositif (embout E et/ou insert 2 et/ou capot 3) avec un matériau plastique contenant un agent chimique bactéricide et/ou antiseptique.In order to strengthen the biological protection of the product, it is planned, if necessary, to make the device (E tip and / or insert 2 and / or cover 3) with a plastic material containing a chemical agent bactericide and / or antiseptic.

Dans le mode de réalisation de la figure 2, l'élément d'obturation porté par le capot 3, est constitué d'un ergot interne 33 destiné à s'introduire dans l'orifice d'évacuation 10 lors de la mise en place du capot 3 sur l'embout E.In the embodiment of Figure 2, the closure element carried by the cover 3, consists of an internal lug 33 intended to enter the evacuation orifice 10 during the installation of the cover 3 on end piece E.

L'extrémité interne de l'ergot 33 vient en contact avec l'insert 2 formé d'une pièce logée dans l'extrémité aval 16 du conduit 1 et qui, après dégagement du capot 3, laisse l'orifice 10 totalement libre pour l'écoulement du produit.The internal end of the lug 33 comes into contact with the insert 2 formed of a part housed in the downstream end 16 of the conduit 1 and which, after release of the cover 3, leaves the orifice 10 completely free for product flow.

L'appui de l'ergot 33 contre l'insert 2 est limité par une face transversale 34 réalisée sur la paroi interne du capot 3 et qui vient en butée à l'extérieur sur le bord d'extrémité de l'orifice 10.The support of the lug 33 against the insert 2 is limited by one face transverse 34 produced on the internal wall of the cover 3 and which comes in stop on the outside on the end edge of the orifice 10.

La figure 3 représente une variante du dispositif de la figure 2 dans laquelle l'insert 2 se prolonge à l'intérieur du conduit 1, en direction du réservoir, par une tige 13 du même matériau.Figure 3 shows a variant of the device of Figure 2 in which the insert 2 extends inside the duct 1, in direction of the reservoir, by a rod 13 of the same material.

La tige 13 a un diamètre plus faible que le diamètre intérieur du conduit 1, ce qui ménage une cavité annulaire coaxiale 1c autour de ladite tige. La tige 13 forme une mèche conduisant le produit liquide jusqu'au coeur de l'insert 2.The rod 13 has a smaller diameter than the inside diameter of the conduit 1, which provides a coaxial annular cavity 1c around said rod. The rod 13 forms a wick leading the liquid product to the heart of insert 2.

Selon une autre variante, non représentée, la tige 13 peut même s'étendre sur toute la longueur de l'embout E et du réservoir jusqu'à plonger dans le produit.According to another variant, not shown, the rod 13 can even extend over the entire length of the nozzle E and of the reservoir up to immerse in the product.

Selon un autre mode de réalisation, non représenté, la porosité est réalisée de façon non uniforme dans l'insert, ce qui délimite dans sa masse, des canaux pour l'écoulement et/ou la circulation préférentiels du produit. According to another embodiment, not shown, the porosity is made in a non-uniform manner in the insert, which delimits in its mass, channels for preferential flow and / or circulation of the product.

Dans le mode de réalisation de la figure 4, l'embout E comporte un clapet 4 dont le siège est formé par les bords de l'orifice d'évacuation 10. Le clapet 4 est associé à des moyens de rappel élastique, ici sous forme d'une couronne 21, portée par l'insert 2 et réalisée avec une matière élastiquement déformable, éventuellement d'une seule pièce avec le corps de l'insert 2.In the embodiment of Figure 4, the tip E has a valve 4 whose seat is formed by the edges of the discharge orifice 10. The valve 4 is associated with elastic return means, here under shape of a crown 21, carried by the insert 2 and produced with a elastically deformable material, possibly in one piece with the body of insert 2.

La couronne 24 est retenue par son bord périphérique sous la paroi interne de l'épaulement 11 de l'embout E.The crown 24 is retained by its peripheral edge under the inner wall of the shoulder 11 of the end piece E.

Le clapet 4 est rendu solidaire de l'insert 2 au moyen d'un collier 24.The valve 4 is made integral with the insert 2 by means of a necklace 24.

