EP1804858B1 - Injection device with internal dose indicator - Google Patents
Injection device with internal dose indicator Download PDFInfo
- Publication number
- EP1804858B1 EP1804858B1 EP05799793A EP05799793A EP1804858B1 EP 1804858 B1 EP1804858 B1 EP 1804858B1 EP 05799793 A EP05799793 A EP 05799793A EP 05799793 A EP05799793 A EP 05799793A EP 1804858 B1 EP1804858 B1 EP 1804858B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- piston rod
- injection device
- dose
- housing
- drive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
- A61M5/31553—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/3159—Dose expelling manners
- A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
Definitions
- the present invention relates to an injection device having an internally positioned dose indicator barrel adapted to display a dose of medicament to be ejected from the injection device.
- injection devices Various types have been described over the years. However, injection devices formed as pen-type injection devices have attracted special attention over recent years.
- EP 0 338 806 discloses pen-like syringe incorporating a dose metering device.
- the pen is provided with a cap rotatable, with respect to a pen body, to a position representing the dose of medicament (for example insulin) to be injected.
- the rotation loads a torsion spring, which is prevented from unwinding by co-operating teeth.
- a trigger slide is moved to the left causing the toothing to come out of engagement. This disengagement allows the spring to unwind.
- the unwinding of the spring causes a drive sleeve, drive gear and a drive plunger to rotate.
- the drive plunger is formed with a quick pitch screw thread so that its rotational movement is accompanied by an axial movement which causes medicament to be discharged from a cartridge and injected through a needle.
- EP 0 338 806 is based on a torsion spring. However, by applying a linear spring the axial movement of an integrated dose metering device could be made independent of the pitch screw threads on the plunger and the integrated dose metering device would be capable of rotating more than one revolution following a helical pattern.
- US 6,673,035 discloses a medical injector and medicament loading system for use therewith.
- the medicament loading system includes cap for a medicament cartridge.
- the cap has a post for causing movement of the cartridge stopper toward the seal when the cap engages the medicament cartridge to thereby eliminate adhesion between the medicament chamber and the stopper.
- the medical injector according to the present invention includes the medicament loading system, i.e. a cartridge assembly, a needle free syringe assembly, and a power pack assembly.
- WO 02/053214 relates to a dose setting and expelling device comprising a drive member and a dose setting mechanism which simultaneously sets a given dose and stores the energy necessary for subsequently driving the drive member in order to expel a dose of medicine from an injection device.
- the dose setting mechanism allows adjustment in both directions, such that a given set dose can be reduced or cancelled by reversing the input motion, typically by rotating a setting member in a backward direction.
- WO 02/053214 discloses a simple dose setting and reverse mechanism.
- it is a disadvantage of the arrangement suggested in WO 02/053214 that the axial movement of an integrated dose metering device is dependent on the pitch screw threads on the plunger
- an injection device comprising
- the dose setting member may engage the dose indicator barrel and the injection device may further comprise
- the drive track arranged in the piston rod may be an indentation in the longitudinal direction of the piston rod. Alternatively, it may also be a planar surface or two opposing planar surfaces as illustrated in for example Fig. 2 .
- the dose setting member may engage the dose indicator barrel and the injection device may further comprise
- the injection device may further comprise
- the injection device may further comprise an intermediate part engaging the dose setting member and the main member of the resilient member housing, the intermediate part being adapted to provided a biasing force to the drive member in a direction towards the toothing.
- the injection device may further comprise
- the injection device may further comprise a locking member adapted to fixate the piston rod in such a way that no relative rotation of the piston rod and the housing is possible when the locking member is in its locking position.
- the injection device may further comprise a release button adapted for releasing the locking member from its locking position. The release button may be positioned in the distal half of the length of the injection device.
- the injection device may further comprise a locking member adapted to fixate the drive member in such a way that no relative rotation of the drive member and the housing is possible when the locking member is in its locking position.
- the injection device may further comprise a release button adapted for releasing the locking member from its locking position, the release button being adapted to be released by a user of the injection device.
- the release button may be positioned in the distal half of the length of the injection device.
- the resilient member may comprise a spring, such as a helical spring.
- the helical spring may be arranged coaxially with the piston rod.
- Fig. 1 is a cross-sectional view showing half of an injection device 1 according to a first embodiment of the present invention.
- the injection device 1 comprises a dose setting member 2 being adapted to rotate about a centre axis of the injection device 1. It further comprises a dose indicator barrel 4, a threaded piston rod 5, a drive member 6 adapted to move the piston rod 5 along the centre axis, a helical spring 7 extending along and concentrically with the centre axis, and a housing 8.
- the dose setting member 2 engages the dose indicator barrel 4 via a key/keyway connection.
- the key/keyway connection ensures that rotation of the dose setting member 2 about the centre axis causes rotation of the dose indicator barrel 4 about the centre axis, and vice versa. Furthermore, the key/keyway connection ensures that the dose setting member 2 and the dose indicator barrel 4 are slidably movable in relation to each other in a direction which is substantially parallel to the centre axis.
- the drive member 6 engages the outer threaded portion of the piston rod 5 via a threaded portion of the drive member.
- the dose indicator barrel 4 is provided with a threaded portion 9 which engages a threaded portion 10 of the drive member 6.
- the injection device 1 is further provided with a locking member 11 which may be switched between a locking state and an unlocking state.
- a locking member 11 When the locking member 11 is in its locking state (as shown in Fig. 1 ) it prevents the drive member 6 from rotating about the centre axis.
- the locking member 11 when the locking member 11 is in its unlocking state, the drive member 6 is free to rotate about the centre axis.
- the dose setting member 2 is connected to the housing 8 via a toothing connection 3.
- the toothing connection 3 allows the dose setting member 2 and the housing 8 to be rotationally movable in relation to each.
- the helical spring 7 provides an axial force to the dose setting member 2 and thereby to the toothing so that the dose setting member 2 stays in a set position.
- the injection device of Fig. 1 is preferably operated in the following manner.
- the locking member 11 When a dose is to be set, the locking member 11 is switched to its locking state. In most cases, the locking state is the default position of the locking member 11.
- the user then causes the dose setting member 2 to rotate about the centre axis by turning a protruding part 12 of the dose setting member 2. Due to the key/keyway connection between the dose setting member 2 and the dose indicator barrel 4, the dose indicator barrel 4 is also caused to rotate about the centre axis. Since the threaded portion 9 of the dose indicator barrel 4 engages the threaded portion 10 of the drive member 6, this rotation forces the dose indicator barrel 4 in a direction parallel to the centre axis and towards the protruding part 12 of the dose setting member 2.
- the dose indicator barrel 4 performs a sliding movement along the key/keyway connection between the dose setting member 2 and the dose indicator barrel 4. This movement causes the helical spring 7 to be compressed, thereby storing energy in the spring 7. Thus, the dose is set without causing any changes to the outer appearance of the injection device 1, including an outward movement of the dose setting member 2.
