EP1157689B1 - Stable pharmaceutical solution formulations for pressurised metered dose inhalers - Google Patents
Stable pharmaceutical solution formulations for pressurised metered dose inhalers Download PDFInfo
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- EP1157689B1 EP1157689B1 EP01112230A EP01112230A EP1157689B1 EP 1157689 B1 EP1157689 B1 EP 1157689B1 EP 01112230 A EP01112230 A EP 01112230A EP 01112230 A EP01112230 A EP 01112230A EP 1157689 B1 EP1157689 B1 EP 1157689B1
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- hfa
- formoterol
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- ethanol
- formulations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A61K9/124—Aerosols; Foams characterised by the propellant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
Definitions
- the invention relates to stable pharmaceutical solutions to be used with pressurised metered dose inhalers (MDIs) suitable for aerosol administration.
- MDIs pressurised metered dose inhalers
- the invention relates to solutions to be used with pressurised metered dose inhalers (MDIs) suitable for aerosol administration containing formoterol fumarate (a ⁇ 2 -agonist) and being stable at room temperature for a pharmaceutically acceptable shelf-life.
- Pressurised metered dose inhalers are well known devices for administering pharmaceutical products to the respiratory tract by inhalation.
- Drugs commonly delivered by inhalation include bronchodilators such as ⁇ 2 -agonists and anticholinergics, corticosteroids, anti-leukotrienes, anti-allergics and other materials that may be efficiently administered by inhalation, thus increasing the therapeutic index and reducing side effects of the active material.
- bronchodilators such as ⁇ 2 -agonists and anticholinergics, corticosteroids, anti-leukotrienes, anti-allergics and other materials that may be efficiently administered by inhalation, thus increasing the therapeutic index and reducing side effects of the active material.
- MDI uses a propellant to expel droplets containing the pharmaceutical product to the respiratory tract as an aerosol.
- Formulations for aerosol administration via MDIs can be solutions or suspensions.
- Solution formulations offer the advantage of being homogeneous with the active ingredient and excipients completely dissolved in the propellant vehicle or its mixture with suitable co-solvents such as ethanol. Solution formulations also obviate physical stability problems associated with suspension formulations so assuring more consistent uniform dosage administration.
- the preferred propellants used in aerosols for pharmaceutical use have been a group of chlorofluorocarbons which are commonly called Freons or CFCs, such as CCl 3 F (Freon 11 or CFC-11), CCl 2 F 2 (Freon 12 or CFC-12), and CClF 2 -CClF 2 (Freon 114 or CFC-114).
- Freons or CFCs such as CCl 3 F (Freon 11 or CFC-11), CCl 2 F 2 (Freon 12 or CFC-12), and CClF 2 -CClF 2 (Freon 114 or CFC-114).
- CFC chlorofluorocarbon
- Hydrofluoroalkanes (HFAs) known also as hydro-fluoro-carbons (HFCs)] contain no chlorine and are considered less destructive to ozone and these are proposed as substitutes for CFCs.
- HFAs and in particular 1,1,1,2-tetrafluoroethane (HFA 134a) and 1,1,1,2,3,3,3-heptafluoropropane (HFA 227) have been acknowledged to be the best candidates for non-CFC propellants and a number of medicinal aerosol formulations using such HFA propellant systems have been disclosed.
- HFA solution formulations may suffer to a greater extent of chemical stability problems with respect to the corresponding CFC formulations.
- TA 2005 8-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl] amino] ethyl]-2(1H)-quinolinone
- TA 2005 8-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl] amino] ethyl]-2(1H)-quinolinone
- salbutamol albuterol
- the currently marketed CFC solution formulation exhibits a limited shelf life, i.e. 12 months at refrigerator temperature, 4 ⁇ 2°C, and only 3 month at room temperature.
- an aerosol composition which comprises as active ingredient formoterol fumarate in a solution of a liquefied HFA 134a propellant and ethanol as co-solvent, and hydrochloric acid in an amount such that the solution has an apparent pH between 3.0 and 3.5.
- the composition comprises 1.0 M hydrochloric acid in an amount between 3 and 3.5 ⁇ l per 1.44 mg formoterol fumarate in 12 mL of the composition.
- the composition of the invention shall be contained in a pressurised MDI having part or all of its internal metallic surfaces made of stainless steel, anodised aluminium or lined with an inert organic coating.
- inert containers allows to avoid the leaching of metal ions or alkali as a consequence of the action of the acid contained in the formulation onto the inner walls of the cans.
- Metal ions such Al 3+ or alkali respectively deriving from the conventional aluminium or glass cans could in turn catalyse radical oxidative or other chemical reactions of the active ingredient which give rise to the formation of degradation products.
- a pressurised MDI for administering pharmaceutical doses consisting of an anodised aluminium container filled with a pharmaceutical composition consisting of a solution of formoterol fumarate in HFA 134a as a propellant in turn containing 12% w / w ethanol as a co-solvent and optionally isopropyl myristate as a low volatility component in an amount less/equal than 1.0% w/w, the apparent pH of said solution having been adjusted to between 3.0 and 3.5 by addition of small amounts of hydrochloric acid.
- the expression '% w/w' means the weight percentage of the component in respect to the total weight of the composition.
- the low volatility component besides increasing the mass median aerodynamic diameter (MMAD) of the aerosol particles on actuation of the inhaler as explained in the following, further improves the stability of the formulation.
- MMAD mass median aerodynamic diameter
- the addition of a low volatility component with a reduced polarity with respect to the co-solvent such as an ester may allow either to reduce the amount of acid to be added for adjusting the pH and diminish the polarity of the medium so limiting the possible uptake of environmental water.
- the shelf-life of the formulation put in the device of the invention could be predicted to be greater than two years at the refrigerator temperature (4-10° C) and three months at room temperature.
