EP1401454A2 - Use of corrinoids in the treatment of skin diseases - Google Patents
Use of corrinoids in the treatment of skin diseasesInfo
- Publication number
- EP1401454A2 EP1401454A2 EP02751075A EP02751075A EP1401454A2 EP 1401454 A2 EP1401454 A2 EP 1401454A2 EP 02751075 A EP02751075 A EP 02751075A EP 02751075 A EP02751075 A EP 02751075A EP 1401454 A2 EP1401454 A2 EP 1401454A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- skin
- dermatitis
- use according
- formula
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7135—Compounds containing heavy metals
- A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Definitions
- the invention relates to a new use of corrinoids for the treatment of acute and chronic skin diseases or damage and for the prophylaxis of certain skin diseases.
- skin care products and corresponding pharmaceutical preparations are used that contain different ingredients and active ingredients, such as moisturizing substances, smoothing substances etc.
- cooling gels are commercially available, which essentially provide relief from the pain, but usually do not support the healing process of the skin.
- UV absorbers or UV protection filters are organic substances that are able to absorb electromagnetic radiation in the UV range.
- the molecules change into an energetically excited state.
- the absorbed energy becomes complete again, but in one less or not harmful form for the skin, for example in the form of heat or light of a longer wavelength and lower frequency.
- Wound healing disorder i.e. the delayed or disturbed healing process of open wounds is often associated with great inconvenience, since open wounds can be painful and can also catch fire.
- the scars remaining during normal wound healing are also undesirable for aesthetic reasons, especially if they are on areas of skin that are usually not covered by clothing, such as the face and hands.
- the object of the present invention is to find an effective active ingredient for prophylaxis in disposition for chronic skin diseases, for the prophylaxis and treatment of allergic skin reactions, such as. B. for sun allergies (dermatitis solaris, dermatitis vernalis aurium, dermatitis bullosa pratensis); and for the treatment of acute skin damage, e.g. B.
- the present invention relates to the use of corrinoids of the formula I.
- R stands for CN, OH, CH 3 or H 2 O, to build up and improve the resilience of the skin.
- corrinoids with the formula I are also known as cobalamins or vitamin B-
- cobalamines the cobamides, cobamic acids, cobinamides, cobinic acids, cobyric acids and cobyric acids can also be mentioned as further derivatives suitable for the use according to the invention.
- Compounds with the formula I are preferably used for the prophylaxis of chronic skin diseases, in particular inflammatory and hyperproliferative skin diseases or cutaneous manifestations of immunologically related diseases, e.g. from: psoriasis, atopic dermatitis, contact dermatitis and other eczematous dermatitis, seborrheic dermatitis, neurodermatitis, decubitus, lying planus,
- Pemphigus, bullous pemphigoid, epidermolysis bullosa, urticaria, angioedema, Vasculitids, erythema, cutaneous eosinophils, lupus erythematosus and from alopecia areata are used.
- Another object of the present invention is the use of the compounds with the formula shown above for the prophylaxis and treatment of allergic
- Skin reactions such as B. for sun allergies (dermatitis solaris, dermatitis vernalis aurium, dermatitis bullosa pratensis), food allergies e.g. Allergies caused by bamboo shoots, bitter almonds, beans, oysters and dates.
- Yet another object of the present invention is the use of the
- the treatment of diseases means that when they manifest, treatment is given that is usually continuous in chronic diseases and, in the case of transient diseases, only during their occurrence.
- Prophylaxis means that the occurrence of diseases should be prevented. For example, in an infant there is a predisposition to chronic
- Skin diseases such as psoriasis or neurodermatitis
- a pharmaceutical preparation containing the compound shown above can be used preventively according to the invention. It was found that in infants treated with preventive measures in infancy, in which such skin diseases usually break out, there was no or only a very weak form of the disease, which was significantly reduced compared to the parents who were also ill.
- the compounds of formula I used according to the invention can be administered in any pharmaceutical dosage form.
- the compounds of the formula I are preferably administered topically.
- the compounds are preferably used in combination with carriers or diluents which are customary in the pharmaceutical industry for topical applications.
- the dose to be administered depends on the compound used, the mode of administration and the type of treatment. Very good results are obtained if one or more compounds of the formula I are administered locally at a concentration of 1 ⁇ 10 4 to 1% by weight once or more daily.
