EP1003493A4 - Use of selective rxr agonists to prevent surgical adhesions - Google Patents

Use of selective rxr agonists to prevent surgical adhesions

Info

Publication number
EP1003493A4
EP1003493A4 EP98938064A EP98938064A EP1003493A4 EP 1003493 A4 EP1003493 A4 EP 1003493A4 EP 98938064 A EP98938064 A EP 98938064A EP 98938064 A EP98938064 A EP 98938064A EP 1003493 A4 EP1003493 A4 EP 1003493A4
Authority
EP
European Patent Office
Prior art keywords
surgical adhesions
rxr agonists
prevent surgical
selective rxr
selective
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98938064A
Other languages
German (de)
French (fr)
Other versions
EP1003493A1 (en
Inventor
Xina Nair
Fred Christopher Zusi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of EP1003493A1 publication Critical patent/EP1003493A1/en
Publication of EP1003493A4 publication Critical patent/EP1003493A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/39—Heterocyclic compounds having sulfur as a ring hetero atom having oxygen in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
EP98938064A 1997-07-29 1998-07-28 Use of selective rxr agonists to prevent surgical adhesions Withdrawn EP1003493A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5401797P 1997-07-29 1997-07-29
US54017P 1997-07-29
PCT/US1998/015625 WO1999006036A1 (en) 1997-07-29 1998-07-28 Use of selective rxr agonists to prevent surgical adhesions

Publications (2)

Publication Number Publication Date
EP1003493A1 EP1003493A1 (en) 2000-05-31
EP1003493A4 true EP1003493A4 (en) 2002-03-27

Family

ID=21988221

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98938064A Withdrawn EP1003493A4 (en) 1997-07-29 1998-07-28 Use of selective rxr agonists to prevent surgical adhesions

Country Status (5)

Country Link
EP (1) EP1003493A4 (en)
JP (1) JP2001511445A (en)
AU (1) AU733236B2 (en)
CA (1) CA2295807A1 (en)
WO (1) WO1999006036A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6624154B1 (en) * 1999-04-23 2003-09-23 Bristol-Myers Squibb Company Compositions and methods for treatment of hyperproliferative diseases
WO2007029760A1 (en) * 2005-09-09 2007-03-15 R & R Inc. Pharmaceutical for use in prevention and/or treatment of bowel disease
JP5055971B2 (en) 2006-11-16 2012-10-24 株式会社ニコン Surface treatment method, surface treatment apparatus, exposure method, exposure apparatus, and device manufacturing method
JP2008179570A (en) * 2007-01-25 2008-08-07 R&R Inc Medicine for preventing and/or treating internal organ adhesion

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993021146A1 (en) * 1992-04-22 1993-10-28 Ligand Pharmaceuticals Incorporated Compounds having selectivity for retinoid x receptors
WO1994012880A2 (en) * 1992-11-25 1994-06-09 La Jolla Cancer Research Foundation Rxr homodimer formation and bridged bicyclic aromatic compounds and their use in modulating gene expression
EP0694301A1 (en) * 1994-07-27 1996-01-31 Centre International De Recherches Dermatologiques Galderma (C.I.R.D. Galderma) Synergistic combination containing at least a RXR specific ligand and a RAR alpha specific ligand
US5534261A (en) * 1995-01-17 1996-07-09 University Of Southern California Retinoid-based compositions and method for preventing adhesion formation using the same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5455265A (en) * 1993-02-11 1995-10-03 Allergan, Inc. Method of treatment with compounds having selective agonist-like activity on RXR retinoid receptors
US5399586A (en) * 1993-03-11 1995-03-21 Allergan, Inc. Treatment of mammals afflicted with tumors with compounds having RXR retinoid receptor agonist activity

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993021146A1 (en) * 1992-04-22 1993-10-28 Ligand Pharmaceuticals Incorporated Compounds having selectivity for retinoid x receptors
WO1994012880A2 (en) * 1992-11-25 1994-06-09 La Jolla Cancer Research Foundation Rxr homodimer formation and bridged bicyclic aromatic compounds and their use in modulating gene expression
EP0694301A1 (en) * 1994-07-27 1996-01-31 Centre International De Recherches Dermatologiques Galderma (C.I.R.D. Galderma) Synergistic combination containing at least a RXR specific ligand and a RAR alpha specific ligand
US5534261A (en) * 1995-01-17 1996-07-09 University Of Southern California Retinoid-based compositions and method for preventing adhesion formation using the same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9906036A1 *

Also Published As

Publication number Publication date
WO1999006036A1 (en) 1999-02-11
CA2295807A1 (en) 1999-02-11
AU733236B2 (en) 2001-05-10
AU8667098A (en) 1999-02-22
EP1003493A1 (en) 2000-05-31
JP2001511445A (en) 2001-08-14

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