- a pressurised MDI consisting of a coated container filled with a pharmaceutical composition consisting of a solution of a combination of formoterol fumarate and beclometasone dipropionate (hereinafter BDP) in HFA 134a as a propellant in turn containing 12% w / w ethanol as a co-solvent with or without isopropyl myristate as low volatility component, the apparent pH of said solution having been adjusted to between 3.0 and 3.5 by addition of small amounts of hydrochloric acid.
- BDP beclometasone dipropionate
- WO 97/47286 EP 513127 , EP 504112 , WO 93/11747 , WO 94/21228 , WO 94/21229 , WO 96/18384 , WO 96/19198 , WO 96/19968 , WO 98/05302 , WO 98/34595 and WO 00/07567 disclose HFA formulations in the form of suspensions in which ⁇ 2 -agonists such formoterol and salbutamol are either exemplified and/or claimed.
- WO 99/65464 refers to HFA formulations containg two or more active ingredients in which at least one is in suspension.
- the preferred formulations comprises salbutamol sulphate in suspension.
- WO 98/34596 the applicant described solution compositions for use in an aerosol inhaler, comprising an active material, a propellant containing a hydrofluoroalkane (HFA), a cosolvent and further comprising a low volatility component to increase the mass median aerodynamic diameter (MMAD) of the aerosol particles on actuation of the inhaler.
- HFA hydrofluoroalkane
- MMAD mass median aerodynamic diameter
- pressurised MDI's for dispensing solution of an active ingredient in a hydrofluorocarbon propellant, a co-solvent and optionally a low-volatility component characterized in that part or all of the internal surfaces of said inhalers consist of stainless steel, anodised aluminium or are lined with an inert organic coating.
- the examples are referred only to steroids and anticholinergic agents.
- the use of coated containers, even in the presence of an organic acid is not sufficient for providing stable solution formulations of a phenylalkylamino derivative such as salbutamol.
- EP 673240 proposes the use of acids as stabilisers preventing the chemical degradation of the active ingredient in aerosol solution formulations comprising HFAs.
- Most examples relate to ipratropium bromide, an anticholinergic drug and only an example is presented for a ⁇ 2 -agonist, i.e. fenoterol.
- fenoterol a ⁇ 2 -agonist
- salbutamol is claimed, no exemplary formulations are provided.
- the stability data are reported only for ipratropium and the patentee does not either make difference between the use of organic and inorganic acids. It is indeed evident from the data reported in the example 1 of the present application, that salbutamol cannot be stabilised at all by addition of organic acids even when stored in coated cans.
- WO 98/34596 refers to solution formulations containing a propellant and a physiologically acceptable polymer which could help the solubilisation and the stability as well of the active ingredients.
- WO 00/06121 refers to propellant mixtures for aerosol dinitrogen monoxide and a hydrofluoroalkane in the preparation of suspension and solution aerosols.
- the use of dinitrogen monoxide may improve the stability at storage of oxidation-sensitive active ingredients.
- ⁇ 2 -agonist such as levosalbutamol sulphate, formoterol fumarate and salmeterol xinafoate, only examples referred to suspensions are reported.
- WO 99/65460 claims pressurised MDI's containing stable formulations of a ⁇ -agonist drug in suspension or solution.
- Examples refer to solutions of formoterol fumarate containing an HFA propellant and ethanol as co-solvent, filled in conventional aluminium or plastic coated glass cans.
- the method of filling an aerosol inhaler with a composition of the invention comprises:
- the active ingredient which is used in the aerosol compositions of the invention is formoterol fumarate which may be used in combinations with steroids such as beclomethasone dipropionate, fluticasone propionate, budesonide and its 22R-epimer or with anticholinergic atropine-like derivatives such as ipratropium bromide, oxitropium bromide, tiotropium bromide.
- steroids such as beclomethasone dipropionate, fluticasone propionate, budesonide and its 22R-epimer or with anticholinergic atropine-like derivatives such as ipratropium bromide, oxitropium bromide, tiotropium bromide.
- the active ingredient is a long acting ⁇ 2 -agonist belonging to the formula sketched below wherein R is 1-formylamino-2-hydroxy- phen-5-yl (formoterol).
- R is 1-formylamino-2-hydroxy- phen-5-yl (formoterol).
- the formulation to be suitable for delivering a therapeutic amount of the active ingredient in one or two actuations.
- the formulation will be suitable for delivering 6-12 ⁇ g/dose of formoterol fumarate either alone or in combination.
- dose we mean the amount of active ingredient delivered by a single actuation of the inhaler.
- the formulations of the invention will be contained in cans having part of all of the internal surfaces made of anodised aluminium, stainless steel or lined with an inert organic coating.
- preferred coatings are epoxy-phenol resins, perfluoroalkoxyalkane, perfluoroalkoxyalkylene, perfluoroalkylenes such as polytetrafluoroethylene, fluorinated-ethylene-propylene, polyether sulfone and a copolymer fluorinated-ethylene-propylene polyether sulfone.
- Other suitable coatings could be polyamide, polyimide, polyamideimide, polyphenylene sulfide or their combinations.
- cans having a rolled-in rim and preferably a part or full rollover rim are used.
- the formulation is actuated by a metering valve capable of delivering a volume of between 50 ⁇ l and 100 ⁇ l.
- Metering valves fitted with gaskets made of chloroprene-based rubbers can preferably be used to reduce the ingress of moisture which, as previously mentioned, can adversely affect the stability of the drug during storage.
- further protection can be achieved by packaging the product in a sealed aluminium pouch.
- the hydrofluorocarbon propellant is HFA 134a.
- the co-solvent is ethanol.
- the low volatility component when present, has a vapour pressure at 25°C lower than 0.1 kPa, preferably lower than 0.05 kPa.
- it could be selected from the group of glycols, particularly propylene glycol, polyethylene glycol and glycerol or esters, for example ascorbyl palmitate, isopropyl myristate and tocopherol esters.