- the dosage forms can be used in the pharmaceutical industry. Contain thinners.
- suitable galenical forms are solutions, emulsions, suspensions, lotions, gels, ointments or creams.
- the compounds of formula I are preferably applied in combination with a synthetic or naturally occurring oil.
- vegetable oils in particular almond oil, peanut oil, sesame oil, olive oil, wheat germ oil, corn oil, diesel oil, soybean oil, sunflower oil, coconut oil, avocado oil, palm kernel oil and cocoa butter, as well as jojoba oil, evening primrose oil, calendula, has proven to be particularly suitable.
- Another object of the present invention is a pharmaceutical composition containing compounds of formula I and a vegetable oil or fat.
- the compounds used according to the invention are used in combination with one or more further active ingredient (s) which have a positive, protective and / or nourishing effect on the skin.
- further active ingredient s
- examples of such substances are light protection filters, plant extracts such as aloe vera or chamomile extracts, biopolymers such as hyaluronic acid, chitin and collagen derivatives, components of the epidermal lipids and vitamins and
- Provitamins e.g. B. panthenol and tocopherol.
- active ingredients can also called hydroxycarboxylic acids (AHA), liposomes and niosomes or nanoparts.
- AHA hydroxycarboxylic acids
- Citric acid depending on the pH, mixed and then with dist. Make up water to 1000ml.
- 3rd degree on the right forearm was treated twice a day for a period of 2 weeks, then once a day until it healed completely.
- the treatment time for patients with 2nd degree burns was dependent on the size of the damaged area and averaged 7 days.
- the patient with the 3rd degree burn took 5 weeks to complete scar-free remission.
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10158215A EP2193796A1 (en) | 2001-06-28 | 2002-06-26 | Use of corrinoids for the treatment of skin diseases |
EP10158218A EP2198872A1 (en) | 2001-06-28 | 2002-06-26 | Use of corrinoids for the treatment of skin diseases. |
EP10158216A EP2198871B1 (en) | 2001-06-28 | 2002-06-26 | Use of corrinoids for the treatment of skin diseases. |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10130846A DE10130846A1 (en) | 2001-06-28 | 2001-06-28 | Use of corrinoids for use in skin diseases |
DE10130846 | 2001-06-28 | ||
PCT/EP2002/007067 WO2003002104A2 (en) | 2001-06-28 | 2002-06-26 | Use of corrinoids in the treatment of skin diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
EP1401454A2 true EP1401454A2 (en) | 2004-03-31 |
Family
ID=7689544
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP02751075A Withdrawn EP1401454A2 (en) | 2001-06-28 | 2002-06-26 | Use of corrinoids in the treatment of skin diseases |
EP10158218A Withdrawn EP2198872A1 (en) | 2001-06-28 | 2002-06-26 | Use of corrinoids for the treatment of skin diseases. |
EP10158216A Expired - Lifetime EP2198871B1 (en) | 2001-06-28 | 2002-06-26 | Use of corrinoids for the treatment of skin diseases. |
EP10158215A Withdrawn EP2193796A1 (en) | 2001-06-28 | 2002-06-26 | Use of corrinoids for the treatment of skin diseases |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP10158218A Withdrawn EP2198872A1 (en) | 2001-06-28 | 2002-06-26 | Use of corrinoids for the treatment of skin diseases. |
EP10158216A Expired - Lifetime EP2198871B1 (en) | 2001-06-28 | 2002-06-26 | Use of corrinoids for the treatment of skin diseases. |
EP10158215A Withdrawn EP2193796A1 (en) | 2001-06-28 | 2002-06-26 | Use of corrinoids for the treatment of skin diseases |