- the dose indicator barrel 4 is provided with a set of numerals (not shown). As the dose indicator barrel 4 moves towards the protruding part 12 of the dose setting member 2, these numerals will be sequentially visible through a window 13 in the drive member 6, thereby indicating the dose which has been set. In order for the user of the injection device to view the numerals on the dose indicator barrel 4, the housing 8 is equipped with a belt-like window aligned with the window 13 in the drive member 6.
- a needle (not shown) positioned opposite the protruding part 12 of the dose setting member 2 is inserted into a desired body part of the user. Then the locking member 11 is switched to its unlocking state, thereby allowing rotation of the drive member 6 about the centre axis. Due to the energy stored in the compressed helical spring 7, the dose indicator barrel 4 is forced towards its initial position, i.e. away from the protruding part 12 of the dose setting member 2.
- the drive member 6 Via the threaded portion 10 and the threaded portion 9 of the dose indicator barrel 4, the drive member 6 is thereby caused to rotate about the centre axis, and due to a key/keyway connection between the housing 8 and the piston rod 5, the piston rod 5 will perform an axial movement away from the protruding part 12, thereby causing the desired and set dose to be ejected from the injection device 1.
- the drive member 6 may comprise a key/keyway connection with the piston rod 5.
- the threaded portion of the drive member 6 will in this case be replaced by the key/keyway connection between the drive member 6 and the piston rod 5.
- the piston rod 5 will rotate about the centre axis when the locking member 11 is switched to its unlocking state.
- the rotational movement causes the piston rod 5 to be moved in a direction parallel to the centre axis and away from the protruding part 12 of the dose setting member 2.
- the reason for this being that the threaded outer surface of the piston rod 5 engages a threaded portion of the housing 8. This movement will cause a dose to be ejected from the injection device 1.
- the various parts of the injection device 1 are again in their initial position, except for the fact that the piston rod 5 has been moved in a direction away from the protruding part 12 of the dose setting member 2 due to the dose having been ejected. Even further, the angular position of the drive member 6 has changed whereby the "new" zero point has been angularly shifted relative to the housing 8. Thus, the injection device 1 is now ready for setting a new dose.
- Fig. 2 is a cross-sectional view showing half of an injection device 1 according to a second embodiment of the present invention.
- This embodiment is similar to the embodiment shown in Fig. 1 , and like parts have therefore been provided with like reference numerals.
- the injection device 1 shown in Fig. 2 also comprises a dose setting member 2 being adapted to rotate about a centre axis of the injection device 1. It further comprises a dose indicator barrel 4, a threaded piston rod 5, a drive member 6 adapted to rotationally drive the piston rod 5 about the centre axis , a helical spring 7 extending along and concentrically with the centre axis , and a housing 8.
- the dose indicator barrel 4 engages a main member 15 via a key/keyway connection similar to the one described above.
- the drive member 6 is connected to the main member 15 via a toothing connection 19 allowing the drive member 6 and the main member 15 to be rotationally movable in relation to each.
- the helical spring 7 provides an axial force to the main member 15 and thereby to the toothing 19 so that the dose setting member 2 stays in a set position.
- An intermediate member 16 engages the dose setting member 2 via a key/keyway connection. It is also operationally connected to the main member 15 in such a way that when the intermediate member 16 rotates about the centre axis the main member 15 also rotates about the centre axis and vice versa.
- the main member 15 engages the threaded portion of the piston rod 5.
- the dose indicator barrel 4 is provided with a threaded portion 9 which engages a threaded portion 17 of the housing 8.
- the injection device 1 is further provided with a locking member 11 which may be switched between a locking state and an unlocking state.
- a locking member 11 When the locking member 11 is in its locking state (as shown in Fig. 2 ) it prevents the piston rod 5 from rotating about the centre axis.
- the locking member 11 when the locking member 11 is in its unlocking state, the piston rod 5 is free to rotate about the centre axis.
- the drive track 21 arranged in the piston rod may be an indentation or groove in the longitudinal direction of the piston rod. Alternatively, it may also be a planar surface or two opposing planar surfaces.
- the injection device 1 of Fig. 2 is preferably operated in the following manner.
- the locking member 11 When a dose is to be set, the locking member 11 is switched to its locking state which may be the default position of the locking member 11. The user then causes the dose setting member 2 to rotate about the centre axis by turning an outer part 18 of the dose setting member 2.
- the outer part 18 of the dose setting member 2 is a part which is positioned on the outside of the housing 8 as illustrated in Fig. 2 . Due to the connections between the various parts of the injection device 1 described above, the rotation of the dose setting member 2 about the centre axis causes the intermediate member 16, the main member 15 and the dose indicator barrel 4 to be rotated about the centre axis.
- the drive member 6 is not rotated due to the toothing connection between the drive member 6 and the main member 15.
- the dose indicator barrel 4 Since the threaded portion 9 of the dose indicator barrel 4 engages the threaded portion 17 of the housing 8, and due to the main member 15 engaging the threaded part of the piston rod 5, the dose indicator barrel 4 and the main member 15/intermediate member 16 will be moved towards each other. This causes the helical spring 7 to be compressed, thereby storing energy in the spring 7. Thus, as it is the case in the embodiment shown in Fig. 1 , the dose is set without causing any changes to the outer appearance of the injection device 1.
- the dose indicator barrel 4 is provided with a set of numerals (not shown). As the dose indicator barrel 4 moves away from the outer part 18 of the dose setting member 2, these numerals will be sequentially visible through a window 13 in the housing 8, thereby indicating the dose which has been set.
- the drive member 6 Due to the toothing connection between the main member 15 and the drive member 6, the drive member 6 is also caused to rotate about the centre axis, and due to the key/keyway connection between the drive member 6 and the piston rod 5, the piston rod 5 is also caused to rotate about the centre axis.
- the threaded part of the piston rod 5 engages a threaded portion 14 of the housing 8. Therefore the rotational movement causes the piston rod to be moved in a direction parallel to the centre axis and away from the outer part 18 of the dose setting member 2, thereby causing the desired and set dose to be ejected from the injection device 1.
- the injection device 1 is now ready for setting a new dose.
- FIGs. 3 and 4 Alternative embodiments are shown in Figs. 3 and 4 .
- the intermediate member 16 has been omitted whereby the mechanical design of the injection device has been significantly simplified.
- the main member 15 is operatively connected to drive member 6 via toothing 19.
- the threaded outer surface of the piston rod 5 engages with a threaded portion 14 of the housing 8
- Fig. 4 the threaded outer surface of the piston rod 5 engages with a threaded portion 20 of the drive member 6.