- compositions of the invention may contain from 0.1 to 10% w/w of said low volatility component, preferably between 0.3 to 5% w/w, more preferably between 0.4 and 2.0% w/w.
- Propylene glycol, polyethylene glycol, glycerol with residual water less than 0.1% w/w and esters of long-chain fatty acids are the preferred low-volatility components. More preferred are those with a dipole moment less than 2.0 or with a dielectric static constant less than 20, preferably less than 10. Particularly preferred is isopropyl myristate.
- the function of the low volatility component is to modulate the MMAD of the aerosol particles and optionally to further improve the stability of the formulation.
- particularly preferred is the use of isopropyl myristate.
- the apparent pH range is comprised between 3.0 and 3.5.
- the strong mineral acid hydrochloric acid is used to adjust the apparent pH.
- the amount of acid to be added to reach the desired apparent pH will be pre-determined in the model vehicle reported before and it will depend on the type and concentration of the active ingredient.
- an amount comprised between 3 and 3.5 ⁇ l of 1.0 M hydrochloric acid should be added.
- Solution formulations were prepared by dissolving 1.44 mg of formoterol fumarate in HFA 134a in turn containing 15% w/w ethanol and 1.3% w/w glycerol.
- pMDIs were stored upright over the range 4-50°C for up to 28 days.
- Formoterol content was determined by HPLC and the percent residual concentrations calculated relative to the 12 ⁇ g/shot nominal dose. The percent residual formoterol concentration is reported in Table 2.
- Derived Arrhenius parameters were used to estimate rate constants at ambient temperature (18-25°) and solutions stored in a domestic refrigerator (4-10°); these rate constants were used to calculate predicted shelf-life for 5% and 10% degradation of formoterol (Table 3).
- Table 3 The calculated shelf-life data in Table 3 indicates that formoterol is not stable in this HFA 134a-ethanol-glycerol vehicle.
- Table 2 Degradation Rate Data for Formoterol-HFA 134a pMDI Solutions (12 ⁇ g/100 ⁇ l) Vehicle: HFA 134a with 1.3% w/w Glycerol, 15.0% w/w Ethanol Epoxy-phenol lacquered cans stored upright Time (days) Percent Residual Conc.
- Table 4 pH' and Formoterol Content of Formoterol-Vertrel XF/HFA Solutions (12 ⁇ g/100 ⁇ l) Vehicle: Vertrel XF/HFA with 20% Ethanol and Hydrochloric Acid St Gobain glass vials stored upright Acidity Function (pH') Percent Residual Conc.
- Formoterol 40 days Initial 10 days 20 days 1.8 2.8 100 4.8 Nil 2.1 4.4 100 75.1 70.7 2.6 4.2 100 97.2 86.7 3.3 4.2 100 97.1 89.9 5.6 6.6 100 95.8 92.1 7.4 6.7 100 85.4 67.2
- Formoterol formulations (12 ⁇ g/100 ⁇ l) were prepared by dissolving 1.44 mg of formoterol fumarate in HFA 134a containing 12% w / w ethanol with and without 1.0% w / w isopropyl myristate. The latter was included as a non-volatile excipient with the potential for increasing MMAD if so desired. It also improves the solubility of formoterol in the vehicle and reduces polarity of the vehicle compared to the addition of glycerol.
- pMDI cans containing 3.1-3.4 ⁇ l 1.0 M hydrochloric acid were set down on storage, upright and inverted, at 4°C to 50°C and samples taken for analysis of formoterol content at appropriate intervals.
- a matrix of formulations containing 1.44 mg (12 ⁇ g/100 ⁇ l) formoterol fumarate were prepared in HFA 134a containing 12.0% w / w ethanol with or without 1.0% w / w isopropyl myristate as non-volatile excipient. Aliquots of drug concentrate were transferred to anodised cans and 3.15-3.35 ⁇ l of 1.0M hydrochloric acid added prior to crimping with 50 ⁇ l valves and gassing between 22 and 28 replicates at each acid strength were prepared.
- Table 5 shows the results obtained at 40° and 50° after 11-40 day's storage. Each value (expressed as per cent nominal drug concentration) is obtained from a different can.
- pMDI coated cans containing 3.25 ⁇ l 1.0 M hydrochloric acid were set down on storage inverted, at 4°C and samples taken for analysis of formoterol and BDP contents at appropriate intervals.
Description
- The invention relates to stable pharmaceutical solutions to be used with pressurised metered dose inhalers (MDIs) suitable for aerosol administration. In particular, the invention relates to solutions to be used with pressurised metered dose inhalers (MDIs) suitable for aerosol administration containing formoterol fumarate (a β2-agonist) and being stable at room temperature for a pharmaceutically acceptable shelf-life.
- Pressurised metered dose inhalers are well known devices for administering pharmaceutical products to the respiratory tract by inhalation.
- Drugs commonly delivered by inhalation include bronchodilators such as β2-agonists and anticholinergics, corticosteroids, anti-leukotrienes, anti-allergics and other materials that may be efficiently administered by inhalation, thus increasing the therapeutic index and reducing side effects of the active material.
- MDI uses a propellant to expel droplets containing the pharmaceutical product to the respiratory tract as an aerosol. Formulations for aerosol administration via MDIs can be solutions or suspensions. Solution formulations offer the advantage of being homogeneous with the active ingredient and excipients completely dissolved in the propellant vehicle or its mixture with suitable co-solvents such as ethanol. Solution formulations also obviate physical stability problems associated with suspension formulations so assuring more consistent uniform dosage administration.
- For many years the preferred propellants used in aerosols for pharmaceutical use have been a group of chlorofluorocarbons which are commonly called Freons or CFCs, such as CCl3F (Freon 11 or CFC-11), CCl2F2 (Freon 12 or CFC-12), and CClF2-CClF2 (Freon 114 or CFC-114).