Country Status (17)
Country | Link |
---|---|
US (3) | US20040171578A1 (en) |
EP (4) | EP1401454A2 (en) |
JP (1) | JP2004535440A (en) |
KR (1) | KR20040019315A (en) |
CN (1) | CN1325057C (en) |
AT (1) | ATE520407T1 (en) |
AU (1) | AU2002352566B2 (en) |
BR (1) | BR0210672A (en) |
CA (1) | CA2451579A1 (en) |
DE (1) | DE10130846A1 (en) |
EA (1) | EA007592B1 (en) |
ES (1) | ES2371739T3 (en) |
IL (1) | IL159070A0 (en) |
MX (1) | MXPA03011810A (en) |
NZ (1) | NZ529912A (en) |
WO (1) | WO2003002104A2 (en) |
ZA (1) | ZA200309976B (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006054757A1 (en) * | 2004-11-16 | 2006-05-26 | Astellas Pharma Inc. | Caspase inhibitor |
DE102005001645A1 (en) * | 2005-01-13 | 2006-07-20 | Gerhard Dr. Sauermann | Topical product for the prevention and treatment of diaper dermatitis |
NL1032238C2 (en) * | 2006-07-27 | 2008-01-29 | Marie Louise Koskamp | Use of a form of vitamin B12 for the preparation of a composition for repairing DNA and for the preparation of a composition for the therapeutic or prophylactic cure of neurofibromatosis. |
EP2322188A1 (en) * | 2009-10-28 | 2011-05-18 | Bodo Melnik | Treatment of Inflammatory and Hyperproliferative Skin disease |
DE102010023324A1 (en) * | 2010-06-10 | 2011-12-15 | Thomas Schütz | Use of corrinoids for cosmetic application in healthy coat or healthy skin, and for cosmetic care in coat and skin diseases in small and large animals (warm and cold-blooded), (eg in fish, birds, horses, cattle, camels, Dogs cats, reptiles) |
DE102010023626A1 (en) * | 2010-06-14 | 2011-12-15 | Thomas Schütz | Use of corrinoids for medical use in coat and skin diseases in small and large animals (warm and cold-blooded), (for example in fish, birds, horses, cattle, camels, dogs, cats, reptiles) |
US11147761B2 (en) * | 2018-01-12 | 2021-10-19 | Nicole Akmenkalns | Topical supplement composition and method of use |
EP4201411A1 (en) * | 2021-12-21 | 2023-06-28 | DSM IP Assets B.V. | Novel use of vitamin b12 |
EP4201410A1 (en) * | 2021-12-21 | 2023-06-28 | DSM IP Assets B.V. | Novel use of vitamin b12 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL9101406A (en) * | 1991-08-20 | 1993-03-16 | Vunderink Ate | Method for the control and prevention of diseases caused by microorganisms. |
US6194452B1 (en) * | 1997-11-07 | 2001-02-27 | Howard Murad | Stable pharmaceutical compositions including ascorbic acid and methods of using same |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4007266A (en) * | 1968-05-03 | 1977-02-08 | Choay S.A. | Pharmaceutical composition containing vitamin B12, process of making the same and method of treatment |
FR7695M (en) * | 1968-05-03 | 1970-02-23 | ||
DE2325809A1 (en) * | 1973-05-22 | 1974-12-19 | 8702 Gerbrunn | Skin agents contg. vitamin B-12 and folic acid - having cosmetic, anti-acne, deodorant and cholesterol-lowering effects |
DE2505114C3 (en) * | 1975-02-07 | 1979-06-13 | Valentin Dr.Med. Koehler | Scalp care products |
NZ195881A (en) * | 1980-12-19 | 1984-08-24 | W Lysaght | Pharmaceutical compositions containing cobalt compounds |
DE3210669A1 (en) * | 1982-03-23 | 1983-09-29 | Hrvoje Dr. Zagreb Krnjević | Pharmaceutical composition for the treatment of disorders of the skin and mucous membranes and of nail growth |
AU680222B2 (en) * | 1992-12-10 | 1997-07-24 | Hemogen, Inc. | Method for stimulating production of heme oxygenase using vitamin B12 |
US6110472A (en) * | 1992-12-10 | 2000-08-29 | Hemogen Inc. | Vitamin B12 containing scalp and skin treatment compositions |
