EP1138392A3 - Centrifuge bowl for separating particles - Google Patents

Centrifuge bowl for separating particles Download PDF

Info

Publication number
EP1138392A3
EP1138392A3 EP01107607A EP01107607A EP1138392A3 EP 1138392 A3 EP1138392 A3 EP 1138392A3 EP 01107607 A EP01107607 A EP 01107607A EP 01107607 A EP01107607 A EP 01107607A EP 1138392 A3 EP1138392 A3 EP 1138392A3
Authority
EP
European Patent Office
Prior art keywords
cavity
centrifuge bowl
particles
separating particles
processing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01107607A
Other languages
German (de)
French (fr)
Other versions
EP1138392A2 (en
Inventor
Koichiro Sakota
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Haemonetics Corp
Original Assignee
Haemonetics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Haemonetics Corp filed Critical Haemonetics Corp
Publication of EP1138392A2 publication Critical patent/EP1138392A2/en
Publication of EP1138392A3 publication Critical patent/EP1138392A3/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A61M1/3696—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B7/00—Elements of centrifuges
    • B04B7/08—Rotary bowls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B04B2005/0464—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation with hollow or massive core in centrifuge bowl
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • B04B2005/0471—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation with additional elutriation separation of different particles

Abstract

A novel centrifuge bowl for processing particles suspended in a fluid is disclosed. The centrifuge bowl 10 includes an annular cavity 20 concentrically located about the rotation axis for suitably separating particles of similar densities but of different diameters. The cavity is preferably configured to have an annular cross sectional area, which is parallel to the rotation axis, that increases from a centrifugal side of the cavity toward a centripetal side of the cavity. This configuration allows to generate an almost rigidly rotating field upon rotation of the centrifuge bowl, which field helps to uniformly disperse Coriolis force throughout the circumference of the cavity to avoid turbulent mixing of the particles. In an alternative embodiment, the cavity is surrounded by an outer cavity for separating particles according to density before processing them through the inner cavity. This construction is particularly suitable for processing whole blood to harvest platelet-rich-plasma with reduced level of white blood cell contamination.
EP01107607A 2000-03-30 2001-03-27 Centrifuge bowl for separating particles Withdrawn EP1138392A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000094690A JP2001276663A (en) 2000-03-30 2000-03-30 Centrifugal separating bowl for particle separation
JP2000094690 2000-03-30

Publications (2)

Publication Number Publication Date
EP1138392A2 EP1138392A2 (en) 2001-10-04
EP1138392A3 true EP1138392A3 (en) 2002-11-06

Family

ID=18609709

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01107607A Withdrawn EP1138392A3 (en) 2000-03-30 2001-03-27 Centrifuge bowl for separating particles

Country Status (3)

Country Link
US (1) US20020142909A1 (en)
EP (1) EP1138392A3 (en)
JP (1) JP2001276663A (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5733253A (en) * 1994-10-13 1998-03-31 Transfusion Technologies Corporation Fluid separation system
US6524231B1 (en) 1999-09-03 2003-02-25 Baxter International Inc. Blood separation chamber with constricted interior channel and recessed passage
US6890291B2 (en) 2001-06-25 2005-05-10 Mission Medical, Inc. Integrated automatic blood collection and processing unit
US8105580B2 (en) 2001-12-07 2012-01-31 Cytori Therapeutics, Inc. Methods of using adipose derived stem cells to promote wound healing
US20050095228A1 (en) 2001-12-07 2005-05-05 Fraser John K. Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders
US7771716B2 (en) 2001-12-07 2010-08-10 Cytori Therapeutics, Inc. Methods of using regenerative cells in the treatment of musculoskeletal disorders
US9597395B2 (en) 2001-12-07 2017-03-21 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions
US7211037B2 (en) 2002-03-04 2007-05-01 Therakos, Inc. Apparatus for the continuous separation of biological fluids into components and method of using same
US7479123B2 (en) 2002-03-04 2009-01-20 Therakos, Inc. Method for collecting a desired blood component and performing a photopheresis treatment
US7297272B2 (en) 2002-10-24 2007-11-20 Fenwal, Inc. Separation apparatus and method
TWM269966U (en) * 2005-01-21 2005-07-11 Tian-Ju Ruan Plasmapheresis centrifuge bowl
EP1683579A1 (en) 2005-01-25 2006-07-26 Jean-Denis Rochat Disposable device for the continuous separation by centrifugation of a physiological liquid
EP1688183A1 (en) * 2005-02-03 2006-08-09 Jean-Denis Rochat Method and disposable device for centrifugal separation of a physiologic liquid
US7473216B2 (en) * 2005-04-21 2009-01-06 Fresenius Hemocare Deutschland Gmbh Apparatus for separation of a fluid with a separation channel having a mixer component
US7998052B2 (en) * 2006-03-07 2011-08-16 Jacques Chammas Rotor defining a fluid separation chamber of varying volume
NL2000116C2 (en) 2006-06-29 2008-01-02 Klip Consultancy B V Device comprising a container system for a body fluid.
JP4548675B2 (en) * 2007-05-28 2010-09-22 紘一郎 迫田 Improved Latham Bowl and Method of Use
US8075468B2 (en) 2008-02-27 2011-12-13 Fenwal, Inc. Systems and methods for mid-processing calculation of blood composition
US8685258B2 (en) 2008-02-27 2014-04-01 Fenwal, Inc. Systems and methods for conveying multiple blood components to a recipient
WO2010021993A1 (en) 2008-08-19 2010-02-25 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of the lymphatic system and malignant disease
US8870733B2 (en) * 2010-11-19 2014-10-28 Kensey Nash Corporation Centrifuge
US20170205322A1 (en) * 2014-07-08 2017-07-20 Cytori Therapeutics, Inc. Centrifuge chamber
US10683478B1 (en) * 2019-05-16 2020-06-16 Shenzhen Eureka biotechnology Co. Ltd Device and system for processing a liquid sample containing cells

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3291387A (en) * 1964-01-16 1966-12-13 Technicon Instr Continuous centrifugal separator
US4670002A (en) * 1985-12-09 1987-06-02 Hitachi Koki Company, Ltd. Centrifugal elutriator rotor
JPS63166450A (en) * 1986-12-26 1988-07-09 Hitachi Koki Co Ltd Structure and passage means of fluid coupling
DE3817664A1 (en) * 1988-05-25 1989-11-30 Josef Dr Theissen Method and device for lavage of blood cells
US5922211A (en) * 1996-03-26 1999-07-13 Nees; Stephan Method for centrifugal particle separation, particularly for use in the biological sector

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3291387A (en) * 1964-01-16 1966-12-13 Technicon Instr Continuous centrifugal separator
US4670002A (en) * 1985-12-09 1987-06-02 Hitachi Koki Company, Ltd. Centrifugal elutriator rotor
JPS63166450A (en) * 1986-12-26 1988-07-09 Hitachi Koki Co Ltd Structure and passage means of fluid coupling
DE3817664A1 (en) * 1988-05-25 1989-11-30 Josef Dr Theissen Method and device for lavage of blood cells
US5922211A (en) * 1996-03-26 1999-07-13 Nees; Stephan Method for centrifugal particle separation, particularly for use in the biological sector

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 012, no. 444 (C - 545) 22 November 1988 (1988-11-22) *

Also Published As

Publication number Publication date
JP2001276663A (en) 2001-10-09
EP1138392A2 (en) 2001-10-04
US20020142909A1 (en) 2002-10-03

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