- Recently, the chlorofluorocarbon (CFC) propellants such as Freon 11 and Freon 12 have been implicated in the destruction of the ozone layer and their production is being phased out.
- Hydrofluoroalkanes [(HFAs) known also as hydro-fluoro-carbons (HFCs)] contain no chlorine and are considered less destructive to ozone and these are proposed as substitutes for CFCs.
- HFAs and in particular 1,1,1,2-tetrafluoroethane (HFA 134a) and 1,1,1,2,3,3,3-heptafluoropropane (HFA 227) have been acknowledged to be the best candidates for non-CFC propellants and a number of medicinal aerosol formulations using such HFA propellant systems have been disclosed.
- Due to the higher polarity of the HFA propellants, in particular of HFA 134a (dielectric constant D ≥ 9.5), with respect to CFC vehicles (D ≤2.3), HFA solution formulations may suffer to a greater extent of chemical stability problems with respect to the corresponding CFC formulations.
- Preparation of stable HFA solution formulations is even more critical when bronchodilator β2-agonists belonging to the class of the phenylalkylamino derivatives are concerned; said drugs, like formoterol, 8-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl] amino] ethyl]-2(1H)-quinolinone (hereinafter referred as TA 2005), and salbutamol (albuterol) and others, may suffer of inherent chemical stability problems due to their susceptibility to oxidative conditions; moreover, in the view of the presence of some functional groups like formamide, a higher polarity of the vehicle may accelerate the rate of solvolysis reactions.
- As far as formoterol, the currently marketed CFC solution formulation (Foradil®) exhibits a limited shelf life, i.e. 12 months at refrigerator temperature, 4± 2°C, and only 3 month at room temperature.
- In consideration of the problems outlined, it would be highly advantageous to provide a formulation in the form ofa HFA solution to be administered by MDIs aimed at providing pharmaceutical doses of formoterol fumarate characterised by adequate shelf-life
- It is an object of the invention to provide a formulation in the form of HFA solution to be administered by MDI's for providing pharmaceutical doses of formoterol fumarate into the low respiratory tract of patients suffering of pulmonary diseases such as asthma, characterised by adequate shelf-life. In particular, it is an object of the invention to provide a formulation in the form of HFA solution to be administered by MDIs for providing pharmaceutical doses of formoterol with a greater shelf-life of that of the formulation currently on the market.
- According to the invention there is provided an aerosol composition which comprises as active ingredient formoterol fumarate in a solution of a liquefied HFA 134a propellant and ethanol as co-solvent, and hydrochloric acid in an amount such that the solution has an apparent pH between 3.0 and 3.5. In a particular embodiment, the composition comprises 1.0 M hydrochloric acid in an amount between 3 and 3.5 µl per 1.44 mg formoterol fumarate in 12 mL of the composition. The composition of the invention shall be contained in a pressurised MDI having part or all of its internal metallic surfaces made of stainless steel, anodised aluminium or lined with an inert organic coating.
- In fact, it has been found that, in the case of certain active ingredients such as β2-agonists, their chemical stability in HFA solution formulations could be dramatically improved by a proper and combined selection of the kind of cans as well as the apparent pH range. The attribution 'apparent' is used as pH is indeed characteristic of aqueous liquids where water is the dominant component (Mole Fraction > 0.95). In relatively aprotic solvents such as the HFA-ethanol vehicles used in these studies, protons are non-hydrated; their activity coefficients differ significantly from those in aqueous solution. Although the Nernst equation with respect to EMF applies and the pH-meter glass electrode system will generate a variable milli-volt output according to proton concentration and vehicle polarity, the "pH" meter reading is not a true pH value. The meter reading represents an apparent pH or acidity function (pH').
- When formoterol fumarate was titrated with a strong acid in a model vehicle system commercially available (HFA 43-10MEE, Vertrel XF, Dupont), according to a method developed by the applicant, the pH' profile exhibits a shallow negative to about pH' = 5.5; thereafter the acidity function drops abruptly. Surprisingly the corresponding HFA formulations turned out to much more stable below pH' 5.5.
- On the other hand, the use of inert containers allows to avoid the leaching of metal ions or alkali as a consequence of the action of the acid contained in the formulation onto the inner walls of the cans. Metal ions such Al3+ or alkali respectively deriving from the conventional aluminium or glass cans could in turn catalyse radical oxidative or other chemical reactions of the active ingredient which give rise to the formation of degradation products.
- In the case of active ingredients such as formoterol, it is well known that humidity could be detrimental to the stability of the active ingredient during storage. According to a particular embodiment of the invention, there is provided a pressurised MDI for administering pharmaceutical doses consisting of an anodised aluminium container filled with a pharmaceutical composition consisting of a solution of formoterol fumarate in HFA 134a as a propellant in turn containing 12% w/w ethanol as a co-solvent and optionally isopropyl myristate as a low volatility component in an amount less/equal than 1.0% w/w, the apparent pH of said solution having been adjusted to between 3.0 and 3.5 by addition of small amounts of hydrochloric acid. The expression '% w/w' means the weight percentage of the component in respect to the total weight of the composition.
- The low volatility component besides increasing the mass median aerodynamic diameter (MMAD) of the aerosol particles on actuation of the inhaler as explained in the following, further improves the stability of the formulation. In fact, the addition of a low volatility component with a reduced polarity with respect to the co-solvent such as an ester may allow either to reduce the amount of acid to be added for adjusting the pH and diminish the polarity of the medium so limiting the possible uptake of environmental water.
- The shelf-life of the formulation put in the device of the invention could be predicted to be greater than two years at the refrigerator temperature (4-10° C) and three months at room temperature.