DE4319629A1 (en) * | 1993-06-15 | 1994-12-22 | Karsten Klingelhoeller | Use of corrinoids for topical use in skin diseases |
US6117119A (en) * | 1998-08-28 | 2000-09-12 | Silipos, Inc. | Gelatinous body protection article having a therapeutic additive |
CA2313659A1 (en) * | 2000-07-06 | 2002-01-06 | Barry J. Barclay | B complex vitamin compositions that protect against cellular damage caused by ultraviolet light |
-
2001
- 2001-06-28 DE DE10130846A patent/DE10130846A1/en not_active Withdrawn
-
2002
- 2002-06-26 EP EP02751075A patent/EP1401454A2/en not_active Withdrawn
- 2002-06-26 EA EA200400096A patent/EA007592B1/en not_active IP Right Cessation
- 2002-06-26 US US10/480,873 patent/US20040171578A1/en not_active Abandoned
- 2002-06-26 CN CNB028128257A patent/CN1325057C/en not_active Expired - Fee Related
- 2002-06-26 JP JP2003508343A patent/JP2004535440A/en active Pending
- 2002-06-26 EP EP10158218A patent/EP2198872A1/en not_active Withdrawn
- 2002-06-26 KR KR10-2003-7016740A patent/KR20040019315A/en not_active Application Discontinuation
- 2002-06-26 EP EP10158216A patent/EP2198871B1/en not_active Expired - Lifetime
- 2002-06-26 WO PCT/EP2002/007067 patent/WO2003002104A2/en active IP Right Grant
- 2002-06-26 CA CA002451579A patent/CA2451579A1/en not_active Abandoned
- 2002-06-26 NZ NZ529912A patent/NZ529912A/en not_active IP Right Cessation
- 2002-06-26 AT AT10158216T patent/ATE520407T1/en active
- 2002-06-26 ES ES10158216T patent/ES2371739T3/en not_active Expired - Lifetime
- 2002-06-26 BR BR0210672-8A patent/BR0210672A/en not_active Application Discontinuation
- 2002-06-26 EP EP10158215A patent/EP2193796A1/en not_active Withdrawn
- 2002-06-26 AU AU2002352566A patent/AU2002352566B2/en not_active Ceased
- 2002-06-26 IL IL15907002A patent/IL159070A0/en unknown
- 2002-06-26 MX MXPA03011810A patent/MXPA03011810A/en not_active Application Discontinuation
-
2003
- 2003-12-23 ZA ZA200309976A patent/ZA200309976B/en unknown
-
2005
- 2005-12-16 US US11/303,596 patent/US20060094686A1/en not_active Abandoned
-
2006
- 2006-12-27 US US11/646,807 patent/US20070129325A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL9101406A (en) * | 1991-08-20 | 1993-03-16 | Vunderink Ate | Method for the control and prevention of diseases caused by microorganisms. |
US6194452B1 (en) * | 1997-11-07 | 2001-02-27 | Howard Murad | Stable pharmaceutical compositions including ascorbic acid and methods of using same |
Non-Patent Citations (1)
Title |
---|
DATABASE WPI Section Ch Week 199314, Derwent World Patents Index; Class B05, AN 1993-114987 * |
Also Published As
Publication number | Publication date |
---|---|
US20070129325A1 (en) | 2007-06-07 |
EA200400096A1 (en) | 2004-04-29 |
WO2003002104A2 (en) | 2003-01-09 |
AU2002352566B2 (en) | 2007-06-14 |
EA007592B1 (en) | 2006-12-29 |
CN1688319A (en) | 2005-10-26 |
EP2198872A1 (en) | 2010-06-23 |
CN1325057C (en) | 2007-07-11 |
EP2198871B1 (en) | 2011-08-17 |
EP2193796A1 (en) | 2010-06-09 |
CA2451579A1 (en) | 2003-01-09 |
BR0210672A (en) | 2004-10-13 |
MXPA03011810A (en) | 2005-03-07 |
US20040171578A1 (en) | 2004-09-02 |
NZ529912A (en) | 2006-09-29 |
ZA200309976B (en) | 2004-09-17 |
KR20040019315A (en) | 2004-03-05 |
WO2003002104A3 (en) | 2003-03-20 |
JP2004535440A (en) | 2004-11-25 |
IL159070A0 (en) | 2004-05-12 |
DE10130846A1 (en) | 2003-01-16 |
EP2198871A1 (en) | 2010-06-23 |
ES2371739T3 (en) | 2012-01-09 |
US20060094686A1 (en) | 2006-05-04 |
ATE520407T1 (en) | 2011-09-15 |
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