- the ejection of the dose is actually effected by the energy stored in the helical spring 7 when setting the dose, and the only effort required from the user of the injection device 1 in order to cause the ejection is the switching of the locking member 11 from its locking state to its unlocking state.
- This is very easily done and an ejection can therefore be caused even by persons having reduced motoric skills or reduced finger strength, such as children, elderly people or disabled people.
Abstract
Description
- The present invention relates to an injection device having an internally positioned dose indicator barrel adapted to display a dose of medicament to be ejected from the injection device.
- Various types of injection devices have been described over the years. However, injection devices formed as pen-type injection devices have attracted special attention over recent years.
- For example,
EP 0 338 806 discloses pen-like syringe incorporating a dose metering device. The pen is provided with a cap rotatable, with respect to a pen body, to a position representing the dose of medicament (for example insulin) to be injected. The rotation loads a torsion spring, which is prevented from unwinding by co-operating teeth. When the dose is to be injected, a trigger slide is moved to the left causing the toothing to come out of engagement. This disengagement allows the spring to unwind. The unwinding of the spring causes a drive sleeve, drive gear and a drive plunger to rotate. The drive plunger is formed with a quick pitch screw thread so that its rotational movement is accompanied by an axial movement which causes medicament to be discharged from a cartridge and injected through a needle. -
EP 0 338 806 is based on a torsion spring. However, by applying a linear spring the axial movement of an integrated dose metering device could be made independent of the pitch screw threads on the plunger and the integrated dose metering device would be capable of rotating more than one revolution following a helical pattern. -
US 6,673,035 discloses a medical injector and medicament loading system for use therewith. The medicament loading system includes cap for a medicament cartridge. The cap has a post for causing movement of the cartridge stopper toward the seal when the cap engages the medicament cartridge to thereby eliminate adhesion between the medicament chamber and the stopper. The medical injector according to the present invention includes the medicament loading system, i.e. a cartridge assembly, a needle free syringe assembly, and a power pack assembly. -
WO 02/053214 WO 02/053214 WO 02/053214 WO 02/053214 - It is an object of the present invention to provide an injection device where the axial movement of the dose metering device is independent of the pitch of the threads on the plunger.
- It is a still further object of the present invention to provide an injection device with a dose metering device allowing larger read-outs compared to known systems.
- The above-mentioned objects are complied with by providing, in a first aspect, an injection device comprising
- a housing,
- a resilient member adapted to provide a force in the axial direction of the injection device, the force being necessary for ejecting a dose from the injection device, and
- a dose setting member operatively connected to a dose indicator barrel positioned within the housing, the dose setting member and the dose indicator barrel being movable relative to each other and cooperating to set the dose to be ejected from the injection device,
- In a first embodiment of the present invention, the dose setting member may engage the dose indicator barrel and the injection device may further comprise
- a piston rod having a threaded outer surface with a drive track arranged in a longitudinal direction of the outer surface of the piston rod,
- a drive member engaging at least part of the drive track of the piston rod and having a threaded inner surface cooperating with a threaded portion arranged on an outer surface of the dose indicator barrel, the drive member being adapted to drive and rotate with the piston rod during ejection of a dose from the injection device,
- The drive track arranged in the piston rod may be an indentation in the longitudinal direction of the piston rod. Alternatively, it may also be a planar surface or two opposing planar surfaces as illustrated in for example
Fig. 2 . - In a second embodiment of the present invention, the dose setting member may engage the dose indicator barrel and the injection device may further comprise
- a piston rod having a threaded outer surface with a track arranged in a longitudinal direction of the outer surface of the piston rod,
- a drive member having a threaded portion cooperating with the threaded outer surface of the piston rod, and having a threaded inner surface cooperating with a threaded portion arranged on an outer surface of the dose indicator barrel, the drive member being adapted to rotate relative to the piston rod during ejection of a dose from the injection device,
- In a third embodiment of the present invention, the injection device may further comprise
- a piston rod having a threaded outer surface with a drive track arranged in a longitudinal direction of the outer surface of the piston rod,
- a resilient member housing being at least partly defined by the dose indictor barrel in combination with a main member, the dose indicator barrel and the main member being movable in relation to each other, the main member having a threaded portion cooperating with the threaded outer surface of the piston rod,
- a drive member operatively connected to the main member via a toothing so that the drive member is movable in relation to the main member during dose setting but rigidly connected to the main member during ejection of a dose from the injection device, the drive member engaging at least part of the drive track on the outer surface of the piston rod,
- In the third embodiment, the injection device may further comprise an intermediate part engaging the dose setting member and the main member of the resilient member housing, the intermediate part being adapted to provided a biasing force to the drive member in a direction towards the toothing.
- In a fourth embodiment of the present invention, the injection device may further comprise
- a piston rod having a threaded outer surface with a drive track arranged in a longitudinal direction of the outer surface of the piston rod,
- a resilient member housing being at least partly defined by the dose indictor barrel and a main member,
- a drive member operatively connected to the main member via a toothing in such a way that the drive member is movable in relation to the main member during dose setting but rigidly connected to the main member during ejection of a dose from the injection device, the drive member having threaded portion cooperating with the threaded outer surface of the piston rod,
- The injection device according to the first and third embodiments may further comprise a locking member adapted to fixate the piston rod in such a way that no relative rotation of the piston rod and the housing is possible when the locking member is in its locking position. The injection device may further comprise a release button adapted for releasing the locking member from its locking position. The release button may be positioned in the distal half of the length of the injection device.
- The injection device according to the second and fourth embodiment may further comprise a locking member adapted to fixate the drive member in such a way that no relative rotation of the drive member and the housing is possible when the locking member is in its locking position. The injection device may further comprise a release button adapted for releasing the locking member from its locking position, the release button being adapted to be released by a user of the injection device. The release button may be positioned in the distal half of the length of the injection device.
- The resilient member may comprise a spring, such as a helical spring. The helical spring may be arranged coaxially with the piston rod.
- The present invention will now be described with reference to the accompanying figures
wherein -
Fig. 1 is a cross sectional view of an injection device according to a first embodiment of the present invention, -
Fig. 2 is a cross sectional view of an injection device according to a second embodiment of the present invention, -
Fig. 3 is a cross sectional view of an injection device according to a third embodiment of the present invention, and -
Fig. 4 is a cross sectional view of an injection device according to a fourth embodiment of the present invention. - While the invention is susceptible to various modifications and alternative forms, specific embodiments have been shown by way of example in the drawings and will be described in detail herein. It should be understood, however, that the invention is not intended to be limited to the particular forms disclosed. Rather, the invention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the invention as defined by the appended claims.