- According to another particular embodiment of the invention, there is provided a pressurised MDI consisting of a coated container filled with a pharmaceutical composition consisting of a solution of a combination of formoterol fumarate and beclometasone dipropionate (hereinafter BDP) in HFA 134a as a propellant in turn containing 12% w/w ethanol as a co-solvent with or without isopropyl myristate as low volatility component, the apparent pH of said solution having been adjusted to between 3.0 and 3.5 by addition of small amounts of hydrochloric acid.
- However, a person sufficiently skilled in the art can easily apply the teaching of the present invention to the preparation of HFA solution formulations containing other active ingredients bearing functional groupssensitive to hydrolytic and/or oxidative reactions, such as formamide and cathecol respectively.
-
WO 97/47286 EP 513127 EP 504112 WO 93/11747 WO 94/21228 WO 94/21229 WO 96/18384 WO 96/19198 WO 96/19968 WO 98/05302 WO 98/34595 WO 00/07567 -
WO 99/65464 - In
WO 98/34596 - In the international application n°
PCT/EP99/09002 filed on 23/11/99 published on June 2, 2000 asWO 00/30608 -
EP 673240 EP 673240 page 5, lines 15 to 16 which says that an amount of inorganic acid should be added to obtain a pH value from 1 to 7, so a very broad and generic range. -
WO 98/34596 -
WO 00/06121 -
WO 99/65460 - Samples stored under accelerated conditions (40° C, 75% relative humidity) for a very short period, one month, exhibited about 10% loss of drug. According to pharmaceutical guidelines on stability, loss of 10% of active ingredient does not meet the criteria of acceptance. Moreover, as it is evident from the data reported in Example 2 of the present application, following the teaching of
WO 99/65460 - The method of filling an aerosol inhaler with a composition of the invention comprises:
- (a) Preparation of a solution of formoterol fumarate, and optionally one or more active ingredients in ethanol, and optionally one or more co-solvents optionally containing an appropriate amount of a low volatility component
- (b) Filling of the device with said solution
- (c) Adding a pre-determined amount of a strong mineral acid
- (d) Adding a propellant containing a hydrofluoroalkane (HFA)
- (e) Crimping with valves and gassing
- The active ingredient which is used in the aerosol compositions of the invention is formoterol fumarate which may be used in combinations with steroids such as beclomethasone dipropionate, fluticasone propionate, budesonide and its 22R-epimer or with anticholinergic atropine-like derivatives such as ipratropium bromide, oxitropium bromide, tiotropium bromide.
- The active ingredient is a long acting β2-agonist belonging to the formula sketched below
Although the preferred formulations of the invention are in the form of solutions, in case of the combinations, one of the two active ingredients could be present in suspension. - We prefer the formulation to be suitable for delivering a therapeutic amount of the active ingredient in one or two actuations. Preferably the formulation will be suitable for delivering 6-12 µg/dose of formoterol fumarate either alone or in combination.
For "dose" we mean the amount of active ingredient delivered by a single actuation of the inhaler. - The formulations of the invention will be contained in cans having part of all of the internal surfaces made of anodised aluminium, stainless steel or lined with an inert organic coating. Examples of preferred coatings are epoxy-phenol resins, perfluoroalkoxyalkane, perfluoroalkoxyalkylene, perfluoroalkylenes such as polytetrafluoroethylene, fluorinated-ethylene-propylene, polyether sulfone and a copolymer fluorinated-ethylene-propylene polyether sulfone. Other suitable coatings could be polyamide, polyimide, polyamideimide, polyphenylene sulfide or their combinations.
- To further improve the stability, cans having a rolled-in rim and preferably a part or full rollover rim are used.
- The formulation is actuated by a metering valve capable of delivering a volume of between 50 µl and 100 µl.
- Metering valves fitted with gaskets made of chloroprene-based rubbers can preferably be used to reduce the ingress of moisture which, as previously mentioned, can adversely affect the stability of the drug during storage. Optionally, further protection can be achieved by packaging the product in a sealed aluminium pouch.
- The hydrofluorocarbon propellant is HFA 134a.
- The co-solvent is ethanol.
- The low volatility component, when present, has a vapour pressure at 25°C lower than 0.1 kPa, preferably lower than 0.05 kPa. Advantageously, it could be selected from the group of glycols, particularly propylene glycol, polyethylene glycol and glycerol or esters, for example ascorbyl palmitate, isopropyl myristate and tocopherol esters.
- The compositions of the invention may contain from 0.1 to 10% w/w of said low volatility component, preferably between 0.3 to 5% w/w, more preferably between 0.4 and 2.0% w/w.
- Propylene glycol, polyethylene glycol, glycerol with residual water less than 0.1% w/w and esters of long-chain fatty acids are the preferred low-volatility components. More preferred are those with a dipole moment less than 2.0 or with a dielectric static constant less than 20, preferably less than 10. Particularly preferred is isopropyl myristate.
- The function of the low volatility component is to modulate the MMAD of the aerosol particles and optionally to further improve the stability of the formulation. With respect to the latter aspect, particularly preferred is the use of isopropyl myristate.
- The apparent pH range is comprised between 3.0 and 3.5.
- The strong mineral acid hydrochloric acid is used to adjust the apparent pH.
- The amount of acid to be added to reach the desired apparent pH will be pre-determined in the model vehicle reported before and it will depend on the type and concentration of the active ingredient. In the case of the formulations of formoterol fumarate and its combination with beclometasone dipropionate, an amount comprised between 3 and 3.5 µl of 1.0 M hydrochloric acid should be added.
- The following examples further illustrate the invention.
- Compositions containing 24 mg of salbutamol (100 µg/dose), 10-20% (w/w) ethanol in HFA 134a put in 12 mL epoxy phenol resin lacquered cans, with or without addition of different organic acids, were stored at 40- 50° C.
- The results in term of stability expressed as percentage of remaining drug determined by HPLC, are reported in Table 1.