Claims (11)

Dispositif pour la distribution et le conditionnement d'un produit liquide stérile du type comprenant un réservoir surmonté d'un embout (E) pourvu d'un conduit interne (1) communiquant à son extrémité amont (1a) avec ledit réservoir et débouchant par son extrémité aval (1b) à l'extérieur via un orifice d'évacuation (10), caractérisé en ce que ledit embout comporte d'une part, un insert (2) de porosité sélective obstruant au moins partiellement le conduit interne (1) et permettant, à la fois, un écoulement dosé du produit vers l'extérieur et une filtration de l'air aspiré vers l'intérieur en arrêtant les contaminants et/ou polluants biologiques, ledit insert (2) comportant un doigt (20) qui est inséré dans l'orifice d'évacuation (10) et dont l'extrémité (20a) fait saillie à l'extérieur, et d'autre part, un capot (3) coiffant ledit embout (E) et portant un élément d'obturation étanche dudit orifice d'évacuation (10).Device for the distribution and packaging of a sterile liquid product of the type comprising a reservoir surmounted by a end piece (E) provided with an internal conduit (1) communicating with its upstream end (1a) with said reservoir and opening through its downstream end (1b) to the outside via a discharge orifice (10), characterized in that said tip comprises on the one hand, an insert (2) of selective porosity at least partially obstructing the internal duct (1) and allowing, at the same time, a metered flow of the product towards the outside and filtration of the air sucked inwards by stopping the contaminants and / or biological pollutants, said insert (2) comprising a finger (20) which is inserted into the discharge orifice (10) and of which the end (20a) protrudes outside, and on the other hand, a cover (3) covering said end piece (E) and carrying a sealed closure element of said discharge orifice (10). Dispositif selon la revendication 1, caractérisé en ce que ledit élément d'obturation est constitué d'une lèvre périphérique interne (30) destinée à venir en appui par l'extérieur, autour de l'orifice d'évacuation (10) lors de la mise en place du capot (3) sur l'embout (E).Device according to claim 1, characterized in that said closure element consists of an internal peripheral lip (30) intended to come to bear from the outside, around the orifice evacuation (10) when placing the cover (3) on the end piece (E). Dispositif selon l'une des revendications précédentes, caractérisé en ce que ledit capot (3) comporte un organe de verrouillage (32) coopérant par encliquetage avec un organe de retenue (12) ménagé sur l'embout(E).Device according to one of the preceding claims, characterized in that said cover (3) comprises a locking member (32) cooperating by snap-fastening with a retaining member (12) formed on the nozzle (E). Dispositif selon l'une des revendications précédentes, caractérisé en ce que ledit capot (3) comporte des éléments raidisseurs (31) prenant appui sur l'embout (E).Device according to one of the preceding claims, characterized in that said cover (3) comprises stiffening elements (31) bearing on the end piece (E). Dispositif selon l'une des revendications précédentes, caractérisé en ce que ledit insert (2) a un profil adapté pour se loger dans l'extrémité aval (1b) dudit conduit (1).Device according to one of the preceding claims, characterized in that said insert (2) has a profile adapted to be housed in the downstream end (1b) of said conduit (1). Dispositif selon l'une des revendications précédentes, caractérisé en ce que ledit embout (E) comporte un clapet (4) dont le siège est formé par les bords de l'orifice d'évacuation (10) et qui est associé à des moyens de rappel élastique portés par ledit insert (2).Device according to one of the preceding claims, characterized in that said end piece (E) comprises a valve (4), the seat is formed by the edges of the discharge opening (10) and which is associated with elastic return means carried by said insert (2). Dispositif selon la revendication 6, caractérisé en ce que lesdits moyens de rappel élastique sont constitués par une couronne (21) élastiquement déformable retenue par son bord périphérique sous un épaulement (11) de l'embout (E).Device according to claim 6, characterized in that said elastic return means consist of a crown (21) elastically deformable retained by its peripheral edge under a shoulder (11) of the end piece (E). Dispositif selon l'une des revendications précédentes, caractérisé en ce qu'il est réalisé au moins partiellement avec un matériau contenant un agent chimique bactéricide et/ou antiseptique.Device according to one of the preceding claims, characterized in that it is made at least partially with a material containing a bactericidal and / or antiseptic chemical agent. Dispositif selon l'une des revendications précédentes, caractérisé en ce que la porosité dudit insert (2) est comprise entre 40 % et 60 %.Device according to one of the preceding claims, characterized in that the porosity of said insert (2) is between 40% and 60%. Dispositif selon l'une des revendications précédentes, caractérisé en ce que le diamètre des pores dudit insert (2) est compris entre 5 et 10 µm.Device according to one of the preceding claims, characterized in that the diameter of the pores of said insert (2) is included between 5 and 10 µm. Dispositif selon l'une des revendications précédentes, caractérisé en ce que la porosité de l'insert (2) est non uniforme et délimite dans sa masse des canaux pour l'écoulement préférentiel dudit produit.Device according to one of the preceding claims, characterized in that the porosity of the insert (2) is non-uniform and delimits in its mass channels for the preferential flow of said product.
EP19980400777 1997-04-02 1998-04-02 Device for dispensing and storing sterile fluids Expired - Lifetime EP0881158B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9703984 1997-04-02
FR9703984A FR2761665B1 (en) 1997-04-02 1997-04-02 DEVICE FOR DISPENSING AND PACKAGING STERILE LIQUID PRODUCTS