-
Fig. 1 is a cross-sectional view showing half of an injection device 1 according to a first embodiment of the present invention. The injection device 1 comprises adose setting member 2 being adapted to rotate about a centre axis of the injection device 1. It further comprises adose indicator barrel 4, a threadedpiston rod 5, adrive member 6 adapted to move thepiston rod 5 along the centre axis, ahelical spring 7 extending along and concentrically with the centre axis, and ahousing 8. - The
dose setting member 2 engages thedose indicator barrel 4 via a key/keyway connection. The key/keyway connection ensures that rotation of thedose setting member 2 about the centre axis causes rotation of thedose indicator barrel 4 about the centre axis, and vice versa. Furthermore, the key/keyway connection ensures that thedose setting member 2 and thedose indicator barrel 4 are slidably movable in relation to each other in a direction which is substantially parallel to the centre axis. - Similarly, the
drive member 6 engages the outer threaded portion of thepiston rod 5 via a threaded portion of the drive member. - The
dose indicator barrel 4 is provided with a threadedportion 9 which engages a threadedportion 10 of thedrive member 6. - The injection device 1 is further provided with a locking
member 11 which may be switched between a locking state and an unlocking state. When the lockingmember 11 is in its locking state (as shown inFig. 1 ) it prevents thedrive member 6 from rotating about the centre axis. On the other hand, when the lockingmember 11 is in its unlocking state, thedrive member 6 is free to rotate about the centre axis. Thedose setting member 2 is connected to thehousing 8 via a toothing connection 3. The toothing connection 3 allows thedose setting member 2 and thehousing 8 to be rotationally movable in relation to each. However, thehelical spring 7 provides an axial force to thedose setting member 2 and thereby to the toothing so that thedose setting member 2 stays in a set position. - The injection device of
Fig. 1 is preferably operated in the following manner. - When a dose is to be set, the locking
member 11 is switched to its locking state. In most cases, the locking state is the default position of the lockingmember 11. The user then causes thedose setting member 2 to rotate about the centre axis by turning a protrudingpart 12 of thedose setting member 2. Due to the key/keyway connection between thedose setting member 2 and thedose indicator barrel 4, thedose indicator barrel 4 is also caused to rotate about the centre axis. Since the threadedportion 9 of thedose indicator barrel 4 engages the threadedportion 10 of thedrive member 6, this rotation forces thedose indicator barrel 4 in a direction parallel to the centre axis and towards the protrudingpart 12 of thedose setting member 2. Thus, thedose indicator barrel 4 performs a sliding movement along the key/keyway connection between thedose setting member 2 and thedose indicator barrel 4. This movement causes thehelical spring 7 to be compressed, thereby storing energy in thespring 7. Thus, the dose is set without causing any changes to the outer appearance of the injection device 1, including an outward movement of thedose setting member 2. - The
dose indicator barrel 4 is provided with a set of numerals (not shown). As thedose indicator barrel 4 moves towards the protrudingpart 12 of thedose setting member 2, these numerals will be sequentially visible through awindow 13 in thedrive member 6, thereby indicating the dose which has been set. In order for the user of the injection device to view the numerals on thedose indicator barrel 4, thehousing 8 is equipped with a belt-like window aligned with thewindow 13 in thedrive member 6. - When the desired dose has been set, a needle (not shown) positioned opposite the protruding
part 12 of thedose setting member 2 is inserted into a desired body part of the user. Then the lockingmember 11 is switched to its unlocking state, thereby allowing rotation of thedrive member 6 about the centre axis. Due to the energy stored in the compressedhelical spring 7, thedose indicator barrel 4 is forced towards its initial position, i.e. away from the protrudingpart 12 of thedose setting member 2. Via the threadedportion 10 and the threadedportion 9 of thedose indicator barrel 4, thedrive member 6 is thereby caused to rotate about the centre axis, and due to a key/keyway connection between thehousing 8 and thepiston rod 5, thepiston rod 5 will perform an axial movement away from the protrudingpart 12, thereby causing the desired and set dose to be ejected from the injection device 1. - Alternatively, the
drive member 6 may comprise a key/keyway connection with thepiston rod 5. Thus, the threaded portion of thedrive member 6 will in this case be replaced by the key/keyway connection between thedrive member 6 and thepiston rod 5. In this case thepiston rod 5 will rotate about the centre axis when the lockingmember 11 is switched to its unlocking state. The rotational movement causes thepiston rod 5 to be moved in a direction parallel to the centre axis and away from the protrudingpart 12 of thedose setting member 2. The reason for this being that the threaded outer surface of thepiston rod 5 engages a threaded portion of thehousing 8. This movement will cause a dose to be ejected from the injection device 1. - When the dose has been ejected, the various parts of the injection device 1 are again in their initial position, except for the fact that the
piston rod 5 has been moved in a direction away from the protrudingpart 12 of thedose setting member 2 due to the dose having been ejected. Even further, the angular position of thedrive member 6 has changed whereby the "new" zero point has been angularly shifted relative to thehousing 8. Thus, the injection device 1 is now ready for setting a new dose. -
Fig. 2 is a cross-sectional view showing half of an injection device 1 according to a second embodiment of the present invention. This embodiment is similar to the embodiment shown inFig. 1 , and like parts have therefore been provided with like reference numerals. Thus, the injection device 1 shown inFig. 2 also comprises adose setting member 2 being adapted to rotate about a centre axis of the injection device 1. It further comprises adose indicator barrel 4, a threadedpiston rod 5, adrive member 6 adapted to rotationally drive thepiston rod 5 about the centre axis , ahelical spring 7 extending along and concentrically with the centre axis , and ahousing 8. - The
dose indicator barrel 4 engages amain member 15 via a key/keyway connection similar to the one described above. Thedrive member 6 is connected to themain member 15 via atoothing connection 19 allowing thedrive member 6 and themain member 15 to be rotationally movable in relation to each. However, thehelical spring 7 provides an axial force to themain member 15 and thereby to thetoothing 19 so that thedose setting member 2 stays in a set position. An intermediate member 16 engages thedose setting member 2 via a key/keyway connection. It is also operationally connected to themain member 15 in such a way that when the intermediate member 16 rotates about the centre axis themain member 15 also rotates about the centre axis and vice versa. Finally, themain member 15 engages the threaded portion of thepiston rod 5. - The
dose indicator barrel 4 is provided with a threadedportion 9 which engages a threaded portion 17 of thehousing 8. - The injection device 1 is further provided with a locking
member 11 which may be switched between a locking state and an unlocking state. When the lockingmember 11 is in its locking state (as shown inFig. 2 ) it prevents thepiston rod 5 from rotating about the centre axis. On the other hand, when the lockingmember 11 is in its unlocking state, thepiston rod 5 is free to rotate about the centre axis. - The
drive track 21 arranged in the piston rod may be an indentation or groove in the longitudinal direction of the piston rod. Alternatively, it may also be a planar surface or two opposing planar surfaces. - The injection device 1 of
Fig. 2 is preferably operated in the following manner. - When a dose is to be set, the locking