Table 1 % SALBUTAMOL Acid t = 42 days t= 1.5 months at 4° C None 69% - Oleic 69-70% - Xinafoic 70% - Citric (0.41 w/w) - 40.0 Citric (0.02 w/w) - 55,1 30% Acetic acid (0.4% w/w) - 49.6 30% Acetic acid (0.14% w/w) - 73.8 - The results show that the addition of organic acids does not improve the stability of salbutamol even when coated cans are used.
- Solution formulations were prepared by dissolving 1.44 mg of formoterol fumarate in HFA 134a in turn containing 15% w/w ethanol and 1.3% w/w glycerol. pMDIs were stored upright over the range 4-50°C for up to 28 days. Formoterol content was determined by HPLC and the percent residual concentrations calculated relative to the 12µg/shot nominal dose. The percent residual formoterol concentration is reported in Table 2. Derived Arrhenius parameters were used to estimate rate constants at ambient temperature (18-25°) and solutions stored in a domestic refrigerator (4-10°); these rate constants were used to calculate predicted shelf-life for 5% and 10% degradation of formoterol (Table 3).
- The calculated shelf-life data in Table 3 indicates that formoterol is not stable in this HFA 134a-ethanol-glycerol vehicle.
Table 2: Degradation Rate Data for Formoterol-HFA 134a pMDI Solutions (12µg/100µl) Vehicle: HFA 134a with 1.3% w/w Glycerol, 15.0% w/w Ethanol Epoxy-phenol lacquered cans stored upright Time (days) Percent Residual Conc. Formoterol 50°C 43°C 40°C 25° C 4°C Initial 99.7 99.7 99.7 99.7 99.7 2 92.5 - - - - 4 87.2 89.4 - - - 6 80.6 - - - - 7 - - 89.0 - - 10 74.9 - - - - 12 72.1 79.4 - - - 14 67.0 - 81.7 92.0 - 16 64.4 75.7 - - - 18 59.5 - - - - 20 59.5 74.5 - - - 24 54.6 68.6 - - - 28 47.2 63.3 71.3 86.6 96.7 r 0.995 0.989 0.993 0.997 - Rate Constant 2.53 1.49 1.17 0.51 0.11 (day-1 x 102) Arrhenius Plot Parameters: K = AeE/RT A = 2.28 x 106 day-1 : E = 49.4 kJ mol-1; r = 0.9985 Table 3: Predicted Shelf Life Data for Formoterol-HFA 134a pMDI Solutions (12µg/100µl) Vehicle: HFA 134a with 1.3% w/w Glycerol, 15% w/w Ethanol Epoxy-phenol lacquered cans stored upright Temperature Rate Constant
(day-1 x 103)Shelf-Life (days) t 10% t 5% 4°C 1.10 95 47 10°C 1.74 60 29 20°C 3.51 30 15 25°C 4.93 21 10 -
- (a) 1.0 M hydrochloric acid was added incrementally to 50 mL of HFA 43-10MEE (Vertrel XF) containing 20% w/w ethanol and pH' measured after each aliquot of acid.
Figure 1 shows the resultant titration curve normalised to the usual fill volume of a pMDI can (12 L). The pH' profile exhibits a shallow negative slope to about pH'=5.5; thereafter the acidity function drops abruptly. - (b) Experiment (a) was repeated with formoterol formulations containing a lower concentration of ethanol (12% w/w) and with the addition of 1.0% isopropyl myristate. The resultant pH profile, for replicate bulk solutions, shown in
Figure 2 is similar in shape with the abrupt fall in pH' per unit increment of acid again commencing at about pH' = 5.5. However, only about half the acid is required to achieve the same reduction in pH'. This is largely due to the reduction in ethanol content;Figure 2 also shows similarity in the profiles obtained with and without isopropyl myristate. - Aliquots of 1.0 M hydrochloric acid were added to 12 mL of formoterol solution in glass vials. After measurement of pH, valves were crimped on and the vials stored upright at 50°C. Vial samples containing different concentrations of acid were assayed for residual formoterol after 10 and 20 days storage. The pH' of a third vial was determined after 40 days storage. Results are shown in Table 4. Table 4 shows changes in pH on storage; this is probably largely associated with leaching of alkali from the soft glass of the vials. However, overall consideration of the pH' and formoterol content data implies that the stability of a solution formulation of the drug in HFA can be improved by the addition of mineral acid to provide a formulation with pH' between 2.5-5.0.
Table 4: pH' and Formoterol Content of Formoterol-Vertrel XF/HFA Solutions (12µg/100µl) Vehicle: Vertrel XF/HFA with 20% Ethanol and Hydrochloric Acid St Gobain glass vials stored upright Acidity Function (pH') Percent Residual Conc. Formoterol Initial 40 days Initial 10 days 20 days 1.8 2.8 100 4.8 Nil 2.1 4.4 100 75.1 70.7 2.6 4.2 100 97.2 86.7 3.3 4.2 100 97.1 89.9 5.6 6.6 100 95.8 92.1 7.4 6.7 100 85.4 67.2 - Formoterol formulations (12µg/100µl) were prepared by dissolving 1.44 mg of formoterol fumarate in HFA 134a containing 12% w/w ethanol with and without 1.0% w/w isopropyl myristate. The latter was included as a non-volatile excipient with the potential for increasing MMAD if so desired. It also improves the solubility of formoterol in the vehicle and reduces polarity of the vehicle compared to the addition of glycerol.
- pMDI cans containing 3.1-3.4µl 1.0 M hydrochloric acid were set down on storage, upright and inverted, at 4°C to 50°C and samples taken for analysis of formoterol content at appropriate intervals.
- Stability data obtained after 70 days of storage are given in Table 5.