Publications (2)

Publication Number Publication Date
EP0881158A1 true EP0881158A1 (en) 1998-12-02
EP0881158B1 EP0881158B1 (en) 2004-03-17

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EP19980400777 Expired - Lifetime EP0881158B1 (en) 1997-04-02 1998-04-02 Device for dispensing and storing sterile fluids

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US (1) US5992701A (en)
EP (1) EP0881158B1 (en)
JP (1) JPH10278936A (en)
CN (1) CN1096993C (en)
AT (1) ATE261867T1 (en)
CA (1) CA2233735C (en)
DE (1) DE69822360T2 (en)
DK (1) DK0881158T3 (en)
ES (1) ES2221130T3 (en)
FR (1) FR2761665B1 (en)
HK (1) HK1016558A1 (en)
PT (1) PT881158E (en)
TW (1) TW399021B (en)

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US20060011654A1 (en) * 2004-07-16 2006-01-19 Webb Garth T Disinfectant cap for sterile liquid dispenser
US20110163114A1 (en) * 2005-09-20 2011-07-07 0736413 B.C. Ltd. Pressurized sterile liquid dispenser
FR2897599B1 (en) * 2006-02-23 2010-08-27 Rexam Pharma LIQUID CONDITIONING AND DISPENSING ASSEMBLY.
AU2008226301B2 (en) * 2007-03-13 2013-08-29 0736413 B.C. Ltd. Disinfectant cap for sterile liquid dispenser
EP2098460A1 (en) 2008-03-08 2009-09-09 Jürgen Schmidt Dispensing device for flowable media
FR2934572A1 (en) * 2008-07-31 2010-02-05 Thea Lab BOTTLE FOR FLASK OF LIQUID CONDITIONING TO DISPENSE DROP GOUTTE.
US9493281B2 (en) * 2009-05-04 2016-11-15 Carmel Pharma Ab Sealing barrier arrangement
FR2963329B1 (en) * 2010-07-30 2013-06-28 Thea Lab HEAD FOR DISPENSING A DROP FLUID LIQUID
CN103826809A (en) * 2011-10-14 2014-05-28 康奈尔有限公司 Apparatus for maintaining a hair treatment device
DE102011086755A1 (en) 2011-11-21 2013-05-23 Aptar Radolfzell Gmbh Dispenser for dispensing pharmaceutical liquids
WO2014095351A1 (en) * 2012-12-21 2014-06-26 Fresenius Kabi Deutschland Gmbh Milk bottle adapter
CN104609014B (en) * 2013-11-01 2018-07-27 艾博生物医药(杭州)有限公司 A kind of liquid bogey
FR3014086B1 (en) 2013-12-04 2015-12-04 Albea Le Treport SYSTEM FOR DISPENSING A FLUID PRODUCT CONTAINED IN A CONTAINER
DE102013226253B4 (en) * 2013-12-17 2016-03-24 Aptar Radolfzell Gmbh Protective cap for a dispenser and dispenser for dispensing pharmaceutical and / or cosmetic liquids
FR3080844B1 (en) * 2018-05-07 2020-06-05 Horus Pharma PACKAGING AND DISPENSING DEVICE OF A PRODUCT WITH BOTTLE AND METERING CAP WITH FILTER
PL241931B1 (en) * 2020-02-03 2022-12-27 Gerresheimer Boleslawiec Spolka Akcyjna Dispenser for dispensing liquid
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Also Published As

Publication number Publication date
EP0881158B1 (en) 2004-03-17
PT881158E (en) 2004-08-31
DE69822360D1 (en) 2004-04-22
FR2761665A1 (en) 1998-10-09
HK1016558A1 (en) 1999-11-05
ES2221130T3 (en) 2004-12-16
ATE261867T1 (en) 2004-04-15
CN1096993C (en) 2002-12-25
DE69822360T2 (en) 2005-05-04
CA2233735A1 (en) 1998-10-02
FR2761665B1 (en) 1999-06-25
JPH10278936A (en) 1998-10-20
US5992701A (en) 1999-11-30
DK0881158T3 (en) 2004-07-19
CN1196323A (en) 1998-10-21
TW399021B (en) 2000-07-21
CA2233735C (en) 2006-09-05

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