member 11 is switched to its locking state which may be the default position of the lockingmember 11. The user then causes thedose setting member 2 to rotate about the centre axis by turning an outer part 18 of thedose setting member 2. The outer part 18 of thedose setting member 2 is a part which is positioned on the outside of thehousing 8 as illustrated inFig. 2 . Due to the connections between the various parts of the injection device 1 described above, the rotation of thedose setting member 2 about the centre axis causes the intermediate member 16, themain member 15 and thedose indicator barrel 4 to be rotated about the centre axis. Thedrive member 6 is not rotated due to the toothing connection between thedrive member 6 and themain member 15. Since the threadedportion 9 of thedose indicator barrel 4 engages the threaded portion 17 of thehousing 8, and due to themain member 15 engaging the threaded part of thepiston rod 5, thedose indicator barrel 4 and themain member 15/intermediate member 16 will be moved towards each other. This causes thehelical spring 7 to be compressed, thereby storing energy in thespring 7. Thus, as it is the case in the embodiment shown inFig. 1 , the dose is set without causing any changes to the outer appearance of the injection device 1. - The
dose indicator barrel 4 is provided with a set of numerals (not shown). As thedose indicator barrel 4 moves away from the outer part 18 of thedose setting member 2, these numerals will be sequentially visible through awindow 13 in thehousing 8, thereby indicating the dose which has been set. - When the desired dose has been set, actions similar to the ones described above in connection with
Fig. 1 are performed. However, when the lockingmember 11 is switched to its unlocking state the following happens. Thepiston rod 5 is now free to rotate about the centre axis. Due to the energy stored in thehelical spring 7, thedose indicator barrel 4 and themain member 15/intermediate member 16 will be forced away from each other. Due to the threadedportion 9 engaging the threaded portion 17 of thehousing 8, thedose indicator barrel 4 is thereby rotated about the centre axis in a rotational direction which is opposite to the direction in which it was rotated when the dose was set. This, in turn, will cause themain member 15, the intermediate member 16 and thedose setting member 2 to rotate about the centre axis in the same direction. Due to the toothing connection between themain member 15 and thedrive member 6, thedrive member 6 is also caused to rotate about the centre axis, and due to the key/keyway connection between thedrive member 6 and thepiston rod 5, thepiston rod 5 is also caused to rotate about the centre axis. The threaded part of thepiston rod 5 engages a threadedportion 14 of thehousing 8. Therefore the rotational movement causes the piston rod to be moved in a direction parallel to the centre axis and away from the outer part 18 of thedose setting member 2, thereby causing the desired and set dose to be ejected from the injection device 1. - As described above, the injection device 1 is now ready for setting a new dose.
- Alternative embodiments are shown in
Figs. 3 and4 . Compared to the second embodiment shown inFig. 2 , the intermediate member 16 has been omitted whereby the mechanical design of the injection device has been significantly simplified. InFigs. 3 and4 themain member 15 is operatively connected to drivemember 6 viatoothing 19. InFig. 3 the threaded outer surface of thepiston rod 5 engages with a threadedportion 14 of thehousing 8, whereas inFig. 4 the threaded outer surface of thepiston rod 5 engages with a threadedportion 20 of thedrive member 6. - Thus, in the embodiment shown in
Fig. 1 as well as in the embodiment shown inFig. 2 , the ejection of the dose is actually effected by the energy stored in thehelical spring 7 when setting the dose, and the only effort required from the user of the injection device 1 in order to cause the ejection is the switching of the lockingmember 11 from its locking state to its unlocking state. This is very easily done and an ejection can therefore be caused even by persons having reduced motoric skills or reduced finger strength, such as children, elderly people or disabled people.
Claims (13)
- An injection device (1) comprising- a housing (8),- a resilient member (7) adapted to provide a force in the axial direction of the injection device (1), the force being necessary for ejecting a dose from the injection device (1), and- a dose setting member (2) operatively connected to a dose indicator barrel (4) positioned within the housing (8), the dose setting member (2) and the dose indicator barrel (4) being movable relative to each other and cooperating to set the dose to be ejected from the injection device (1), the dose indicator barrel (4) engaging a threaded portion of the housing (8),wherein the dose indicator barrel (4), both during dose setting and during injection, is adapted to undergo a combined rotational and translational movement within the housing (8) and relative to the housing (8).
- An injection device (1) according to claim 1, wherein the dose setting member (2) engages the dose indicator barrel (4), the injection device (1) further comprising- a piston rod (5) having a threaded outer surface with a drive track (21) arranged in a longitudinal direction of the outer surface of the piston rod (5),- a drive member (6) engaging at least part of the drive track (21) of the piston rod (5) and having a threaded inner surface (10) cooperating with a threaded portion (9) arranged on an outer surface of the dose indicator barrel (4), the drive member (6) being adapted to drive and rotate with the piston rod (5) during ejection of a dose from the injection device (1)wherein the housing (8) has a threaded portion (14) cooperating with the threaded outer surface of the piston rod (5) so that rotation of the piston rod (5) results in an axial movement of the piston rod (5).
- An injection device (1) according to claim 1, wherein the dose setting member (2) engages the dose indicator barrel (4), the injection device (1) further comprising- a piston rod (5) having a threaded outer surface with a track arranged in a longitudinal direction of the outer surface of the piston rod (5),- a drive member (6) having a threaded portion cooperating with the threaded outer surface of the piston rod (5), and having a threaded inner surface (10) cooperating with a threaded portion (9) arranged on an outer surface of the dose indicator barrel (4), the drive member (6) being adapted to rotate relative to the piston rod (5) during ejection of a dose from the injection device,wherein the housing (8) engages at least part of the track of the piston rod (5) so that rotation of the drive member (6) results in an axial movement of the piston rod (5).
- An injection device (1) according to claim 1, further comprising- a piston rod (5) having a threaded outer surface with a drive track (21) arranged in a longitudinal direction of the outer surface of the piston rod (5),- a resilient member housing being at least partly defined by the dose indictor barrel (4) in combination with a main member (15), the dose indicator barrel (4) and the main member (15) being movable in relation to each other, the main member (15) having a threaded portion cooperating with the threaded outer surface of the piston rod (5),- a drive member (6) operatively connected to the main member (15) via a toothing (19) so that the drive member (6) is movable in relation to the main member (15) during dose setting but rigidly connected to the main member (15) during ejection of a dose from the injection device, the drive member (6) engaging at least part of the drive track (21) on the outer surface of the piston rod (5),wherein the housing (8) has a threaded portion (14) cooperating with the threaded outer surface of the piston rod (5) so that rotation of the piston rod (5) by the drive member (6) results in an axial movement of the piston rod (5).
- An injection device according to claim 4, further comprising an intermediate part (16) engaging the dose setting member (2) and the main member (15) of the resilient member housing, the intermediate part (16) being adapted to provide a biasing force to the drive member (6) in a direction towards the toothing (19).