- A matrix of formulations containing 1.44 mg (12µg/100µl) formoterol fumarate were prepared in HFA 134a containing 12.0% w/w ethanol with or without 1.0% w/w isopropyl myristate as non-volatile excipient. Aliquots of drug concentrate were transferred to anodised cans and 3.15-3.35 µl of 1.0M hydrochloric acid added prior to crimping with 50µl valves and gassing between 22 and 28 replicates at each acid strength were prepared.
- To determine residual formoterol, 30 x 50µl shots were discharges into DUSA tubes. The acid range selected was anticipated to give pH' values of 3.0-3.5 and to determine the formulation sensitivity to small changes in acid concentration. Cans were placed on stored upright and inverted (valve up and down respectively) at 25-50°C.
- Table 5 shows the results obtained at 40° and 50° after 11-40 day's storage. Each value (expressed as per cent nominal drug concentration) is obtained from a different can.
- Initial values were obtained for two cans of each acid strength. Inspection of the data shows all assay values to within the reproducibility of the HPLC assay and independent of acid strength. A similar conclusion was drawn for the storage time point replicates, i.e., independent of acid strength (3.2-3.3µl) or whether cans were stored upright or inverted. Consequently for kinetics calculation the mean value for initial (n=10) and subsequent time points (n=6) was used.
- In Table 6 are reported the Arrhenius parameters together with estimated shelf lives at 4, 10 and 25°C. The t5% is predicted to be greater than 3 months at ambient temperature and approximately 2 years at 4°C.
Table 5: Stability Data for Formoterol Fumarate Solutions (12µg/100µl) in HFA 134a containing 12.0% Ethanol ± 1.0% Isopropyl Myristate (values are expressed as percent nominal) Anodised cans fitted with 50µl valves/30 doses collected per can Different cans assessed at each condition Cans stored upright (* inverted) 1.0M HCl
µl per CanSTORAGE CONDITION/No isopropyl myristate Initial 40°C; 40 days 50°C; 11 days 50°C; 33 days 1st Can 2nd Can 1st Can 2nd Can 1st Can 2ndCan 1stCan 2nd Can 3.15 99.8 99.6 - - - - - - 3.20 100.8 99.7 96.0 93.2* 96.7 96.5 88.5 89.9* 3.25 97.9 98.8 93.9 94.3* 96.4 96.5 92.2 91.5* 3.30 97.3 98.9 93.7 93.7* 97.0 89.1 90.9 92.8* 3.35 100.0 98.3 - - - - - - Mean 99.1 94.1 95.4 91.0 C.V. 1.1% 1.0% 3.2% 1.8% 1.0M Hcl
µl per CanSTORAGE CONDITION/1.0% isopropyl myristate Initial 40°C; 33days 50°C; 11 days 50°C; 31 days 1st Can 2nd Can 1st Can 2nd Can 1st Can 2nd Can 1st Can 2nd Can 3.15 101.1 99.3 - - - - - - 3.20 97.0 100.2 94.4 93.2* 93.8 93.6 90.6 92.7* 3.25 101.4 100.2 98.6 95.0* 96.1 95.9 91.6 89.7* 3.30 99.9 100.8 92.8 95.3* 95.6 95.7 90.0 89.6* 3.35 99.2 97.2 - - - - - - Mean 99.6 94.9 95.1 90.7 C.V. 1.5% 2.2% 1.2% 1.4% Table 6: Shelf Life Prediction for Acidified Formoterol Fumarate Solution (12µg/100µl) in HFA 134a containing 12% w/w Ethanol ± 1.0% w/w isopropyl Myristate (IPM) Anodised aluminium cans TIME
(days)FORMOTEROL FUMARATE (percent nominal) 40° C Nil IPM 1% IPM Nil IPM 1 % IPM 0 99.1 99.6 99.1 99.6 11 95.4 95.1 - - 31 - 90.7 - - 33 91.0 - - 94.9 40 - - 94.1 - Rate Const.
(day-1 x 103)2.52 2.94 1.29 1.46 Arrhenius Parameters Frequency Activation Factor (day-1) Energy (kJ mol-1) Nil IPM 3.19 x106 56.3 1% w/w IPM 9.63x106 58.9 TEMPERATURE Nil IPM 1.0% w/w IPM Rate Const. t10% t5% Rate Const. t10% t5%, (day-1) (days) (day-1) (days) 4°C 7.8x10-5 1344 657 7.8x10-5 1360 664 10°C 1.3x10-4 802 392 1.3x10-4 789 386 25°C 4.4x10-4 240 117 4.4x10-4 225 110 - Formoterol and BDP combination formulations equivalent to doses of 6 µg/50 µl and 100 µg/50 µl respectively, were prepared by dissolving 1.44 mg of formoterol fumarate and 24 mg of BDP in HFA 134a containing 12% w/w ethanol and 0.4% w/w of isopropyl myristate. pMDI coated cans containing 3.25 µl 1.0 M hydrochloric acid were set down on storage inverted, at 4°C and samples taken for analysis of formoterol and BDP contents at appropriate intervals.
- Stability data obtained are given in Table 7.
- Each value is expressed as per cent nominal drug concentration.
- The results indicate that the formulation is stable for at least 4 months at 4° C.
Table 7: Formoterol/BDP combination formulations of Ex 6 - Stability data at 4°C Storage Condition Initial 4°C; 64 days
inverted4°C; 123 days
invertedFormoterol 104.7 95.10 99.9 BDP 99.4 100.10 102.6
Claims (4)
- An aerosol composition which comprises as active ingredient formoterol fumarate in a solution of a liquefied HFA 134a propellant and ethanol as a co-solvent, and hydrochloric acid in an amount such that the solution has an apparent pH between 3.0 and 3.5.
- An aerosol composition according to claim 1 which comprises as active ingredient formoterol fumarate in a solution of a liquefied HFA 134a propellant and ethanol as a co-solvent, and 1.0 M hydrochloric acid in an amount between 3 and 3.5 µl per 1.44 mg formoterol fumarate in 12 mL of the composition.