- An injection device (1) according to claim 1, further comprising- a piston rod (5) having a threaded outer surface with a drive track (21) arranged in a longitudinal direction of the outer surface of the piston rod (5),- a resilient member housing being at least partly defined by the dose indictor barrel (4) and a main member (15),- a drive member (6) operatively connected to the main member (15) via a toothing (19) in such a way that the drive member (6) is movable in relation to the main member (15) during dose setting but rigidly connected to the main member (15) during ejection of a dose from the injection device, the drive member (6) having threaded portion cooperating with the threaded outer surface of the piston rod (5),wherein the housing (8) engages at least part of the track of the piston rod (5) so that rotation of the drive member (6) results in an axial movement of the piston rod (5).
- An injection device according to any of claims 2, 4 or 5, further comprising a locking member (11) adapted to fixate the piston rod (5) in such a way that no relative rotation of the piston rod (5) and the housing (8) is possible when the locking member (11) is in its locking position.
- An injection device according to claim 7, further comprising a release button adapted for releasing the locking member (11) from its locking position.
- An injection device according to claim 8, wherein the release button is positioned in the distal half of the length of the injection device.
- An injection device according to claim 3 or 6, further comprising a locking member (11) adapted to fixate the drive member (6) in such a way that no relative rotation of the drive member (6) and the housing (8) is possible when the locking member (11) is in its locking position.
- An injection device according to claim 10, further comprising a release button adapted for releasing the locking member (11) from its locking position, the release button being adapted to be released by a user of the injection device.
- An injection device according to claim 11, wherein the release button is positioned in the distal half of the length of the injection device.
- An injection device according to any of the preceding claims, wherein the resilient member (7) comprises a helical spring arranged coaxially with the piston rod (5).
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05799793A EP1804858B1 (en) | 2004-10-21 | 2005-10-20 | Injection device with internal dose indicator |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04077901 | 2004-10-21 | ||
PCT/EP2005/011288 WO2006045529A1 (en) | 2004-10-21 | 2005-10-20 | Injection device with internal dose indicator |
EP05799793A EP1804858B1 (en) | 2004-10-21 | 2005-10-20 | Injection device with internal dose indicator |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1804858A1 EP1804858A1 (en) | 2007-07-11 |
EP1804858B1 true EP1804858B1 (en) | 2009-10-14 |
Family
ID=34928587
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP05799793A Active EP1804858B1 (en) | 2004-10-21 | 2005-10-20 | Injection device with internal dose indicator |
Country Status (7)
Country | Link |
---|---|
US (1) | US8083711B2 (en) |
EP (1) | EP1804858B1 (en) |
JP (1) | JP4990151B2 (en) |
CN (1) | CN101060872B (en) |
AT (1) | ATE445429T1 (en) |
DE (1) | DE602005017171D1 (en) |
WO (1) | WO2006045529A1 (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10004852B2 (en) | 2013-04-10 | 2018-06-26 | Sanofi | Injection device |
US10010679B2 (en) | 2013-04-10 | 2018-07-03 | Sanofi | Injection device |
US10092705B2 (en) | 2013-04-10 | 2018-10-09 | Sanofi | Injection device |
US10124119B2 (en) | 2013-04-10 | 2018-11-13 | Sanofi | Injection device |
US10130772B2 (en) | 2013-04-10 | 2018-11-20 | Sanofi | Injection device |
US10213560B2 (en) | 2013-04-10 | 2019-02-26 | Sanofi | Injection device |
US10238808B2 (en) | 2013-04-10 | 2019-03-26 | Sanofi | Injection device |
US11439500B2 (en) | 2018-12-20 | 2022-09-13 | Alcon Inc. | IOL injector with automatic driver or assisted manual drive force |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6663602B2 (en) | 2000-06-16 | 2003-12-16 | Novo Nordisk A/S | Injection device |
JP3993169B2 (en) | 2002-02-11 | 2007-10-17 | アンタレス・ファーマ・インコーポレーテッド | Intradermal syringe |
ATE444090T1 (en) | 2004-10-21 | 2009-10-15 | Novo Nordisk As | SELECTION MECHANISM FOR A ROTARY PIN |
DE102004059126B4 (en) * | 2004-12-08 | 2014-01-16 | Roche Diagnostics Gmbh | Adapter for injection device |
CN101132820B (en) | 2005-01-24 | 2010-05-19 | 安塔雷斯制药公司 | Prefilled needle assisted jet injector |
WO2006114396A1 (en) | 2005-04-24 | 2006-11-02 | Novo Nordisk A/S | Injection device |
GB0524604D0 (en) | 2005-12-02 | 2006-01-11 | Owen Mumford Ltd | Injection method and apparatus |
GB2434103B (en) | 2006-01-12 | 2009-11-25 | Owen Mumford Ltd | Lancet firing device |
WO2007131013A1 (en) | 2006-05-03 | 2007-11-15 | Antares Pharma, Inc. | Two-stage reconstituting injector |
US9144648B2 (en) * | 2006-05-03 | 2015-09-29 | Antares Pharma, Inc. | Injector with adjustable dosing |
WO2007132019A1 (en) | 2006-05-16 | 2007-11-22 | Novo Nordisk A/S | A gearing mechanism for an injection device |
JP5253387B2 (en) | 2006-05-18 | 2013-07-31 | ノボ・ノルデイスク・エー/エス | Injection device with mode locking means |
CN102895718B (en) | 2006-09-29 | 2015-01-14 | 诺沃—诺迪斯克有限公司 | An injection device with electronic detecting means |
WO2008116766A1 (en) * | 2007-03-23 | 2008-10-02 | Novo Nordisk A/S | An injection device comprising a locking nut |
US9108006B2 (en) | 2007-08-17 | 2015-08-18 | Novo Nordisk A/S | Medical device with value sensor |
CN101909673B (en) | 2007-12-31 | 2012-12-26 | 诺沃-诺迪斯克有限公司 | Electronically monitored injection device |
ES2548447T3 (en) | 2008-03-10 | 2015-10-16 | Antares Pharma, Inc. | Injector safety device |
NZ588808A (en) | 2008-05-02 | 2012-04-27 | Sanofi Aventis Deutschland | Medication delivery device including piston with two threaded sections |
NZ588809A (en) * | 2008-05-02 | 2013-02-22 | Sanofi Aventis Deutschland | Medication delivery device including piston guiding means |
US8376993B2 (en) | 2008-08-05 | 2013-02-19 | Antares Pharma, Inc. | Multiple dosage injector |
GB2465390A (en) | 2008-11-17 | 2010-05-19 | Owen Mumford Ltd | Syringe needle cover remover |
EP2198903A1 (en) | 2008-12-19 | 2010-06-23 | Sanofi-Aventis Deutschland GmbH | Motor mechanism for a drug delivery device and drug delivery device |
EP2198904A1 (en) | 2008-12-19 | 2010-06-23 | Sanofi-Aventis Deutschland GmbH | Interlock mechanism for a drug delivery device and drug delivery device |
EP2208503A1 (en) * | 2009-01-20 | 2010-07-21 | Sanofi-Aventis Deutschland GmbH | Drive assembly and medication delivery device |
DE102009015303B4 (en) * | 2009-03-19 | 2012-10-31 | Ing. Erich Pfeiffer Gmbh | Device for applying a cosmetic powder on a sponge |
AU2010226442A1 (en) | 2009-03-20 | 2011-10-13 | Antares Pharma, Inc. | Hazardous agent injection system |
SE0900371A1 (en) * | 2009-03-24 | 2010-09-25 | Istvan Bartha | Device for distribution of liquid drugs |
BRPI1013156A2 (en) * | 2009-03-31 | 2016-04-05 | Sanofi Aventis Deutschland | spring element for a drug delivery device, use thereof and a drug delivery device. |
AU2010278894B2 (en) | 2009-07-30 | 2014-01-30 | Tandem Diabetes Care, Inc. | Infusion pump system with disposable cartridge having pressure venting and pressure feedback |
GB0918145D0 (en) | 2009-10-16 | 2009-12-02 | Owen Mumford Ltd | Injector apparatus |
EP2536452B1 (en) | 2010-02-18 | 2018-08-29 | Sanofi-Aventis Deutschland GmbH | Auto-injector |
EP2399635A1 (en) | 2010-06-28 | 2011-12-28 | Sanofi-Aventis Deutschland GmbH | Auto-injector |
TWI464003B (en) * | 2010-11-18 | 2014-12-11 | Shl Group Ab | Medicament delivery device |
EP2460552A1 (en) * | 2010-12-06 | 2012-06-06 | Sanofi-Aventis Deutschland GmbH | Drug delivery device with locking arrangement for dose button |
EP2468333A1 (en) | 2010-12-21 | 2012-06-27 | Sanofi-Aventis Deutschland GmbH | Auto-injector |
EP2468330A1 (en) | 2010-12-21 | 2012-06-27 | Sanofi-Aventis Deutschland GmbH | Auto-injector |
USRE48593E1 (en) | 2010-12-21 | 2021-06-15 | Sanofi-Aventis Deutschland Gmbh | Auto-injector |
US9421334B2 (en) * | 2011-03-16 | 2016-08-23 | Becton, Dickinson And Company | Multiple use disposable injection pen |
US9220660B2 (en) | 2011-07-15 | 2015-12-29 | Antares Pharma, Inc. | Liquid-transfer adapter beveled spike |
US8496619B2 (en) | 2011-07-15 | 2013-07-30 | Antares Pharma, Inc. | Injection device with cammed ram assembly |
US9533106B2 (en) | 2011-12-29 | 2017-01-03 | Novo Nordisk A/S | Torsion-spring based wind-up auto injector pen with dial-up/dial-down mechanism |
EP2822618B1 (en) | 2012-03-06 | 2024-01-10 | Antares Pharma, Inc. | Prefilled syringe with breakaway force feature |
EP2833944A4 (en) | 2012-04-06 | 2016-05-25 | Antares Pharma Inc | Needle assisted jet injection administration of testosterone compositions |
US9364610B2 (en) | 2012-05-07 | 2016-06-14 | Antares Pharma, Inc. | Injection device with cammed ram assembly |
US9180242B2 (en) | 2012-05-17 | 2015-11-10 | Tandem Diabetes Care, Inc. | Methods and devices for multiple fluid transfer |
EP2953667B1 (en) | 2013-02-11 | 2019-10-23 | Antares Pharma, Inc. | Needle assisted jet injection device having reduced trigger force |
WO2014164786A1 (en) | 2013-03-11 | 2014-10-09 | Madsen Patrick | Dosage injector with pinion system |
WO2014165136A1 (en) | 2013-03-12 | 2014-10-09 | Antares Pharma, Inc. | Constant volume prefilled syringes and kits thereof |
US10300207B2 (en) * | 2013-03-13 | 2019-05-28 | Antares Pharma, Inc. | Multiple dosage injector with rotating screw dosage system |
US9173998B2 (en) | 2013-03-14 | 2015-11-03 | Tandem Diabetes Care, Inc. | System and method for detecting occlusions in an infusion pump |
TW201505679A (en) | 2013-04-10 | 2015-02-16 | Sanofi Sa | Injection device |
EP2823841A1 (en) | 2013-07-09 | 2015-01-14 | Sanofi-Aventis Deutschland GmbH | Autoinjector |
DK3041532T3 (en) * | 2013-09-03 | 2018-10-29 | Sanofi Sa | DRIVE DEVICE FOR A PHARMACEUTICAL ADMINISTRATION AND PHARMACEUTICAL ADMINISTRATION, INCLUDING A DRIVE DEVICE |
WO2015090320A2 (en) | 2013-12-18 | 2015-06-25 | Cpu Innovation | Dose delivery device with improved handling |
EP2923714A1 (en) | 2014-03-28 | 2015-09-30 | Sanofi-Aventis Deutschland GmbH | Autoinjector triggered by skin contact |
CN107106778A (en) * | 2015-01-08 | 2017-08-29 | 诺和诺德股份有限公司 | The medicament injection apparatus of indicator system is emptied with vision content thing |
EP4332516A2 (en) | 2015-07-12 | 2024-03-06 | Patients Pending Ltd. | Cover for a liquid delivery system with intergrated plunger position sensing, and corresponding method |
PL239937B1 (en) * | 2015-12-11 | 2022-01-31 | Copernicus Spolka Z Ograniczona Odpowiedzialnoscia | Control and drive system for the device intended for injection of constant dose of a pharmaceutical and the device equipped with such a system |
WO2018111709A1 (en) * | 2016-12-15 | 2018-06-21 | Eli Lilly And Company | Medication delivery device with sensing system |
CN110234379B (en) * | 2017-02-01 | 2023-01-03 | 诺和诺德股份有限公司 | Rotary dose sensing module for and in a disposable pen-type drug delivery device |
US20190022330A1 (en) * | 2017-07-21 | 2019-01-24 | Verily Life Sciences Llc | Strain based dosage measurement |
WO2019058382A1 (en) | 2017-09-19 | 2019-03-28 | Bharat Serums And Vaccines Ltd | An automated multi-use injecting system for administration of injectable medicaments |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8809115D0 (en) | 1988-04-18 | 1988-05-18 | Turner R C | Syringes |
AU748277B2 (en) * | 1998-01-30 | 2002-05-30 | Novo Nordisk A/S | An injection syringe |
US6673035B1 (en) * | 1999-10-22 | 2004-01-06 | Antares Pharma, Inc. | Medical injector and medicament loading system for use therewith |
GB0007071D0 (en) * | 2000-03-24 | 2000-05-17 | Sams Bernard | One-way clutch mechanisms and injector devices |
US6899699B2 (en) * | 2001-01-05 | 2005-05-31 | Novo Nordisk A/S | Automatic injection device with reset feature |
GB0304824D0 (en) * | 2003-03-03 | 2003-04-09 | Dca Internat Ltd | Improvements in and relating to a pen-type injector |
-
2005
- 2005-10-20 JP JP2007537216A patent/JP4990151B2/en not_active Expired - Fee Related
- 2005-10-20 WO PCT/EP2005/011288 patent/WO2006045529A1/en active Application Filing
- 2005-10-20 EP EP05799793A patent/EP1804858B1/en active Active
- 2005-10-20 US US11/665,485 patent/US8083711B2/en not_active Expired - Fee Related
- 2005-10-20 DE DE602005017171T patent/DE602005017171D1/en active Active
- 2005-10-20 AT AT05799793T patent/ATE445429T1/en not_active IP Right Cessation
- 2005-10-20 CN CN2005800396154A patent/CN101060872B/en not_active Expired - Fee Related
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10004852B2 (en) | 2013-04-10 | 2018-06-26 | Sanofi | Injection device |
US10010679B2 (en) | 2013-04-10 | 2018-07-03 | Sanofi | Injection device |
US10092705B2 (en) | 2013-04-10 | 2018-10-09 | Sanofi | Injection device |
US10124119B2 (en) | 2013-04-10 | 2018-11-13 | Sanofi | Injection device |
US10130772B2 (en) | 2013-04-10 | 2018-11-20 | Sanofi | Injection device |
US10213560B2 (en) | 2013-04-10 | 2019-02-26 | Sanofi | Injection device |
US10238808B2 (en) | 2013-04-10 | 2019-03-26 | Sanofi | Injection device |
US11439500B2 (en) | 2018-12-20 | 2022-09-13 | Alcon Inc. | IOL injector with automatic driver or assisted manual drive force |
Also Published As
Publication number | Publication date |
---|---|
US20080188797A1 (en) | 2008-08-07 |
WO2006045529A1 (en) | 2006-05-04 |
CN101060872A (en) | 2007-10-24 |
ATE445429T1 (en) | 2009-10-15 |
CN101060872B (en) | 2010-05-05 |
DE602005017171D1 (en) | 2009-11-26 |
JP2008516713A (en) | 2008-05-22 |