- A composition according to any one of claim 1 or 2, which is filled in a container having part or all of its internal metallic surfaces made of stainless steel, anodised aluminium or lined with an inert organic coating.
- A composition according to claim 3, wherein said container is lined with an inert organic coating selected from epoxy-phenol resins, perfluoroalkoxyalkane, perfluoroalkoxyalkylene, perfluoroalkylenes such as polytetrafluoroethylene, fluorinated-ethylene-propylene, polyether sulfone and a copolymer fluorinated-ethylene-propylene polyether sulfone.
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EP07004772A EP1787639B1 (en) | 2000-05-22 | 2001-05-18 | Stable pharmaceutical solution formulations for pressurised metered dose inhalers |
SI200130907T SI1157689T1 (en) | 2000-05-22 | 2001-05-18 | Stable pharmaceutical solution formulations for pressurised metered dose inhalers |
EP04011423A EP1466594B1 (en) | 2000-05-22 | 2001-05-18 | Stable pharmaceutical solution formulations for pressurised metered dose inhalers |
EP01112230A EP1157689B1 (en) | 2000-05-22 | 2001-05-18 | Stable pharmaceutical solution formulations for pressurised metered dose inhalers |
EP10166800A EP2223682B1 (en) | 2000-05-22 | 2001-05-18 | Stable pharmaceutical solution formulations for pressurised metered dose inhalers |
DK07004772.5T DK1787639T3 (en) | 2000-05-22 | 2001-05-18 | Stable pharmaceutical formulations for pressure dose inhalers |
NO20025568A NO342935B1 (en) | 2000-05-22 | 2002-11-20 | Stable pharmaceutical solution formulations for use in metered dose inhalers |
CY20091100391T CY1108968T1 (en) | 2000-05-22 | 2009-04-03 | STABLE PHARMACEUTICAL PHARMACEUTICAL SOLUTIONS FOR SOLID PRESSURE INHIBITION DEVICES |
CY2009009C CY2009009I1 (en) | 2000-05-22 | 2009-07-03 | STABLE PHARMACEUTICAL PHARMACEUTICAL SOLUTION FORMS FOR PRESSURE METERED DOSE INHALATION DEVICES |
LTPA2011011C LTC1787639I2 (en) | 2000-05-22 | 2011-09-20 | Stable pharmaceutical solution preparations for pressure metered dose inhalers |
BE2011C032C BE2011C032I2 (en) | 2000-05-22 | 2011-09-20 | |
CY2011014C CY2011014I1 (en) | 2000-05-22 | 2011-09-22 | PHARMACEUTICAL FORMS OF STABLE PHARMACEUTICAL SOLUTION FOR PRESSURE METERED DOSE INHALATION DEVICES |
FR11C0041C FR11C0041I2 (en) | 2000-05-22 | 2011-09-23 | FORMULATIONS OF STABLE PHARMACEUTICAL SOLUTIONS FOR PRESSURIZED MEASUREMENT INHALERS |
NO2019003C NO2019003I1 (en) | 2000-05-22 | 2019-01-16 | Combination of formoterol fumarate dihydrate and beclomethasone dipropionate |
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EP2010190A2 (en) | 2006-04-21 | 2009-01-07 | CHIESI FARMACEUTICI S.p.A. | Pharmaceutical solution formulations for pressurised metered dose inhalers |
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ES2165768B1 (en) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | NEW DERIVATIVES OF QUINUCLIDINE AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM. |
IT1313553B1 (en) | 1999-07-23 | 2002-09-09 | Chiesi Farma Spa | OPTIMIZED FORMULATIONS CONSTITUTED BY SOLUTIONS OF STEROIDS GIVEN BY INHALATION. |
DE60017450T2 (en) * | 1999-11-23 | 2006-03-02 | Glaxo Group Ltd., Greenford | PHARMACEUTICAL FORMULATIONS CONTAINING SALMETEROL |
IT1317720B1 (en) * | 2000-01-07 | 2003-07-15 | Chiesi Farma Spa | DEVICE FOR THE ADMINISTRATION OF AEROSOL DOSED PRESSURIZED INPROPELLENT HYDROFLUOROALKANS. |
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IT1318514B1 (en) | 2000-05-12 | 2003-08-27 | Chiesi Farma Spa | FORMULATIONS CONTAINING A GLUCOCORTICOSTEROID DRUG FOR THE TREATMENT OF BRONCOPOLMONARY DISEASES. |
ME00220B (en) * | 2000-05-22 | 2010-10-10 | Chiesi Farm Spa | Stable pharmaceutical solution formulations for pressurised metered dose inhalers |
EP1340492A1 (en) * | 2002-03-01 | 2003-09-03 | CHIESI FARMACEUTICI S.p.A. | Aerosol formulations for pulmonary administration of medicaments having systemic effects |
HUE049426T2 (en) * | 2002-03-01 | 2020-09-28 | Chiesi Farm Spa | Formoterol superfine formulation |
EP1595531A1 (en) * | 2004-05-13 | 2005-11-16 | CHIESI FARMACEUTICI S.p.A. | Stable pharmaceutical solution formulations for pressurized metered dose inhalers |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
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US8114912B2 (en) | 2003-07-10 | 2012-02-14 | Mylan Pharmaceuticals, Inc. | Bronchodilating β-agonist compositions and methods |
US8623922B2 (en) | 2003-07-10 | 2014-01-07 | Dey Pharma, L.P. | Bronchodilating Beta-agonist compositions and methods |
JP2007500676A (en) * | 2003-07-31 | 2007-01-18 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Inhalable drugs including anticholinergics and beta receptor stimulants |
EP2010190A2 (en) | 2006-04-21 | 2009-01-07 | CHIESI FARMACEUTICI S.p.A. | Pharmaceutical solution formulations for pressurised metered dose inhalers |
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