JP4990151B2 (en) | 2012-08-01 |
EP1804858A1 (en) | 2007-07-11 |
US8083711B2 (en) | 2011-12-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1804858B1 (en) | Injection device with internal dose indicator | |
EP1996260B1 (en) | An injection device having a gearing arrangement | |
CA2681023C (en) | An injection device comprising a locking nut | |
JP4350525B2 (en) | Drug dispensing device with gear set giving mechanical advantages | |
JP4970282B2 (en) | Automatic injection device with release mechanism on top | |
JP6423362B2 (en) | Medical injection system with dose collection function | |
US10159802B2 (en) | Medicament delivery device | |
US20090137964A1 (en) | Injection device with visual end-of-content indication | |
US10022501B2 (en) | Medicament delivery device | |
JP6961681B2 (en) | Drug delivery device with overtorque protection mechanism | |
WO2015090320A2 (en) | Dose delivery device with improved handling | |
JP2018519949A (en) | Drug delivery device with end-of-dose trigger arrangement | |
TW201505677A (en) | Dispensing speed control mechanism and injection device | |
US11331433B2 (en) | Drive arrangement with rotationally geared drive rod | |
US11633540B2 (en) | Spring straining mechanism for torsion spring based device | |
WO2015091819A1 (en) | Drug delivery device with mechanical feed-forward interface |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20070521 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR |
|
TPAC | Observations filed by third parties |
Free format text: ORIGINAL CODE: EPIDOSNTIPA |
|
DAX | Request for extension of the european patent (deleted) | ||
17Q | First examination report despatched |
Effective date: 20080307 |
|
GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
GRAS | Grant fee paid |
Free format text: ORIGINAL CODE: EPIDOSNIGR3 |
|
GRAA | (expected) grant |
Free format text: ORIGINAL CODE: 0009210 |
|
AK | Designated contracting states |
Kind code of ref document: B1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR |
|
REG | Reference to a national code |
Ref country code: GB Ref legal event code: FG4D |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: EP |
|
REG | Reference to a national code |
Ref country code: IE Ref legal event code: FG4D |
|
REF | Corresponds to: |
Ref document number: 602005017171 Country of ref document: DE Date of ref document: 20091126 Kind code of ref document: P |
|
LTIE | Lt: invalidation of european patent or patent extension |
Effective date: 20091014 |
|
NLV1 | Nl: lapsed or annulled due to failure to fulfill the requirements of art. 29p and 29m of the patents act | ||
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: IS Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20100214 Ref country code: FI Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20091014 Ref country code: LT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20091014 Ref country code: SE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20091014 Ref country code: PT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20100215 Ref country code: ES Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20100125 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: SI Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20091014 Ref country code: PL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20091014 Ref country code: LV Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20091014 Ref country code: MC Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20091031 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: BE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20091014 Ref country code: AT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20091014 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: DK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20091014 Ref country code: BG Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20100114 Ref country code: RO Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20091014 Ref country code: EE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20091014 |
|
PLBE | No opposition filed within time limit |
Free format text: ORIGINAL CODE: 0009261 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: SK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20091014 Ref country code: CZ Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20091014 |
|
26N | No opposition filed |
Effective date: 20100715 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: GR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20100115 Ref country code: IE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20091020 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: IT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20091014 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LU Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20091020 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: HU Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20100415 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: TR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20091014 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: CY Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20091014 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: NL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20091014 |
|
REG | Reference to a national code |
Ref country code: FR Ref legal event code: PLFP Year of fee payment: 12 |
|
REG | Reference to a national code |
Ref country code: FR Ref legal event code: PLFP Year of fee payment: 13 |
|
REG | Reference to a national code |
Ref country code: FR Ref legal event code: PLFP Year of fee payment: 14 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: FR Payment date: 20200917 Year of fee payment: 16 Ref country code: GB Payment date: 20200921 Year of fee payment: 16 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: CH Payment date: 20200917 Year of fee payment: 16 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: DE Payment date: 20200917 Year of fee payment: 16 |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R119 Ref document number: 602005017171 Country of ref document: DE |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: PL |
|
GBPC | Gb: european patent ceased through non-payment of renewal fee |
Effective date: 20211020 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: GB Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20211020 Ref country code: DE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20220503 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LI Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20211031 Ref country code: CH Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20211031 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: FR Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20211031 |